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    SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION
    41.
    发明申请
    SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
    闭环神经刺激的系统和方法

    公开(公告)号：US20130165998A1

    公开(公告)日：2013-06-27

    申请号：US13709271

    申请日：2012-12-10

    申请人： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    发明人： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36053 ,  A61N1/36117

    摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.

    摘要翻译： 各种装置实施例包括脉冲发生器，信号处理模块和控制器。 脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。 信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。 控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。 控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。 本文提供了其它方面和实施例。

    System and method for neural stimulation
    42.
    发明授权
    System and method for neural stimulation 有权

    公开(公告)号：US08457734B2

    公开(公告)日：2013-06-04

    申请号：US11468135

    申请日：2006-08-29

    申请人： Imad Libbus ,  Andrew P. Kramer ,  Anthony V. Caparso ,  Kristofer J. James ,  Stephen Ruble ,  Weiying Zhao

    发明人： Imad Libbus ,  Andrew P. Kramer ,  Anthony V. Caparso ,  Kristofer J. James ,  Stephen Ruble ,  Weiying Zhao

    IPC分类号： A61N1/365

    CPC分类号： A61N1/365 ,  A61N1/36053 ,  A61N1/36114

    摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

    System and method for closed-loop neural stimulation
    44.
    发明授权
    System and method for closed-loop neural stimulation 有权
    闭环神经刺激的系统和方法

    公开(公告)号：US08396560B2

    公开(公告)日：2013-03-12

    申请号：US10992319

    申请日：2004-11-18

    申请人： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    发明人： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36117 ,  A61N1/08 ,  A61N1/36171

    摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.

    摘要翻译： 本主题的各个方面提供了一种装置。 在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并且适于接收和处理 神经交通信号从引导到指示神经交通的信号。 该装置包括连接到脉冲发生器和信号处理模块的控制器。 控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。 本文提供了其他方面。

    CARDIAC RHYTHM MANAGEMENT SYSTEM SELECTING BETWEEN MULTIPLE SAME-CHAMBER ELECTRODES FOR DELIVERING CARDIAC THERAPY
    46.
    发明申请
    CARDIAC RHYTHM MANAGEMENT SYSTEM SELECTING BETWEEN MULTIPLE SAME-CHAMBER ELECTRODES FOR DELIVERING CARDIAC THERAPY 有权
    CARDIAC RHYTHM管理系统选择用于提供心脏治疗的多个相同电极

    公开(公告)号：US20130030485A1

    公开(公告)日：2013-01-31

    申请号：US13646720

    申请日：2012-10-07

    申请人： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

    发明人： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368

    摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

    摘要翻译： 心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及 在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。 随后的收缩诱导刺激疗法从所选择的电极递送。

    AUTONOMIC MODULATION USING TRANSIENT RESPONSE WITH INTERMITTENT NEURAL STIMULATION
    49.
    发明申请
    AUTONOMIC MODULATION USING TRANSIENT RESPONSE WITH INTERMITTENT NEURAL STIMULATION 有权
    使用瞬时响应与间歇性神经刺激的自动调制

    公开(公告)号：US20110257708A1

    公开(公告)日：2011-10-20

    申请号：US13086806

    申请日：2011-04-14

    申请人： Andrew P. Kramer ,  Jason J. Hamann

    发明人： Andrew P. Kramer ,  Jason J. Hamann

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36139 ,  A61N1/0551 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36117

    摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.

    摘要翻译： 在用于操作可植入神经刺激器以将神经刺激疗法递送至自主神经靶标的各种方法实施例中，该方法包括使用可植入神经刺激器将神经刺激疗法递送至自主神经靶标，以及评估对神经元的诱发反应 刺激爆发。 神经刺激治疗包括多个神经刺激脉冲串，其中每个神经刺激脉冲串包括多个神经刺激脉冲，并且连续神经刺激脉冲串在没有神经刺激脉冲的情况下被分离一段时间。 评估诱发反应包括感测对神经刺激突发的诱发反应，其中感测诱发反应包括感测受神经刺激突发影响的至少一个生理参数，将感测的诱发反应与基线进行比较，以及确定诱发反应是否基本上返回 到神经刺激爆发之间的基线。

    System and method for testing neural stimulation threshold
    50.
    发明授权
    System and method for testing neural stimulation threshold 有权
    神经刺激阈值检测系统及方法

    公开(公告)号：US08041423B2

    公开(公告)日：2011-10-18

    申请号：US13024120

    申请日：2011-02-09

    申请人： Imad Libbus ,  Andrew P. Kramer

    发明人： Imad Libbus ,  Andrew P. Kramer

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： Various system embodiments comprise a neural stimulator, a premature ventricular contraction (PVC) event detector, a heart rate detector, an analyzer, and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to stimulate an autonomic neural target. The analyzer is adapted to, in response to a PVC event signal from the PVC event detector, generate an autonomic balance indicator (ABI) as a function of pre-PVC heart rate data and post-PVC heart rate data. Other aspects and embodiments are provided herein.

    摘要翻译： 各种系统实施例包括神经刺激器，早产性心室收缩（PVC）事件检测器，心率检测器，分析器和控制器。 神经刺激器适于产生适于刺激自主神经靶标的刺激信号。 分析器适于响应来自PVC事件检测器的PVC事件信号，产生作为PVC前心率数据和PVC后心率数据的函数的自主平衡指示器（ABI）。 本文提供了其它方面和实施例。