-
41.发明申请BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开双酚尿素，硫脲，胍和氰尿嘧啶化合物可用于治疗疼痛公开(公告)号：US20160355521A1
公开(公告)日：2016-12-08
申请号：US14442609
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC.
Inventor： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
IPC: C07D491/048 , C07D231/56 , C07D405/14 , C07D405/12 , C07D403/14 , C07D471/08 , C07D401/14 , C07D231/52 , C07D403/04 , C07D401/04 , C07D413/12 , C07D409/14 , C07D231/40 , C07D401/12
CPC classification number: C07D491/048 , C07D231/40 , C07D231/52 , C07D231/54 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D453/02 , C07D471/08
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
-
公开(公告)号：US20160303126A1
公开(公告)日：2016-10-20
申请号：US15197479
申请日：2016-06-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: A61K31/506 , C07D403/14 , C07D471/04 , A61K31/4439 , C07D417/14 , C07D403/04 , C07D401/14 , A61K31/444 , A61K45/06 , C07D405/14
CPC classification number: A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
-
43.发明申请公开(公告)号：US20160297796A1
公开(公告)日：2016-10-13
申请号：US14442522
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC.
Inventor： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Shannon L. Winski
IPC: C07D401/12 , C07D417/14 , C07D417/12 , C07D413/12 , C07D401/14 , C07D403/12
CPC classification number: C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
-
44.发明申请N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权作为TRKA激酶抑制剂的N-（ARYLALKYL）-N'-吡唑并 - 尿素，硫脲，胍和氰基胍化合物公开(公告)号：US20160272592A1
公开(公告)日：2016-09-22
申请号：US14442576
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC.
Inventor： James F. Blake , Barbara J. Brandhuber , Julia Haas , Brad Newhouse , Allen A. Thomas , Shannon L. Winski
IPC: C07D231/52 , C07D401/04 , C07D405/14 , C07D401/14 , C07D231/54 , C07D453/02 , C07D495/04 , C07D413/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D403/04 , C07D231/40
CPC classification number: C07D231/52 , C07D231/38 , C07D231/40 , C07D231/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D453/02 , C07D495/04
Abstract: Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 式I或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药的化合物，其中环A，环C，X，R a，R b，R c，R d和n如本文所定义，是TrkA激酶的抑制剂，并且是有用的 治疗可用TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征治疗的疾病。
-
公开(公告)号：US09365568B2
公开(公告)日：2016-06-14
申请号：US14591691
申请日：2015-01-07
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D495/14 , C07D471/04 , C07D401/06
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
-
Patent Agency Ranking
46.发明授权Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors 有权羟基化和甲氧基化的嘧啶基环戊烷作为Akt蛋白激酶抑制剂公开(公告)号：US09359340B2
公开(公告)日：2016-06-07
申请号：US14458062
申请日：2014-08-12
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Leivers , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
IPC: C07D239/70 , C07D403/04 , C07D413/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D407/12 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/28 , A61P15/00 , A61P17/00 , A61K31/517 , A61K31/496
CPC classification number: A61K31/517 , C07D239/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了包含分解的对映异构体，分解的非对映异构体，溶剂合物和其药学上可接受的盐的化合物，其包含式I：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病 癌症。
-
公开(公告)号：US20160152601A9
公开(公告)日：2016-06-02
申请号：US14086717
申请日：2013-11-21
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Josef Bencsik , James F. Blake , James M. Graham , Martin F. Hentemann , Nicholas C. Kallan , Ian S. Mitchell , Stephen T. Schlachter , Keith L. Spencer , Dengming Xiao , Rui Xu , Mike Welch , Jun Liang , Brian S. Safina
IPC: C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D401/12 , C07D405/14
CPC classification number: C07D403/12 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12
Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
-
48.发明申请公开(公告)号：US20160152574A9
公开(公告)日：2016-06-02
申请号：US14457582
申请日：2014-08-12
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith Lee Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
IPC: C07D239/70
CPC classification number: C07D239/70
Abstract: The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.
Abstract translation: 本发明提供包含式I的化合物，包括其药学上可接受的盐：还提供使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
-
49.发明申请HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 有权羟基和甲氧基吡咯烷酮作为AKT蛋白激酶抑制剂公开(公告)号：US20140349997A1
公开(公告)日：2014-11-27
申请号：US14458062
申请日：2014-08-12
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlacter , Anna L. Banka , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
IPC: C07D413/12 , C07D401/12 , C07D409/14 , C07D407/12 , C07D409/12 , C07D239/70 , C07D403/12
CPC classification number: A61K31/517 , C07D239/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了包含分解的对映异构体，分解的非对映异构体，溶剂合物和其药学上可接受的盐的化合物，其包含式I：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病 癌症。
-
公开(公告)号：US08758830B2
公开(公告)日：2014-06-24
申请号：US13974895
申请日：2013-08-23
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: A61K31/4545 , A61K31/437 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/444 , A61K31/501 , A61K35/00 , A61K33/24
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
-
-
-
-
-
-
-
-
-
Search Results
139
records
(took 0.071 seconds)
