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公开(公告)号：US20120148555A1
公开(公告)日：2012-06-14
申请号：US13374500
申请日：2011-12-28
CPC分类号： A61K38/47 , A61K9/0048 , A61K38/00 , A61K39/395 , A61K47/48215 , A61K2039/505 , C12N9/2474 , C12Y302/01035 , Y02A50/475
摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.
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42.发明授权公开(公告)号：US07846431B2
公开(公告)日：2010-12-07
申请号：US12660869
申请日：2010-03-04
CPC分类号： A61K38/47 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C12N9/2408 , C12Y302/01035 , A61K2300/00
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated form of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
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43.发明申请Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof 有权人类软骨素酶糖蛋白（chasegp），其制备方法和由其组成的药物组合物公开(公告)号：US20070148156A1
公开(公告)日：2007-06-28
申请号：US10539110
申请日：2003-12-15
申请人： Gregory Frost , Anirban Kundu , Louis Bookbinder
发明人： Gregory Frost , Anirban Kundu , Louis Bookbinder
CPC分类号： C12N9/88 , A61K38/47 , C12Y402/02004
摘要： The invention relates to the discovery of a novel Chondroitinase Glycoproteins (CHASEGP's), methods of manufacture, and potential uses in conditions where removal of chondroitin sulfates may be of therapeutic benefit. Chondroitinase Glycoproteins require both a substantial portion of the catalytic domain of the CHASEGP polypeptide and asparagine-linked glycosylation for optimal chondroitinase activity. The invention also includes carboxy-terminal deletion variants of CHASEGP that result in secreted variants of the protein to facilitate manufacture of a recombinant CHASEGP. Further described are suitable formulations of a substantially purified recombinant CHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. CHASEGP is useful for the degradation of glycosaminoglycans and chondroitin sulfate proteoglycans under clinical conditions where their removal is of therapeutic value.
摘要翻译： 本发明涉及新型软骨素酶糖蛋白（CHASEGP）的发现，其制备方法和潜在用途，其中去除硫酸软骨素可具有治疗益处。 软骨素酶糖蛋白需要CHASEGP多肽的大部分催化结构域和天冬酰胺连接的糖基化以获得最佳的软骨素酶活性。 本发明还包括CHASEGP的羧基末端缺失变体，其导致蛋白质的分泌型变体以促进重组CHASEGP的制备。 进一步描述了衍生自真核细胞的基本上纯化的重组CHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。 CHASEGP可用于在其去除具有治疗价值的临床条件下降解糖胺聚糖和硫酸软骨素蛋白聚糖。
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公开(公告)号：US20060031346A1
公开(公告)日：2006-02-09
申请号：US11080258
申请日：2005-03-14
申请人： Hao Zheng , Bruce Chu , Anirban Kundu , Miles Libbey , David Nakayama , Jing Zhu
发明人： Hao Zheng , Bruce Chu , Anirban Kundu , Miles Libbey , David Nakayama , Jing Zhu
IPC分类号： G06F15/16
CPC分类号： G06Q10/107 , H04L51/12
摘要： The invention relates to determining electronic text communication distributed in bulk is likely solicited. In one step, a first electronic and a second electronic submission are received. It is determined that the first electronic submission is likely solicited. A first portion is extracted from the first electronic submission and a second portion from the second electronic submission. The content of the first electronic submission influences extraction of the first portion, and the content of the second electronic submission influences extraction of the second portion. A first code is determined for the first portion and a second code is determined for the second portion, where the first code is indicative of the first portion and the second code is indicative of the second portion. The first code is compared to the second code. It is determined that the second electronic submission is likely solicited, at least in part, in response to comparing the first code to the second code.
摘要翻译： 本发明涉及确定批量散布的电子文本通信可能被请求。 一步，接收第一个电子和第二个电子提交。 确定可能要求第一次电子提交。 从第一电子提交中提取第一部分，并从第二电子提交中提取第二部分。 第一电子提交的内容影响第一部分的提取，并且第二电子提交的内容影响第二部分的提取。 为第一部分确定第一代码，并且为第二部分确定第二代码，其中第一代码指示第一部分，而第二代码指示第二部分。 第一个代码与第二个代码进行比较。 确定可以至少部分地响应于将第一代码与第二代码进行比较来请求第二电子提交。
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45.发明授权System and method for detection and deployment of virtualization capable assets in a managed datacenter 有权在托管数据中心中检测和部署虚拟化能力的资产的系统和方法公开(公告)号：US09411655B2
公开(公告)日：2016-08-09
申请号：US13340817
申请日：2011-12-30
IPC分类号： G06F15/173 , G06F9/50 , H04L12/24
CPC分类号： G06F17/2241 , G06F3/0482 , G06F9/451 , G06F9/45558 , G06F9/5077 , H04L41/046 , H04L41/0806
摘要： A datacenter management server includes a datacenter operations manager and a datacenter infrastructure manager with an infrastructure viewer and an asset deployment tool. The datacenter operations manager compiles datacenter hierarchy information for a datacenter, including identity information for a virtualized environment and identity information for a virtualization capable system. The virtualization capable system is deployed as a stand-alone system of the datacenter. The datacenter infrastructure manager receives the datacenter hierarchy information, directs the infrastructure viewer to display a hierarchical overview of the datacenter, including depictions of the virtualized environment and the virtualization capable system. The hierarchical overview is based on the identity information. The datacenter infrastructure manager also receives a selection of the depictions from a user and directs the asset deployment tool to deploy the virtualization capable system to the virtualized environment.
摘要翻译： 数据中心管理服务器包括数据中心操作管理器和具有基础设施查看器和资产部署工具的数据中心基础架构管理器。 数据中心运营经理编译数据中心的数据中心层级信息，包括虚拟化环境的身份信息和虚拟化系统的身份信息。 虚拟化能力系统被部署为数据中心的独立系统。 数据中心基础架构管理器接收数据中心层次结构信息，指导基础设施查看器显示数据中心的分层概况，包括虚拟化环境和具有虚拟化功能的系统的描述。 分层概述是基于身份信息。 数据中心基础设施管理器还接收来自用户的描述的选择，并指导资产部署工具将虚拟化功能的系统部署到虚拟化环境。
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公开(公告)号：US20140344024A1
公开(公告)日：2014-11-20
申请号：US13955882
申请日：2013-07-31
申请人： Dirk Kempf , Daniel Huber , Martin Ebert , Marcus Behrens , Christoph Boehm , Marcel Waechter , Holger Bohle , Harish Rama Rao , Anirban Kundu , Thomas Fleckenstein
发明人： Dirk Kempf , Daniel Huber , Martin Ebert , Marcus Behrens , Christoph Boehm , Marcel Waechter , Holger Bohle , Harish Rama Rao , Anirban Kundu , Thomas Fleckenstein
IPC分类号： G06Q10/06 , G06F17/22 , G06F3/0482
CPC分类号： G06Q10/06393 , G06F3/0483
摘要： Embodiments of the present disclosure provide systems and methods for a lightweight monitoring application with key performance indicators (KPI) reporting and management. The method may include displaying a page with a plurality of tiles on a user device. The tiles displayed on the page may include a plurality of key performance indicator (KPI) tiles and at least one of a report tile, a news tile and a collaboration tile. The method may retrieve metadata from an in-memory database, the metadata from the in-memory database may correspond to content displayed in at least one of the KPI tiles on the page. In response to an input from a user input apparatus selecting one of the tiles displayed on the page, the method may display additional details or controls for the selected tile.
摘要翻译： 本公开的实施例提供了具有关键性能指标（KPI）报告和管理的轻量级监控应用的系统和方法。 该方法可以包括在用户设备上显示具有多个瓦片的页面。 显示在页面上的瓦片可以包括多个关键性能指标（KPI）瓦片和报告瓦片，新闻瓦片和协作瓦片中的至少一个。 该方法可以从内存数据库检索元数据，来自内存数据库的元数据可以对应于在页面上的至少一个KPI瓦片中显示的内容。 响应于来自用户输入装置的输入选择页面上显示的瓦片之一，该方法可以显示所选择的瓦片的附加细节或控制。
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公开(公告)号：US08782472B2
公开(公告)日：2014-07-15
申请号：US13284625
申请日：2011-10-28
IPC分类号： G06F11/00
CPC分类号： G06F11/0778 , G06F11/0748 , G06F11/0769 , G06F11/0775 , G06F11/079
摘要： An information handling system (IHS) troubleshooting system includes a customer IHS including a plurality of components. A customer management system in the customer IHS detects a failure in a managed system and, in response, immediately triggers a device snapshot of the customer IHS. At least one managed system in the customer IHS includes a device snapshot engine that, in response to the customer management system triggering the device snapshot of the customer IHS, immediately create the device snapshot of the customer IHS. A device snapshot storage in the customer IHS stores the device snapshot of the customer IHS. A snapshot communication engine in the customer IHS sends the device snapshot of the customer IHS over the network to a support IHS. The support IHS may load the device snapshot into a virtual IHS and manage the virtual IHS to replicate the failure detected in the managed system for troubleshooting.
摘要翻译： 信息处理系统（IHS）故障排除系统包括包括多个组件的客户IHS。 客户IHS中的客户管理系统检测受管系统中的故障，并作为响应，立即触发客户IHS的设备快照。 客户IHS中的至少一个受管系统包括设备快照引擎，响应于客户管理系统触发客户IHS的设备快照，立即创建客户IHS的设备快照。 客户IHS中的设备快照存储存储客户IHS的设备快照。 客户IHS中的快照通信引擎将客户IHS的设备快照通过网络发送到支持IHS。 支持IHS可以将设备快照加载到虚拟IHS中，并管理虚拟IHS以复制受管系统中检测到的故障，以进行故障排除。
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公开(公告)号：US20130111275A1
公开(公告)日：2013-05-02
申请号：US13284625
申请日：2011-10-28
IPC分类号： G06F11/14
CPC分类号： G06F11/0778 , G06F11/0748 , G06F11/0769 , G06F11/0775 , G06F11/079
摘要： An information handling system (IHS) troubleshooting system includes a customer IHS including a plurality of components. A customer management system in the customer IHS detects a failure in a managed system and, in response, immediately triggers a device snapshot of the customer IHS. At least one managed system in the customer IHS includes a device snapshot engine that, in response to the customer management system triggering the device snapshot of the customer IHS, immediately create the device snapshot of the customer IHS. A device snapshot storage in the customer IHS stores the device snapshot of the customer IHS. A snapshot communication engine in the customer IHS sends the device snapshot of the customer IHS over the network to a support IHS. The support IHS may load the device snapshot into a virtual IHS and manage the virtual IHS to replicate the failure detected in the managed system for troubleshooting.
摘要翻译： 信息处理系统（IHS）故障排除系统包括包括多个组件的客户IHS。 客户IHS中的客户管理系统检测受管系统中的故障，并作为响应，立即触发客户IHS的设备快照。 客户IHS中的至少一个受管系统包括设备快照引擎，响应于客户管理系统触发客户IHS的设备快照，立即创建客户IHS的设备快照。 客户IHS中的设备快照存储存储客户IHS的设备快照。 客户IHS中的快照通信引擎将客户IHS的设备快照通过网络发送到支持IHS。 支持IHS可以将设备快照加载到虚拟IHS中，并管理虚拟IHS以复制受管系统中检测到的故障，以进行故障排除。
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49.发明授权公开(公告)号：US07829081B2
公开(公告)日：2010-11-09
申请号：US12660893
申请日：2010-03-04
CPC分类号： A61K38/47 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C12N9/2408 , C12Y302/01035 , A61K2300/00
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated form of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
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50.发明授权Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof 有权可溶性透明质酸酶糖蛋白（sHASEGP），其制备方法，用途及其组合物公开(公告)号：US07767429B2
公开(公告)日：2010-08-03
申请号：US10795095
申请日：2004-03-05
IPC分类号： C12N9/26 , A61K38/47 , C12P21/02 , C07K14/435
CPC分类号： A61K38/47 , A61K9/0048 , A61K38/00 , A61K39/395 , A61K47/48215 , A61K2039/505 , C12N9/2474 , C12Y302/01035 , Y02A50/475
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
摘要翻译： 本发明涉及新型可溶性中性活性透明质酸酶糖蛋白（sHASEGP's）的发现，其制备方法及其用于促进其它分子的施用或减轻糖胺聚糖相关病理学的用途。 描述了可溶性中性活性sHASEGP结构域的微活性多肽结构域，其包括功能性中性活性透明质酸酶结构域所需的天冬酰胺连接的糖部分。 包括改进的氨基末端前导肽，其增强sHASEGP的分泌。 本发明还包含重组sHASEGP的唾液酸化和聚乙二醇化形式，以增强天然存在的屠宰酶的稳定性和血清药代动力学。 进一步描述了衍生自真核细胞的基本上纯化的重组sHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。
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