公开(公告)号：US20230339854A1

公开(公告)日：2023-10-26

申请号：US17796387

申请日：2021-02-01

申请人： Emory University

发明人： Dennis C. Liotta ,  Stephen Traynelis ,  Hongjie Yuan ,  Matthew Epplin ,  Samantha Summer ,  David Menaldino ,  Leon Jacobs ,  Adam McCallum

IPC分类号： C07D209/46 ,  C07D217/24 ,  C07D401/06 ,  C07D401/12

CPC分类号： C07D209/46 ,  C07D217/24 ,  C07D401/06 ,  C07D401/12

摘要： Disclosed are negative allosteric modulators of GluN3-containing NMDA receptors. In general, these compounds are highly selective for GluN3 (such as GluN3A and/or GluN3B) over GluN1 and/or GluN2. They can function as non-competitive antagonists with activity that is independent of membrane potential, glycine concentration, and extracellular pH. Also disclosed are pharmaceutical formulations of the negative allosteric modulators. These compounds can be used to enhance synaptic function and/or treating a neurological condition or disorder. Exemplary neurological conditions or disorders include, but are not limited to, major mental disorders, conditions that involve basal ganglia or altered dopamine, substance abuse/addiction or predisposition to substance abuse/addiction, pain disorders, developmental delay or situations with impaired learning, memory, and/or cognition, acute neuronal or glial injuries, and circuit disorders.

公开(公告)号：US20210401836A1

公开(公告)日：2021-12-30

申请号：US17462175

申请日：2021-08-31

申请人： EMORY UNIVERSITY

发明人： Michael G. Natchus ,  Richard Arrendale ,  Dennis C. Liotta ,  Ketan Desai ,  Hyunsuk Shim

IPC分类号： A61K31/506 ,  A61K45/06 ,  A61K31/4166 ,  A61K31/57 ,  A61K31/575 ,  A61K31/58 ,  C07D403/12 ,  A61K31/505 ,  C07D213/74 ,  C07D401/12 ,  C07C211/53 ,  C07D239/42 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/444 ,  A61K38/20 ,  C07C233/64 ,  C07C255/58 ,  C07D213/72

摘要： The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

公开(公告)号：US11053276B2

公开(公告)日：2021-07-06

申请号：US16599892

申请日：2019-10-11

申请人： EMORY UNIVERSITY

发明人： David Brian Guthrie ,  Mark Andrew Lockwood ,  Michael G. Natchus ,  Dennis C. Liotta ,  Donald G. Stein ,  Iqbal Sayeed

IPC分类号： C07J41/00 ,  A61K45/06 ,  A61K31/57 ,  A61K31/661 ,  C07J43/00 ,  C07J51/00 ,  A61K31/58

摘要： This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.

公开(公告)号：US10336787B2

公开(公告)日：2019-07-02

申请号：US14932231

申请日：2015-11-04

申请人： EMORY UNIVERSITY

发明人： David B Guthrie ,  Mark A Lockwood ,  Dennis C. Liotta ,  Michael G Natchus ,  Donald G. Stein ,  Iqbal Sayeed

IPC分类号： C07J41/00 ,  A61K31/57 ,  A61K31/58 ,  A61K45/06 ,  C07J43/00

摘要： This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.

公开(公告)号：US10149859B2

公开(公告)日：2018-12-11

申请号：US14917681

申请日：2014-09-10

申请人： Emory University

发明人： Dennis C. Liotta ,  George R. Painter ,  Gregory R. Bluemling ,  Abel de la Rosa

IPC分类号： A61K31/7068 ,  C07H19/06 ,  A61K45/06 ,  A61K9/127 ,  C07H19/10

摘要： This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

公开(公告)号：US20180221390A1

公开(公告)日：2018-08-09

申请号：US15945678

申请日：2018-04-04

申请人： Emory University

发明人： Christopher MacNevin ,  Donald G. Stein ,  Dennis C. Liotta ,  Iqbal Sayeed ,  David B. Guthrie ,  Mark A. Lockwood ,  Michael G. Natchus

IPC分类号： A61K31/573 ,  C07J9/00

摘要： Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.

公开(公告)号：US20170313719A1

公开(公告)日：2017-11-02

申请号：US15528087

申请日：2015-11-18

申请人： Emory University

发明人： Stephen F. Traynelis ,  Lanny S. Liebeskind ,  Dennis C. Liotta ,  Ethel C. Garnier-Amblard ,  PavanKumar Reddy Gangireddy

IPC分类号： C07D495/04

CPC分类号： C07D495/04

摘要： The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing conditions related to cognition, typically prevention or treatment of neurological conditions related to the NMDA receptor.

公开(公告)号：US20170137401A1

公开(公告)日：2017-05-18

申请号：US15311573

申请日：2015-05-15

申请人： Emory University

发明人： Bryan D. Cox ,  Lawrence J. Wilson ,  Anthony Prosser ,  Dennis C. Liotta ,  James P. Snyder

IPC分类号： C07D401/04 ,  A61K31/496 ,  A61K31/4155 ,  A61K31/4545 ,  A61K31/454 ,  C07D403/04 ,  C07D417/12 ,  C07D401/14

CPC分类号： C07D401/04 ,  A61K31/4155 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K45/06 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D417/12 ,  C07D417/14

摘要： The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of viral infections such as HIV or for managing cancer.

公开(公告)号：US20170065615A1

公开(公告)日：2017-03-09

申请号：US15355416

申请日：2016-11-18

申请人： Emory University

发明人： Christopher MacNevin ,  Donald G. Stein ,  Dennis C. Liotta ,  Iqbal Sayeed ,  David B. Guthrie ,  Mark A. Lockwood ,  Michael G. Natchus

IPC分类号： A61K31/573

CPC分类号： A61K31/573 ,  C07J9/00

摘要： Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.

摘要翻译： 提供的是在类固醇环系统的C3和/或C20位置上被极性取代基官能化的类固醇类似物，其具有改善的水溶性。 还提供了包含类固醇类似物的药物组合物和使用新型类固醇类似物在中枢神经系统损伤后治疗和预防患者神经变性的方法。

公开(公告)号：US20160002174A1

公开(公告)日：2016-01-07

申请号：US14790531

申请日：2015-07-02

申请人： Emory University

发明人： Hyunsuk Shim ,  Dennis C. Liotta ,  James P. Snyder ,  Weiqiang Zhan ,  Zhongxing Liang

IPC分类号： C07D239/42 ,  C07C51/41

CPC分类号： C07D239/42 ,  A61K31/4402 ,  A61K31/444 ,  A61K31/505 ,  A61K31/506 ,  C07C51/412

摘要： The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis.

摘要翻译： 本发明提供化合物，药物组合物和使用作为趋化因子CXCR4受体的拮抗剂的某些化合物用于治疗CXCR4受体介导的增殖性病症的化合物，药物组合物和方法。 所提供的化合物干扰SDF1与受体的结合。 这些化合物特别可用于通过抑制转移来治疗或降低过度增殖性疾病的严重性。