公开(公告)号：US10358667B2

公开(公告)日：2019-07-23

申请号：US14772282

申请日：2014-03-07

Applicant: University of Maryland, Baltimore ,  University of Washington through its Center for Commercialization

Inventor： Robert K. Ernst ,  Mark Pelletier ,  Adeline Hajjar

IPC: C12P21/00 ,  C12P19/26 ,  A61K31/715 ,  C12P19/12 ,  C12P19/44 ,  A61K39/02 ,  A61K39/39 ,  A61K31/739 ,  C07H11/04 ,  A61K39/00

Abstract: Embodiments of the disclosure provide for unique lipooligosaccharide/lipid A-based mimetics for use as adjuvants. Methods of generating lipooligosaccharide/lipid A-based mimetics are provided that utilize recombinantly engineered bacteria to produce the mimetics, including, for example, addition of one or more particular enzymes such as acyltransferases, deacylases, phosphatases, or glycosyltransferases.

公开(公告)号：US10301446B2

公开(公告)日：2019-05-28

申请号：US15023109

申请日：2014-09-19

Applicant: DART CONTAINER CORPORATION ,  THE UNIVERSITY OF WASHINGTON through its CENTER FOR COMMERCIALIZATION

Inventor： Krishna V. Nadella ,  Vipin Kumar ,  Huimin Guo

IPC: C08J9/16 ,  C08J9/12 ,  B29B13/00 ,  B29C44/34 ,  B29K67/00 ,  B29K101/12 ,  B29K105/04 ,  B29K105/00

Abstract: A method for generating a microstructure that includes microcellular bubbles, in a material that includes molecules of a thermoplastic polymer, comprises: determining a size-index for the material that represents an average size of the thermoplastic polymer molecules included in the material, and in response to the determined size-index, setting a parameter of a process to generate a microstructure in the material that includes microcellular bubbles. The process to generate a microstructure in the material includes: 1) infusing into the material, during a first period, a gas that does not react with the material, 2) making the gas-infused material thermodynamically unstable.

公开(公告)号：US20190144834A1

公开(公告)日：2019-05-16

申请号：US16245459

申请日：2019-01-11

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Edward CLARK ,  Jay Wesley CHAPLIN

IPC: C12N7/00 ,  A61K39/29 ,  A61K39/385 ,  A61K47/68 ,  C07K16/28 ,  A61K39/12

Abstract: The present invention provides compositions of CD180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.

公开(公告)号：US10287631B2

公开(公告)日：2019-05-14

申请号：US15660785

申请日：2017-07-26

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Jesse Salk ,  Lawrence A. Loeb ,  Michael Schmitt

IPC: C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6869 ,  C12Q1/6806

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.

公开(公告)号：US20190120857A1

公开(公告)日：2019-04-25

申请号：US16171918

申请日：2018-10-26

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. Chiu ,  Perry G. Schiro ,  Jason S. Kuo

IPC: G01N33/68 ,  G01N33/574 ,  G01N33/53

Abstract: Provided herein, among other aspects, are methods and apparatuses for ranking aliquots from a suspension containing bioparticles. In certain embodiments, the bioparticles may be cells, organelles, proteins, DNAs, debris of biological origin, microbeads coated with biological compounds, or viral particles. As such, the methods and apparatuses provided herein may be used to quantify rare cells such as circulating cancer cells, fetal cells and other rare cells present in bodily fluids for disease diagnosis, prognosis, or treatment.

公开(公告)号：US10266815B2

公开(公告)日：2019-04-23

申请号：US14911630

申请日：2014-08-13

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Bloomfield Siegel ,  David Baker ,  Ingrid Swanson Pultz

IPC: C12N9/52 ,  C12N9/64 ,  A61K38/00

Abstract: The invention provides compositions and methods for treating celiac sprue.

公开(公告)号：US20190106740A1

公开(公告)日：2019-04-11

申请号：US16029396

申请日：2018-07-06

Applicant: University of Washington through its Center for Commercialization ,  Illumina, Inc.

Inventor： Jens H. Gundlach ,  Andrew Laszlo ,  Ian Derrington ,  Jeffrey G. Mandell

IPC: C12Q1/6869

Abstract: The present disclosure provides method and systems for improving nanopore-based analysis of polymers. The disclosure provides methods for selectively modifying one or more monomeric subunit(s) of a kind in a re-analyte polymer that results in a polymer analyte with a modified subunit. The polymer analyte produces a detectable signal in a nanopore-based system. The detectable signal, and/or its deviation from a reference signal, indicates the location of the modified subunit in the polymer analyte and, thus, permits the identification of the subunit at that location in the original pre-analyte polymer.

公开(公告)号：US10251657B1

公开(公告)日：2019-04-09

申请号：US14268414

申请日：2014-05-02

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.

公开(公告)号：US10248758B2

公开(公告)日：2019-04-02

申请号：US14759308

申请日：2014-02-07

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： David Baker ,  Neil King ,  Jacob Bale ,  William Sheffler

IPC: G06F19/18 ,  C07K14/00 ,  G01N33/68 ,  G06F19/16 ,  G06F19/12 ,  C07K14/195 ,  B82Y5/00

Abstract: Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.

公开(公告)号：US10196614B2

公开(公告)日：2019-02-05

申请号：US14426635

申请日：2013-09-16

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Edward Clark ,  Jay Wesley Chaplin

IPC: A61K47/48 ,  C12N7/00 ,  A61K39/12 ,  A61K39/385 ,  C07K16/28 ,  A61K39/29 ,  A61K47/68 ,  A61K39/00

Abstract: The present limiting provides compositions of CD 180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.