-
公开(公告)号：US20110137037A1
公开(公告)日：2011-06-09
申请号：US12971649
申请日：2010-12-17
Applicant: Steven Durrant , Jean-Damien Charrier , John Studley
Inventor： Steven Durrant , Jean-Damien Charrier , John Studley
IPC: C07D498/04
CPC classification number: C07D498/04
Abstract: This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors.This invention also relates to the processes for preparing these prodrugs of caspase inhibitors.This invention further relates to pharmaceutical compositions comprising said prodrugs and to the use thereof for the treatment of diseases related to inflammatory or degenerative conditions.
Abstract translation: 本发明涉及包含呋喃并[3,2-d]恶唑啉-5-酮部分的胱天蛋白酶抑制剂的前体药物，其在特定条件下可转化为生物活性化合物，特别是胱天蛋白酶抑制剂。 本发明还涉及制备这些半胱天冬酶抑制剂前药的方法。 本发明还涉及包含所述前药的药物组合物及其用于治疗与炎性或退行性疾病相关的疾病的用途。
-
公开(公告)号：US07879891B2
公开(公告)日：2011-02-01
申请号：US11489939
申请日：2006-07-20
Applicant: Steven Durrant , Jean-Damien Charrier , John Studley
Inventor： Steven Durrant , Jean-Damien Charrier , John Studley
IPC: C07D498/14 , A61K31/4725 , A61K31/4439 , A61K31/424
CPC classification number: C07D498/04
Abstract: This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors.This invention also relates to the processes for preparing these prodrugs of caspase inhibitors.This invention further relates to pharmaceutical compositions comprising said prodrugs and to the use thereof for the treatment of diseases related to inflammatory or degenerative conditions.
Abstract translation: 本发明涉及包含呋喃并[3,2-d]恶唑啉-5-酮部分的胱天蛋白酶抑制剂的前体药物，其在特定条件下可转化为生物活性化合物，特别是胱天蛋白酶抑制剂。 本发明还涉及制备这些半胱天冬酶抑制剂前药的方法。 本发明还涉及包含所述前药的药物组合物及其用于治疗与炎性或退行性疾病相关的疾病的用途。
-
公开(公告)号：US20100105914A1
公开(公告)日：2010-04-29
申请号：US12630350
申请日：2009-12-03
Applicant: Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John R. Studley , Martin Trudeau , Adam Looker
Inventor： Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John R. Studley , Martin Trudeau , Adam Looker
IPC: C07D405/14 , C07D417/14 , C07D405/12
CPC classification number: C07D405/12 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/12 , C07K5/0202 , Y02A50/385 , Y02A50/387 , Y02A50/389
Abstract: The present invention provides a compound of formula I: wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula I, and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
Abstract translation: 本发明提供式I化合物：其中变量如本文所定义。 本发明还提供制备式I化合物的方法及其中间体，包含这些化合物的药物组合物，以及使用该化合物和组合物的方法。
-
公开(公告)号：US07691885B2
公开(公告)日：2010-04-06
申请号：US11511895
申请日：2006-08-29
Applicant: Jean-Damien Charrier , Sharn Ramaya , Steven Durrant
Inventor： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant
IPC: A61K31/4439 , C07D403/04
CPC classification number: C07D401/04 , C07D401/12
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
-
公开(公告)号：US20070219205A1
公开(公告)日：2007-09-20
申请号：US11656876
申请日：2007-01-23
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/519 , A61K31/498 , A61K31/4745 , C07D487/04 , C07D471/02
CPC classification number: C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
-
Patent Agency Ranking
公开(公告)号：US20070179156A1
公开(公告)日：2007-08-02
申请号：US11511086
申请日：2006-08-28
Applicant: Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
Inventor： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
IPC: A61K31/497 , A61K31/4709 , A61K31/444 , C07D401/14 , C07D403/14
CPC classification number: C07D213/64 , C07D401/14 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
-
公开(公告)号：US20060183911A1
公开(公告)日：2006-08-17
申请号：US11304057
申请日：2005-12-15
Applicant: Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
Inventor： Jean-Damien Charrier , Steven Durrant , Sharn Ramaya , Juan-Miguel Jimenez , Alistair Rutherford
IPC: A61K31/44 , C07D401/00
CPC classification number: C07D401/14 , C07D213/22 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention and intermediate compounds useful in these processes.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法和用于这些方法的中间体化合物。
-
公开(公告)号：US20050233979A1
公开(公告)日：2005-10-20
申请号：US11069895
申请日：2005-02-28
Applicant: Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John Studley , Martin Trudeau , Adam Looker
Inventor： Jean-Damien Charrier , Steven Durrant , Michael Mortimore , Michael O'Donnell , Alistair Rutherford , Sharn Ramaya , John Studley , Martin Trudeau , Adam Looker
IPC: A61K38/04 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04 , C07D45/14
CPC classification number: C07D405/12 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/12 , C07K5/0202 , Y02A50/385 , Y02A50/387 , Y02A50/389
Abstract: The present invention provides a compound of formula wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula I, and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
Abstract translation: 本发明提供了式的化合物，其中变量如本文所定义。 本发明还提供制备式I化合物的方法及其中间体，包含这些化合物的药物组合物，以及使用该化合物和组合物的方法。
-
公开(公告)号：US08445681B2
公开(公告)日：2013-05-21
申请号：US13193739
申请日：2011-07-29
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily , Jingrong Cao
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily , Jingrong Cao
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/02 , C07D471/04 , C07D487/02
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
-
公开(公告)号：US08399478B2
公开(公告)日：2013-03-19
申请号：US13033872
申请日：2011-02-24
Applicant: Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegiel , Sharn Ramaya , Shazia Sadiq
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegiel , Sharn Ramaya , Shazia Sadiq
IPC: A61K31/44
CPC classification number: C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase represented by formula (I): or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作由式（I）表示的蛋白激酶抑制剂的化合物或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
-
-
-
-
-
-
-
-
-
Search Results
56
records
(took 0.032 seconds)
