公开(公告)号：US20090202491A1

公开(公告)日：2009-08-13

申请号：US12315893

申请日：2008-12-08

申请人： Ulf Eriksson ,  Kari Alitalo ,  Marko Uutela

发明人： Ulf Eriksson ,  Kari Alitalo ,  Marko Uutela

IPC分类号： A61K48/00 ,  A61K31/7052 ,  A61P9/00

CPC分类号： A61K38/1858 ,  A61K48/00

摘要： A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.

公开(公告)号：US20090041755A1

公开(公告)日：2009-02-12

申请号：US11914036

申请日：2006-05-10

申请人： Ulf Eriksson

发明人： Ulf Eriksson

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/04

CPC分类号： C07K16/22 ,  A61K38/1858

摘要： Methods for inhibiting angiogenesis comprising administering urokinase plasminogen activator (uPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the uPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering uPA or an agonist thereof to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of uPA or an agonist thereof for the methods of stimulation. The present invention discloses that uPA is a specific PDGF-D activatin rotease.

摘要翻译： 用于抑制血管发生的方法包括给予尿激酶纤溶酶原激活物（uPA）抑制剂和适用于包含uPA抑制剂的方法的药物组合物。 还提供了用于刺激血管发生的方法，其包括向有需要的患者施用uPA或其激动剂，以及包含有效量的uPA或其激动剂用于刺激方法的药物组合物。 本发明公开了uPA是特定的PDGF-D激活质素。

公开(公告)号：US07341996B2

公开(公告)日：2008-03-11

申请号：US10948736

申请日：2004-09-24

申请人： Ulf Eriksson ,  Birgitta Olofsson ,  Kari Alitalo ,  Katri Pajusola

发明人： Ulf Eriksson ,  Birgitta Olofsson ,  Kari Alitalo ,  Katri Pajusola

IPC分类号： A61K38/18 ,  C07K14/515

CPC分类号： C07K14/52 ,  A61K38/00

摘要： VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

摘要翻译： 具有促进血管内皮细胞有丝分裂和增殖的生长因子的PDGF家族的VEGF-B多肽，编码这些多肽的DNA序列，含有它们的药物组合物和与其反应的抗体。 VEGF-B多肽可用于刺激血管发生以及诊断应用。

公开(公告)号：US07148037B2

公开(公告)日：2006-12-12

申请号：US10086623

申请日：2002-03-04

申请人： Ulf Eriksson ,  Karin Aase ,  Xuri Li ,  Annica Ponten ,  Marko Uutela ,  Kari Alitalo ,  Arne Oestman ,  Carl-Henrik Heldin

发明人： Ulf Eriksson ,  Karin Aase ,  Xuri Li ,  Annica Ponten ,  Marko Uutela ,  Kari Alitalo ,  Arne Oestman ,  Carl-Henrik Heldin

IPC分类号： C12P21/06 ,  C12N5/08 ,  C07H21/04 ,  A61K39/00 ,  A61K38/27 ,  C07K2/00

CPC分类号： C07K14/49 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.

公开(公告)号：US07105481B2

公开(公告)日：2006-09-12

申请号：US10260539

申请日：2002-10-01

申请人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

发明人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

IPC分类号： A61K38/18

CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/158

摘要： PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

公开(公告)号：US20060030695A1

公开(公告)日：2006-02-09

申请号：US11140284

申请日：2005-05-31

申请人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

发明人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/158

摘要： PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

摘要翻译： PDGF-D，PDGF / VEGF家族生长因子的新成员，以及编码它的核苷酸序列，其生产方法，抗体和其它拮抗剂，转染和转化的表达它的宿主细胞，含有它的药物组合物 以及其在医学和诊断应用中的应用，包括刺激结缔组织生长或愈合哺乳动物伤口的方法，该方法包括向哺乳动物施用有效量的PDGF-D多肽或编码PDGF-D多肽的多核苷酸 。

公开(公告)号：US06670125B2

公开(公告)日：2003-12-30

申请号：US09858891

申请日：2001-05-17

申请人： Xuri Li ,  Karin Aase ,  Ulf Eriksson

发明人： Xuri Li ,  Karin Aase ,  Ulf Eriksson

IPC分类号： C12Q168

CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2333/49

摘要： A method and kit for detecting the presence of tumor cells in an animal by detecting expression of VEGF-B186, determining an increased expression of VEGF-B186, or by determining an increased expression of VEGF-B186 relative to expression of VEGF-B167. The kit comprises a receptacle adapted to receive a sample and a means for detecting expression of VEGF-B186 from the sample. Also, a method for screening for anti-tumor agents.

公开(公告)号：US06358728B1

公开(公告)日：2002-03-19

申请号：US09880427

申请日：2001-06-13

申请人： András Simon ,  Ulf Eriksson ,  Thaddeaus P. Dryja ,  Eliot L. Berson ,  Hioyuji Yamamoto

发明人： András Simon ,  Ulf Eriksson ,  Thaddeaus P. Dryja ,  Eliot L. Berson ,  Hioyuji Yamamoto

IPC分类号： C12N120

CPC分类号： C12N9/0006 ,  C12N2799/021 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Y101/01105

摘要： The invention relates to mutations in the gene encoding 11-cis retinal dehyrogenase. The mutations in the gene and in the resulting encoded protein are correlated to ocular disorders, such as fundus albipunctatus.

公开(公告)号：US5840693A

公开(公告)日：1998-11-24

申请号：US609443

申请日：1996-03-01

申请人： Ulf Eriksson ,  Birgitta Olofsson ,  Kari Alitalo ,  Katri Pajusola

发明人： Ulf Eriksson ,  Birgitta Olofsson ,  Kari Alitalo ,  Katri Pajusola

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/515 ,  C07K14/52 ,  C07K16/22 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/566 ,  A61K38/18

CPC分类号： C07K14/52 ,  A61K38/00

摘要： VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

摘要翻译： 具有促进血管内皮细胞有丝分裂和增殖的生长因子的PDGF家族的VEGF-B多肽，编码这些多肽的DNA序列，含有它们的药物组合物和与它们反应的抗体。 VEGF-B多肽可用于刺激血管发生以及诊断应用。

公开(公告)号：US08765671B2

公开(公告)日：2014-07-01

申请号：US13407270

申请日：2012-02-28

申请人： Ulf Eriksson ,  Daniel Lawrence ,  Enming Joe Su ,  Dudley Strickland ,  Manuel Yepes ,  Linda Fredriksson

发明人： Ulf Eriksson ,  Daniel Lawrence ,  Enming Joe Su ,  Dudley Strickland ,  Manuel Yepes ,  Linda Fredriksson

IPC分类号： A61K38/17

CPC分类号： C07K16/2863 ,  A61K9/0019 ,  A61K38/43 ,  A61K39/39533 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  C12N9/6454

摘要： Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.

摘要翻译： 用于调节血液神经屏障（BNB）的方法和组合物用于治疗中枢神经系统疾病如水肿，以及用于增加穿过BNB的药物递送功效。 本发明还涉及改善的缺血性脑血管和相关疾病的tPA治疗以及PDGF信号通路的拮抗作用。 本发明的方法和组合物特别适用于使用tPA和抗PDGF-C拮抗剂或抗PDGFR-α拮抗剂的缺血性中风的联合治疗。