摘要:
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.
摘要:
The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection
摘要:
A compound, represented by formula (I): wherein A, B, R1, R2, R3, R5, R6, R7, R9, and R10 are as defined herein, or an enantiomer, diastereoisomer or tautomer thereof, including a salt, ester or derivative thereof, as an inhibitor of HCV NS5B polymerase.
摘要:
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.
摘要翻译:由式I表示的化合物的对映体,非对映异构体或互变异构体:其中A,B,R 1,R 2,R 3, R 4,R 5,R 6,R 7,R 8, R 9和R 10如本文所定义,或其盐或酯作为HCV NS5B聚合酶的抑制剂。
摘要:
A compound of formula (I) useful for the treatment or prevention of hepatitis C viral infection, (Formula (I)) wherein: X1 and X2 are each independently CRB or N; RB is H, (C1-6)alkyl, (C1-6)haloalkyl, halo. —O—(C1-6)alkyl, NH2, NH(C1-6)alkyl or N((C1-6)alkyl)2; R1 and R2 are each independently (C1-6)alkyl optionally mono- or di-substituted with —O—(C1-6)alkyl, NH2, NH(C1-6)alkyl or N((C1-6)alkyl)2; or R1 and R2, together with the carbon to which they are attached, are linked to form a (C3-7)cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with —(C1-6)alkyl; RA is —C(═O)N(R3)(R4), —C(═O)O(R4), heterocyclyl or heteroaryl, wherein each said heterocyclyl and heteroaryl is optionally substituted 1 to 3 times with R41; R5 and R6 are each independently H or (C1-6)alkyl optionally mono- or di-substituted with —O—(C1-6)alkyl, NH2, NH(C1-6)alkyl or N((C1-6)alkyl)2; or R5 and R6, together with the carbon to which they are attached, are linked to form a (C3-7)cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with —(C1-6)alkyl; and n is 0, 1 or 2.
摘要:
A sanitizing system is provided for use in a bathing unit system including a receptacle for holding water in which a halide salt has been dissolved and a circulating system for removing and returning water from and to the receptacle. The sanitizing system includes a sanitizing device having a housing configured to be positioned in fluid communication with the circulation system and an electrolytic cell positioned within the housing so that when power is applied to the electrolytic cell, the halide salt dissolved in water flowing through the housing is converted to an amount of free halogen. A controller controls an amount of power supplied to the electrolytic cell so as to control the amount of free halogen being generated. The amount of power supplied may be adjusted, for example, based on an amount of usage of the bathing unit system, a usage of a circulation pump and/or based on a water temperature. A user control interface for the sanitizing device is also provided.
摘要:
A controller for a bathing unit system comprising a memory unit for storing program instructions, an interface for establishing a communication link with an external memory medium and a processing unit. The controller is operative for controlling a set of bathing unit components at least in part on the basis of the program instructions stored in the memory unit. The external memory medium stores update information associated with the program instructions and relevancy information indicative of a characteristic of the update information. The processing unit is operative for detecting the presence of an external memory medium at the interface, accessing the relevancy information stored in the memory medium, processing the relevancy information and causing the program instructions to be updated on the basis of the update information.
摘要:
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.
摘要:
A compound, represented by formula (I): wherein A, B, R1, R2, R3, R5, R6, R7, R9, and R10 are as defined herein, or an enantiomer, diastereoisomer or tautomer thereof, including a salt, ester or derivative thereof, as an inhibitor of HCV NS5B polymerase.