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公开(公告)号：US11480575B2
公开(公告)日：2022-10-25
申请号：US16702176
申请日：2019-12-03
Inventor： Daniel T. Chiu , Mengxia Zhao , Wyatt Nelson , Perry G. Schiro
IPC: G01N33/574 , B01L3/00 , G01N15/06 , G01N15/14 , G01N33/49 , G01N21/64 , G01N33/53 , G01N35/10 , G01N35/00 , G01N15/10
Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.
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公开(公告)号：US11408884B2
公开(公告)日：2022-08-09
申请号：US16702228
申请日：2019-12-03
Inventor： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC: G01N33/58 , C09K11/06 , G01N33/543 , C09K11/02 , C08G61/02 , C08G73/00 , C08G75/32 , G01N33/533
Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
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公开(公告)号：US20200011874A1
公开(公告)日：2020-01-09
申请号：US16556006
申请日：2019-08-29
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US20190120857A1
公开(公告)日：2019-04-25
申请号：US16171918
申请日：2018-10-26
Inventor： Daniel T. Chiu , Perry G. Schiro , Jason S. Kuo
IPC: G01N33/68 , G01N33/574 , G01N33/53
Abstract: Provided herein, among other aspects, are methods and apparatuses for ranking aliquots from a suspension containing bioparticles. In certain embodiments, the bioparticles may be cells, organelles, proteins, DNAs, debris of biological origin, microbeads coated with biological compounds, or viral particles. As such, the methods and apparatuses provided herein may be used to quantify rare cells such as circulating cancer cells, fetal cells and other rare cells present in bodily fluids for disease diagnosis, prognosis, or treatment.
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公开(公告)号：US10067139B2
公开(公告)日：2018-09-04
申请号：US14373835
申请日：2013-02-01
Inventor： Daniel T. Chiu , Yuhui Jin , Fangmao Ye , Changfeng Wu , Yang-Hsiang Chan
Abstract: Polymer nanoparticles and related methods include polymer dots having a coating including a polyelectrolyte polymer. The polymer dots can have a polyelectrolyte coating that can improve colloidal stability of the particles as compared to polymer dots not having the coating. A method of preparing a population of nanoparticles. The methods can include, e.g., providing the population of nanoparticles having a condensed semiconducting polymer; and combining, in a first aqueous solution comprising polyelectrolytes, the population of nanoparticles having the condensed semiconducting polymer to form a population of nanoparticles having a polyelectrolyte coating surrounding the condensed semiconducting polymer of each of the nanoparticles in the population. The methods can include a step of forming the condensed semiconducting polymer using nanoprecipitation or miniemulsion techniques. The polyelectrolyte coating can completely surround the condensed semiconducting polymer.
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Patent Agency Ranking
公开(公告)号：US20170145490A1
公开(公告)日：2017-05-25
申请号：US15230162
申请日：2016-08-05
Inventor： Daniel T. Chiu , Bryant S. Fujimoto , Alexander R. Gansen , Gloria S. Yen , Robert M. Lorenz
IPC: C12Q1/68
CPC classification number: C12Q1/6851 , C12Q1/6806 , C12Q2527/146 , C12Q2531/113 , C12Q2545/114
Abstract: Methods, devices and systems for performing digital measurements are provided.
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公开(公告)号：US20170003293A1
公开(公告)日：2017-01-05
申请号：US15100056
申请日：2014-11-25
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
CPC classification number: G01N33/58 , C09B23/0066 , C09B23/04 , C09B57/007 , C09B69/109 , C09K11/02 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
Abstract translation: 本公开提供了能够例如分析物的光学和/或生物分子编码的经编码的发色聚合物颗粒。 本公开还提供了包含多个编码的发色聚合物颗粒的悬浮液。 本公开还提供了使用经编码的发色聚合物颗粒和系统用编码的发色聚合物颗粒进行多重分析的方法。
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公开(公告)号：US20140302516A1
公开(公告)日：2014-10-09
申请号：US14213290
申请日：2014-03-14
Inventor： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC: G01N33/569
Abstract: Lyophilized polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions and kits supplying the compositions.
Abstract translation: 提供冻干聚合物点组合物。 还公开了制备和使用冻干组合物和提供组合物的试剂盒的方法。
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公开(公告)号：US20250035636A1
公开(公告)日：2025-01-30
申请号：US18911931
申请日：2024-10-10
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/12 , C08J3/11 , C09K11/02 , C09K11/06 , H10K85/10
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US11697713B2
公开(公告)日：2023-07-11
申请号：US16138732
申请日：2018-09-21
Inventor： Daniel T. Chiu , Changfeng Wu , Yu Rong , Yong Zhang , Yi-Che Wu , Yang-Hsiang Chan , Xuanjun Zhang , Jiangbo Yu , Wei Sun
IPC: A61K47/32 , C08G77/00 , C08G77/398 , C08G75/32 , G01N33/58 , A61K49/00 , C09B69/10 , H10K85/10 , C08G79/00 , B82Y40/00 , B82Y30/00 , G01N21/64 , H10K50/11
CPC classification number: C08G75/32 , A61K49/0019 , A61K49/0067 , C08G79/00 , C09B69/105 , G01N33/582 , G01N33/587 , H10K85/10 , H10K85/113 , H10K85/115 , H10K85/151 , B82Y30/00 , B82Y40/00 , G01N2021/6439 , H10K50/11
Abstract: Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
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