公开(公告)号：US20070275402A1

公开(公告)日：2007-11-29

申请号：US11784499

申请日：2007-04-06

Applicant: Yuk Lo ,  Rossa Chiu ,  Stephen Chim ,  Chunming Ding ,  Shengnan Jin ,  Tracy Lee ,  Fiona Lun

Inventor： Yuk Lo ,  Rossa Chiu ,  Stephen Chim ,  Chunming Ding ,  Shengnan Jin ,  Tracy Lee ,  Fiona Lun

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2523/125

Abstract: This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.

Abstract translation: 该应用提供了新颖的胎儿标记物用于产前诊断和监测某些妊娠相关病症的用途。 更具体地，本发明在于发现位于胎儿染色体21上的某些CpG岛表现出与位于母体染色体21上的相应CpG岛不同的甲基化谱。该应用还提供用于诊断或监测相关 条件。

公开(公告)号：US20070059707A1

公开(公告)日：2007-03-15

申请号：US10575119

申请日：2004-10-08

Applicant: Charles Cantor ,  Chunming Ding

Inventor： Charles Cantor ,  Chunming Ding

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/6876 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/166 ,  C12Q2521/331

Abstract: Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus, for instance differences in their methylation states, as a means to enrich for fetal DNA in maternal plasma sample. The methods described herein can be used to detect chromosomal DNA deletions and duplications. In a preferred embodiment, the methods are used to diagnose chromosomal aneuploidy and related disorders, such as Down's and Turner's Syndrome.

Abstract translation: 染色体异常负责大量的出生缺陷，包括精神发育迟滞。 本发明涉及基于母体血液样品分析的非侵入性和快速，产前诊断染色体异常的方法。 本发明利用母体和胎儿之间的DNA差异，例如甲基化状态的差异，作为富集母体血浆样品中胎儿DNA的手段。 本文描述的方法可用于检测染色体DNA缺失和重复。 在优选的实施方案中，所述方法用于诊断染色体非整倍体和相关疾病，例如唐氏和特纳综合征。

公开(公告)号：US20050239636A1

公开(公告)日：2005-10-27

申请号：US10503515

申请日：2003-01-30

Applicant: Mingzhi Gao ,  Haitao Liu ,  Zhulan Li ,  Jun Wang ,  Juxiu Yang ,  Tianyi Li ,  Xiaodong Wang ,  Changxiu Li ,  Chunming Ding

Inventor： Mingzhi Gao ,  Haitao Liu ,  Zhulan Li ,  Jun Wang ,  Juxiu Yang ,  Tianyi Li ,  Xiaodong Wang ,  Changxiu Li ,  Chunming Ding

IPC: C08F4/649 ,  C08F4/654 ,  C08F10/00 ,  C08F110/06 ,  B01J31/00 ,  C08F4/44

CPC classification number: C08F10/00 ,  C08F110/06 ,  C08F4/651 ,  C08F4/6494 ,  C08F4/6492 ,  C08F4/6465 ,  C08F2500/18 ,  C08F2500/12 ,  C08F2500/15 ,  C08F2500/04

Abstract: The present invention provides a solid catalyst component for the polymerization of olefins, comprising magnesium, titanium, a halogen and an electron donor, wherein said electron donor comprises at least one selected from the group consisting of polyol ester compounds of the formula (I): R1CO—O—CR3R4-A-CR5R6—O—CO—R2 (I) wherein, R1 and R2 groups, which may be identical or different, can be substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R3-R6 groups, which may be identical or different, can be selected from the group consisting of hydrogen, halogen or substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R1-R6 groups optionally contain one or more hetero-atoms replacing carbon, hydrogen atom or the both, said hetero-atom is selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus and halogen atom, two or more of R3-R6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring; A is a single bond or bivalent linking group with chain length between two free radicals being 1-10 atoms, wherein said bivalent linking group is selected from the group consisting of aliphatic, alicyclic and aromatic bivalent radicals, and can carry C1-C20 linear or branched substituents; one or more of carbon atom and/or hydrogen atom on above-mentioned bivalent linking group and substituents can be replaced by a hetero-atom selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus, and halogen atom, and two or more said substituents on the linking group as well as above-mentioned R3-R6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring.