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    2-O sulfatase nucleic acid compositions
    44.
    发明授权
    2-O sulfatase nucleic acid compositions 有权
    2-O硫酸酯酶核酸组合物

    公开(公告)号：US07396824B2

    公开(公告)日：2008-07-08

    申请号：US11433224

    申请日：2006-05-11

    申请人： Ram Sasisekharan ,  James Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    发明人： Ram Sasisekharan ,  James Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    IPC分类号： A61K31/70 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C12N9/16 ,  A61K38/00 ,  C12P19/04 ,  G01N33/5041 ,  G01N2400/40

    摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

    摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

    DATA STRUCTURES REPRESENTING POLYSACCHARIDES AND DATABASES AND METHODS RELATED THERETO
    50.
    发明申请
    DATA STRUCTURES REPRESENTING POLYSACCHARIDES AND DATABASES AND METHODS RELATED THERETO 审中-公开
    代表多糖和数据库的数据结构及其相关方法

    公开(公告)号：US20080301178A1

    公开(公告)日：2008-12-04

    申请号：US12133334

    申请日：2008-06-04

    申请人： Ganesh Venkataraman ,  Zachary Shriver ,  Rahul Raman ,  Ram Sasisekharan ,  Nishla Keiser

    发明人： Ganesh Venkataraman ,  Zachary Shriver ,  Rahul Raman ,  Ram Sasisekharan ,  Nishla Keiser

    IPC分类号： G06F17/30

    CPC分类号： C07K1/00 ,  G16B50/00 ,  G16C20/20 ,  Y10S707/99936 ,  Y10S707/99943

    摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.

    摘要翻译： 公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。 数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。 聚合物可以是例如多糖，化学单元可以是糖。 还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。 查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于 查询序列和聚合物。 本发明还涉及称为属性编码术语的符号系统。