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    Phosphorus-containing compounds & uses thereof
    41.
    发明申请
    Phosphorus-containing compounds & uses thereof 有权
    含磷化合物及其用途

    公开(公告)号：US20100197907A1

    公开(公告)日：2010-08-05

    申请号：US12798501

    申请日：2010-04-06

    Applicant: David L. Berstein ,  Leonard W. Rozamus ,  Yihan Wang ,  Chester A. Metcalf, III

    Inventor： David L. Berstein ,  Leonard W. Rozamus ,  Yihan Wang ,  Chester A. Metcalf, III

    IPC: C07D267/00

    CPC classification number: A61K45/06 ,  A61K31/675 ,  C07F9/6561

    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which:A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.

    Abstract translation: 本发明涉及一种含有部分JQA-的含磷化合物的新家族，其中：A不存在或为-O - ， - S-或-NR2-; Q不存在或（如果A是-O-，-S-或-NR2-）Q可以是-V-，-OV-，-SV-或-NR2V-，其中V是脂族，杂脂族，芳基， 或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR2VA直接与环己基环连接; K为O或S; 每个出现的Y独立地是-O - ， - S - ， - NR2-或连接R 5部分与P的键; R 2和R 5各自独立地为脂族，杂脂族，芳基或杂芳基部分，或H; 并且每个出现的R 6独立地是-PK（YR 5）（YR 5），-SO 2（YR 5）或-C（O）（YR 5）; 只要直接与P连接的任何R 2或R 5部分不是H; 其中两个R2，R5和/或R6部分可以彼此化学连接以形成环; 每次出现的G独立为-O - ， - S - ， - NR2-或（M）x; 每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立为1-6的整数; 其他变量如本文所定义。

    Phosphorus-containing compounds & uses thereof
    45.
    发明申请
    Phosphorus-containing compounds & uses thereof 有权
    含磷化合物及其用途

    公开(公告)号：US20070190106A1

    公开(公告)日：2007-08-16

    申请号：US11650017

    申请日：2007-01-05

    Applicant: David Berstein ,  Leonard Rozamus ,  Yihan Wang ,  Chester Metcalf

    Inventor： David Berstein ,  Leonard Rozamus ,  Yihan Wang ,  Chester Metcalf

    IPC: A61F2/00 ,  A61K31/675

    CPC classification number: A61K45/06 ,  A61K31/675 ,  C07F9/6561

    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.

    Abstract translation: 本发明涉及含有部分JQA-的新的含磷化合物族，其中：A不存在或为-O - ， - S-或-NR 2 - 。 Q不存在或（如果A是-O-，-S-或-NR 2 - ）Q可以是-V-，-OV-，-SV-或-NR 2 V-，其中V是脂族，杂脂族，芳基或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR 2 O直接与环己基环连接 > VA; K为O或S; 每次出现的Y独立地是-O - ， - S - ， - NR 2 - 或 - 连接R 5部分与P的键; 每个出现的R 2和R 5独立地是脂族，杂脂族，芳基或杂芳基部分，或H; 且每次出现的R 6独立地为-PK（YR 5），（YR 5）， - SO 2 - （YR 5）或-C（O）（YR 5）; 只要与P直接连接的任何R“或R 5”部分不是H; 其中两个R 2，R 5和/或R 6 O 6部分可以彼此化学连接以形成环; 每次出现的G独立地为-O - ， - S - ， - NR 2 - 或（M）x X; 每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立地为1-6的整数; 其他变量如本文所定义。

    Phosphorus-containing compounds & uses thereof
    46.
    发明申请
    Phosphorus-containing compounds & uses thereof 有权
    含磷化合物及其用途

    公开(公告)号：US20060264456A1

    公开(公告)日：2006-11-23

    申请号：US11494418

    申请日：2006-07-27

    Applicant: Chester Metcalf ,  Leonard Rozamus ,  Yihan Wang ,  David Berstein

    Inventor： Chester Metcalf ,  Leonard Rozamus ,  Yihan Wang ,  David Berstein

    IPC: A61K31/4745 ,  C07D491/14

    CPC classification number: A61K45/06 ,  A61K31/675 ,  C07F9/6561

    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.

    Abstract translation: 本发明涉及含有部分JQA-的新的含磷化合物族，其中：A不存在或为-O - ， - S-或-NR 2 - 。 Q不存在或（如果A是-O-，-S-或-NR 2 - ）Q可以是-V-，-OV-，-SV-或-NR 2 V-，其中V是脂族，杂脂族，芳基或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR 2 O直接与环己基环连接 > VA; K为O或S; 每次出现的Y独立地是-O - ， - S - ， - NR 2 - 或 - 连接R 5部分与P的键; 每个出现的R 2和R 5独立地是脂族，杂脂族，芳基或杂芳基部分，或H; 且每次出现的R 6独立地为-PK（YR 5），（YR 5）， - SO 2 - （YR 5）或 - （O）（YR 5）; 只要与P直接连接的任何R“或R 5”部分不是H; 其中两个R 2，R 5和/或R 6 O 6部分可以彼此化学连接以形成环; 每次出现的G独立地是-O - ， - S - ， - NR 2 - 或（M）x。 每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立为1-6的整数; 其他变量如本文所定义。

    Phosphorus-containing compounds and uses thereof
    47.
    发明授权
    Phosphorus-containing compounds and uses thereof 有权
    含磷化合物及其用途

    公开(公告)号：US07091213B2

    公开(公告)日：2006-08-15

    申请号：US10862149

    申请日：2004-06-04

    Applicant: Chester A. Metcalf, lll ,  Leonard W. Rozamus ,  Yihan Wang ,  David L. Berstein

    Inventor： Chester A. Metcalf, lll ,  Leonard W. Rozamus ,  Yihan Wang ,  David L. Berstein

    IPC: C07D491/06 ,  A61K31/395 ,  A61P35/00 ,  A61P35/02

    CPC classification number: A61K45/06 ,  A61K31/675 ,  C07F9/6561

    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1–6; and the other variables are as defined herein.

    Abstract translation: 本发明涉及含有部分JQA-的新的含磷化合物族，其中：A不存在或为-O - ， - S-或-NR 2 - 。 Q不存在或（如果A是-O-，-S-或-NR 2 - ）Q可以是-V-，-OV-，-SV-或-NR 2 V-，其中V是脂族，杂脂族，芳基或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR 2 O直接与环己基环连接 > VA; K为O或S; 每次出现的Y独立地是-O - ， - S - ， - NR 2 - 或 - 连接R 5部分与P的键; 每个出现的R 2和R 5独立地是脂族，杂脂族，芳基或杂芳基部分，或H; 且每次出现的R 6独立地为-PK（YR 5），（YR 5）， - SO 2 - （YR 5）或-C（O）（YR 5）; 只要与P直接连接的任何R“或R 5”部分不是H; 其中两个R 2，R 5和/或R 6 O 6部分可以彼此化学连接以形成环; 每次出现的G独立地是-O - ， - S - ， - NR 2 - 或（M）x。 每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立为1-6的整数; 其他变量如本文所定义。

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