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公开(公告)号：US07060739B2
公开(公告)日：2006-06-13
申请号：US10424024
申请日：2003-04-25
申请人： Bhawan Patel , David L. Morris
发明人： Bhawan Patel , David L. Morris
CPC分类号： C08K5/0025 , A01N59/16 , C08K3/013 , C08K3/015 , A01N25/10 , A01N2300/00 , C08L27/12
摘要： Fluoroelastomer (FKM) rubber-containing articles that exhibit highly desirable long-term effective antimicrobial characteristics are provided. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of applications. This invention utilizes the presence of non-sulfur-based curing systems and agents, such as bisphenols, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the rubber article. This invention further provides a simple method of producing such an antimicrobial vulcanized fluoroelastomer rubber-containing article. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of FKM rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate cured FKM articles made therefrom.
摘要翻译： 提供了显示出非常期望的长期有效抗微生物特性的含氟弹性体（FKM）橡胶制品。 这样的制品是固体或吹制（泡沫或海绵）状态（或多层形式的两者的组合），并且可以用于各种应用中。 本发明利用了非硫基固化体系和诸如双酚的试剂，其允许硫化并且不会不可逆地结合银离子，从而导致橡胶制品的长期抗菌性能。 本发明还提供了一种制备这种抗微生物硫化含氟弹性体橡胶的制品的简单方法。 本发明还包括由至少大部分重量比的FKM橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在由其制成的最终固化的FKM制品中提供高度期望的长期抗微生物特性。
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公开(公告)号：US08986297B2
公开(公告)日：2015-03-24
申请号：US11335295
申请日：2006-01-18
申请人： Steven A. Daniel , David L. Morris
发明人： Steven A. Daniel , David L. Morris
CPC分类号： A61B18/1477 , A61B18/1815 , A61B2018/0016 , A61B2018/00702 , A61B2018/00875 , A61B2018/143
摘要： Energy delivery systems and methods are provided for use in biological tissue. The energy delivery system includes an energy source and an electrode array. The electrode array includes bipolar electrodes positioned so a first spacing between a pair of adjacent electrodes is different relative to a second spacing between at least one other pair of adjacent electrodes. The electrode array and the energy source are coupled and configured to generate uniform energy density in target tissue according to impedance of the target tissue.
摘要翻译： 提供能量输送系统和方法用于生物组织。 能量输送系统包括能量源和电极阵列。 电极阵列包括双极电极，所述双极电极定位成使得一对相邻电极之间的第一间隔相对于至少一对其它相邻电极之间的第二间隔是不同的。 电极阵列和能量源被耦合和配置成根据目标组织的阻抗在目标组织中产生均匀的能量密度。
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公开(公告)号：US08835478B2
公开(公告)日：2014-09-16
申请号：US13457860
申请日：2012-04-27
IPC分类号： A61K31/337 , A61K31/4184 , A61K31/427
CPC分类号： A61K31/427 , A61K31/337 , A61K31/4184
摘要： The present invention provides methods for the treatment of tumors, comprising administration of an effective amount of at least one taxoid and an effective amount of at least one benzimidazol carbamate compound of formula (I). The invention also provides a method for the treatment of tumors insensitive to one or more anti-mitotic drugs, the method comprising administering a effective amount of at least one benzimidazole carbamate compound of formula (I). Also provide are compositions for carrying out methods of the invention.
摘要翻译： 本发明提供了治疗肿瘤的方法，包括施用有效量的至少一种类紫杉素和有效量的至少一种式（I）的苯并咪唑氨基甲酸酯化合物。 本发明还提供了治疗对一种或多种抗有丝分裂药物不敏感的肿瘤的方法，所述方法包括施用有效量的式（I）的至少一种苯并咪唑氨基甲酸酯化合物。 还提供了用于实施本发明方法的组合物。
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公开(公告)号：US20090286838A1
公开(公告)日：2009-11-19
申请号：US11720884
申请日：2005-12-06
IPC分类号： A61K31/4184 , A61P35/00 , A61K31/427
CPC分类号： A61K31/427 , A61K31/337 , A61K31/4184
摘要： The present invention provides methods for the treatment of tumors, comprising administration of an effective amount of at least one taxoid and an effective amount of at least one benzimidazol carbamate compound of formula (I). The invention also provides a method for the treatment of tumors insensitive to one or more anti-mitotic drugs, the method comprising administering an effective amount of at least one benzimidazole carbamate compound of formula (I). Also provide are compositions for carrying out methods of the invention.
摘要翻译： 本发明提供了治疗肿瘤的方法，包括施用有效量的至少一种类紫杉素和有效量的至少一种式（I）的苯并咪唑氨基甲酸酯化合物。 本发明还提供了治疗对一种或多种抗有丝分裂药物不敏感的肿瘤的方法，所述方法包括施用有效量的式（I）的至少一种苯并咪唑氨基甲酸酯化合物。 还提供了用于实施本发明方法的组合物。
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公开(公告)号：US07422586B2
公开(公告)日：2008-09-09
申请号：US09797409
申请日：2001-02-28
IPC分类号： A61B18/18
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A tissue surface reatment apparatus includes a housing having a proximal end, a distal end including a tissue contacting surface, an interior defined by the housing and a handpiece coupled to the housing. The contactine surface has a plurality of apertures. An energy delivery device including an electrode is positionable in the housing interior. The electrode includes a tissue penetrating distal end in substantial alignment with an aperture. The electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy deliveru device and is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the electrode fdro the housing interior into the target tissuesite and withdrawal the electrode into the housing interior. A cable is coupled to the housing or the energy delivery device and is configured to be coupled to an energy source.
摘要翻译： 组织表面恢复装置包括具有近端，远端包括组织接触表面的壳体，由壳体限定的内部和联接到壳体的手持件。 接触面具有多个孔。 包括电极的能量输送装置可定位在壳体内部。 电极包括与孔基本对准的穿透远端的组织。 电极被配置为从壳体内部通过孔推进到目标组织部位以限定至少部分地由组织表面限定的消融体积。 进给装置联接到能量输送装置，并且至少部分地可定位在壳体或手持件中的至少一个中。 推进装置被配置为使电极将壳体内部推进到目标组织中并将电极撤回到壳体内部。 电缆耦合到壳体或能量输送装置，并且被配置为耦合到能量源。
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公开(公告)号：US07278991B2
公开(公告)日：2007-10-09
申请号：US09938276
申请日：2001-08-22
IPC分类号： A61B18/18
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A method of controlling ablation volume depth includes providing a treatment apparatus. The apparatus comprises a housing having a proximal and distal end including a tissue contacting surface. The housing defines an interior with an energy delivery device positionable in the interior. The energy delivery device includes at least one electrode with a tissue penetrating distal end and is configured to be advanced from the interior into a target tissue site to define an ablation volume. An advancement device is coupled to the energy delivery device and is configured to advance the at least one electrode. The at least one electrode is advanced to a selected deployment depth beneath a tissue surface while avoiding a critical structure. Energy is delivered from the energy delivery device. An ablation volume is created at a controlled depth below the tissue surface responsive to the deployment depth while minimizing injury to the critical structure.
摘要翻译： 控制消融体积深度的方法包括提供治疗装置。 该装置包括具有包括组织接触表面的近端和远端的壳体。 壳体限定具有可定位在内部的能量输送装置的内部。 能量递送装置包括至少一个具有组织穿透远端的电极，并被构造成从内部前进到目标组织部位以限定消融体积。 一个前进装置耦合到能量输送装置，并被配置成使该至少一个电极前进。 将至少一个电极推进到组织表面下方的选定的部署深度，同时避免关键结构。 能量从能量输送装置输送。 在组织表面下方的受控深度处产生消融体积，以响应于部署深度，同时最小化对关键结构的损伤。
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公开(公告)号：US07093481B2
公开(公告)日：2006-08-22
申请号：US10986706
申请日：2004-11-12
申请人： David L. Morris
发明人： David L. Morris
CPC分类号： G01N33/2805 , Y10T29/47
摘要： A process for placing a roller burnished finish on the central portion of an unfinished lathe-turned heater tube includes controlling the rotational speed of the burnishing rollers and the pressure of the burnishing rollers against the central portion of the heater tube so that tooling marks are no longer apparent under substantially 10× magnification and the length of the central portion of the heater tube increases by no more than 0.002 inches per inch of length of the central portion of the heater tube.
摘要翻译： 在未完成的车床加热器管的中心部分放置辊抛光处理的方法包括将抛光辊的旋转速度和抛光辊的压力控制在加热器管的中心部分上，使得加工标记不为 在基本上10倍的放大倍率下更长的表观，并且加热器管的中心部分的长度在加热器管的中心部分的每英寸长度上增加不超过0.002英寸。
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48.发明授权Method of preparing an enzyme-labeled ligand for use in specific binding assays and the labeled conjugate produced thereby 失效制备用于特异性结合测定的酶标记配体的方法和由此产生的标记的缀合物
公开(公告)号：US4376165A
公开(公告)日：1983-03-08
申请号：US244047
申请日：1981-03-16
申请人： William E. Hornby , David L. Morris
发明人： William E. Hornby , David L. Morris
IPC分类号： C12N9/96 , G01N33/542 , C12N9/02 , C12N9/04 , G01N33/54
CPC分类号： G01N33/542 , C12N9/96 , Y10S435/964
摘要： A method of preparing an enzyme-labeled ligand for use in specific binding assays for determining said ligand or a specific binding partner thereof, by covalently coupling said ligand or a binding analog thereof to an organic prosthetic group and combining the resulting coupled product with an apoenzyme to form a conjugated enzyme complex with said prosthetic group in said coupled product. Preferably, the conjugated enzyme complex in the resulting labeled conjugate exhibits holoenzyme activity which is affected by binding of said labeled conjugate by a specific binding partner of said ligand. Preferred prosthetic groups are flavin mononucleotide, heme, and, especially, flavin adenine dinucleotide, with preferred apoenzymes being apoperoxidase and, especially, apoglucose oxidase.
摘要翻译： 通过将所述配体或其结合类似物共价偶联到有机修饰基团并将所得偶联产物与脱辅基酶联合来制备用于特异性结合测定法用于测定所述配体或其特异性结合配偶体的酶标记配体的方法 以在所述偶联产物中与所述假基团形成缀合的酶复合物。 优选地，所得标记的缀合物中的缀合酶复合物显示出由所述配体的特异性结合配偶体与所述标记的缀合物的结合影响的全酶活性。 优选的辅基是黄素单核苷酸，血红素，特别是黄素腺嘌呤二核苷酸，优选的脱辅基酶是过氧化物酶，特别是糖苷氧化酶。
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公开(公告)号：US10043611B1
公开(公告)日：2018-08-07
申请号：US15140721
申请日：2016-04-28
申请人： David L. Morris
发明人： David L. Morris
摘要： A seismic resistant cluster bracket for mounting to an electrical power-line pole and supporting power distribution transformers includes a rectangular support frame which has upper and lower horizontal cross beams secured to left, right, and center vertical strong-back struts. Pole-mount brackets protruding rearward from the center strong-back are provided with bolt holes for receiving bolts to attach the support frame to a power pole. Top and bottom safety mount brackets, each having vertical stabilizer ribs for engaging indentations of a rear transformer bracket are attached to the front of each strong-back. A pair of adjustable extension length diagonal braces spaced equal distances laterally outwards from the center strong-back are pivotal mounted to the rear side of the support frame, extendable to adjustable lengths and boltable to a power pole to secure the frame against movements relative to the power pole as a result of static weight loading or seismic vibrations.
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50.发明授权Devices and methods for thermal ablation of biological tissue using geometric ablation patterns 有权使用几何消融模式的生物组织的热消融的装置和方法公开(公告)号：US09060782B2
公开(公告)日：2015-06-23
申请号：US12107034
申请日：2008-04-21
申请人： Steven A. Daniel , David L. Morris , Kee Sein Lee
发明人： Steven A. Daniel , David L. Morris , Kee Sein Lee
CPC分类号： A61B18/148 , A61B18/1477 , A61B18/1487 , A61B2018/00267
摘要： A tissue ablation system including numerous components and methods is described herein for encircling target tissue and generating tissue ablation volumes in various biological tissues. The biological tissue includes tissue of a variety of organs of the human body including the liver, spleen, kidney, lung, breast and other organs, but is not so limited. The tissue ablation device comprises an energy source and at least one trocar coupled to the energy source, the trocar having a body, a proximal end, and a distal end. The trocar carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the trocar when moved from a retracted state to a deployed state, and to have at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state.
摘要翻译： 本文描述了包括许多组分和方法的组织消融系统，用于环绕靶组织并在各种生物组织中产生组织消融体积。 生物组织包括人体各种器官的组织，包括肝，脾，肾，肺，乳腺和其他器官，但不限于此。 组织消融装置包括能量源和耦合到能量源的至少一个套管针，套管针具有主体，近端和远端。 套针针携带包括多个电极的电极阵列，多个电极中的每个电极构造成当套管针从缩回状态移动到展开状态时延伸，并且在所展开的部分中具有至少一个曲率半径 使得电极阵列形成处于展开状态的一系列成形电极。
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