公开(公告)号：US20100198020A1

公开(公告)日：2010-08-05

申请号：US12757920

申请日：2010-04-09

申请人： Clifton A. Alferness ,  Gust H. Bardy

发明人： Clifton A. Alferness ,  Gust H. Bardy

IPC分类号： A61B5/00

CPC分类号： G06F19/3475 ,  G06F19/3456 ,  G06F19/3481 ,  G16H15/00 ,  G16H50/50

摘要： A computer-implemented method for actively managing increased insulin resistance in Type 2 diabetes mellitus is provided. A computer-generated model of glycemic effect for a Type 2 diabetic patient for digestive response is established on a computer workstation. A rise in postprandial blood glucose from a meal planned for ingestion by the patients estimated as displayed through the digestive response model. A coefficient applied to the digestive response model for an initial degree of insulin resistance experienced by the patient is adjusted. Following a physiologic increase in insulin resistance, a rise in postprandial blood glucose from a subsequent meal planned for ingestion by the patient is estimated as displayed through the digestive response model. The coefficient applied to the digestive response model for a subsequent degree of insulin resistance experienced by the patient is adjusted.

摘要翻译： 提供了一种主动管理2型糖尿病胰岛素抵抗增加的计算机实现方法。 在计算机工作站上建立了计算机生成的2型糖尿病患者消化反应的血糖效应模型。 膳食中餐后血糖升高，计划由通过消化反应模型显示的患者进行摄入。 调整用于患者经历的初始胰岛素抵抗程度的消化反应模型的系数。 在胰岛素抵抗的生理上升后，通过消化反应模型估计出计划由患者摄取的随后的膳食中餐后血糖的升高。 调整用于患者经历的随后的胰岛素抵抗程度的消化反应模型的系数。

公开(公告)号：US20100168847A1

公开(公告)日：2010-07-01

申请号：US12719758

申请日：2010-03-08

申请人： Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

发明人： Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2250/001 ,  A61F2250/0059

摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

摘要翻译： 血管内支持装置包括支撑件或再生线，近端锚和远端锚。 支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。 锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。 该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。 锚固件可以锁定到位以将支撑件固定在容器内。

公开(公告)号：US20100145670A1

公开(公告)日：2010-06-10

申请号：US12030130

申请日：2008-02-12

申请人： Clifton A. Alferness ,  Gust H. Hardy

发明人： Clifton A. Alferness ,  Gust H. Hardy

IPC分类号： G06G7/58

CPC分类号： G06F19/3475 ,  G06F19/3456 ,  G06F19/3481 ,  G16H15/00 ,  G16H50/50

摘要： A system and method for managing Type 2 diabetes mellitus through a personal predictive management tool is provided. An insulin resistance for a Type 2 diabetes patient is identified. A time course curve is maintained for a patient population including expected blood glucose levels for a type of human-consumable food. The blood glucose levels following consumption of the food is estimated by adjusting the time course curve as a function of the patient-specific insulin resistance that has been manifested.

摘要翻译： 提供了一种通过个人预测管理工具管理2型糖尿病的系统和方法。 确定2型糖尿病患者的胰岛素抵抗。 对于患者群体维持时间过程曲线，包括一种人类可食用食物的预期血糖水平。 通过调整作为患者特异性胰岛素抵抗的函数的时程曲线来估计消费食物后的血糖水平。

公开(公告)号：US20100138453A1

公开(公告)日：2010-06-03

申请号：US12030104

申请日：2008-02-12

申请人： Clifton A. Alferness ,  Gust H. Bardy

发明人： Clifton A. Alferness ,  Gust H. Bardy

IPC分类号： G06F17/30 ,  G06Q99/00 ,  G06F7/00

CPC分类号： G06Q50/22 ,  G06F19/3456 ,  G16H50/50

摘要： A system and method for generating a personalized diabetes management tool for diabetes mellitus is provided. An insulin activity curve for a patient population for an insulin preparation for diabetes mellitus treatment is identified. A personal insulin activity model for the patient is generated. An insulin sensitivity is determined by taking a derivative of the rate of change of blood glucose over time for the insulin preparation. An insulin sensitivity coefficient for the insulin preparation for a patient of diabetes mellitus is established. The insulin sensitivity coefficient is applied to the patient population insulin activity curve over a duration of action of the insulin preparation.

摘要翻译： 提供了一种用于产生用于糖尿病的个性化糖尿病管理工具的系统和方法。 鉴定用于糖尿病治疗的胰岛素制剂的患者群体的胰岛素活性曲线。 产生患者的个人胰岛素活性模型。 胰岛素敏感性是通过取胰岛素制剂随时间变化的血糖变化率来确定的。 建立糖尿病患者胰岛素制剂的胰岛素敏感性系数。 在胰岛素制剂的作用持续时间内，将胰岛素敏感性系数应用于患者群体胰岛素活性曲线。

公开(公告)号：US07674287B2

公开(公告)日：2010-03-09

申请号：US11467105

申请日：2006-08-24

申请人： Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

发明人： Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

IPC分类号： A61F2/24 ,  A61F2/06

CPC分类号： A61F2/2451 ,  A61F2250/001 ,  A61F2250/0059

摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

摘要翻译： 血管内支持装置包括支撑件或再生线，近端锚和远端锚。 支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。 锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。 该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。 锚固件可以锁定到位以将支撑件固定在容器内。

公开(公告)号：US20090048578A1

公开(公告)日：2009-02-19

申请号：US12205655

申请日：2008-09-05

申请人： John M. Adams ,  Clifton A. Alferness

发明人： John M. Adams ,  Clifton A. Alferness

IPC分类号： A61M5/32

CPC分类号： A61M5/14248 ,  A61M5/425 ,  A61M2005/1405 ,  A61M2005/1585

摘要： A device and method facilitates the forming of a skin fold during deployment of a cannula. The device may be a disposable infusion device and the method comprises adhering, to a skin surface, a base member having a port for receiving a cannula, forming a skin fold having skin surfaces sloping away from opposite sides of the base member, driving a cannula through the port of the base member while maintaining the skin fold, and releasing the skin fold. To facilitate the forming of the skin fold, the device comprises a base having a base surface and a flexible layer member. The flexible layer member has a first surface adjacent the base surface and a second surface adapted to be adhered to a patient's skin. The first surface has a first portion adhered to a portion of the base surface and a second portion adherable to the base surface.

摘要翻译： 装置和方法有助于在插管期间形成皮肤褶皱。 该装置可以是一次性输注装置，并且该方法包括将具有用于接收插管的端口的基部构件粘附到皮肤表面，形成具有从基部构件的相对侧倾斜的皮肤表面的皮肤褶皱， 通过基底构件的端口，同时保持皮肤折叠，并释放皮肤褶皱。 为了促进皮肤褶皱的形成，该装置包括具有基底表面和柔性层部件的基部。 柔性层构件具有邻近基底表面的第一表面和适于粘附到患者皮肤的第二表面。 第一表面具有粘附到基部表面的一部分的第一部分和可粘附到基底表面的第二部分。

公开(公告)号：US20080288060A1

公开(公告)日：2008-11-20

申请号：US11631832

申请日：2005-07-06

申请人： David Martin Kaye ,  John Melmouth Power ,  Clifton A. Alferness ,  Adam Lucas Bilney ,  Mark L. Mathis

发明人： David Martin Kaye ,  John Melmouth Power ,  Clifton A. Alferness ,  Adam Lucas Bilney ,  Mark L. Mathis

IPC分类号： A61F2/24

CPC分类号： A61B17/0401 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/068 ,  A61B17/221 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0441 ,  A61B2017/0445 ,  A61B2017/0448 ,  A61B2017/0453 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0649 ,  A61B2017/081 ,  A61B2017/2215 ,  A61F2/2445

摘要： In a method of treating valvular insufficiency in a patient, a plurality of filaments (2) are used to engage tissue at spaced apart locations of an annulus (1) of the valve being treated. The engaged filaments (2) are drawn inward so as to draw the engaged tissue around the valve annulus (1) inward. The filaments (2) are then secured with the engaged tissue in the drawn-in configuration. Inward drawing of the engaged tissue improves valve function by reducing the valve annulus (1). Alternatively or additionally, anchor means may be used to secure the filaments to a region of robust tissue, thus drawing the engaged tissue toward the anchor means to further improve valve function.

摘要翻译： 在治疗患者瓣膜功能不全的方法中，多个细丝（2）用于在所治疗的瓣膜（1）的间隔开的位置处接合组织。 所接合的细丝（2）向内拉，以便将所接合的组织向内抽吸到瓣膜环（1）周围。 然后，细丝（2）以接合的组织固定在牵引构造中。 通过减小瓣膜环（1）来改变接合组织的内部抽吸来提高瓣膜功能。 或者或另外，锚固装置可以用于将细丝固定到坚固的组织的区域，从而将接合的组织拉向锚固装置以进一步改善瓣膜功能。

公开(公告)号：US20080058718A1

公开(公告)日：2008-03-06

申请号：US11516812

申请日：2006-09-06

申请人： John M. Adams ,  Clifton A. Alferness ,  Daniel Hawkins

发明人： John M. Adams ,  Clifton A. Alferness ,  Daniel Hawkins

IPC分类号： A61M37/00

CPC分类号： A61M5/152 ,  A61M5/14248

摘要： A wearable infusion device delivers a liquid medicant to a patient. The infusion device comprises a base that contacts a patient's skin and a reservoir arranged to be filled with a liquid medicant to be delivered beneath a patient's skin. The reservoir has an outlet through which the medicant flows. The infusion device further comprises a flexible conduit communicating with the outlet of the reservoir, a pump that causes the medicant to flow down the conduit, an actuator that performs a function related to the operation of the device, and an enable mechanism that enables the actuator in response to the filling of the reservoir with the liquid medicant.

摘要翻译： 可戴式输液装置将液体药剂递送给患者。 输液装置包括接触患者皮肤的基部和布置成填充有待在患者皮肤下方递送的液体药物的储存器。 储存器具有药物流过的出口。 输液装置还包括与储存器的出口连通的柔性导管，使得药剂沿着管道流下的泵，执行与装置的操作有关的功能的致动器，以及启动机构，其使致动器 响应于用液体药物填充储存器。

公开(公告)号：US20070282269A1

公开(公告)日：2007-12-06

申请号：US11641596

申请日：2006-12-18

申请人： Brett J. Carter ,  Clifton A. Alferness ,  John M. Adams ,  Daniel Hawkins

发明人： Brett J. Carter ,  Clifton A. Alferness ,  John M. Adams ,  Daniel Hawkins

IPC分类号： A61M5/162

CPC分类号： A61M5/14248 ,  A61M5/152 ,  A61M2005/14252 ,  A61M2005/14256 ,  A61M2005/1585 ,  A61M2209/045

摘要： An infusion system comprises a disposable wearable infusion device having a body arranged to be adhered to a patient's skin and a reservoir for holding a liquid medicant to be infused into the patient. The infusion system further includes a cannula driver arranged to be detachably joined with the infusion device. The cannula driver includes a cannula and is arranged to drive the cannula into a deployed position extending from the infusion device to beneath the patient's skin.

摘要翻译： 输液系统包括一次性穿戴式输注装置，其具有被布置成粘附到患者皮肤上的主体和用于保持待注入患者体内的液体药物的储存器。 输液系统还包括布置成可与输液装置可拆卸地连接的套管驱动器。 插管驱动器包括插管并且被布置成将插管驱动到从输注装置延伸到患者皮肤下方的展开位置。

公开(公告)号：US07166071B2

公开(公告)日：2007-01-23

申请号：US10668918

申请日：2003-09-23

申请人： Clifton A. Alferness

发明人： Clifton A. Alferness

IPC分类号： A61F2/02

CPC分类号： A61F2/2481 ,  A61F2002/2484 ,  A61F2250/0003 ,  A61M1/1008 ,  A61M1/106 ,  A61M1/1068 ,  A61M1/12

摘要： The present disclosure is directed to a cardiac reinforcement device (CRD) and method for the treatment of cardiomyopathy. The CRD provides for reinforcement of the walls of the heart by constraining cardiac expansion, beyond a predetermined limit, during diastolic expansion of the heart. A CRD of the invention can be applied to the epicardium of the heart to locally constrain expansion of the cardiac wall or to circumferentially constrain the cardiac wall during cardiac expansion.