公开(公告)号：US10472337B2

公开(公告)日：2019-11-12

申请号：US16220046

申请日：2018-12-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/5513 ,  C07D243/14 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D413/06 ,  C07D417/06 ,  C07D267/14 ,  C07D413/12 ,  C07D413/04 ,  C07D291/08 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10464909B2

公开(公告)日：2019-11-05

申请号：US16219381

申请日：2018-12-13

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Heather Davis ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  Kenneth W. Bair ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/553 ,  C07D498/04 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10450283B2

公开(公告)日：2019-10-22

申请号：US16218132

申请日：2018-12-12

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin ,  Kenneth W. Bair

IPC: A61K31/553 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US20190308946A1

公开(公告)日：2019-10-10

申请号：US16449675

申请日：2019-06-24

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Bingsong Han ,  Nicholas Barczak ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  Kenneth W. Bair

IPC: C07D265/36 ,  C07D279/14 ,  C07D265/34 ,  C07D487/04 ,  C07D513/04 ,  C07D417/06 ,  C07D413/12 ,  C07D413/10 ,  C07D491/107 ,  C07D279/16 ,  C07D401/04 ,  C07D413/06 ,  C07D471/04

Abstract: The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10414738B2

公开(公告)日：2019-09-17

申请号：US16218108

申请日：2018-12-12

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin ,  Kenneth W. Bair

IPC: A61K31/553 ,  C07D498/04 ,  C07D267/14 ,  C07D413/12 ,  C07D267/12 ,  C07D413/06 ,  C07D401/06 ,  C07D417/04 ,  C07D471/04 ,  C07D243/14 ,  C07D291/08 ,  C07D498/08 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D495/10 ,  C07D491/107 ,  C07D413/08 ,  C07D493/08 ,  C07D413/04

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US20190241506A1

公开(公告)日：2019-08-08

申请号：US16387937

申请日：2019-04-18

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, JR. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/4439 ,  C07D417/04 ,  A61K31/495 ,  C07D241/08 ,  A61K31/44 ,  C07D213/56 ,  A61K31/417 ,  C07D233/68 ,  A61K31/4184 ,  C07D235/14 ,  A61K31/397 ,  A61K31/407 ,  C07D487/10 ,  A61K31/435 ,  C07D471/10 ,  A61K31/451 ,  C07D295/155 ,  A61K31/4035 ,  C07D209/44 ,  A61K31/277 ,  A61K31/438 ,  A61K31/185 ,  C07D495/10 ,  C07D221/20 ,  C07D307/68 ,  C07D213/65 ,  C07D295/192 ,  C07D211/58 ,  C07D211/16 ,  C07D513/10 ,  C07D209/46 ,  C07D209/42 ,  C07D277/56 ,  C07D209/08 ,  C07D498/04 ,  C07D207/267 ,  C07D493/08 ,  C07D207/10 ,  C07D491/10 ,  C07D487/08 ,  C07D487/04 ,  C07D261/18 ,  C07D257/04 ,  C07D249/18 ,  C07D417/12 ,  C07D241/12 ,  C07D409/12 ,  C07D409/04 ,  C07D405/12 ,  C07D239/22 ,  C07D239/20 ,  C07D235/30 ,  C07D401/12 ,  C07D401/04 ,  C07D333/70 ,  C07D233/38 ,  C07D233/36 ,  C07D231/18 ,  C07D231/14 ,  C07D317/68 ,  C07D215/12 ,  C07D213/81 ,  C07D213/75 ,  C07D401/14

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US20190127339A1

公开(公告)日：2019-05-02

申请号：US16219669

申请日：2018-12-13

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Heather Davis ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  Kenneth W. Bair ,  David S. Millan ,  Matthew W. Martin

IPC: C07D267/14 ,  C07D413/04 ,  C07D267/12 ,  C07D413/06 ,  C07D401/06 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D243/14 ,  C07D291/08 ,  C07D498/08 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D495/10 ,  C07D491/107 ,  C07D413/08 ,  C07D493/08 ,  C07D413/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US20190119234A1

公开(公告)日：2019-04-25

申请号：US16220049

申请日：2018-12-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  David S. Millan ,  Matthew W. Martin

IPC: C07D267/14 ,  C07D413/04 ,  C07D267/12 ,  C07D413/06 ,  C07D401/06 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D243/14 ,  C07D291/08 ,  C07D498/08 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D495/10 ,  C07D491/107 ,  C07D413/08 ,  C07D493/08 ,  C07D413/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US20190119232A1

公开(公告)日：2019-04-25

申请号：US16220041

申请日：2018-12-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  David S. Millan ,  Matthew W. Martin

IPC: C07D267/14 ,  C07D413/04 ,  C07D267/12 ,  C07D413/06 ,  C07D401/06 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D243/14 ,  C07D291/08 ,  C07D498/08 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D495/10 ,  C07D491/107 ,  C07D413/08 ,  C07D493/08 ,  C07D413/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US20190119231A1

公开(公告)日：2019-04-25

申请号：US16220035

申请日：2018-12-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, JR. ,  David S. Millan ,  Matthew W. Martin

IPC: C07D267/14 ,  C07D413/04 ,  C07D267/12 ,  C07D413/06 ,  C07D401/06 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D243/14 ,  C07D291/08 ,  C07D498/08 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D495/10 ,  C07D491/107 ,  C07D413/08 ,  C07D493/08 ,  C07D413/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.