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公开(公告)号：US20240277631A1
公开(公告)日：2024-08-22
申请号：US18438308
申请日：2024-02-09
申请人： West Virginia University Board of Governors on behalf of West Virginia University , Temple University-Of the Commonwealth System of Higher Education , University of Pittsburgh-Of the Commonwealth System of Higher Education
IPC分类号： A61K31/136 , A61K31/69 , A61P35/00
CPC分类号： A61K31/136 , A61K31/69 , A61P35/00
摘要： A method of inhibiting the development of osteoclasts in patients having multiple myeloma comprising administering to a patient having multiple myeloma a therapeutically effective amount of N-Methyl-dichloropropionaniline (i.e. also known as ELP-004) for inhibiting the development of osteoclasts. The method includes wherein said N-Methyl-dichloropropionaniline is administered to said patient in a pharmaceutically acceptable vehicle.
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公开(公告)号：US11932789B2
公开(公告)日：2024-03-19
申请号：US17095520
申请日：2020-11-11
CPC分类号： C09K11/06 , C07F5/027 , C07F9/6506 , C07F9/65515 , H10K85/371 , C09K2211/188 , H10K50/11
摘要： Provided herein are luminescent compounds, compositions including the same, and use and synthesis thereof.
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公开(公告)号：US20240058026A1
公开(公告)日：2024-02-22
申请号：US18498210
申请日：2023-10-31
发明人： Riyaz Bashir , Nicholas A. Green
IPC分类号： A61B17/221 , A61B17/22 , A61B18/00 , A61M25/00 , A61M25/01
CPC分类号： A61B17/221 , A61B17/22 , A61B18/00 , A61M25/0043 , A61M25/007 , A61M25/0108 , A61B2017/22084 , A61B2017/2217 , A61B17/320725 , A61M25/0074 , A61M2205/0266
摘要： An infusion catheter has an elongate flexible shaft including a wall and a lumen extending between a proximal end and a distal end. The catheter also has a sealing member within the shaft lumen including a wall and a lumen. The catheter also has a slidable, retractable elongate central axis member extending through the shaft and sealing member lumens connected to an end cap. The catheter also has a plurality of eluting arms extending radially around the central axis member, including lumens fluidly connected to the shaft lumen and the distal end cap. A method for treating a thrombus is also disclosed.
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公开(公告)号：US11897942B2
公开(公告)日：2024-02-13
申请号：US17058575
申请日：2019-05-24
申请人： Temple University—Of The Commonwealth System of Higher Education , LANKENAU INSTITUTE OF MEDICAL RESEARCH
发明人： Cagla Tukel Wilson , Scott Dessain
CPC分类号： C07K16/1235 , A61P31/04 , C07K16/1228 , C07K16/1232
摘要： The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.
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公开(公告)号：US11896037B2
公开(公告)日：2024-02-13
申请号：US16323018
申请日：2017-08-03
发明人： Gregory S. Smutzer , Kevin Lee , Dhruti Patel
IPC分类号： A23L27/00 , A23P10/35 , A61K8/60 , A23G1/54 , A61K8/11 , A61Q11/00 , A61K8/42 , A23G4/20 , A61K8/92 , A23G1/00 , A23G9/48 , A61K8/36 , A61K9/50 , A61K9/00 , A23G3/54 , A23L27/30 , A01N25/00 , A01N25/28
CPC分类号： A23L27/72 , A01N25/002 , A01N25/28 , A23G1/00 , A23G1/54 , A23G3/54 , A23G4/20 , A23G9/48 , A23L27/30 , A23L27/79 , A23L27/86 , A23P10/35 , A61K8/11 , A61K8/361 , A61K8/42 , A61K8/60 , A61K8/922 , A61K9/0056 , A61K9/5015 , A61Q11/00 , A23V2002/00 , A61K2800/412 , A23V2002/00 , A23V2200/16 , A23V2200/224 , A23V2250/1886 , A23V2250/264
摘要： The present invention relates to compositions and methods for masking the taste of an agent. In certain aspects, the invention comprises a microsphere and at least one sweetener therein. In another aspect, the invention comprises an edible material comprising at least one microsphere comprising an agent and at least one microsphere comprising a sweetener.
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公开(公告)号：US20240009154A1
公开(公告)日：2024-01-11
申请号：US18040515
申请日：2021-08-04
发明人： Mark Feitelson , Alla ARZUMANYAN , lra Spector
摘要： Disclosed herein are methods and pharmaceutical compositions to treat systemic inflammatory response syndrome. In some embodiments, a pharmaceutical composition disclosed herein comprises at least two short chain fatty acids or pharmaceutically-acceptable salts thereof in a ratio of at least 4:1. In some embodiments, administering a pharmaceutical composition of the disclosure reduces a level of a cytokine in the subject.
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公开(公告)号：US20230417669A1
公开(公告)日：2023-12-28
申请号：US18252724
申请日：2021-11-12
IPC分类号： G01N21/63
CPC分类号： G01N21/636
摘要： The present invention generally relates to improved methods for characterizing the cell wall complex composition of a bacterial specimen via differential transport kinetics of a small molecule. The present invention also relates to improved and automated methods for Gram differentiation of a bacterial specimen using nonlinear optical techniques.
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公开(公告)号：US20230390367A1
公开(公告)日：2023-12-07
申请号：US18249569
申请日：2021-10-19
发明人： Kamel Khalili , Rafal Kaminski , Shuren Liao
IPC分类号： A61K38/46 , C12N15/113 , A61K45/06
CPC分类号： A61K38/465 , C12N15/1131 , A61K45/06 , C12N2310/20
摘要： Compositions include gene editing agents, e.g. CRISPR that employ Cas13a for editing and inactivating sequences in the Coronavirus genome.
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公开(公告)号：US11826065B2
公开(公告)日：2023-11-28
申请号：US17222588
申请日：2021-04-05
发明人： Riyaz Bashir , Nicholas A. Green
IPC分类号： A61M25/00 , A61B17/22 , A61B17/221 , A61B18/00 , A61M25/01 , A61B17/3207 , A61B17/00
CPC分类号： A61B17/221 , A61B17/22 , A61B18/00 , A61M25/007 , A61M25/0043 , A61M25/0108 , A61B17/320725 , A61B2017/00871 , A61B2017/2217 , A61B2017/22038 , A61B2017/22084 , A61M25/0074 , A61M2025/0057 , A61M2205/0266
摘要： An infusion catheter has an elongate flexible shaft including a wall and a lumen extending between a proximal end and a distal end. The catheter also has a sealing member within the shaft lumen including a wall and a lumen. The catheter also has a slidable, retractable elongate central axis member extending through the shaft and sealing member lumens connected to an end cap. The catheter also has a plurality of eluting arms extending radially around the central axis member, including lumens fluidly connected to the shaft lumen and the distal end cap. A method for treating a thrombus is also disclosed.
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公开(公告)号：US11807642B2
公开(公告)日：2023-11-07
申请号：US17541682
申请日：2021-12-03
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
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