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    Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
    1.
    发明申请
    Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases 有权
    可溶性糖胺聚糖酶和制备和使用可溶性糖胺聚糖酶的方法

    公开(公告)号：US20050260186A1

    公开(公告)日：2005-11-24

    申请号：US11065716

    申请日：2005-02-23

    申请人： Louis Bookbinder ,  Anirban Kundu ,  Gregory Frost ,  Michael Haller ,  Gilbert Keller ,  Tyler Dylan

    发明人： Louis Bookbinder ,  Anirban Kundu ,  Gregory Frost ,  Michael Haller ,  Gilbert Keller ,  Tyler Dylan

    IPC分类号： A01K67/027 ,  A61K38/17 ,  A61K38/47 ,  C07H21/04 ,  C12N9/24 ,  C12P21/06

    CPC分类号： A61K38/47 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C12N9/2408 ,  C12Y302/01035 ,  A61K2300/00

    摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

    摘要翻译： 本发明涉及新型可溶性中性活性透明质酸酶糖蛋白（sHASEGPs）的发现，其制备方法及其用于促进其它分子的施用或减轻糖胺聚糖相关病理学的用途。 描述了可溶性中性活性sHASEGP结构域的微活性多肽结构域，其包括功能性中性活性透明质酸酶结构域所需的天冬酰胺连接的糖部分。 包括改进的氨基末端前导肽，其增强sHASEGP的分泌。 本发明还包含重组sHASEGP的唾液酸化和聚乙二醇化形式，以增强天然存在的屠宰酶的稳定性和血清药代动力学。 进一步描述了衍生自真核细胞的基本上纯化的重组sHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。

    Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof
    2.
    发明申请
    Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof 有权
    人类软骨素酶糖蛋白（chasegp），其制备方法和由其组成的药物组合物

    公开(公告)号：US20070148156A1

    公开(公告)日：2007-06-28

    申请号：US10539110

    申请日：2003-12-15

    申请人： Gregory Frost ,  Anirban Kundu ,  Louis Bookbinder

    发明人： Gregory Frost ,  Anirban Kundu ,  Louis Bookbinder

    IPC分类号： A61K38/47 ,  C12N9/24

    CPC分类号： C12N9/88 ,  A61K38/47 ,  C12Y402/02004

    摘要： The invention relates to the discovery of a novel Chondroitinase Glycoproteins (CHASEGP's), methods of manufacture, and potential uses in conditions where removal of chondroitin sulfates may be of therapeutic benefit. Chondroitinase Glycoproteins require both a substantial portion of the catalytic domain of the CHASEGP polypeptide and asparagine-linked glycosylation for optimal chondroitinase activity. The invention also includes carboxy-terminal deletion variants of CHASEGP that result in secreted variants of the protein to facilitate manufacture of a recombinant CHASEGP. Further described are suitable formulations of a substantially purified recombinant CHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. CHASEGP is useful for the degradation of glycosaminoglycans and chondroitin sulfate proteoglycans under clinical conditions where their removal is of therapeutic value.

    摘要翻译： 本发明涉及新型软骨素酶糖蛋白（CHASEGP）的发现，其制备方法和潜在用途，其中去除硫酸软骨素可具有治疗益处。 软骨素酶糖蛋白需要CHASEGP多肽的大部分催化结构域和天冬酰胺连接的糖基化以获得最佳的软骨素酶活性。 本发明还包括CHASEGP的羧基末端缺失变体，其导致蛋白质的分泌型变体以促进重组CHASEGP的制备。 进一步描述了衍生自真核细胞的基本上纯化的重组CHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。 CHASEGP可用于在其去除具有治疗价值的临床条件下降解糖胺聚糖和硫酸软骨素蛋白聚糖。

    Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
    3.
    发明申请
    Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases 审中-公开
    可溶性糖胺聚糖酶及其制备和使用可溶性糖胺聚糖的方法

    公开(公告)号：US20060104968A1

    公开(公告)日：2006-05-18

    申请号：US11238171

    申请日：2005-09-27

    申请人： Louis Bookbinder ,  Anirban Kundu ,  Gregory Frost ,  Michael Haller ,  Gilbert Keller ,  Tyler Dylan

    发明人： Louis Bookbinder ,  Anirban Kundu ,  Gregory Frost ,  Michael Haller ,  Gilbert Keller ,  Tyler Dylan

    IPC分类号： A61K38/47 ,  C12N9/24

    CPC分类号： A61K47/6811 ,  A61K35/768 ,  A61K38/465 ,  A61K38/47 ,  A61K39/395 ,  A61K39/3955 ,  A61K47/60 ,  A61K2039/505 ,  C12N7/00 ,  C12N9/2408 ,  C12N9/2474 ,  Y02A50/466 ,  A61K2300/00

    摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

    摘要翻译： 本发明涉及新型可溶性中性活性透明质酸酶糖蛋白（sHASEGPs）的发现，其制备方法及其用于促进其它分子的施用或减轻糖胺聚糖相关病理学的用途。 描述了可溶性中性活性sHASEGP结构域的微活性多肽结构域，其包括功能性中性活性透明质酸酶结构域所需的天冬酰胺连接的糖部分。 包括改进的氨基末端前导肽，其增强sHASEGP的分泌。 本发明还包含重组sHASEGP的唾液酸化和聚乙二醇化形式，以增强天然存在的屠宰酶的稳定性和血清药代动力学。 进一步描述了衍生自真核细胞的基本上纯化的重组sHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。

    Myeloid colony stimulating factor and uses thereof
    6.
    发明申请
    Myeloid colony stimulating factor and uses thereof 有权
    骨髓集落刺激因子及其用途

    公开(公告)号：US20060247201A1

    公开(公告)日：2006-11-02

    申请号：US11431181

    申请日：2006-05-09

    申请人： Gregory Frost ,  Per Borgstrom

    发明人： Gregory Frost ,  Per Borgstrom

    IPC分类号： A61K48/00 ,  A61K38/47

    CPC分类号： C12N9/2408 ,  A61K38/193 ,  A61K38/47 ,  A61K48/00

    摘要： The identification of the HYAL1 hyaluronidase enzyme as a human plasma-derived myeloid colony-stimulating factor (CSF), herein designated CSF5-hyaluronidase, its recombinant production and methods of use are described. This protein may be used for the treatment of myelosuppression as may occur after irradiation, chemotherapy or other diseases where an increase in leukocyte levels may be beneficial. For example, CSF5- may be used to enhance the immune response to viral infection or other diseases associated with immune suppression.

    摘要翻译： 描述了HYAL1透明质酸酶作为人血浆衍生的骨髓集落刺激因子（CSF），本文命名为CSF5-透明质酸酶，其重组生产和使用方法的鉴定。 该蛋白质可用于治疗照射，化学疗法或白细胞水平升高可能有益的其它疾病发生的骨髓抑制。 例如，CSF5-可用于增强对病毒感染或与免疫抑制相关的其它疾病的免疫应答。

    Article for use in a fluid diversion system
    7.
    发明申请
    Article for use in a fluid diversion system 审中-公开
    用于流体分流系统的条款

    公开(公告)号：US20060242915A1

    公开(公告)日：2006-11-02

    申请号：US11118312

    申请日：2005-04-29

    申请人： Gregory Frost

    发明人： Gregory Frost

    IPC分类号： E02D19/00

    CPC分类号： E02D19/00 ,  E03F1/005

    摘要： A synthetic resin article is provided for use in a fluid diversion system with one or more distribution lines. The article's frame has a top, at least one side, a bottom and an interior. At least one aperture is formed at the top. An intake port is disposed on at least one side of the frame, for engagement with the system distribution line. A drainage structure is disposed on the bottom of the frame for downward drainage of standing water into the surrounding soil or other environment. When the system delivers fluid through the distribution line, it is received in the interior of the frame and drains slowly out through the drainage structure but normally when the system delivers fluid to the interior at a sufficient rate, the fluid rises to the top of the frame and percolates out of the outlet aperture. In preferred embodiments, the top includes a plurality of small outlet gratings for additional percolation. In particularly preferred embodiments, the outlet gratings are formed as a plurality of slots for optimized percolation and diffusion.

    摘要翻译： 提供了一种用于具有一个或多个分配线的流体分配系统的合成树脂制品。 该物品的框架有顶部，至少一面，底部和内部。 在顶部形成至少一个孔。 入口端口设置在框架的至少一侧上，用于与系统配线相接合。 排水结构设置在框架的底部，用于将立式水向下排放到周围的土壤或其他环境中。 当系统通过分配管道输送流体时，它被容纳在框架的内部并通过排水结构缓慢排出，但通常当系统以足够的速率将流体输送到内部时，流体上升到 框架并渗出出口孔。 在优选实施例中，顶部包括用于额外渗滤的多个小出口光栅。 在特别优选的实施例中，出口光栅形成为多个槽，用于优化渗滤和扩散。