公开(公告)号：US20140214133A1

公开(公告)日：2014-07-31

申请号：US13777901

申请日：2013-02-26

Applicant: VALENCIA TECHNOLOGIES CORPORATION

Inventor： Chuladatta H. Thenuwara ,  David K. L. Peterson

IPC: A61N1/375

CPC classification number: A61N1/375 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3754 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats a disease or medical condition of a patient through application of stimulation pulses applied at a specified acupoint or other target tissue location. In a preferred implementation, the IEAD is an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在特定穴位或其他目标组织位置施加的刺激脉冲来治疗患者的疾病或医学状况。 在优选的实施方案中，IEAD是可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20140214127A1

公开(公告)日：2014-07-31

申请号：US13736041

申请日：2013-01-07

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00

CPC classification number: A61H39/002 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/3606 ,  A61N1/36085 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats dyslipidemia conditions of a patient through application of stimulation pulses applied at acupoint ST40, or its underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位ST40施加的刺激脉冲或其潜伏的神经​​隐匿和腓骨来治疗患者的血脂异常状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20140214125A1

公开(公告)日：2014-07-31

申请号：US13736033

申请日：2013-01-07

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00

CPC classification number: A61H39/002 ,  A61F5/0026 ,  A61H2201/50 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36085 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An Implantable ElectroAcupuncture System (IEAS) treats dyslipidemia or obesity through application of stimulation pulses applied at at least one of acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, or LR8, or underlying nerves saphenous or peroneal. The IEAS includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.

Abstract translation: 可植入电针刺系统（IEAS）通过施加在穴位ST36，SP4，ST37，ST40，SP6，SP9，K16或LR8中的至少一个或隐匿性或腓神经的下面的神经施加刺激脉冲来治疗血脂异常或肥胖。 IEAS包括密封的可植入电针（EA）装置，其具有位于其壳体外部的至少两个电极。 外壳包含主电源，脉冲发生电路和无线感应外部生成的操作命令的传感器。 脉冲产生电路至少部分地通过通过传感器感测的操作命令来产生刺激脉冲。 刺激脉冲根据指定的刺激方案通过电极施加到指定的穴位或神经。 这种刺激方案要求在非常低的占空比不大于0.05的情况下施用刺激会话。

公开(公告)号：US20140214116A1

公开(公告)日：2014-07-31

申请号：US13786447

申请日：2013-03-05

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson ,  Stacy O. Greiner

IPC: A61N1/36

CPC classification number: A61N1/36117 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5041 ,  A61H2201/5097 ,  A61N1/3605 ,  A61N1/36135 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3782

Abstract: A coin-sized implantable electroacupuncture (EA) device defines a stimulation paradigm, or stimulation regimen, that controls when EA stimulation pulses are applied to a selected acupoint, or other specified tissue location, to treat hypertension or nondipping. The stimulation regimen is applied when the patient is sleeping in order to minimize or mitigate the occurrence of nondipping or reverse dipping of the patient's blood pressure. In one embodiment, medical personnel, set a timing reference marker at the time of implant that defines how much time should elapse before a nighttime stimulation window opens that allows an EA stimulation session to be applied to the patient. In another embodiment, the patient sets the time when the nighttime stimulation window opens or when the EA stimulation session begins. Typically, an EA stimulation session is applied to the patient at a low duty cycle, e.g., only once a week during the nighttime.

Abstract translation: 硬币大小的可植入电针（EA）装置定义了刺激范例或刺激方案，其控制何时将EA刺激脉冲施加到选定的穴位或其他指定的组织位置以治疗高血压或非浸润。 当患者睡觉时应用刺激方案以便最小化或减轻患者血压的非浸没或反浸渍的发生。 在一个实施例中，医务人员在植入时设置定时参考标记，其定义在夜间刺激窗口打开之前经过多少时间，其允许将EA刺激会话应用于患者。 在另一个实施例中，患者设定夜间刺激窗口打开或EA刺激会话开始时的时间。 通常，EA刺激会话以低工作周期应用于患者，例如在夜间仅每星期一次。

公开(公告)号：US20140214112A1

公开(公告)日：2014-07-31

申请号：US13784573

申请日：2013-03-04

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  H05K13/04

CPC classification number: A61F5/41 ,  A61F2005/418 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61H2205/087 ,  A61N1/18 ,  A61N1/36107 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加施加在穴位BL52，BL23或GV4中的至少一个穴位下方或附近的目标组织位置处的刺激脉冲来治疗患者的勃起功能障碍状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US11357984B2

公开(公告)日：2022-06-14

申请号：US16667346

申请日：2019-10-29

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Stacy Greiner Chambliss

IPC: A61N1/36 ,  A61N1/372 ,  A61H39/00 ,  A61N1/05 ,  A61N1/375 ,  A61N1/378

Abstract: A method of treating osteoarthritis in a knee includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of a patient, stimulation sessions at a duty cycle that is less than 0.05, and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a location that includes at least one of an acupoint labeled ST35, an acupoint labeled EX-LE-4, and a location on a line that intersects the acupoints labeled ST35 and EX-LE-4. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US10792219B2

公开(公告)日：2020-10-06

申请号：US16394932

申请日：2019-04-25

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/36 ,  A61H39/00 ,  A61N1/375 ,  A61N1/372 ,  A61N1/378 ,  A61F5/00

Abstract: A method comprises generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a patient. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US20200164214A1

公开(公告)日：2020-05-28

申请号：US16776935

申请日：2020-01-30

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson ,  Jeffrey H. Greiner

IPC: A61N1/378 ,  A61N1/372 ,  A61N1/36 ,  A61H39/00 ,  A61N1/375

Abstract: An implantable stimulator includes a housing configured to be implanted beneath a skin surface of a patient and having a first surface adapted to face inwardly into tissue of the patient at or near a target tissue location; pulse generation circuitry located within the housing and electrically coupled to at least two electrodes, the pulse generation circuitry being adapted to deliver stimulation sessions by way of the at least two electrodes to the target tissue location, wherein each stimulation session included in the stimulation sessions has a duration of T3 minutes and a rate of occurrence of once every T4 minutes, wherein a ratio of T3 to T4 is no greater than 0.05; and a primary battery contained within the housing and electrically coupled to the pulse generation circuitry, the primary battery having an internal impedance greater than 5 ohms.

公开(公告)号：US10576293B2

公开(公告)日：2020-03-03

申请号：US15793913

申请日：2017-10-25

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson ,  Jeffrey H. Greiner

IPC: A61N1/378 ,  A61N1/375 ,  A61H39/00 ,  A61N1/36 ,  A61N1/372

Abstract: An implantable electroacupuncture device for treating a medical condition of a patient through application of electroacupuncture stimulation pulses to a target tissue location within the patient includes 1) a housing configured to be implanted beneath a skin surface of the patient, 2) pulse generation circuitry located within the housing and electrically coupled to at least two electrodes, the pulse generation circuitry being adapted to deliver stimulation sessions by way of the at least two electrodes to the target tissue location in accordance with a stimulation regimen, and 3) a primary battery contained within the housing and electrically coupled to the pulse generation circuitry, the primary battery having an internal impedance greater than 5 ohms and a capacity of less than 60 mAh, wherein the primary battery is the only battery that provides power to the pulse generation circuitry.

公开(公告)号：US10518082B2

公开(公告)日：2019-12-31

申请号：US15700013

申请日：2017-09-08

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372 ,  A61N1/375 ,  A61H39/00 ,  A61N1/378

Abstract: An electroacupuncture device for treating hypertension in a patient includes 1) a housing configured to be implanted beneath a skin surface of the patient at an acupoint corresponding to a target tissue location within the patient, the acupoint comprising at least one of PC5, PC6, ST36, and ST37, 2) a central electrode of a first polarity and centrally located and substantially planar on a first surface of the housing, 3) an annular electrode of a second polarity and that surrounds the central electrode on the first surface of the housing, the annular electrode being spaced apart from the central electrode, and 4) pulse generation circuitry located within the housing and electrically coupled to the annular and central electrodes.