公开(公告)号：US07413859B2

公开(公告)日：2008-08-19

申请号：US10841413

申请日：2004-05-07

申请人： Christian Paulus ,  Petra T. Schindler-Bauer

发明人： Christian Paulus ,  Petra T. Schindler-Bauer

IPC分类号： C21Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/5438

摘要： Method for detecting macromolecular biopolymers using a unit for immobilizing macromolecular biopolymers, in which the unit is provided with first molecules serving as capture molecules. The method includes the steps of bringing a sample into contact with the unit, it being possible for the sample to contain the macromolecular biopolymers, and the macromolecular biopolymers or the first molecules having a marking which is used to generate a detectable signal, binding macromolecular biopolymers contained in the sample to the capture molecules, thereby forming complexes comprising capture molecules and macromolecular biopolymers, exciting the emission of a signal by means of the marking, detecting the signal emitted by means of the marking, separating the complexes comprising capture molecules and macromolecular biopolymers, thereby altering the intensity of the emitted signal, and detecting the separation of the complexes comprising capture molecules and macromolecular biopolymers by means of the change in the intensity of the signal.

摘要翻译： 使用用于固定大分子生物聚合物的单元检测大分子生物聚合物的方法，其中该单元具有用作捕获分子的第一分子。 该方法包括使样品与单元接触的步骤，样品可以含有大分子生物聚合物，大分子生物聚合物或具有用于产生可检测信号的标记的第一分子，结合大分子生物聚合物 包含在捕获分子中的样品，从而形成包含捕获分子和大分子生物聚合物的复合物，通过标记激发信号的发射，检测通过标记发射的信号，分离包含捕获分子和大分子生物聚合物的复合物 从而改变发射信号的强度，并通过信号强度的变化来检测包含捕获分子和大分子生物聚合物的络合物的分离。

公开(公告)号：US07315271B2

公开(公告)日：2008-01-01

申请号：US10536764

申请日：2003-10-29

申请人： Christian Paulus

发明人： Christian Paulus

IPC分类号： H03M1/34

CPC分类号： H03M1/362

摘要： The invention relates to an analog-to-digital converter. The analog-to-digital converter, for conversion of a signal for digitization into a digital signal, contains a number of comparators, each of which has a first and second input and an output. The digitized signal is provided at said output. Each comparator is further provided with an impedance network, coupled to at least one input of the comparator, whereby an impedance network is wired between the corresponding comparator and the signal for digitization and between the corresponding comparator and a first electrical reference potential. The impedance networks are arranged such that the comparators are essentially brought to the same working point in the region of the specific decision threshold thereof.

摘要翻译： 本发明涉及一种模拟 - 数字转换器。 用于将用于数字化的信号转换为数字信号的模拟 - 数字转换器包含多个比较器，每个比较器具有第一和第二输入和输出。 在所述输出处提供数字化信号。 每个比较器进一步具有耦合到比较器的至少一个输入的阻抗网络，由此阻抗网络被布线在对应的比较器和用于数字化的信号之间以及相应的比较器和第一电参考电位之间。 阻抗网络布置成使得比较器在其特定判定阈值的区域中基本上被带到相同的工作点。

公开(公告)号：US20060292708A1

公开(公告)日：2006-12-28

申请号：US10503275

申请日：2003-01-17

申请人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

IPC分类号： H01L21/00

CPC分类号： G01N27/3277

摘要： A circuit arrangement has a sensor electrode, a control circuit which is coupled to the sensor electrode via an input, and a current source which is coupled via a control input to a control output of the control circuit. The current source can be controlled by the control circuit. The control circuit is arranged so that if the current signal at its input is outside a predetermined current intensity range, the control circuit controls the current source so that the current source sets the electric current generated by it so that the electric current flowing into the input of the control circuit is brought to a predetermined current intensity value. Furthermore, the control circuit is set up in such a way that if the current signal at its input is within the predetermined current intensity range, the control circuit controls the current source so that the current source holds the electric current generated by it at the present value. Furthermore, the circuit arrangement has a detection unit which can detect the event that the current signal flowing into the control circuit via its input is outside the predetermined current intensity range.

摘要翻译： 电路装置具有传感器电极，通过输入耦合到传感器电极的控制电路和经由控制输入耦合到控制电路的控制输出的电流源。 电流源可由控制电路控制。 控制电路被布置成使得如果其输入端的电流信号在预定的电流强度范围之外，则控制电路控制电流源，使得电流源设置由其产生的电流，使得流入输入端的电流 使控制电路达到预定的电流强度值。 此外，控制电路被设置成如果其输入端的电流信号在预定电流强度范围内，则控制电路控制电流源，使得电流源保持当前产生的电流 值。 此外，电路装置具有检测单元，该检测单元可以检测通过其输入流入控制电路的电流信号超出预定电流强度范围的事件。

公开(公告)号：US20050029099A1

公开(公告)日：2005-02-10

申请号：US10826881

申请日：2004-04-16

申请人： Bjorn-Oliver Eversmann ,  Christian Paulus ,  Guido Stromberg ,  Roland Thewes

发明人： Bjorn-Oliver Eversmann ,  Christian Paulus ,  Guido Stromberg ,  Roland Thewes

IPC分类号： G01N27/414 ,  G01N33/487 ,  G06K9/00 ,  G01N27/26

CPC分类号： G06K9/0002 ,  G01N27/4145 ,  G01N33/4836

摘要： Sensor arrangement having row and column lines arranged in first and second directions, respectively, sensor arrays arranged in crossover regions of the row and column lines, a detector, and a decoding device. The sensor arrays have a coupling device for electrically coupling respective row and column lines, and a sensor element to influence electric current flow through the coupling device. The detector is electrically coupled to a respective end section of at least a portion of the row and column lines, and detects a respective accumulative current flow from the individual electrical current flows provided by the sensor arrays of the respective lines. The decoding device is coupled to the row and column lines, and evaluates at least a portion of the accumulative electric current flows fed to the decoding device via the row and column lines to determine at which of the sensor elements a sensor signal is present.

摘要翻译： 分别具有沿第一和第二方向布置的行和列线的传感器布置，布置在行和列线的交叉区域中的传感器阵列，检测器和解码装置。 传感器阵列具有用于电耦合相应的行和列线的耦合装置和用于影响通过耦合装置的电流的传感器元件。 检测器电耦合到行和列线的至少一部分的相应端部，并且检测来自各线的传感器阵列提供的各个电流的相应的累积电流。 解码装置耦合到行和列线，并且通过行和列线评估馈送到解码装置的累积电流的至少一部分，以确定在哪个传感器元件处存在传感器信号。

公开(公告)号：US06556070B2

公开(公告)日：2003-04-29

申请号：US10082337

申请日：2002-02-25

申请人： Christian Paulus

发明人： Christian Paulus

IPC分类号： G05F110

CPC分类号： G05F3/242

摘要： An electrical current source with a high output resistance has a current determining transistor and a regulating switch. The regulating switch has an amplifier circuit with transistors and a regulating transistor, and allows the electrical supply to have a high output resistance. To enable the electrical supply to be used at even very low operating voltages, a sourcing circuit is provided, which is used for setting a freely selectable minimal decrease in voltage over the supply. The sourcing circuit has one or more transistors and influences the voltage at the current determining transistor. The output resistance of the electrical source can be further improved by utilizing a correcting circuit that has resistors.