公开(公告)号：US3723250A

公开(公告)日：1973-03-27

申请号：US3723250D

申请日：1968-09-23

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： AUNSTRUP KNUD ,  ANDRESEN OTTO ,  OUTTRUP HELLE

IPC: A61K8/66 ,  A61Q9/04 ,  C11D3/386 ,  C12N9/54 ,  C14C1/06 ,  C12D13/10

CPC classification number: A61Q9/04 ,  A61K8/66 ,  C11D3/386 ,  C12N9/54 ,  C14C1/065 ,  Y10S435/832

Abstract: The invention relates to enzyme preparations containing novel proteolytic enzymes produced by cultivation of novel species of the genus Bacillus and showing useful activity at high alkalinities. The invention also relates to production of the novel proteolytic enzymes by cultivation of the novel species of the genus Bacillus in a nutrient medium having a pH-value within the range of 7 to 12. Finally the invention relates to a process of isolating the novel species referred to by effecting the isolation on nutrient media having a pH-value within the range of 9 to 11. The novel enzymes are particularly useful in detergent and dehairing compositions.

Abstract translation: 本发明涉及含有通过培养芽孢杆菌属新品种而产生的新型蛋白水解酶的酶制剂，并且在高浓度条件下显示出有用的活性。 本发明还涉及通过在pH值在7至12范围内的营养培养基中培养芽孢杆菌属的新物种来生产新的蛋白水解酶。最后本发明涉及一种分离新物种的方法 通过对pH值在9至11范围内的营养介质进行隔离来提及。新型酶特别可用于洗涤剂和脱毛组合物中。

公开(公告)号：US3716578A

公开(公告)日：1973-02-13

申请号：US3716578D

申请日：1970-03-18

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： JOHNK P

IPC: C07C69/145 ,  C07D309/12 ,  C07C69/02

CPC classification number: C07D309/12 ,  C07C2603/26

Abstract: IN WHICH R is hydrogen or OR1; R1 is hydrogen, benzyl, lower alkyl or cycloalkyl; R2 is hydrogen, lower alkyl, cycloalkyl, cycloalkyl containing a hetero atom, or OCR3; R3 is hydrogen, lower alkyl or CH2SO2X; X is chlorine, OR4, or OMe; R4 is hydrogen or lower alkyl; R5 and R6 are hydrogen or lower alkyl, or R5 and R6 together with the attached N-atom form a heterocyclic ring; and Me is an alkali metal or an earth alkali metal atom, useful anti-fertility compositions for oral administration, as well as processes for their production.

Novel hexahydrophenanthrene derivatives of the general formula

Abstract translation: 新型的六氢菲衍生物，其通式为：其中R为氢或OR 1; R1是氢，苄基，低级烷基或环烷基; R2是氢，低级烷基，环烷基，含有杂原子的环烷基，或OCR3; R3是氢，低级烷基或CH2SO2X; X是氯，OR4或OMe; R4是氢或低级烷基; R5和R6是氢或低级烷基，或R5和R6与连接的N-原子一起形成杂环; Me是碱金属或碱土金属原子，用于口服给药的有用的抗生育组合物，以及它们的生产方法。

公开(公告)号：US3674643A

公开(公告)日：1972-07-04

申请号：US3674643D

申请日：1968-11-01

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： AUNSTRUP KNUD ,  ANDRESEN OTTO ,  OUTTRUP HELLE

IPC: C02F3/34 ,  C11D3/386 ,  C12N9/54 ,  C12D13/10

CPC classification number: C12N9/54 ,  C02F3/34 ,  C02F3/342 ,  C11D3/386 ,  Y10S435/832 ,  Y10S435/839

Abstract: A method of making proteolytic enzyme preparations having maximum activity at high alkalinity by submerged aerobic cultivation of strains of Bacillus alcalophilus in a nutrient medium containing assimilable carbon and nitrogen sources, while maintaining the pH-value of the nutrient medium between 7.5 and 11.

Abstract translation: 一种制备蛋白水解酶制剂的方法，其通过在含有可同化碳和氮源的营养培养基中浸没嗜碱芽孢杆菌菌株浸没好氧培养，在高碱度下具有最大活性，同时保持营养培养基的pH值在7.5和11之间。

公开(公告)号：US3346573A

公开(公告)日：1967-10-10

申请号：US48225565

申请日：1965-08-24

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： FABRICIUS IMRE L

IPC: C07C209/18 ,  C07D209/86 ,  C07D219/14 ,  C07D223/26 ,  C07D223/28 ,  C07D265/38 ,  C07D279/28

CPC classification number: C07D209/86 ,  C07C209/18 ,  C07D219/14 ,  C07D223/26 ,  C07D223/28 ,  C07D265/38 ,  C07D279/28

公开(公告)号：US3332852A

公开(公告)日：1967-07-25

申请号：US44133865

申请日：1965-03-19

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： JOHANNES JENSEN VILLY

IPC: C12N9/68

CPC classification number: C12N9/6435 ,  C12Y304/21007 ,  Y10S435/816

公开(公告)号：US3230254A

公开(公告)日：1966-01-18

申请号：US37207964

申请日：1964-06-02

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： GERT SVANHOLM

IPC: C07C233/00 ,  C12P29/00

CPC classification number: C07C233/00 ,  C12P29/00 ,  Y10S435/803

公开(公告)号：US3161634A

公开(公告)日：1964-12-15

申请号：US16027861

申请日：1961-12-18

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： WILLIAM ANDERSEN

IPC: C07D499/00 ,  C07D499/60

CPC classification number: C07D499/00

公开(公告)号：US3108592A

公开(公告)日：1963-10-29

申请号：US19918162

申请日：1962-05-31

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： VAGN HASSING ,  HENNING JUNCHER ,  ERIK RASMUSSEN KUND

IPC: A61M5/28

CPC classification number: A61M5/28

公开(公告)号：US3091573A

公开(公告)日：1963-05-28

申请号：US75163658

申请日：1958-07-29

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： JPHIRGEN SCHLICHTKRULL

IPC: A61K38/00 ,  C07K14/625

CPC classification number: C07K14/625 ,  A61K38/00

公开(公告)号：US2882203A

公开(公告)日：1959-04-14

申请号：US29533752

申请日：1952-06-24

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： KARL PETERSEN ,  JORGEN SCHLICHTKRULL ,  KNUD HALLAS-MOLLER

IPC: A61K38/28

CPC classification number: A61K38/28