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公开(公告)号:US1643701A
公开(公告)日:1927-09-27
申请号:US8175826
申请日:1926-01-16
申请人: WILLIAM DALTON
发明人: WILLIAM DALTON
IPC分类号: E01B9/32
CPC分类号: E01B9/32
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公开(公告)号:US20090227489A1
公开(公告)日:2009-09-10
申请号:US12420704
申请日:2009-04-08
申请人: Hua Yu , Drew Pardoll , Richard Jove , William Dalton
发明人: Hua Yu , Drew Pardoll , Richard Jove , William Dalton
IPC分类号: A61K38/02 , A61K31/7105 , A61K31/711
CPC分类号: C12N5/0693 , A61K38/1709 , A61K38/204 , A61K48/005 , C12N2501/60 , C12N2510/00
摘要: The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.
摘要翻译: 本发明涉及调节,即激动或拮抗Stat3(Transcription3的信号转导和激活因子)用于基因治疗的信号传导活性的方法。 Stat3信号传导的抑制和/或激活是调节血管生成和用于治疗和/或预防炎症,感染,炎症,免疫疾病和缺血的免疫应答的有效方法。
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公开(公告)号:US20080288685A1
公开(公告)日:2008-11-20
申请号:US12168278
申请日:2008-07-07
IPC分类号: G06F13/42
CPC分类号: G06F1/3209 , G06F1/3221 , Y02D10/154
摘要: Local drive presence is provided for local and remote drives by maintaining a plurality of uninterrupted protocol connections between a plurality of I/O controllers and a plurality of device interfaces through which peripheral bus commands are transmitted. Preferably, the I/O controllers are each housed in a separate server blade and provide each blade with access to the local and remote drives. At each of the device interfaces, rather than attaching an actual storage device, peripheral bus commands received at the device interfaces are serialized and conditionally passed or suppressed to and from the shared drive which is shared amongst the plurality of uninterrupted protocol connections. Preferably, the plurality of uninterrupted protocol connections is maintained such that the shared drives can be simultaneously shared. In one embodiment, the local drives are provided in a media tray which is shared amongst a plurality blades.
摘要翻译: 通过在多个I / O控制器和通过其发送外围总线命令的多个设备接口之间维持多个不间断的协议连接来为本地和远程驱动器提供本地驱动器存在。 优选地,I / O控制器各自容纳在单独的服务器刀片中,并且为每个刀片提供对本地和远程驱动器的访问。 在每个设备接口上,而不是附加实际的存储设备,在设备接口处接收的外围设备总线命令被串行化并有条件地传递或抑制到在多个不间断协议连接之间共享的共享驱动器。 优选地,保持多个不间断的协议连接,使得共享驱动器可以被同时共享。 在一个实施例中,本地驱动器设置在介于多个叶片之间共享的介质托盘中。
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公开(公告)号:US20050256745A1
公开(公告)日:2005-11-17
申请号:US10846977
申请日:2004-05-14
申请人: William Dalton
发明人: William Dalton
IPC分类号: G06F15/173 , G06Q10/00 , G06F17/60
摘要: The invention provides a computer network comprising a first computer and one or more second computers that are in electronic communication with each other. The first computer is associated with a first health care facility and has instructions for retrieving, over a network, one or more data structures for a patient enrolled in a health care program. The one or more data structures for the patient collectively comprise (i) a patient identifier, (ii) a molecular profile from a biological specimen obtained from the patient at the first health care facility; and (iii) a clinical characterization of the patient that was made at the first health care facility. The first computer has instructions for retrieving, over the network connection, one or a plurality of treatment regimens that are deemed suitable for the patient based upon the molecular profile and the clinical characterization of the patient. The one or more second computers are at one or more locations other than the first health care facility and have one or more data structures for each patient in a plurality of patients enrolled in the health care program
摘要翻译: 本发明提供一种包括第一计算机和彼此电子通信的一个或多个第二计算机的计算机网络。 第一计算机与第一保健设施相关联并且具有用于通过网络检索登记在医疗保健程序中的患者的一个或多个数据结构的指令。 用于患者的一个或多个数据结构共同包括(i)患者标识符,(ii)来自第一保健设施中的患者获得的生物样本的分子谱; 和(iii)在第一个保健设施制造的患者的临床表征。 第一计算机具有用于通过网络连接检索基于患者的分子特征和临床表征被认为适合于患者的一种或多种治疗方案的指令。 一个或多个第二计算机位于除了第一保健设施之外的一个或多个位置处,并且在登记在医疗保健程序中的多个患者中具有每个患者的一个或多个数据结构
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公开(公告)号:US20050066648A1
公开(公告)日:2005-03-31
申请号:US10657828
申请日:2003-09-09
申请人: William Dalton
发明人: William Dalton
摘要: A multi-mode shutdown system in combination with a fuel metering unit of an engine to prevent normal fuel delivery during engine malfunction such as the engine overspeeding. The multi-mode shutdown system includes a shutdown solenoid capable of closing a pressurizing valve to prevent fuel flow to the engine for creating a shutdown mode of operation with no fuel flow to the engine. The multi-mode shutdown system also includes a minimum flow solenoid in fluid communication a source of fuel at a minimum flow rate for creating a minimum flow mode of operation with fuel provided to the engine at the minimal flow rate. In the minimum flow mode, the shutdown solenoid and minimum flow solenoid establish a flow path for the fuel to the engine manifold at the minimal flow rate. During normal operation, the fuel metering unit regulates the fuel flow to the engine.
摘要翻译: 多模式停机系统与发动机的燃料计量单元结合,以防止诸如发动机超速的发动机故障期间的正常燃料输送。 多模式停机系统包括能够关闭加压阀的关闭螺线管,以防止燃料流向发动机以产生没有燃料流向发动机的关闭运行模式。 多模式关闭系统还包括最小流量电磁阀,其以最小流量使燃料源流体连通,以最小流量产生提供给发动机的燃料的最小流动模式。 在最小流量模式中,关闭电磁阀和最小流量电磁阀以最小的流量建立到发动机歧管的燃料的流路。 在正常操作期间,燃料计量单元调节到发动机的燃料流量。
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公开(公告)号:US2708072A
公开(公告)日:1955-05-10
申请号:US39353453
申请日:1953-11-23
申请人: WILLIAM DALTON
发明人: WILLIAM DALTON
IPC分类号: E01B3/22
CPC分类号: E01B3/22
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公开(公告)号:US2625116A
公开(公告)日:1953-01-13
申请号:US8513749
申请日:1949-04-02
申请人: WILLIAM DALTON
发明人: WILLIAM DALTON
IPC分类号: B61C9/48
CPC分类号: B61C9/48
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公开(公告)号:US2446129A
公开(公告)日:1948-07-27
申请号:US71230346
申请日:1946-11-26
申请人: WILLIAM DALTON
发明人: WILLIAM DALTON
IPC分类号: F02C7/00
CPC分类号: F02C7/00
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公开(公告)号:US1979825A
公开(公告)日:1934-11-06
申请号:US64565732
申请日:1932-12-05
申请人: WILLIAM DALTON
发明人: WILLIAM DALTON
IPC分类号: E01B9/48
CPC分类号: E01B9/486
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