公开(公告)号：US20230115463A1

公开(公告)日：2023-04-13

申请号：US17959327

申请日：2022-10-04

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel OFFEN ,  Felix BENNINGER ,  Nataly YOM TOV

IPC: A61K47/54 ,  A61K9/127 ,  A61K35/28 ,  A61K31/05 ,  A61P31/00 ,  A61P25/28 ,  A61P25/08

Abstract: Compositions comprising a cell-derived particle associated with Cannabidiol (CBD), and uses thereof in treating medical conditions that can benefit from Cannabidiol (CBD) are provided.

公开(公告)号：US11619634B2

公开(公告)日：2023-04-04

申请号：US16640392

申请日：2018-08-20

Applicant: Savicell Diagnostic Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Giora Davidovits ,  Fernando Patolsky ,  David Eyal Davidovits ,  Irit Arbel ,  Shoval Tirman ,  Aviv Lutaty ,  Tali Scienmann ,  Reuven Tirosh ,  Hagit Peretz-Soroka

IPC: G01N33/574 ,  G01N33/50 ,  A61K45/06

Abstract: A method of diagnosing lung cancer in a subject-in-need thereof is provided. The method comprises: (a) providing a biological sample of the subject which comprises peripheral blood mononuclear cells (PBMCs); (b) in vitro contacting the PBMCs with a stimulant selected from the group consisting of the stimulants listed in Tables 3 and 4; and (c) measuring metabolic activity of the PBMCs having been contacted according to (b), wherein a statistically significant change in the metabolic activity of the PBMCs as compared to a control sample is indicative of lung cancer.

公开(公告)号：US11613605B2

公开(公告)日：2023-03-28

申请号：US17023463

申请日：2020-09-17

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Moshe Kol ,  Tomer Rosen

IPC: C08G63/08 ,  C08G63/82 ,  C07F3/02 ,  C07D213/38 ,  B01J31/18

Abstract: Novel processes of preparing block polyester copolymers while precisely controlling the stereoconfiguration (e.g., tacticity), chemical composition and/or length of each unit (block) are provided. Block polyester copolymers featuring desirable combinations of two or more blocks featuring different stereoconfiguration (e.g., tacticity), chemical composition and/or length, including triblock, tetrablock and higher block copolymers are also provided. A novel family of organometallic magnesium complexes and uses thereof in preparing polyesters and block polyester copolymers are also provided.

公开(公告)号：US11544061B2

公开(公告)日：2023-01-03

申请号：US17131034

申请日：2020-12-22

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  Ramot at Tel Aviv University Ltd.

Inventor： Malte Johannes Rasch ,  Oguzhan Murat Onen ,  Tayfun Gokmen ,  Chai Wah Wu ,  Mark S. Squillante ,  Tomasz J. Nowicki ,  Wilfried Haensch ,  Lior Horesh ,  Vasileios Kalantzis ,  Haim Avron

IPC: G06F13/00 ,  G06F17/16 ,  G06F9/30 ,  G06F9/50

Abstract: Methods and systems for solving a linear system include setting resistances in an array of settable electrical resistances in accordance with values of an input matrix. A series of input vectors is applied to the array as voltages to generate a series of respective output vectors. Each input vector in the series of vectors is updated based on comparison of the respective output vectors to a target vector. A solution of a linear system is determined that includes the input matrix based on the updated input vectors.

公开(公告)号：US20220390471A1

公开(公告)日：2022-12-08

申请号：US17831232

申请日：2022-06-02

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ehud GAZIT ,  Dana LAOR ,  Dorin SADE YAZDI

IPC: G01N33/68

Abstract: The present disclosure provides yeast screening system/s and methods for screening of candidate therapeutic compound/s for treating, at least one proteniopathy and/or protein misfolding disorder. More specifically, the present disclosure provides systems and methods for identifying a therapeutic compound that inhibit Hcy fibril formation and uses thereof in treating Alzheimer's disease.

公开(公告)号：US11519914B2

公开(公告)日：2022-12-06

申请号：US16480342

申请日：2018-01-25

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Esther Rabizadeh

IPC: G01N33/86 ,  G01N33/574

Abstract: A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.

公开(公告)号：US20220372622A1

公开(公告)日：2022-11-24

申请号：US17305209

申请日：2021-07-01

Applicant: MELLANOX TECHNOLOGIES, LTD. ,  BAR-ILAN UNIVERSITY ,  RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  SIMTAL NANO-COATINGS LTD

Inventor： Elad Mentovich ,  Yaniv ROTEM ,  Yaakov GRIDISH ,  Doron NAVEH ,  Chen STERN ,  Yosi BEN-NAIM ,  Ariel ISMACH ,  Eran BAR-RABI ,  Tal KAUFMAN

IPC: C23C16/455 ,  F15D1/06 ,  C23C16/46

Abstract: A first and a second flange assembly configured for facilitating uniform and laminar flow in a system are provided. The first flange assembly includes a first flange body configured to introduce a gas into a chamber. The first flange assembly includes a plurality of outlet tubes disposed on an interior surface of the first flange body and a plurality of inlet tubes disposed on an exterior surface of the first flange body and in fluid communication with the plurality of outlet tubes. The second flange assembly includes a second flange body configured to remove the gas from the chamber. The second flange assembly includes a plurality of through holes extending from an interior surface to an exterior surface of the second flange body and a plurality of exit tubes extending from the exterior surface of the second flange body and in fluid communication with the plurality of through holes.

公开(公告)号：US11500963B2

公开(公告)日：2022-11-15

申请号：US17060883

申请日：2020-10-01

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  Ramot at Tel Aviv University Ltd.

Inventor： Shashanka Ubaru ,  Vasileios Kalantzis ,  Lior Horesh ,  Mark S. Squillante ,  Haim Avron

IPC: G06F17/16 ,  G06G7/16 ,  G06F7/57

Abstract: A method of performing Principal Component Analysis is provided. The method includes receiving, by a computing device, evolving data for processing/visualization. The method further includes, by the computing device, a dimensionality for reducing of the evolving data using the PCA, wherein the PCA is performed on analog crossbar hardware. The method also includes using, by the computing device, the evolving data for visualization having the dimensionality thereof reduced by the principal component analysis for a further application.

公开(公告)号：US20220281960A1

公开(公告)日：2022-09-08

申请号：US17627167

申请日：2019-07-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Natalia FREUND ,  Ronen WEISS

IPC: C07K16/12 ,  A61P31/06 ,  C12P21/00 ,  C12N1/20 ,  C12N15/70 ,  G01N33/569

Abstract: A human antibody comprising an antigen binding domain which binds PstS1 of Mycobacterium tuberculosis (TB) for use in preventing or treating TB infection in a subject in need thereof is provided. Also provided are vaccine compositions and conjugates of such antibodies.

公开(公告)号：US11427531B2

公开(公告)日：2022-08-30

申请号：US16754386

申请日：2018-10-09

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Asher Peretz ,  Bernard Attali

IPC: C07C233/22 ,  C07C237/20 ,  A61K31/165 ,  A61P25/02 ,  A61P43/00

Abstract: Novel compounds usable in modulating an activity or function of a voltage-dependent potassium channel and/or of TRPV1 are provided. The compounds are represented by Formula I as described and defined in the specification.