公开(公告)号：US4956358A

公开(公告)日：1990-09-11

申请号：US72144

申请日：1987-07-10

申请人： Akira Morimoto ,  Noriyoshi Noguchi ,  Nobuo Choh

发明人： Akira Morimoto ,  Noriyoshi Noguchi ,  Nobuo Choh

IPC分类号： C07D501/14 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D513/14

CPC分类号： C07D513/14

摘要： The compounds having a 4,11-dioxo-3-oxa-8(or 7)-thia-1-azatricyclo[7,2,0,0.sup.2,6 ]undecane-2-carboxylic acid skeleton as the base structures, their esters and their salts are useful antibacterial agents.

公开(公告)号：US4953926A

公开(公告)日：1990-09-04

申请号：US322030

申请日：1989-03-13

申请人： Akira Morimoto

发明人： Akira Morimoto

IPC分类号： G02B27/00 ,  H04N1/113

CPC分类号： H04N1/1135 ,  G02B27/0031

摘要： An optical scanning system for use in a laser beam printer is disclosed which comprises a cylindrical lens for imaging laser light in an auxiliary scanning cross section at a point in front of a deflector and an anamorphic scanning lens unit which converges the light rays deflected by the deflector at a point on a scanning surface. The scanning lens unit has, in order from the deflector side, a first lens which is a negative lens element having a concave toric surface with a stronger curvature in the auxiliary scanning cross section and a second lens having a convex toric surface with a stronger curvature in the auxiliary scanning cross section. The optical system further satisfying the following condition:0.015f

摘要翻译： 公开了一种用于激光束打印机的光学扫描系统，其包括用于在偏转器前面的点处的辅助扫描横截面中的激光成像的柱面透镜和使由该偏转器偏转的光线会聚的变形扫描透镜单元 偏转器在扫描表面上的一个点处。 扫描透镜单元从偏转器侧依次具有作为副透镜元件的第一透镜，所述第一透镜具有在辅助扫描横截面中具有较强曲率的凹曲面，并且具有凸曲面的第二透镜具有较强曲率 在辅助扫描横截面。 进一步满足以下条件的光学系统：0.015f

公开(公告)号：US4930850A

公开(公告)日：1990-06-05

申请号：US267892

申请日：1988-11-07

申请人： Akira Morimoto

发明人： Akira Morimoto

IPC分类号： G02B13/08 ,  B41J2/44 ,  G02B13/00 ,  G02B26/10 ,  G02B26/12 ,  G02B27/00 ,  G02B27/09 ,  G03G15/04

CPC分类号： G02B27/09 ,  G02B19/0014 ,  G02B19/0052 ,  G02B27/0031 ,  G02B27/0933 ,  G02B27/0966

摘要： A scanning optical system for use in a laser beam printer which is small and available at low cost, and yet is capable of effectively compensating for tilting and beam shaping. The scanning lens unit in this optical system has two-element composition consisting of, in order from a deflector side, a first lens of a negative lens element having a concave spherical surface on the deflector side and a concave cylindrical surface oon the scanning surface side having a curvature in the auxiliary scanning cross section, and the second lens having a planar surface on the deflector side and a convex toric surface on the scanning surface side which has a stronger curvature in the auxiliary scanning cross section. The scanning lens unit has a shorter focal length in the auxiliary scanning cross section than in the main scanning direction and forms an image at a finite distance with the object point lying at focusing point where image is formed by the cylindrical lens. Thus, the scanning lens unit greatly reduces the effects of tilting of the deflector positioned between the focusing point and the scanning lens unit.

摘要翻译： 一种用于激光束打印机的扫描光学系统，其小型且可用于低成本，并且能够有效地补偿倾斜和光束成形。 该光学系统中的扫描透镜单元具有由偏转器侧依次排列的偏转器侧的具有凹球面的负透镜元件的第一透镜和扫描面侧的凹圆柱面的双元件结构 在辅助扫描横截面中具有曲率，并且第二透镜在偏转器侧具有平坦表面，在辅助扫描横截面上具有较强曲率的扫描表面侧上的凸面复曲面。 扫描透镜单元在辅助扫描横截面中的焦距比在主扫描方向上更短，并且形成有限距离的图像，其中物点位于由柱面透镜形成图像的聚焦点处。 因此，扫描透镜单元大大降低了位于聚焦点和扫描透镜单元之间的偏转器的倾斜效果。

公开(公告)号：US4756583A

公开(公告)日：1988-07-12

申请号：US11566

申请日：1987-02-06

申请人： Akira Morimoto

发明人： Akira Morimoto

IPC分类号： G02B26/12 ,  B41J2/44 ,  G02B13/00 ,  G02B13/08 ,  G02B26/10 ,  G02B27/00 ,  G02B9/12 ,  G02B9/04 ,  G02B9/34 ,  G02B26/08

CPC分类号： G02B9/12 ,  B41J2/442 ,  G02B13/08 ,  G02B26/10 ,  G02B27/0031

摘要： An optical system particularly for a laser beam printer comprising a semiconductor laser, a collimating lens, a cylindrical lens having curvature in the sub-scanning cross section, a deflector and anamorphic scanning lens system concentrating the light on a scanning plane. The anamorphic scanning lens system may have one to four lenses but has one lens with a convex toric surface facing the scanning plane. The anamorphic scanning lens system has stronger power in the sub-scanning cross section than in the main scanning cross section.

摘要翻译： 一种特别用于激光束打印机的光学系统，包括半导体激光器，准直透镜，在副扫描横截面中具有曲率的柱面透镜，偏转器和变形扫描透镜系统将光集中在扫描平面上。 变形扫描透镜系统可以具有一至四个透镜，但是具有一个具有面向扫描平面的凸曲面的透镜。 变形扫描透镜系统在副扫描横截面中比在主扫描横截面中具有更强的功率。

公开(公告)号：US4715699A

公开(公告)日：1987-12-29

申请号：US823236

申请日：1986-01-28

申请人： Akira Morimoto

发明人： Akira Morimoto

IPC分类号： G06K15/12 ,  G02B26/08

CPC分类号： G06K15/1228

摘要： A scanning optical system such as a laser beam printer that comprising a semiconductor laser, a collimator lens that produces substantially parallel rays of light from the beam emitted from the semiconductor laser, a convex cylinder lens having a curvature within a cross section taken in the auxiliary scanning direction, a deflector, and a scanning lens that focuses the deflected rays to form a spot on a scanning surface. The normal direction of light emitting from the semiconductor laser being in alignment with the scanning direction of the scanning lens system, and the scanning lens system having an anamorphic configuration.

摘要翻译： 一种扫描光学系统，例如激光束打印机，其包括半导体激光器，准直透镜，其从半导体激光器发射的光束产生基本上平行的光线;凸圆柱透镜，其具有在辅助部件内的横截面中的曲率 扫描方向，偏转器和聚焦偏转光线以在扫描表面上形成斑点的扫描透镜。 从半导体激光器发出的光的正常方向与扫描透镜系统的扫描方向对准，并且具有变形构型的扫描透镜系统。

公开(公告)号：US4680390A

公开(公告)日：1987-07-14

申请号：US657778

申请日：1984-10-04

申请人： Michihiko Ochiai ,  Akira Morimoto ,  Yoshihiro Matsushita

发明人： Michihiko Ochiai ,  Akira Morimoto ,  Yoshihiro Matsushita

IPC分类号： A61K31/545 ,  C07D257/04 ,  C07D277/20 ,  C07D277/40 ,  C07D277/46 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46

CPC分类号： C07D257/04 ,  C07D277/20 ,  C07D277/587

摘要： The compounds are of the class of esters of 7-[2-(2-aminothiazol-4-yl-)-2-(syn)methoxyiminoacetamido] cephalosporin derivatives, including lower alkoxymethyl, .alpha.-lower alkoxy-.alpha.-substituted methyl, lower alkylthiomethyl, acyloxymethyl, ethoxycarbonyloxy-1-methylmethyl and .alpha.- acyloxy-.alpha.-substituted methyl esters. The compounds are useful against a broad spectrum of bacteria, particularly gram-negative bacteria, and may be administered in the form of injections, capsules, tablets and granules.

摘要翻译： 这些化合物是7- [2-（2-氨基噻唑-4-基） - 2-（顺））甲氧基亚氨基乙酰胺基]头孢菌素衍生物的酯类，包括低级烷氧基甲基，α-低级烷氧基-α-取代甲基，低级 烷硫基甲基，酰氧基甲基，乙氧基羰基氧基-1-甲基甲基和α-酰氧基-α-取代的甲基酯。 该化合物可用于广谱的细菌，特别是革兰氏阴性细菌，并且可以以注射剂，胶囊剂，片剂和颗粒剂的形式施用。

公开(公告)号：US4668783A

公开(公告)日：1987-05-26

申请号：US824578

申请日：1986-01-23

申请人： Michihiko Ochiai ,  Taiiti Okada ,  Osami Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

发明人： Michihiko Ochiai ,  Taiiti Okada ,  Osami Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

IPC分类号： C07D277/20 ,  C07D277/48 ,  C07D501/20 ,  A61K31/545

CPC分类号： C07D277/20 ,  C07D277/48

摘要： Novel cephem compounds of the formula: ##STR1## wherein R.sup.4 is a residue of a nucleophilic compound selected from hydroxyl, mercapto, cyano, azido, amino, carbamoyloxy, carbamoylthio and thiocarbamoyloxy, said group being unsubstituted or substituted by alkyl of up to three carbons, and R.sup.5 is hydroxyl or lower alkoxy, or a pharmaceutically acceptable ester thereof, have strong antibiotic properties against a wide variety of microorganisms.

摘要翻译： 新的头孢烯化合物，其分子式为：其中R 4是选自羟基，巯基，氰基，叠氮基，氨基，氨基甲酰氧基，氨基甲酰硫基和硫代氨基甲酰氧基的亲核化合物的残基，所述基团是未取代的或被至多三个碳的烷基取代 R5为羟基或低级烷氧基，或其药学上可接受的酯对各种微生物具有较强的抗生素性能。

公开(公告)号：US4520194A

公开(公告)日：1985-05-28

申请号：US922423

申请日：1978-07-06

申请人： Michihiko Ochiai ,  Akira Morimoto ,  Yoshihiro Matsushita

发明人： Michihiko Ochiai ,  Akira Morimoto ,  Yoshihiro Matsushita

IPC分类号： A61K31/545 ,  C07D257/04 ,  C07D277/20 ,  C07D277/40 ,  C07D277/46 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46

CPC分类号： C07D257/04 ,  C07D277/20 ,  C07D277/587

摘要： A 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivative of the formula; ##STR1## wherein R.sub.3 is hydrogen or a residue of a nucleophilic compound; R.sub.2 NH is an amino group which may optionally be protected, pharmaceutically acceptable salt or ester thereof, is found to have excellent anti-bacterial activity against a broad spectrum of bacteria inclusive of gram-negative bacteria such as Escherichia coli, Serratia marcescens, Proteus rettgeri, Enterobacter cloacae and Citrobacter freundii. Thus, this compound may be used for an antibacterial agent in therapeutical purposes.

摘要翻译： 具有下式的7- [2-（2-氨基噻唑-4-基）-2-（顺式） - 甲氧基亚氨基乙酰胺基]头孢菌素衍生物; 其中R 3是氢或亲核化合物的残基; 发现R2NH是可任选被保护的氨基，其药学上可接受的盐或酯被发现对包括革兰氏阴性菌如大肠杆菌，粘质沙雷氏菌，变形杆菌的广谱细菌具有优异的抗细菌活性， 阴沟肠杆菌和弗氏柠檬酸杆菌。 因此，该化合物可用于治疗目的的抗菌剂。

公开(公告)号：US4298606A

公开(公告)日：1981-11-03

申请号：US71032

申请日：1979-08-28

申请人： Michihiko Ochiai ,  Taiiti Okada ,  Osami Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

发明人： Michihiko Ochiai ,  Taiiti Okada ,  Osami Aki ,  Akira Morimoto ,  Kenji Kawakita ,  Yoshihiro Matsushita

IPC分类号： C07D277/20 ,  C07D277/48 ,  C07D501/20

CPC分类号： C07D277/20 ,  C07D277/48 ,  C07D277/587

摘要： Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into methoxy group, R.sup.4 represents hydrogen or a residue of a nucleophilic compound and R.sup.8 represents hydrogen or a halogen, or a pharmaceutically acceptable salt or ester thereof, have strong antibiotic properties against a wide variety of microorganisms including gram-positive bacteria as well as gram-negative ones, especially by oral administration and can be used as therapeutic agent for various bacterial infections of animals including human beings.

摘要翻译： 新型头孢烯化合物的配方; 其中R 1表示可被保护的氨基或羟基，R 2表示氨基或羟基或可转化成这些基团的基团，R 3表示氢或甲氧基或可转化为甲氧基的基团，R 4表示氢或 亲核化合物和R8代表氢或卤素或其药学上可接受的盐或酯，对各种微生物（包括革兰氏阳性细菌以及革兰氏阴性细菌）尤其是口服给药具有很强的抗生素特性，并且可以是 用作包括人在内的动物的各种细菌感染的治疗剂。

公开(公告)号：US4182868A

公开(公告)日：1980-01-08

申请号：US794818

申请日：1977-05-06

申请人： Michihiko Ochiai ,  Akira Morimoto ,  Yoshihiro Matsushita ,  Osami Aki ,  Taiiti Okada ,  Kenji Kawakita

发明人： Michihiko Ochiai ,  Akira Morimoto ,  Yoshihiro Matsushita ,  Osami Aki ,  Taiiti Okada ,  Kenji Kawakita

IPC分类号： C07D501/36 ,  C07D501/57

CPC分类号： C07D501/57

摘要： A compound of the formula: ##STR1## wherein R.sup.2 is hydrogen or a halogen and R.sup.3 stands for methyl, acetoxymethyl, carbamoyloxymethyl, an alkoxymethyl, an alkylthiomethyl, 2-carboxy-1-ethenyl, or a heterocyclic thiomethyl, or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against Gram-negative bacteria including Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Serratia marcescense as well as Gram-positive ones including antibiotic resistant strains. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

摘要翻译： 下式的化合物：其中R 2是氢或卤素，R 3代表甲基，乙酰氧基甲基，氨基甲酰氧基甲基，烷氧基甲基，烷硫基甲基，2-羧基-1-乙烯基或杂环硫甲基或其药学上可接受的盐 被发现具有广泛的抗菌谱，特别是对革兰氏阴性菌有效，包括大肠杆菌，普通变形杆菌，铜绿假单胞菌，粘质沙雷氏菌以及包括抗生素抗性菌株在内的革兰氏阳性细菌。 因此，这些化合物可用于治疗目的的抗微生物剂。