公开(公告)号：US20120321845A1

公开(公告)日：2012-12-20

申请号：US13516761

申请日：2010-10-25

Applicant: Karl Forsch ,  Marco Schneiders ,  Guido Stopp ,  Ralf Burkholder ,  Andreas Strasser

Inventor： Karl Forsch ,  Marco Schneiders ,  Guido Stopp ,  Ralf Burkholder ,  Andreas Strasser

IPC: B24B33/02 ,  B32B3/24

CPC classification number: B24B33/02 ,  Y10T428/24322

Abstract: The invention relates to a method for producing a honed segment bore (5-8) in work pieces (1-4), which each have a segment bore (5-8). The work pieces (1-4) are arranged relative to each other such that the segment bores (5-8) of the work pieces (1-4) are aligned to a common longitudinal axis (9) and a closed circle (12) is formed in a projection along the common longitudinal axis (9). The segment bores (5-8) of the work pieces (1-4) arranged relative to each other are then honed together. An elaborate grinding process can thus be replaced by a honing process, in which a plurality of work pieces (1-4) can be processed simultaneously, thus reducing the cycle time.

Abstract translation: 本发明涉及一种用于在工件（1-4）中生产珩磨段孔（5-8）的方法，其中每个具有段孔（5-8）。 工件（1-4）相对于彼此布置，使得工件（1-4）的段孔（5-8）与公共纵向轴线（9）和闭合圆圈（12）对准， 沿着共同纵向轴线（9）形成在突起中。 然后将相对于彼此布置的工件（1-4）的段孔（5-8）磨成一体。 因此，可以通过珩磨处理来代替精细的研磨工艺，其中可以同时处理多个工件（1-4），从而减少循环时间。

公开(公告)号：US20110256152A1

公开(公告)日：2011-10-20

申请号：US13021279

申请日：2011-02-04

Applicant: Andreas Strasser ,  Mark McKenzie ,  Helen Thomas ,  Janette Allison ,  Tom Kay

Inventor： Andreas Strasser ,  Mark McKenzie ,  Helen Thomas ,  Janette Allison ,  Tom Kay

IPC: A61K39/395 ,  C12Q1/68 ,  G01N33/53 ,  C12N5/00 ,  A61K35/39 ,  A61K38/00 ,  A61K31/7088 ,  A61P3/10 ,  A61K35/36 ,  A61K35/12 ,  C12N5/02

CPC classification number: C12N15/1135 ,  A61K31/7088 ,  A61K31/713 ,  C07K16/22

Abstract: The present invention relates to a method for treating and/or preventing a disease associated with glucose toxicity in a subject which may comprise administering to the subject a compound that reduces the level of Bim, PUMA and/or Bax activity in a cell of the subject. Furthermore, provided is a method for culturing cells susceptible to exposure to high concentrations of glucose, which may comprise delivering to the cells, or progenitor cells thereof, a compound that reduces the level of Bim, PUMA and/or Bax activity in the cells.

Abstract translation: 本发明涉及用于治疗和/或预防与受试者中葡萄糖毒性相关的疾病的方法，其可包括向受试者施用降低受试者细胞中Bim，PUMA和/或Bax活性水平的化合物 。 此外，提供了培养容易暴露于高浓度葡萄糖的细胞的方法，所述细胞可以包含向细胞或其祖细胞递送降低细胞中Bim，PUMA和/或Bax活性水平的化合物。

公开(公告)号：US07818141B2

公开(公告)日：2010-10-19

申请号：US11914775

申请日：2007-01-15

Applicant: Markus Roth ,  Andreas Strasser

Inventor： Markus Roth ,  Andreas Strasser

IPC: G06F19/00 ,  G06F17/40

CPC classification number: G01H1/00

Abstract: The invention relates to a vibration dosimeter (2) and a method for determining the daily vibrational loading of persons who are exposed to mechanical oscillations at their place of work due to the operation of a work means and in particular of a manually operated electronic tool (4, 6). What is provided is that the dosimeter (2) comprises a determination device (12, 18) for determining the effective daily operating duration of the work means (4, 6), a computer device (22) for calculating a daily work time until a specified trigger value or exposition limit value of the vibrational loading is reached from a work-means-typical vibration value and the trigger value or exposition limit value, and a comparison device (24) for comparing the determined effective daily operating duration of the work means with the calculated daily work time until the specified trigger value is reached.

Abstract translation: 本发明涉及一种振动剂量计（2）和一种用于确定由于工作装置的操作而暴露于其工作地点的机械振荡的人的日常振动负载的方法，特别是涉及一种手动操作的电子工具 4，6）。 提供的是剂量计（2）包括用于确定工作装置（4,6）的有效日工作持续时间的确定装置（12,18），计算机装置（22），用于计算直到 根据工作装置典型振动值和触发值或曝光极限值达到振动载荷的指定触发值或曝光极限值;以及比较装置（24），用于比较所确定的工作装置的有效日工作持续时间 与计算的每日工作时间，直到达到指定的触发值。

公开(公告)号：US20090294144A1

公开(公告)日：2009-12-03

申请号：US12539816

申请日：2009-08-12

Applicant: Karl Frauhammer ,  Gerhard Meixner ,  Heiko Roehm ,  Willy Braun ,  Axel Kuhnle ,  Andreas Strasser ,  Ralph Dammertz ,  Joachim Schadow ,  Christian Koepf ,  Juergen Lennartz

Inventor： Karl Frauhammer ,  Gerhard Meixner ,  Heiko Roehm ,  Willy Braun ,  Axel Kuhnle ,  Andreas Strasser ,  Ralph Dammertz ,  Joachim Schadow ,  Christian Koepf ,  Juergen Lennartz

IPC: B25D17/24 ,  B25D17/04

CPC classification number: B25D17/043

Abstract: A hand-held power tool has a main element; a main handle fastened to the main element, the main handle being supported such that the main handle is movable relative to the main element, the main element including a tool fitting that defines a tool axis and the center of gravity that defines a normal direction oriented perpendicular to the tool axis and pointing toward the center of gravity, the main element being moved out of a stationary position toward the main handle so that a portion of at least 10% by weight of the main element is guided with a movement component in the normal direction along a trajectory.

Abstract translation: 手持式电动工具具有主要元件; 主把手被固定到主元件，主把手被支撑为使得主手柄相对于主元件可移动，主元件包括限定工具轴线的工具配件和限定法线方向取向的重心 垂直于工具轴线并指向重心，主元件从静止位置移动到主把手，使得主元件的至少10重量％的部分被引导到主元件的移动部件 正常方向沿轨迹。

公开(公告)号：US07582439B2

公开(公告)日：2009-09-01

申请号：US11409944

申请日：2006-04-24

Applicant: Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

Inventor： Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

IPC: G01N33/536

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.

Abstract translation: 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bim”，以及编码它们的遗传序列。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。

公开(公告)号：US07572900B2

公开(公告)日：2009-08-11

申请号：US10479307

申请日：2002-05-30

Applicant: Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine Ann O'Reilly ,  David Ching Siang Huang

Inventor： Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine Ann O'Reilly ,  David Ching Siang Huang

IPC: C07H21/04

CPC classification number: C07K14/4747 ,  A01K2217/05 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells.

Abstract translation: 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bmf”，以及编码它们的遗传序列以及调节序列，例如引导Bmf表达的启动子序列。 Bmf包含BH3结构域，其促进与生存Bcl-2家族成员的相互作用，从而引发细胞凋亡。 因此，Bmf被认为是仅BH3分子。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。 本发明进一步考虑了遗传修饰的动物，其中Bmf的一个或两个等位基因单独突变或部分或全部缺失，或与另一个Bcl-2型分子的一个或两个等位基因中的突变组合，例如但不限于Bim 。 遗传修饰的动物尤其可用于筛选改善由凋亡缺陷引起的疾病症状或特异性促进靶细胞凋亡的药剂。

公开(公告)号：US20090140154A1

公开(公告)日：2009-06-04

申请号：US11914775

申请日：2007-01-15

Applicant: Markus Roth ,  Andreas Strasser

Inventor： Markus Roth ,  Andreas Strasser

IPC: G01T1/02

CPC classification number: G01H1/00

Abstract: The invention relates to a vibration dosimeter (2) and a method for determining the daily vibrational loading of persons who are exposed to mechanical oscillations at their place of work due to the operation of a work means and in particular of a manually operated electronic tool (4, 6). What is provided is that the dosimeter (2) comprises a determination device (12, 18) for determining the effective daily operating duration of the work means (4, 6), a computer device (22) for calculating a daily work time until a specified trigger value or exposition limit value of the vibrational loading is reached from a work-means-typical vibration value and the trigger value or exposition limit value, and a comparison device (24) for comparing the determined effective daily operating duration of the work means with the calculated daily work time until the specified trigger value is reached.

Abstract translation: 本发明涉及一种振动剂量计（2）和一种用于确定由于工作装置的操作而暴露于其工作地点的机械振荡的人的日常振动负载的方法，特别是涉及一种手动操作的电子工具 4，6）。 提供的是剂量计（2）包括用于确定工作装置（4,6）的有效日工作持续时间的确定装置（12,18），计算机装置（22），用于计算直到 根据工作装置典型振动值和触发值或曝光极限值达到振动载荷的指定触发值或曝光极限值;以及比较装置（24），用于比较所确定的工作装置的有效日工作持续时间 与计算的每日工作时间，直到达到指定的触发值。

公开(公告)号：US07527272B2

公开(公告)日：2009-05-05

申请号：US11446431

申请日：2006-06-02

Applicant: Karl Frauhammer ,  Manfred Hellbach ,  Heinz Schnerring ,  Joerg Friedrich ,  Andreas Strasser ,  Michael Mayer ,  Werner Huser

Inventor： Karl Frauhammer ,  Manfred Hellbach ,  Heinz Schnerring ,  Joerg Friedrich ,  Andreas Strasser ,  Michael Mayer ,  Werner Huser

IPC: B25D17/08

CPC classification number: B25D17/088 ,  B23B31/1072 ,  B25D2217/0049 ,  Y10S279/904 ,  Y10T279/17042 ,  Y10T279/17811 ,  Y10T279/32

Abstract: A chuck is described, in particular for a hammer drill or chisel hammer, having a chuck body having an insertion opening for holding a tool shank, and a locking element for axially locking the tool shank in the insertion opening, the locking element being movable between a locked position and an unlocked position, and having an arresting pin, mounted in the locking element and radially displaceable between an arresting position and a release position, which axially arrests the locking element in its arresting position and axially releases it in its release position.

Abstract translation: 一种卡盘，特别是一种用于锤钻或凿锤的卡盘，具有卡盘主体，该卡盘主体具有用于保持工具柄的插入开口，以及用于将工具柄轴向锁定在插入开口中的锁定元件，该锁定元件可在 锁定位置和解锁位置，并且具有安装在锁定元件中并可在止动位置和释放位置之间径向移位的止动销，所述止动销轴向地将锁定元件阻止在其止动位置并将其轴向地释放到其释放位置。

公开(公告)号：US20060185867A1

公开(公告)日：2006-08-24

申请号：US11326046

申请日：2006-01-05

Applicant: Karl Frauhammer ,  Gerhard Meixner ,  Heiko Roehm ,  Willy Braun ,  Axel Kuhnle ,  Andreas Strasser ,  Ralph Dammertz ,  Joachim Schadow ,  Christian Koepf ,  Juergen Lennartz

Inventor： Karl Frauhammer ,  Gerhard Meixner ,  Heiko Roehm ,  Willy Braun ,  Axel Kuhnle ,  Andreas Strasser ,  Ralph Dammertz ,  Joachim Schadow ,  Christian Koepf ,  Juergen Lennartz

IPC: E21B19/16

CPC classification number: B25D17/043

Abstract: A hand-held power tool has a main element; a main handle fastened to the main element, the main handle being supported such that the main handle is movable relative to the main element, the main element including a tool fitting that defines a tool axis and the center of gravity that defines a normal direction oriented perpendicular to the tool axis and pointing toward the center of gravity, the main element being moved out of a stationary position toward the main handle so that a portion of at least 10% by weight of the main element is guided with a movement component in the normal direction along a trajectory.

公开(公告)号：US20060183687A1

公开(公告)日：2006-08-17

申请号：US11409944

申请日：2006-04-24

Applicant: Suzanne Cory ,  Jerry Adams ,  David Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

Inventor： Suzanne Cory ,  Jerry Adams ,  David Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

IPC: A61K38/54 ,  C07H21/04 ,  C12P21/06 ,  C12N9/99

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.

Abstract translation: 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bim”，以及编码它们的遗传序列。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。