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公开(公告)号：US20250135032A1
公开(公告)日：2025-05-01
申请号：US18834040
申请日：2023-01-30
Inventor： Kamel KHALILI , Chen CHEN , Shuren LIAO , Hong LIU
IPC: A61K48/00 , A61K38/46 , C12N15/11 , C12N15/86 , C12Q1/6883
Abstract: Compositions include gene-editing complexes for the treatment of myopathies, cancer and neurodegenerative diseases. Specifically, the disclosure provides methods of identifying in a subject's biological sample, ‘at least one Bcl2-associated anthanogene 3 (BAGS) genetic mutation as compared to a control BAGS nucleic acid sequence, and administering to the subject a therapeutically effective amount of a gene-editing complex, wherein the gene-editing complex corrects the bag3 mutation to a wild-type bag3, thereby, treating the subject.
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公开(公告)号：US12282147B2
公开(公告)日：2025-04-22
申请号：US17780044
申请日：2020-11-25
Inventor： Weidong Yang , Andrew Ruba
Abstract: The present invention discloses a photon enhancement apparatus comprising a reflective component and 4f coherent imaging system, which increases a photon collection efficiency. The present invention also provides a microscope comprising said photon enhancement apparatus and methods of improving photon collection efficiency, signal-to-noise ratio, and/or optical resolution using the said photon enhancement apparatus.
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公开(公告)号：US12251429B2
公开(公告)日：2025-03-18
申请号：US17017037
申请日：2020-09-10
Inventor： Kamel Khalili , Wenhui Hu , Yonggang Zhang
Abstract: Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to one or more target nucleic acid sequences in a retrovirus genome.
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公开(公告)号：US20250082778A1
公开(公告)日：2025-03-13
申请号：US18921813
申请日：2024-10-21
Inventor： Kamel Khalili , Wenhui Hu , Hassen Wollebo
IPC: A61K48/00 , C12N9/22 , C12N15/113 , C12N15/63
Abstract: The present invention includes methods and compositions for elimination of polyomaviruses, such as John Cunningham Virus (JVC), from host cells, and the treatment of polyomavirus related diseases, such as progressive multifocal leukoencephalopathy (PML). The compositions include isolated nucleic acid sequences comprising an CRISPR-associated endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a polyomavirus.
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公开(公告)号：US20250057808A1
公开(公告)日：2025-02-20
申请号：US18789242
申请日：2024-07-30
Inventor： Magid Abou-Gharbia , Wayne Childers , Youssef Sari
IPC: A61K31/397 , A61K31/498 , A61K31/695 , A61P25/32
Abstract: A method is provided for treating or preventing alcohol dependence and/or an alcohol associated disease or condition. Such a method includes administrating a pharmaceutical composition comprising an effective amount of a compound having formula (I): or a hydrates, a solvate, a pharmaceutically acceptable salt, a prodrug, or a complex thereof to a subject in need thereof. For example, (3S, 4R)-3-((R)-(1-hydroxy-ethyl)-4-((R)-[1-methyl-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-azetidin-2-one (MC-100093) is an exemplary compound. The composition can be used to prevent or treat alcohol dependence, attenuate alteration in glutamate transporters, reduce alcohol associated neuroinflammation, and treat or prevent alcohol associated fatty liver diseases.
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Patent Agency Ranking
6.发明授权公开(公告)号：US12207934B2
公开(公告)日：2025-01-28
申请号：US16479910
申请日：2018-01-16
Inventor： William Geoffrey Wright
Abstract: A method of assessing the balance impairment of a subject includes the steps of presenting the subject with a static scene on a display, collecting a first set of orientation measurements, presenting the subject with an unstable scene on a display, collecting a second set of orientation measurements, storing the first and second sets of orientation measurements on a computing device, referenced to a set of time indices, and calculating a balance score for the subject by comparing the second set of orientation measurements with the first set of orientation measurements. A system for assessing the balance impairment of a subject is also disclosed.
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公开(公告)号：US12195424B2
公开(公告)日：2025-01-14
申请号：US17456244
申请日：2021-11-23
Applicant: The General Hospital Corporation , Temple University—Of The Commonwealth System of Higher Education , Rhode Island Hospital, A Lifespan-Partner
Inventor： Frederick M. Ausubel , Wooseong Kim , Eleftherios Mylonakis , William M. Wuest
IPC: A61P31/00 , A61K31/192 , A61P31/04 , A61P31/06 , A61P31/08 , C07C39/17 , C07C65/11 , C07C65/17 , C07C235/66 , A01N31/08 , A61K31/05 , A61K45/06
Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
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公开(公告)号：US20250011425A1
公开(公告)日：2025-01-09
申请号：US18754353
申请日：2024-06-26
Abstract: The invention provides compositions and methods for generating improved T cells having increased Ezh2 activity and methods of use thereof in the treatment of cancer and chronic infection.
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公开(公告)号：US20240277631A1
公开(公告)日：2024-08-22
申请号：US18438308
申请日：2024-02-09
Applicant: West Virginia University Board of Governors on behalf of West Virginia University , Temple University-Of the Commonwealth System of Higher Education , University of Pittsburgh-Of the Commonwealth System of Higher Education
Inventor： John B. Barnett , Werner Geldenhuys , Jonathan Soboloff , Harry Colbert Blair , Jamie McCall
IPC: A61K31/136 , A61K31/69 , A61P35/00
CPC classification number: A61K31/136 , A61K31/69 , A61P35/00
Abstract: A method of inhibiting the development of osteoclasts in patients having multiple myeloma comprising administering to a patient having multiple myeloma a therapeutically effective amount of N-Methyl-dichloropropionaniline (i.e. also known as ELP-004) for inhibiting the development of osteoclasts. The method includes wherein said N-Methyl-dichloropropionaniline is administered to said patient in a pharmaceutically acceptable vehicle.
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公开(公告)号：US11932789B2
公开(公告)日：2024-03-19
申请号：US17095520
申请日：2020-11-11
CPC classification number: C09K11/06 , C07F5/027 , C07F9/6506 , C07F9/65515 , H10K85/371 , C09K2211/188 , H10K50/11
Abstract: Provided herein are luminescent compounds, compositions including the same, and use and synthesis thereof.
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