公开(公告)号：US11173171B2

公开(公告)日：2021-11-16

申请号：US16820126

申请日：2020-03-16

申请人： Glycom A/S

发明人： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC分类号： A61K31/702 ,  C07H3/06 ,  C12P19/14 ,  C12P19/26 ,  C07H1/00 ,  C12P19/00 ,  C07H5/06 ,  C12P19/18 ,  A61P31/04 ,  A61P31/12 ,  A61K31/7016

摘要： A mixture of human milk oligosaccharides that consists essentially of 3′-O-sialyllactose, a component A which is either 3-O-fucosyllactose or lacto-N-tetraose, a component B which is 3-0-fucosyl-3′-O-sialyllactose when component A is 3-O-fucosyllactose and sialyllacto-N-tetraose a, when component A is lacto-N-tetraose and optionally lactose as a fourth component. The mixtures are made by treating 3′-O-sialyllactose and component A with an α2,3-transsialidase. The mixtures are for use in anti-bacterial and anti-viral compositions, and for promoting the development of Bifidobacterium and Barnesiella.

公开(公告)号：US10428318B2

公开(公告)日：2019-10-01

申请号：US15579843

申请日：2016-06-09

申请人： Glycom A/S

发明人： Andreas Vogel ,  Ramona Schmiedel ,  Elise Champion ,  Gyula Dekany

IPC分类号： C12N9/10 ,  C12P21/00 ,  C07H3/06 ,  C12P19/18 ,  C12P19/04

摘要： The invention provides engineered enzymes of transsialidase and/or sialyl transferase activity that have increased regioselectivity and/or increased thermostability.

公开(公告)号：US09896470B2

公开(公告)日：2018-02-20

申请号：US14407256

申请日：2013-06-14

申请人： Glycom A/S

发明人： Andreas Schroven ,  Gyula Dekany ,  Peter Erdmann ,  Andrea Schwarz

IPC分类号： C07H1/06 ,  C07H3/06 ,  A61K31/702 ,  A23L29/30 ,  A23L33/00 ,  A23L33/10

CPC分类号： C07H1/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/702 ,  C07H3/06 ,  A23V2200/30 ,  A23V2200/3204 ,  A23V2250/28

摘要： The present application discloses a method for enhancing the stability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend when stored for extended periods at temperatures above 25° C. by spray-drying an aqueous solution of the HMO or HMO precursor to remove at least 90% of the water and providing a HMO or a HMO precursor or a HMO blend with a specific glass transition temperature. Also disclosed is a method for removing organic solvent residues from a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying. Also disclosed is a method of enhancing the bioavailability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying.

公开(公告)号：US20150183816A1

公开(公告)日：2015-07-02

申请号：US14408877

申请日：2013-06-24

申请人： GLYCOM A/S

发明人： Elise Champion ,  Dóra Molnár-Gábor ,  Gyula Dekany

IPC分类号： C07H3/06 ,  A23L1/30 ,  A23L1/29 ,  C12P19/04 ,  C12P19/18

CPC分类号： C07H3/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C12P19/04 ,  C12P19/18

摘要： The invention relates to a method for making modified galactooligosaccharides comprising the step of enzymatic glycosylation, the modified galactooligosaccharides obtainable by the method and consumable products containing them.

摘要翻译： 本发明涉及一种制备改性低聚半乳糖的方法，包括酶促糖基化步骤，可通过该方法获得的改良的低聚半乳糖和含有它们的消费品。

公开(公告)号：US20150182549A1

公开(公告)日：2015-07-02

申请号：US14408495

申请日：2013-06-24

申请人： Glycom A/S

发明人： Elise Champion ,  Dóra Molnár-Gábor ,  Gyula Dekany

IPC分类号： A61K31/715 ,  A23L1/30 ,  A23L1/29

CPC分类号： A61K31/715 ,  A23L29/275 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H1/00 ,  C07H9/06 ,  C07H13/04 ,  C12P19/00 ,  C12P19/18 ,  C12P19/26 ,  C12Y302/01038 ,  C12Y302/01051 ,  A23V2200/304 ,  A23V2200/3202 ,  A23V2200/324 ,  A23V2250/28

摘要： A method for modifying galactosyl disaccharides in order to enhance their bifidogenic effect, comprising reacting at least one glycosyl donor with a precursor galactosyl disaccharide or a mixture of precursor galactosyl disaccharides using enzyme catalysis, compounds obtainable by said method and the use of such compounds in consumable products.

摘要翻译： 一种用于改善半乳糖二糖以增强其双发效应的方法，包括使用酶催化使至少一种糖基供体与前体半乳糖二糖或前体半乳糖二糖的混合物反应，可通过所述方法获得的化合物和这些化合物在消耗品中的用途 产品。

公开(公告)号：US20220235388A1

公开(公告)日：2022-07-28

申请号：US17657787

申请日：2022-04-04

申请人： GLYCOM A/S

发明人： Margit Pedersen ,  Manos Papadakis ,  Peter Becker ,  Eric Samain ,  Pauline Peltier-Pain ,  Katrine Bych ,  Ted Johanson ,  Elise Champion ,  Gyula Dekany

IPC分类号： C12P19/18 ,  C07K14/245 ,  C12N15/52 ,  C12P19/12 ,  C12N9/10 ,  C12N9/12 ,  C12N9/24 ,  C12N9/38

摘要： The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

公开(公告)号：US10946032B2

公开(公告)日：2021-03-16

申请号：US16435949

申请日：2019-06-10

申请人： Glycom A/S

发明人： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC分类号： A61K31/702 ,  C07H5/06 ,  C12P19/26 ,  A61K31/715 ,  C12P19/18 ,  A61K31/7016

摘要： The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

公开(公告)号：US10415021B2

公开(公告)日：2019-09-17

申请号：US15521580

申请日：2015-10-23

申请人： Glycom A/S

发明人： Elise Champion ,  Andreas Vogel ,  Sebastian Bartsch ,  Gyula Dekany

IPC分类号： C12N9/26 ,  C12N15/00 ,  C12P19/18 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C12N9/10 ,  C12N9/24 ,  C12P19/04

摘要： Mutated fucosidases are provided demonstrating improved properties in terms of thermal stability and transfucosidase synthetic performance compared with a wild type transfucosidase isolated from Bifidobacterium longum subsp. infantis.

公开(公告)号：US10314852B2

公开(公告)日：2019-06-11

申请号：US15521582

申请日：2015-10-23

申请人： Glycom A/S

发明人： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC分类号： C12P19/18 ,  C12P19/26 ,  A61K31/702 ,  C07H5/06 ,  A61K31/715 ,  A61K31/7016

摘要： The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

公开(公告)号：US09834574B2

公开(公告)日：2017-12-05

申请号：US14442017

申请日：2013-09-19

申请人： Glycom A/S

发明人： Martin Matwiejuk ,  Gyula Dekany

IPC分类号： C07H3/06 ,  C07H1/06 ,  A23L33/10 ,  A23L33/00

CPC分类号： C07H3/06 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H1/06

摘要： Crystalline 3-O-fucosyllactose, useful in a pharmaceutical composition and a nutritional formulation, is disclosed.