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1.发明授权Autonomic modulation using transient response with intermittent neural stimulation 有权使用间歇神经刺激的瞬态响应的自主调制公开(公告)号：US09126044B2
公开(公告)日：2015-09-08
申请号：US13086806
申请日：2011-04-14
申请人： Andrew P. Kramer , Jason J. Hamann
发明人： Andrew P. Kramer , Jason J. Hamann
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
摘要翻译： 在用于操作可植入神经刺激器以将神经刺激疗法递送至自主神经靶标的各种方法实施例中，该方法包括使用可植入神经刺激器将神经刺激疗法递送至自主神经靶标，以及评估对神经元的诱发反应 刺激爆发。 神经刺激治疗包括多个神经刺激脉冲串，其中每个神经刺激脉冲串包括多个神经刺激脉冲，并且连续神经刺激脉冲串在没有神经刺激脉冲的情况下被分离一段时间。 评估诱发反应包括感测对神经刺激突发的诱发反应，其中感测诱发反应包括感测受神经刺激突发影响的至少一个生理参数，将感测的诱发反应与基线进行比较，以及确定诱发反应是否基本上返回 到神经刺激爆发之间的基线。
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2.发明申请AUTONOMIC MODULATION USING TRANSIENT RESPONSE WITH INTERMITTENT NEURAL STIMULATION 有权使用瞬时响应与间歇性神经刺激的自动调制公开(公告)号：US20110257708A1
公开(公告)日：2011-10-20
申请号：US13086806
申请日：2011-04-14
申请人： Andrew P. Kramer , Jason J. Hamann
发明人： Andrew P. Kramer , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
摘要翻译： 在用于操作可植入神经刺激器以将神经刺激疗法递送至自主神经靶标的各种方法实施例中，该方法包括使用可植入神经刺激器将神经刺激疗法递送至自主神经靶标，以及评估对神经元的诱发反应 刺激爆发。 神经刺激治疗包括多个神经刺激脉冲串，其中每个神经刺激脉冲串包括多个神经刺激脉冲，并且连续神经刺激脉冲串在没有神经刺激脉冲的情况下被分离一段时间。 评估诱发反应包括感测对神经刺激突发的诱发反应，其中感测诱发反应包括感测受神经刺激突发影响的至少一个生理参数，将感测的诱发反应与基线进行比较，以及确定诱发反应是否基本上返回 到神经刺激爆发之间的基线。
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公开(公告)号：US09937353B2
公开(公告)日：2018-04-10
申请号：US13306745
申请日：2011-11-29
CPC分类号： A61N1/37282 , A61N1/0556 , A61N1/36132 , A61N1/3615 , A61N1/36178 , A61N1/36185 , A61N1/37252
摘要： According to an embodiment of a method performed by an implantable medical device to deliver a neural stimulation therapy to a patient, a lower dose of the neural stimulation therapy is delivered to the patient. The dose of the neural stimulation therapy is automatically increased from the lower dose to a higher dose, and the higher dose of the neural stimulation therapy is delivered to the patient. A trigger that is controlled by the patient is detected, and the dose of the neural stimulation therapy is automatically returned from the higher dose back to the lower dose in response to detecting the trigger.
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公开(公告)号：US08594805B2
公开(公告)日：2013-11-26
申请号：US13586432
申请日：2012-08-15
申请人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
发明人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61B5/0492 , A61B5/0488 , A61B5/4035 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： Some embodiments provide a system for delivering neurostimulation. Some system embodiments comprise a lead configured to be implanted in the body, a stimulation output circuit configured to deliver neurostimulation pulses to the vagus nerve through the lead, an EMG sensing circuit configured to use the lead to sense EMG signals from laryngeal muscle activity, and an evoked muscular response detection circuit configured to use the EMG signals sensed by the EMG sensing circuit to detect evoked laryngeal muscle activity evoked by the neurostimulation pulse.
摘要翻译： 一些实施例提供用于递送神经刺激的系统。 一些系统实施例包括被配置为植入体内的引线，刺激输出电路，其经配置以通过引线将神经刺激脉冲输送到迷走神经; EMG感测电路，被配置为使用引线来感测来自喉部肌肉活动的EMG信号;以及 诱发肌肉反应检测电路，被配置为使用由EMG感测电路感测的EMG信号来检测由神经刺激脉冲诱发的诱发喉部肌肉活动。
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公开(公告)号：US08483821B2
公开(公告)日：2013-07-09
申请号：US12843444
申请日：2010-07-26
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.
摘要翻译： 可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。 此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。
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公开(公告)号：US08285373B2
公开(公告)日：2012-10-09
申请号：US12835288
申请日：2010-07-13
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate info nation using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译： 一个实施例使用加速度计来感测心脏声音，并且使用所感测到的心脏声音来确定心率信息国家。 一个实施例使用加速计来感测呼吸活动。 实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，随后是刺激关闭部分。 电连接到植入的神经刺激装置的电极用于远程检测心脏活动。 远程检测到的心脏活动用于在刺激ON部分期间检测心率信息，并在刺激OFF部分期间检测心率信息。 检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激器装置执行的神经刺激治疗和/或用于提供患者状况的诊断信息。
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公开(公告)号：US20110137360A1
公开(公告)日：2011-06-09
申请号：US12962168
申请日：2010-12-07
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61B5/0028 , A61B5/4848 , A61B5/7207 , A61N1/37 , A61N1/37288
摘要： Various method embodiments detect a concurrent therapy, where the concurrent therapy includes a plurality of therapy pulses. Detecting the concurrent therapy includes detecting at least one electrical pulse, extracting at least one characteristic from the at least one electrical pulse, comparing the at least one characteristic of the detected pulse to at least one characteristic of therapy pulses, and detecting that the concurrent therapy is being applied if the at least one characteristic of the detected pulse favorably compares to the at least one characteristic of the therapy pulses.
摘要翻译： 各种方法实施例检测并行治疗，其中并发治疗包括多个治疗脉冲。 检测并行治疗包括检测至少一个电脉冲，从至少一个电脉冲中提取至少一个特征，将检测到的脉冲的至少一个特征与治疗脉冲的至少一个特征进行比较，以及检测并发治疗 如果检测到的脉冲的至少一个特性有利地与治疗脉冲的至少一个特性相比较，则被应用。
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公开(公告)号：US20110015702A1
公开(公告)日：2011-01-20
申请号：US12835288
申请日：2010-07-13
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate info nation using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译： 一个实施例使用加速度计来感测心脏声音，并且使用所感测到的心脏声音来确定心率信息国家。 一个实施例使用加速计来感测呼吸活动。 实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，随后是刺激关闭部分。 电连接到植入的神经刺激装置的电极用于远程检测心脏活动。 远程检测到的心脏活动用于在刺激ON部分期间检测心率信息，并在刺激OFF部分期间检测心率信息。 检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激器装置执行的神经刺激治疗和/或用于提供患者状况的诊断信息。
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9.发明授权公开(公告)号：US09314627B2
公开(公告)日：2016-04-19
申请号：US13453279
申请日：2012-04-23
申请人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
发明人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/36053 , A61N1/3611 , A61N1/36132 , A61N1/36135
摘要： Some embodiments provide a method, comprising performing a neural stimulation test routine for stimulating a neural target in a cervical region of a patient, wherein for each of a plurality of head positions, performing the neural stimulation test routine includes testing a plurality of electrode configurations. The method further comprises recording threshold data for each of the tested electrode configurations for the plurality of head positions, and recommending an electrode configuration based on the recorded threshold data.
摘要翻译： 一些实施例提供了一种方法，包括执行用于刺激患者的子宫颈区域中的神经靶标的神经刺激测试程序，其中对于多个头部位置中的每一个，执行神经刺激测试程序包括测试多个电极配置。 该方法还包括记录针对多个头部位置的每个测试电极配置的阈值数据，以及基于记录的阈值数据推荐电极配置。
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10.发明授权Method and apparatus for adaptive control of neurostimulation using cardiac restitution 有权使用心脏恢复法进行神经刺激的自适应控制的方法和装置公开(公告)号：US09126045B2
公开(公告)日：2015-09-08
申请号：US13586503
申请日：2012-08-15
CPC分类号： A61N1/36114 , A61N1/36139
摘要： A neurostimulation system measures a cardiac parameter at various cardiac intervals and analyzes its restitution, including computing a restitution slope being a rate of change of the restitution parameter with respect to change in the cardiac interval. In various embodiments, the system uses the restitution slope to provide for adaptive control of neurostimulation. In various embodiments, one or more cardiac parameters such as action potential duration (APD), conduction velocity (CV), QT interval (QT), and/or T-wave morphology (TM) parameter are measured and analyzed for restitution of each parameter, which is then used to control the delivery of the neurostimulation.
摘要翻译： 神经刺激系统以各种心脏间隔测量心脏参数并分析其恢复，包括计算相对于心脏间隔变化的恢复参数的变化率的恢复斜率。 在各种实施例中，系统使用恢复斜率来提供神经刺激的自适应控制。 在各种实施例中，测量并分析一个或多个心脏参数，例如动作电位持续时间（APD），传导速度（CV），QT间期（QT）和/或T波形态（TM）参数，以分析每个参数的恢复 ，然后用于控制神经刺激的递送。
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