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公开(公告)号：US6090064A
公开(公告)日：2000-07-18
申请号：US192728
申请日：1998-11-16
CPC分类号： A61M5/14546 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M5/14566 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.
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42.发明授权Injection system, pump system for use therein and method of use of pumping system 失效注射系统，其中使用的泵系统和泵送系统的使用方法
公开(公告)号：US5916197A
公开(公告)日：1999-06-29
申请号：US801706
申请日：1997-02-14
申请人： David M. Reilly , Alan D. Hirschman
发明人： David M. Reilly , Alan D. Hirschman
CPC分类号： A61M5/16827 , A61M2206/22
摘要： The present invention provides an injection system and a pump system for use therein for pressurizing a liquid medium for injection into a patient. In general, the pump system comprises a pressurizing unit having at least one chamber. Each chamber has disposed therein a pressurizing mechanism to pressurize liquid medium within the chamber. Preferably, the pressurizing mechanism positively displaces the liquid medium through generally linear motion of the pressurizing mechanism within the chamber. Through reciprocating linear motion of the pressurizing mechanism (for example, a piston), the liquid medium is alternatively drawn into the chamber from a source of liquid medium (for example, a container) and forced out of the chamber under a desired pressure. Each chamber comprises an inlet port and an outlet port. The pump system also preferably comprises an inlet port check valve which allows the liquid medium to flow into the chamber through the inlet port, but substantially prevents the liquid medium from flowing out of the chamber through the inlet port. Likewise, the pump system preferably comprises an outlet port check valve which allows pressurized liquid medium to flow out of the chamber through the outlet port, but substantially prevents the liquid medium from flowing into the chamber through the outlet port. Each inlet port is connected to a source of liquid medium. Each outlet port is connected to a common outlet line or channel leading to the patient.
摘要翻译： 本发明提供一种注射系统和用于其中的用于将注射到患者体内的液体介质加压的泵系统。 通常，泵系统包括具有至少一个室的加压单元。 每个室都设置有加压机构以对腔室内的液体介质加压。 优选地，加压机构通过腔室内的加压机构的大致线性运动来使液体介质正向移位。 通过加压机构（例如，活塞）的往复直线运动，液体介质被替代地从液体介质（例如，容器）的源拉入室中，并在期望的压力下被迫离开室。 每个室包括入口和出口。 泵系统还优选地包括入口端口止回阀，其允许液体介质通过入口端口流入室中，但是基本上防止液体介质通过入口端口流出室。 类似地，泵系统优选地包括出口端口止回阀，其允许加压液体介质通过出口端口流出室，但是基本上防止液体介质通过出口端口流入室中。 每个入口连接到液体介质源。 每个出口端口连接到通向病人的公共出口管线或通道。
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公开(公告)号：USRE35979E
公开(公告)日：1998-12-01
申请号：US804433
申请日：1991-12-10
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/31511 , A61M5/14566 , A61M5/31515
摘要： An angiographic injector has an injector portion which includes a rotating turret for housing two angiographic syringes in readiness for injection. The injector further employs a driving mechanism for connecting with and controlling the movement of a syringe plunger once one of the syringes is in place for injection. Through the use of guide means on each syringe and corresponding alignment means on a pressure jacket, the syringe is alignably and securely mounted within the pressure jacket on the rotating turret. Each syringe plunger is releasably connected to the driving mechanism for an injection operation, and released from the driving mechanism when the injection operation has been completed, such that the driving mechanism can be withdrawn from the syringe relative to the plunger without drawing body fluid of a patient into the syringe. Various types of plunger release mechanisms for this purpose are disclosed. The questions raised in reexamination request No. 90/003,918 filed Aug. 7, 1995, have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e).
摘要翻译： 血管造影注射器具有注射器部分，其包括用于容纳注射用的两个血管造影注射器的旋转转台。 一旦注射器在注射器就位之后，注射器还采用驱动机构来连接和控制注射器柱塞的移动。 通过使用每个注射器上的引导装置和压力套上的相应对准装置，注射器可对准地且牢固地安装在旋转转台上的压力套内。 每个注射器柱塞可释放地连接到用于注射操作的驱动机构，并且当注射操作已经完成时从驱动机构释放，使得驱动机构可以相对于柱塞从注射器中抽出而不抽出体液 病人进入注射器。 公开了用于此目的的各种类型的柱塞释放机构。 + RR已经考虑了1995年8月7日提交的第90 / 003,918号复审请求中提出的问题，其结果反映在构成35U.S.C.所要求的复审证书的该再发行专利中。 307如第37 CFR 1.570（e）条所规定。
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公开(公告)号：US4677980A
公开(公告)日：1987-07-07
申请号：US782586
申请日：1985-10-01
CPC分类号： A61M5/31511 , A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/31515 , Y10S128/01
摘要： An angiographic injector has an injector portion which includes a rotating turret for housing two angiographic syringes in readiness for injection. The injector further employs a driving mechanism for connecting with and controlling the movement of a syringe plunger once one of the syringes is in place for injection. Through the use of guide means on each syringe and corresponding alignment means on a pressure jacket, the syringe is alignably and securely mounted within the pressure jacket on the rotating turret. Each syringe plunger is releasably connected to the driving mechanism for an injection operation, and released from the driving mechanism when the injection operation has been completed, such that the driving mechanism can be withdrawn from the syringe relative to the plunger without drawing body fluid of a patient into the syringe. Various types of plunger release mechanisms for this purpose are disclosed.
摘要翻译： 血管造影注射器具有注射器部分，其包括用于容纳注射用的两个血管造影注射器的旋转转台。 一旦注射器在注射器就位之后，注射器还采用驱动机构来连接和控制注射器柱塞的移动。 通过使用每个注射器上的引导装置和压力套上的相应对准装置，注射器可对准地且牢固地安装在旋转转台上的压力套内。 每个注射器柱塞可释放地连接到用于注射操作的驱动机构，并且当注射操作已经完成时从驱动机构释放，使得驱动机构可以相对于柱塞从注射器中抽出而不抽出体液 病人进入注射器。 公开了用于此目的的各种类型的柱塞释放机构。
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45.发明授权Pumping devices, systems including multiple pistons and methods for use with medical fluids 有权泵送装置，包括多个活塞的系统和与医用流体一起使用的方法公开(公告)号：US08944780B2
公开(公告)日：2015-02-03
申请号：US13071939
申请日：2011-03-25
申请人： David M. Reilly
发明人： David M. Reilly
CPC分类号： A61M39/223 , A61M5/007 , A61M5/16877 , A61M2039/224 , B01F15/00422 , B01F15/0237 , B01F15/0247 , B01F15/0429 , B01F15/0454 , F04B1/128 , F04B9/02 , F04B9/042 , F04B11/0058 , Y10T137/86879 , Y10T137/8766 , Y10T137/87676
摘要： A system for delivery of medical fluid to a patient which includes a pump system and a drive system. The pump system has at least three chambers, where each chamber includes an inlet for fluid intake and an outlet for fluid expulsion, a common outlet channel in fluid communication with the outlet of each chamber, and at least three pistons, where each piston is slidably disposed within one of the chambers. The drive system includes a cam shaft having at least three cam lobes, each having a profile, and at least three cam lobe followers, each in operative connection with one of the cam lobes and adapted to be placed in operative connection with a respective piston. The profile of each of the cam lobes is adapted to provide a transient increase or spike in calculated theoretical output of the pump system to reduce periodic variation in measured output thereof.
摘要翻译： 一种用于将医用流体输送给患者的系统，包括泵系统和驱动系统。 泵系统具有至少三个室，其中每个室包括用于流体进入的入口和用于流体排出的出口，与每个室的出口流体连通的公共出口通道以及至少三个活塞，其中每个活塞可滑动地 设置在一个室内。 所述驱动系统包括凸轮轴，所述凸轮轴具有至少三个凸轮凸角，每个凸轮凸角具有轮廓，以及至少三个凸轮凸角凸起凸角，每个与所述凸轮凸角中的一个可操作地连接，并且适于与相应的活塞可操作地连接。 每个凸轮凸角的轮廓适于在泵系统的计算理论输出中提供瞬时增加或尖峰，以减少其测量输出的周期性变化。
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公开(公告)号：US08382704B2
公开(公告)日：2013-02-26
申请号：US11960968
申请日：2007-12-20
申请人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
IPC分类号： A61M37/00
CPC分类号： A61M5/1407 , A61M5/14216 , A61M5/14236 , A61M5/1723 , A61M2202/09 , B01F7/00258 , B01F7/00566 , B01F7/00908 , B01F7/086 , B01F9/103 , B01F11/0071 , B01F11/0074 , B01F11/0082 , B01F11/025 , B01F13/002 , B01F13/0023 , B01F13/0818 , G06F19/00
摘要： A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movement of the dilated cell-slurry.
摘要翻译： 用于将细胞浆料递送到患者的系统可以包括流体，在流体中不可溶或不混溶的细胞，从而形成细胞浆液，适于容纳细胞浆液和细胞上清液的注射器 - 注射器限定具有出口的第一端，细胞浆料通过该出口传送到患者，与注射器相关联的适于用一部分上清液进行细胞浆液的扩张的流化系统，形成 扩张的细胞浆液，将扩张的细胞浆液从流化系统转移到注射器，同时保持至少一部分上清液，细胞浆液和上清液从流化系统转移到注射器，加压机构 适于产生压力以使得包含在注射器内的扩张的细胞浆液流动以传递给患者，以及与控制流化系统连通并适于控制流化系统的控制单元 扩散细胞浆的机制和运动。
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公开(公告)号：US08182444B2
公开(公告)日：2012-05-22
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , David M. Reilly , Kevin P. Cowan , Barry L. Tucker , David Mishler
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , David M. Reilly , Kevin P. Cowan , Barry L. Tucker , David Mishler
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient includes a container holding an injection fluid and a powered drive. A sensor system provides a measurement indicative of at least shear forces on the cells to a control system. Based at least in part on this measurement, the control system is adapted to transmit a control signal to the powered drive for pressurizing the contents of the container to deposit cells within the tissue of a patient via a fluid path and a patient interface. As an example, the cells can be pregenitor or stem cells.
摘要翻译： 用于将包含细胞的流体输送到患者的组织的系统包括容纳注射流体和动力驱动器的容器。 传感器系统提供至少指示细胞上的至少剪切力到控制系统的测量。 至少部分地基于该测量，控制系统适于将控制信号传输到动力驱动器，用于对容器的内容物进行加压，以经由流体路径和患者接口将细胞沉积在患者组织内。 例如，细胞可以是祖细胞或干细胞。
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48.发明申请PUMPING DEVICES, SYSTEMS AND METHODS FOR USE WITH MEDICAL FLUIDS INCLUDING COMPENSATION FOR VARIATIONS IN PRESSURE OR FLOW RATE 有权用于医疗流体的泵送装置，系统和方法，包括用于压力或流量变化的补偿公开(公告)号：US20110152681A1
公开(公告)日：2011-06-23
申请号：US12974549
申请日：2010-12-21
申请人： David M. Reilly
发明人： David M. Reilly
CPC分类号： A61M5/1452 , A61M5/007 , A61M5/1422 , A61M5/16881 , A61M2005/14533 , A61M2206/22
摘要： A system for delivery of a medical fluid to a patient includes a pump system including a pressurizing unit to pressurize the medical fluid and a drive system in operative connection with the pressurizing unit. The pump system exhibits variation in pressure during operation. The system further includes a compensating system in fluid connection with the medical fluid pressurized by the pressurizing unit. The compensating system defines a displacement volume in fluid connection with the pressurized medical fluid that is altered in a predetermined manner to alter the variation in pressure. The compensating system can, for example, reduce pulsatility of pressure during flow.
摘要翻译： 用于将医疗流体输送到患者的系统包括泵系统，其包括用于对医用流体加压的加压单元和与加压单元可操作地连接的驱动系统。 泵系统在运行期间表现出压力变化。 该系统还包括与由加压单元加压的医用流体流体连接的补偿系统。 补偿系统限定了与预定方式改变以改变压力变化的加压医用流体流体连接的排量。 例如，补偿系统可以减少流量期间的压力脉动。
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公开(公告)号：US20090012497A1
公开(公告)日：2009-01-08
申请号：US11960968
申请日：2007-12-20
申请人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
CPC分类号： A61M5/1407 , A61M5/14216 , A61M5/14236 , A61M5/1723 , A61M2202/09 , B01F7/00258 , B01F7/00566 , B01F7/00908 , B01F7/086 , B01F9/103 , B01F11/0071 , B01F11/0074 , B01F11/0082 , B01F11/025 , B01F13/002 , B01F13/0023 , B01F13/0818 , G06F19/00
摘要： A system for delivering a slurry to a patient includes a fluid, a material that is non-dissolvable or immiscible in the fluid, thereby forming a slurry, a container adapted to contain the slurry and a supernate of the slurry, the container defining an outlet through which the slurry is delivered to the patient, a fluidizing system associated with the container, a pressurizing mechanism adapted to create a pressure to cause the slurry contained within the container to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system and the pressurizing mechanism. The fluidizing system is adapted to effect dilation of the slurry while maintaining at least a portion of the supernate.
摘要翻译： 用于将浆料递送到患者的系统包括流体，在流体中不可溶或不混溶的材料，从而形成浆料，适于容纳浆料的容器和浆料的上清液，容器限定出口 通过其将浆料输送到患者，与容器相关联的流化系统，适于产生压力以使容纳在容器内的浆液流动以输送到患者的加压机构，以及与该患者连接并适应的控制单元 以控制流化系统和加压机构。 流化系统适于在保持至少一部分上清液的同时实现浆料的扩张。
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公开(公告)号：US20070272311A1
公开(公告)日：2007-11-29
申请号：US11420094
申请日：2006-05-24
IPC分类号： F16K21/04
CPC分类号： A61M39/24 , A61M5/14546 , A61M5/16827 , A61M39/223 , A61M39/228 , A61M2039/2473 , A61M2039/2486 , A61M2039/2493 , Y10T137/2567 , Y10T137/2569 , Y10T137/2572 , Y10T137/2622 , Y10T137/7838 , Y10T137/7843 , Y10T137/7849 , Y10T137/86726 , Y10T137/87338 , Y10T137/87555
摘要： A valve system for use in a system including a first source of a first pressurized fluid and a second source of a second pressurized fluid includes a valve housing including a first inlet port adapted to be placed in fluid connection with the first source, a second inlet port adapted to be placed in fluid connection with the second source and an outlet port. The valve system further includes a backflow prevention system to prevent flow of the first pressurized fluid through the second inlet and to prevent flow of the second pressurized fluid through the first inlet port. The valve system is adapted to provide a fluid path between at least the first inlet port and the outlet port to enable fluid to be drawn from the outlet port to the first inlet port. Several of the valve systems of the present invention provide for flow from the first inlet port to the outlet port and concurrent flow from the second inlet port to the outlet port.
摘要翻译： 一种用于包括第一加压流体的第一源和第二加压流体的第二源的系统的阀系统包括阀壳体，其包括适于与第一源流体连接的第一入口端口，第二入口 端口适于与第二源和出口端口流体连接。 阀系统还包括防止流体流动的第一加压流体通过第二入口并防止第二加压流体通过第一入口流动的防回流系统。 阀系统适于在至少第一入口和出口之间提供流体路径，以使流体能够从出口到第一入口端口被抽出。 本发明的几个阀门系统提供从第一入口到出口的流动以及从第二入口到出口的并流。
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