公开(公告)号：US10751354B2

公开(公告)日：2020-08-25

申请号：US15759754

申请日：2016-09-14

Applicant: GLYCOM A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  A61P3/04 ,  A61P3/10 ,  A61P1/00 ,  A61K9/00

Abstract: A human milk oligosaccharide (HMO) or a synthetic composition comprising said HMO, for use in increasing the abundance, particularly the relative abundance, of a Bifidobacterium of the B. adolescentis phylogenic group in the microbiota in the gastro-intestinal tract of a human, preferably a non-infant human. The HMO(s) and/or synthetic composition is useful in; increasing particularly the relative abundance of B. adolescentis and/or B. pseudocatenulatum; for treating or preventing in said non-infant human with type 2 diabetes and/or obesity; an enteropathogenic infection; impaired gut barrier function and/or; an inflammation related to gastro intestinal condition, preferably irritable bowel disease (IBD) or irritable bowel syndrome (IBS); as a nutritional composition. The HMO is a fucosylated neutral HMO, a non-fucosylated neutral HMO, or a mixture of a fucosylated and a non-fucosylated neutral HMO. The HMOs comprises 2′-fucosyllactose (preferred), 2′-fucosyllactose (preferred), 3-fucosyllactose, difucosyllactose (preferred), lacto-N-fucopentaose, fucosyl-lacto-N-hexaose, fucosyl-para-lacto-N-hexaose, lacto-N-tetraose (preferred), lacto-N-neotetraose (preferred), lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose and para-lacto-N-neohexaose.

公开(公告)号：US10695359B2

公开(公告)日：2020-06-30

申请号：US15579818

申请日：2016-06-09

Applicant: Glycom A/S

Inventor： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC: A61K31/702 ,  C07H3/04 ,  C07H5/06 ,  C07H1/00 ,  A61P31/12 ,  A61P31/04 ,  C07H3/06 ,  C12P19/18

Abstract: A mixture of human milk oligosaccharides that consists essentially of 6′-SL, LNnT and LSTc, made by treating 6′-SL and LNnT in the presence of an α2,6-transsialidase.

公开(公告)号：US20200155580A1

公开(公告)日：2020-05-21

申请号：US16616338

申请日：2018-05-24

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  A61K9/00 ,  A61P1/00

Abstract: A method and a composition comprising human milk oligosaccharides for decreasing the production of detrimental proteolytic metabolites such as ammonia and branched chain fatty acids in the intestinal microbiota of humans, which is useful for the treatment of brain-gut disorders like autism, stress, anxiety, and depressive disorders, are disclosed. Methods of treatment of colon cancer and liver damage are also disclosed.

公开(公告)号：US10588917B2

公开(公告)日：2020-03-17

申请号：US15561684

申请日：2016-03-31

Applicant: Glycom A/S

Inventor： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC: A61K31/702 ,  C12P19/14 ,  C07H3/06 ,  C12P19/00 ,  C07H5/06 ,  C12P19/18 ,  C12P19/26 ,  C07H1/00 ,  A61K31/7016

Abstract: A mixture of human milk oligosaccharides that consists essentially of 3′-O-sialyllactose, a component A which is either 3-O-fucosyllactose or lacto-N-tetraose, a component B which is 3-O-fucosyl-3′-O-sialyllactose when component A is 3-O-fucosyllactose and sialyllacto-N-tetraose a, when component A is lacto-N-tetraose and optionally lactose as a fourth component. The mixtures are made by treating 3′-O-sialyllactose and component A with an α2,3-transsialidase. The mixtures are for use in anti-bacterial and anti-viral compositions, and for promoting the development of Bifidobacterium and Barnesiella.

公开(公告)号：US20160287637A1

公开(公告)日：2016-10-06

申请号：US15183456

申请日：2016-06-15

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  Emma Salomonsson

IPC: A61K35/20

CPC classification number: A61K35/20 ,  A61K31/702

Abstract: The invention relates to a method for treating or preventing the development of emotion and/or mood disorders in a human individual.

Abstract translation: 本发明涉及一种治疗或预​​防人类情绪和/或情绪障碍发展的方法。

公开(公告)号：US12233079B2

公开(公告)日：2025-02-25

申请号：US17417029

申请日：2019-12-19

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61K9/00 ,  A61K9/16 ,  A61K9/48 ,  A61K35/20 ,  A61K47/24 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61P1/14

Abstract: A synthetic composition and method for use in providing a source of oligosaccharides to a human consuming a low-FODMAP diet, increasing the abundance of bifidobacteria in the colon of a human consuming a low-FODMAP diet, and/or reintroducing FODMAPs into the diet of a human consuming a low-FODMAP diet. The composition contains one or more human milk oligosaccharides.

公开(公告)号：US11896605B2

公开(公告)日：2024-02-13

申请号：US17353749

申请日：2021-06-21

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Elison

IPC: A61K31/702 ,  A61K31/706 ,  A61P1/00 ,  A61K31/7016

CPC classification number: A61K31/702 ,  A61K31/7016 ,  A61P1/00

Abstract: This disclosure relates generally to compositions and methods for preventing or treating mast cell mediated visceral pain.

公开(公告)号：US11602545B2

公开(公告)日：2023-03-14

申请号：US16770336

申请日：2018-11-30

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC: A61P25/06 ,  A61K31/702 ,  A61P1/00 ,  A61K35/20

Abstract: The invention relates to a human milk oligosaccharide (HMO) for use in, a synthetic composition comprising an HMO for use in and a method for preventing or treating migraine in a human.

公开(公告)号：US11554131B2

公开(公告)日：2023-01-17

申请号：US17059942

申请日：2019-05-31

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Kristine Rothaus Christensen

IPC: A61K31/702 ,  A61P37/02

Abstract: The invention relates to a method, compounds and compositions for the secondary prevention, treatment or dietary management of symptomatic and asymptomatic non-intestinal autoimmune diseases in a non-infant human including Sjogren's syndrome and type 1 diabetes. Said method, compounds and compositions for the secondary prevention, treatment or dietary management include human milk oligosaccharide (HMO), preferably mixtures of human milk oligosaccharides selected from the group of 2′-FL, LNnT, LNT, DFL, and 6′-SL.

公开(公告)号：US11541067B2

公开(公告)日：2023-01-03

申请号：US16616338

申请日：2018-05-24

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  A61K9/00 ,  A61P1/00

Abstract: A method and a composition comprising human milk oligosaccharides for decreasing the production of detrimental proteolytic metabolites such as ammonia and branched chain fatty acids in the intestinal microbiota of humans, which is useful for the treatment of brain-gut disorders like autism, stress, anxiety, and depressive disorders, are disclosed. Methods of treatment of colon cancer and liver damage are also disclosed.