公开(公告)号：US08457726B2

公开(公告)日：2013-06-04

申请号：US12933612

申请日：2008-04-29

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61B5/04

CPC分类号： A61N1/3702 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/7239 ,  A61B5/7275 ,  A61N1/36521 ,  G06F19/00

摘要： An implantable medical device has an event detector that detects a predetermined cardiac event during a heart cycle of a subject. A reference time is assigned to this detected cardiac event. An onset detector detects the onset of ventricular filling of the heart during the heart cycle. The relative time of the detected filling onset is determined based on the assigned time reference. An increased risk of heart failure of the subject is automatically determined based on the determined relative time for the filling onset. Generally, a reduction in the relative time, as determined at different points in time, indicates an increased heart failure risk or the presence of a heart failure condition.

摘要翻译： 可植入医疗装置具有事件检测器，其在对象的心脏周期期间检测预定的心脏事件。 参考时间被分配给该检测到的心脏事件。 发作检测器检测在心脏周期期间心脏心脏充盈的发作。 根据分配的时间参考确定检测到的填充开始的相对时间。 基于所确定的填充开始的相对时间自动确定受试者心脏衰竭的风险增加。 通常，在不同时间点确定的相对时间的减少表示心力衰竭风险增加或心力衰竭状况的存在。

公开(公告)号：US20130023947A1

公开(公告)日：2013-01-24

申请号：US13514273

申请日：2009-12-09

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61N1/365

CPC分类号： A61B5/053 ,  A61N1/36521 ,  A61N1/36564

摘要： Implantable heart stimulator comprising a control unit including a memory, a sensing unit, a pulse stimulation unit adapted to generate stimulation pulses separated by a variable predetermined pacing interval (PI), and also a method in a heart stimulator. The heart stimulator is adapted to be connected to one or many heart electrode leads provided with stimulating and sensing electrodes in order to stimulate heart tissue by said stimulation pulses and sense electrical heart events. The heart stimulator comprises a control parameter measurement unit adapted to derive a control parameter value indicative of end-diastolic pressure (EDP). At specified intervals, the control unit is adapted to vary the predetermined pacing interval (PI) according to a predetermined pacing interval (PI) search session scheme, and that control parameter values are determined, by said control parameter measurement unit at the different pacing intervals tested during said PI search session, and in that determined control parameter values and corresponding pacing intervals are stored in said memory. The maximum control parameter value obtained during one PI search session is determined and the corresponding pacing interval, denoted PIopt, is identified and used when stimulating the heart resulting in a maximal end-diastolic pressure.

摘要翻译： 可植入心脏刺激器，其包括控制单元，其包括存储器，感测单元，适于产生由可变预定起搏间隔（PI）分离的刺激脉冲的脉冲刺激单元，以及心脏刺激器中的方法。 心脏刺激器适于连接到设置有刺激和感测电极的一个或多个心脏电极引线，以便通过所述刺激脉冲刺激心脏组织并感测电心脏事件。 心脏刺激器包括适于导出指示舒张末期压力（EDP）的控制参数值的控制参数测量单元。 以规定的间隔，控制单元适于根据预定的起搏间隔（PI）搜索会话方案来改变预定的起搏间隔（PI），并且通过所述控制参数测量单元以不同的起搏间隔确定控制参数值 在所述PI搜索会话期间进行测试，并且将所确定的控制参数值和相应的起搏间隔存储在所述存储器中。 确定在一个PI搜索会话期间获得的最大控制参数值，并且在刺激心脏导致最大舒张末期压力时识别并使用表示为PIopt的相应起搏间隔。

公开(公告)号：US08321016B2

公开(公告)日：2012-11-27

申请号：US12602533

申请日：2007-06-13

申请人： Nils Holmström ,  Andreas Blomqvist ,  Sven-Erik Hedberg ,  Malin Öhlander

发明人： Nils Holmström ,  Andreas Blomqvist ,  Sven-Erik Hedberg ,  Malin Öhlander

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3702 ,  A61B5/0464 ,  A61B5/053 ,  A61B5/7264

摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.

摘要翻译： 在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。 在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性​​室性快速性心律失常。

公开(公告)号：US20120221071A1

公开(公告)日：2012-08-30

申请号：US13355696

申请日：2012-01-23

申请人： Andreas Karlsson ,  Andreas Blomqvist ,  Karin Jarverud

发明人： Andreas Karlsson ,  Andreas Blomqvist ,  Karin Jarverud

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36528 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36592

摘要： In an implantable medical device, such as a cardiac stimulator such as a pacemaker, and method for predicting patient responses to physical exertion, the patient response is monitored over time to evaluate disease progression and pacing therapies of cardiac stimulators are adapted based on the predicted patient response. A current cardiac status indicator for the patient is created indicating a response of the patient to an increased physical activity as a primarily heart rate response or as a primarily a stroke volume response. The pacing parameters of the cardiac stimulator can thereafter be adapted depending on the current cardiac status indicator, wherein the adapted pacing parameters include a first pacing setting if the current cardiac status indicator indicates a primarily heart rate response or a second pacing setting if the current cardiac status indicator indicates a primarily stroke volume response.

摘要翻译： 在诸如心脏起搏器等心脏刺激器的可植入医疗装置中，以及用于预测患者对体力消耗的反应的方法，随着时间的推移监视患者反应以评估心脏刺激器的疾病进展和起搏疗法，基于预测患者 响应。 产生患者的当前心脏状态指示符，指示患者作为主要心率反应或作为主要的中风体积响应的增加的身体活动的反应。 心脏刺激器的起搏参数随后可以根据当前的心脏状态指示器进行调整，其中如果当前心脏状态指示符指示主要的心率响应或第二起搏设置，如果当前的心脏 状态指示器表示主要是中风体积响应。

公开(公告)号：US20110202102A1

公开(公告)日：2011-08-18

申请号：US13119992

申请日：2008-09-23

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61N1/36

CPC分类号： A61N1/36585 ,  A61N1/3682 ,  A61N1/3702

摘要： An implantable medical device measures an AV delay in connection with measurement of N physiological patient parameters. The parameters are used for identifying a sub-space of an N-dimensional parameter space. An expected AV delay is assigned to the identified sub-space based on the measured AV delay, where the parameter space with expected AV delays constitute decision support information to be used by the device for performing a selective heart pacing. This selective pacing is performed based on a priori probability determined using the support information and a measured set of N parameters. The a priori probability represents the probability of successful AV conduction at a current patient condition determined based on the measured parameters.

摘要翻译： 可植入医疗装置测量与N个生理学患者参数的测量相关的AV延迟。 这些参数用于识别N维参数空间的子空间。 基于所测量的AV延迟，将预期的AV延迟分配给所识别的子空间，其中具有预期AV延迟的参数空间构成要由设备用于执行选择性心脏起搏的决策支持信息。 基于使用支持信息确定的先验概率和N个参数的测量集来执行该选择性起搏。 先验概率表示在基于测量的参数确定的当前患者状况下AV传导成功的概率。

公开(公告)号：US20110046691A1

公开(公告)日：2011-02-24

申请号：US12990136

申请日：2008-06-18

申请人： Anders Björling ,  Andreas Blomqvist ,  Karin Järverud

发明人： Anders Björling ,  Andreas Blomqvist ,  Karin Järverud

IPC分类号： A61N1/36

CPC分类号： A61B5/0215 ,  A61B5/053 ,  A61N1/36521

摘要： An implantable heart stimulator has an impedance measurement a cardiogenic impedance waveform using an impedance configuration arranged to measure myocardial contractility of the heart. The heart stimulator further has a calculating unit that calculates an estimate value being related to at least two impedance values of the waveform, or of an average waveform of several consecutive waveforms, during a predetermined time period of the waveform, or average waveform, the calculated estimate value being an estimate of the left ventricular (LV) systolic pressure.

摘要翻译： 可植入心脏刺激器具有使用布置成测量心脏的心肌收缩力的阻抗配置的心源阻抗波形的阻抗测量。 心脏刺激器还具有计算单元，该计算单元在波形的预定时间段期间，计算与波形的至少两个阻抗值或几个连续波形的平均波形有关的估计值，或者计算出平均波形 估计值是左心室（LV）收缩压的估计值。

公开(公告)号：US20110028855A1

公开(公告)日：2011-02-03

申请号：US12933612

申请日：2008-04-29

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61B5/02 ,  A61B5/0452

CPC分类号： A61N1/3702 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/7239 ,  A61B5/7275 ,  A61N1/36521 ,  G06F19/00

摘要： An implantable medical device has an event detector that detects a predetermined cardiac event during a heart cycle of a subject. A reference time is assigned to this detected cardiac event. An onset detector detects the onset of ventricular filling of the heart during the heart cycle. The relative time of the detected filling onset is determined based on the assigned time reference. An increased risk of heart failure of the subject is automatically determined based on the determined relative time for the filling onset. Generally, a reduction in the relative time, as determined at different points in time, indicates an increased heart failure risk or the presence of a heart failure condition.

摘要翻译： 可植入医疗装置具有事件检测器，其在对象的心脏周期期间检测预定的心脏事件。 参考时间被分配给该检测到的心脏事件。 发作检测器检测在心脏周期期间心脏心脏充盈的发作。 根据分配的时间参考确定检测到的填充开始的相对时间。 基于所确定的填充开始的相对时间自动确定受试者心脏衰竭的风险增加。 通常，在不同时间点确定的相对时间的减少表示心力衰竭风险增加或心力衰竭状况的存在。

公开(公告)号：US20100298904A1

公开(公告)日：2010-11-25

申请号：US12863381

申请日：2008-01-28

申请人： Andreas Blomqvist ,  Nils Holmström ,  Malin Öhlander ,  Sven-Erik Hedberg

发明人： Andreas Blomqvist ,  Nils Holmström ,  Malin Öhlander ,  Sven-Erik Hedberg

IPC分类号： A61N1/365

CPC分类号： A61N1/36521 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/3684

摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.

摘要翻译： 可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。 根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。 分离指数值是心脏不同程度的机械不同步的度量。

公开(公告)号：US20090281584A1

公开(公告)日：2009-11-12

申请号：US12519416

申请日：2006-12-20

申请人： Andreas Blomqvist ,  Anders Bjorling ,  Göran Budgivars ,  Dominic Rivas ,  Maria Torpo

发明人： Andreas Blomqvist ,  Anders Bjorling ,  Göran Budgivars ,  Dominic Rivas ,  Maria Torpo

IPC分类号： A61N1/362 ,  A61B5/04 ,  A61N1/39 ,  H01R43/00

CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61B5/416 ,  A61B5/418 ,  A61N1/365 ,  Y10T29/49002

摘要： An implantable medical sensor arrangement has a sensor body configured for implantation in a subject, to which at least one sensor head is connected through at least one connective wire. The sensor head(s) and at least a portion of the connective wire(s) are tightly packed and enclosed by a protective sensor shell. This sensor shell is composed of a dissolvable material that will dissolve or can be triggered to dissolve following introduction of the sensor arrangement into a subject.

摘要翻译： 可植入医疗传感器装置具有构造成用于植入受试者的传感器主体，至少一个传感器头通过至少一个连接线连接到该主体上。 传感头和至少一部分连接线被一个保护传感器外壳紧密地包住并包围。 该传感器外壳由可溶解的材料组成，其可以在将传感器装置引入被摄体之后溶解或者被触发以溶解。

公开(公告)号：US09522275B2

公开(公告)日：2016-12-20

申请号：US13884934

申请日：2010-11-30

申请人： Andreas Blomqvist ,  Torbjorn Persson ,  Rolf Hill

发明人： Andreas Blomqvist ,  Torbjorn Persson ,  Rolf Hill

IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/368

CPC分类号： A61N1/365 ,  A61N1/3627 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684

摘要： Methods and systems for optimizing stimulation of a heart of a patient are disclosed. The method comprises: determining recommended pacing settings including recommended AV delays and/or recommended VV delays based on IEGM data. Further, at least one hemodynamical parameter is determined based on measured at least one hemodynamical signal. Reference pacing settings are determined including reference AV delays and/or reference VV delays based on said hemodynamical parameters. An AV delay correction value and a VV delay correction value are calculated as a difference between recommended AV and/or VV delays and reference AV and/or VV delays, respectively. The correction values are used for updating recommended AV and/or VV delays, respectively.

摘要翻译： 公开了用于优化患者心脏刺激的方法和系统。 该方法包括：根据IEGM数据确定推荐的起搏设置，包括推荐的AV延迟和/或推荐的VV延迟。 此外，基于测量的至少一个血液动力学信号来确定至少一个血液动力学参数。 基于所述血液动力学参数确定参考起搏设置，包括参考AV延迟和/或参考VV延迟。 AV延迟校正值和VV延迟校正值被分别计算为推荐的AV和/或VV延迟与参考AV和/或VV延迟之间的差。 校正值分别用于更新推荐的AV和/或VV延迟。