公开(公告)号：US20200317648A1

公开(公告)日：2020-10-08

申请号：US16861075

申请日：2020-04-28

Applicant: Temple University Of The Commonwealth System of Higher Education

Inventor： Daniel J. Canney ,  Benjamin E. Blass ,  Rong Gao ,  Magid Abou-Gharbia

IPC: C07D405/12 ,  C07D405/06 ,  C07D307/94 ,  C07D307/33

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US20200282025A1

公开(公告)日：2020-09-10

申请号：US16875271

申请日：2020-05-15

Applicant: Temple University - of the Commonwealth System of Higher Education

Inventor： Kamel Khalili

IPC: A61K38/46 ,  C12N15/113 ,  A61K48/00 ,  A61P31/18 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

Abstract: Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to one or more target nucleic acid sequences in a retrovirus genome.

公开(公告)号：US20200205665A1

公开(公告)日：2020-07-02

申请号：US16634445

申请日：2018-07-26

Applicant: Temple University - Of The Commonwealth System Of Higher Education

Inventor： Chang-Hee WON

IPC: A61B5/00 ,  H04M1/04 ,  G06T7/00 ,  G01N3/08 ,  G01N19/00

Abstract: A mobile-platform imaging device uses compression of the target region to generate an image of an object. A tactile sensor has an optical waveguide with a flexible, transparent first layer. Light is directed into the waveguide. Light is scattered out of the first layer when the first layer is deformed. The first layer is deformed by the tactile sensor being pressed against the object, A force sensor detects a force pressing the tactile sensor against the object and outputs corresponding force information. A first communication unit receives the force information from the force sensor. A receptacle holds a mobile device with a second communication unit and an imager that can generate image information using light scattered out of the first layer. The first communication unit communicates with the second communication unit and the mobile device communicates with an external network.

公开(公告)号：US10690668B2

公开(公告)日：2020-06-23

申请号：US14375263

申请日：2013-01-29

Applicant: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Kamel Khalili ,  Ilker K. Sariyer

IPC: G01N33/53 ,  G01N33/569

Abstract: The invention provides methods of detection and monitoring of polyomavirus reactivation and active polyomavirus infections using a biological fluid sample. Also provided are methods of risk assessment and risk monitoring of developing a polyomavirus-associated disease.

公开(公告)号：US20200090104A1

公开(公告)日：2020-03-19

申请号：US16286910

申请日：2019-02-27

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Munir Y. Mandviwalla ,  Manoj J. Chacko ,  Laurel A. Miller

IPC: G06Q10/06

Abstract: A method for quantifying the professional development of a subject includes storing, on a non-transitory computer-readable medium, a base professional development score for a subject, receiving a submission pertaining to a professional development activity of the subject, approving the submission based on at least one professional development criteria, assigning a value to the approved submission, adjusting the base professional development score according to the approved submission value, comparing the adjusted professional development score to a threshold value, and determining that the subject has achieved a professional development goal when the adjusted professional development score is greater than the threshold value. A system for quantifying the professional development, a system for network-assisted recruitment, and a system for network-assisted learning are also described.

公开(公告)号：US10544117B2

公开(公告)日：2020-01-28

申请号：US15510152

申请日：2015-09-10

Applicant: Temple University—Of the Commonwealth System of Higher Education

Inventor： Daniel J. Canney ,  Benjamin E. Blass ,  Rong Gao ,  Magid Abou-Gharbia

IPC: C07D405/12 ,  A61K31/496 ,  C07D307/33 ,  C07D307/94 ,  C07D405/06

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives of formula (I) having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US20200018745A1

公开(公告)日：2020-01-16

申请号：US16334808

申请日：2017-09-20

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Jay Rappaport ,  Sarah Vakili

IPC: G01N33/50 ,  C12N5/0786 ,  C07K14/73 ,  C07K14/735 ,  C07K14/705

Abstract: The invention provides monocytes expressing CD16 and CD163 and experimental system for drug screening or evaluating drug candidates where the modulation of CD16 and CD163 is desired.

公开(公告)号：US20190352272A1

公开(公告)日：2019-11-21

申请号：US16479317

申请日：2018-01-19

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Wayne C. Childers ,  Magid A. Abou-Gharbia ,  George C. Morton ,  Jean-Pierre J. Issa ,  Hanghang Zhang

IPC: C07D277/42 ,  C07D417/06 ,  A61P35/00

Abstract: The present invention includes novel bridged bicycloalkyl-substituted aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

公开(公告)号：US20190321298A1

公开(公告)日：2019-10-24

申请号：US16459700

申请日：2019-07-02

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： David B. Lebo ,  Suzan Owaisat

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/192 ,  A61K31/734 ,  A61K9/00 ,  A61K31/522 ,  A61K31/09

Abstract: An alginate and stearic acid composition is described, including methods of molding it into tablets further comprising a drug, and methods of controlling the drug release from the tablets.

公开(公告)号：US20190256844A1

公开(公告)日：2019-08-22

申请号：US16308348

申请日：2017-05-26

Applicant: Temple University - of the Commonwealth System of Higher Education

Inventor： Kamel Khalili ,  Hassen Wollebo

IPC: C12N15/11 ,  C12N9/22 ,  A61K31/7088 ,  A61K38/46 ,  A61P31/20

Abstract: Compositions that specifically cleave target sequences in Hepadnaviridae, for example Hepatitis B virus (HBV) include nucleic acids encoding a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in HBV. These compositions are administered to a subject for eradicating an infection, latent or otherwise, or at risk for contracting HBV infection.