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公开(公告)号：US20060110331A1
公开(公告)日：2006-05-25
申请号：US11284109
申请日：2005-11-22
申请人： Phuong Dang , Brian Lawrence , Gul Balwani , Alexander D'Addio
发明人： Phuong Dang , Brian Lawrence , Gul Balwani , Alexander D'Addio
CPC分类号： A61K47/26 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/0073 , A61K9/7007 , A61K31/55 , A61K45/06 , Y02A90/22 , Y02A90/26 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.
摘要翻译： 本发明提供包含氮卓斯汀或其药学上可接受的盐或酯的药物组合物，包括盐酸萘曲斯汀和任选的一种或多种另外的活性剂。 优选的这种组合物还包含一种或多种药学上可接受的载体或赋形剂，其减少鼻后滴液的量，和/或将组合物与鼻腔滴注相关的令人不快的苦味最小化或掩盖到口腔中 鼻内或眼部给药组合物。 用于本发明组合物中的特别有效的赋形剂是作为粘度调节剂的羟丙甲纤维素和作为掩味剂的三氯蔗糖。 本发明还提供了通过将本发明的组合物给予患者来治疗或预防某些疾病或症状缓解的方法，例如用于过敏性鼻炎，非过敏性血管舒缩性鼻炎，过敏性结膜炎的症状缓解以及 其他疾病。 本发明的组合物和方法在患者可接受性，方便性和依从性方面提供了显着的价值。
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42.发明申请公开(公告)号：US20050228890A1
公开(公告)日：2005-10-13
申请号：US11103377
申请日：2005-04-11
申请人： Brian Lawrence
发明人： Brian Lawrence
CPC分类号： G06F3/0481 , G06F9/451 , H04L67/02 , H04L67/14
摘要： A system manages operating sessions of an executable application initiated via a browser application on a workstation. The system includes a detector, a monitor, a communicator, and a command processor. The detector detects initiation of a first operational session of an executable application on a workstation, wherein the initiation occurs in response to user activation of a displayed URL link. The monitor determines whether a previously initiated second operational session of the executable application is concurrently operational on the workstation by comparing a portion of the URL with stored data representing one or more URLs corresponding to one or more executable applications currently operational on the workstation. The command processor redirects the first operational session to a URL of the previously initiated second operational session of the executable application in response to a URL match determined by the comparison. The communicator terminates establishment of the first operational session.
摘要翻译： 系统管理通过工作站上的浏览器应用程序启动的可执行应用程序的操作会话。 该系统包括检测器，监视器，通信器和命令处理器。 检测器检测工作站上可执行应用程序的第一操作会话的启动，其中响应于用户激活显示的URL链接而发生启动。 监视器通过将URL的一部分与表示与工作站上当前可操作的一个或多个可执行应用程序相对应的一个或多个URL的存储数据进行比较来确定先前启动的可执行应用程序的第二操作会话是否在工作站上同时运行。 响应于由比较确定的URL匹配，命令处理器将第一操作会话重定向到可执行应用的先前启动的第二操作会话的URL。 通信者终止第一个操作会话的建立。
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公开(公告)号：US08529835B2
公开(公告)日：2013-09-10
申请号：US12513441
申请日：2007-11-05
IPC分类号： C12Q1/68
CPC分类号： B29D11/0074 , B29C41/02
摘要： A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
摘要翻译： 一种制备生物聚合物传感器的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，在生物聚合物基质中添加生物材料，提供基材，将基质溶液浇铸在基材上，并将生物聚合物基质溶液干燥 在基材上形成凝固的生物聚合物传感器。 还提供了一种生物聚合物传感器，其包括具有嵌入的生物材料的固化的生物聚合物膜。
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公开(公告)号：US20100191328A1
公开(公告)日：2010-07-29
申请号：US12528634
申请日：2008-02-27
申请人： David L. Kaplan , Fiorenzo Omenetto , Jeffrey K. Marchant , Noorjahan Panjwani , Brian Lawrence
发明人： David L. Kaplan , Fiorenzo Omenetto , Jeffrey K. Marchant , Noorjahan Panjwani , Brian Lawrence
CPC分类号： A61L27/3604 , A61L27/225 , A61L27/227 , A61L27/3804 , A61L27/3839 , A61L27/3891 , A61L27/56 , A61L2300/412 , C12N5/0068 , C12N5/0621 , C12N2533/50 , G01N33/5044
摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
摘要翻译： 本发明涉及一种薄片组织层，其包括含有组织特异性细胞的开槽丝素蛋白底物。 丝素蛋白底物提供了控制和培养细胞和细胞外基质发育的极好手段。 可以使用多个薄片组织层来产生组织工程化器官，例如组织工程角膜。 组织工程化器官是非免疫原性和生物相容性的。
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公开(公告)号：US20100070068A1
公开(公告)日：2010-03-18
申请号：US12513441
申请日：2007-11-05
IPC分类号： G06F19/00
CPC分类号： B29D11/0074 , B29C41/02
摘要： A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
摘要翻译： 一种制备生物聚合物传感器的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，在生物聚合物基质中添加生物材料，提供基材，将基质溶液浇铸在基材上，并将生物聚合物基质溶液干燥 在基材上形成凝固的生物聚合物传感器。 还提供了一种生物聚合物传感器，其包括具有嵌入的生物材料的固化的生物聚合物膜。
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46.发明申请公开(公告)号：US20100065784A1
公开(公告)日：2010-03-18
申请号：US12513392
申请日：2007-11-05
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
摘要翻译： 制造生物聚合物光学器件的方法包括提供聚合物，提供基底，将聚合物浇注到基底上，以及将有机化合物酶促聚合以在所提供的聚合物和基底之间产生导电聚合物。 聚合物可以是诸如丝的生物聚合物，并且可以使用有机化合物如酪氨酸进行改性，以通过酪氨酸 - 酶聚合提供生物聚合物光学器件的所提供的本体生物聚合物与底物或其它导电层之间的分子水平界面。 酶促聚合可包括用过氧化物酶反应催化有机化合物。 结果是碳 - 碳共轭骨架提供用于聚合物和生物聚合物光学器件的聚合物“丝线”。 由此提供了提供光学功能和特征的全部有机生物聚合物电活性材料。
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