公开(公告)号：US20160367577A1

公开(公告)日：2016-12-22

申请号：US15183404

申请日：2016-06-15

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  Emma Salomonsson

IPC: A61K31/702 ,  A61K9/00

CPC classification number: A61K31/702 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/2054

Abstract: The invention relates to a method for stabilising or reducing insulin resistance in patients having an obesity-related, metabolic disorder, the method comprising administering to the patient an effective amount of one or more human milk oligosaccharides (HMOs).

Abstract translation: 本发明涉及一种用于在具有肥胖相关代谢紊乱的患者中稳定或降低胰岛素抵抗的方法，所述方法包括向患者施用有效量的一种或多种人乳寡糖（HMO）。

公开(公告)号：US20160287637A1

公开(公告)日：2016-10-06

申请号：US15183456

申请日：2016-06-15

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  Emma Salomonsson

IPC: A61K35/20

CPC classification number: A61K35/20 ,  A61K31/702

Abstract: The invention relates to a method for treating or preventing the development of emotion and/or mood disorders in a human individual.

Abstract translation: 本发明涉及一种治疗或预​​防人类情绪和/或情绪障碍发展的方法。

公开(公告)号：US20160287619A1

公开(公告)日：2016-10-06

申请号：US15183431

申请日：2016-06-15

Applicant: GLYCOM A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Salomonsson

IPC: A61K31/702 ,  A61K9/48 ,  A61K9/20 ,  A61K35/745 ,  A61K9/00

CPC classification number: A61K31/702 ,  A23L33/135 ,  A23L33/21 ,  A23V2002/00 ,  A61K9/2054 ,  A61K9/4841 ,  A61K35/745 ,  A61K2035/115 ,  A61K2300/00

Abstract: The invention relates to HMOs and compositions comprising thereof for reducing the risk of, preventing, or treating CVD and/or CDV associated pathological conditions or diseases in humans, particularly in overweight and obese humans.

Abstract translation: 本发明涉及包含它们的HMO及其组合物，用于降低人类，特别是超重和肥胖人类中的CVD和/或CDV相关病理状况或疾病的风险，预防或治疗。

公开(公告)号：US20160243139A1

公开(公告)日：2016-08-25

申请号：US15147115

申请日：2016-05-05

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Salomonsson

IPC: A61K31/702 ,  A61K31/7004

CPC classification number: A61K31/702 ,  A61K31/7004 ,  A61K45/06 ,  A61K2300/00

Abstract: The application relates to synthetic compositions containing one or more human milk mono- or oligosaccharides for treating visceral pain.

Abstract translation: 本申请涉及含有一种或多种用于治疗内脏痛的人乳单糖或寡糖的合成组合物。

公开(公告)号：US20210052615A1

公开(公告)日：2021-02-25

申请号：US17093337

申请日：2020-11-09

Applicant: GLYCOM A/S

Inventor： Emma Salomonsson ,  Bruce McConnell ,  Thierry Hennet ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61K31/7012 ,  A61K31/7004 ,  A61K9/00

Abstract: A method for treating metabolic disorders in non-infant includes administering to an obese non-infant human during a treatment period an effective amount of a mixture of two or more synthetic neutral human milk oligosaccharides (HMOs) selected from 2′-fucosyllactose (2′FL), 3-fucosyllactose (3-FL), difucosyllactose (DFL), lacto-N-fucopentaose I (LNFP-I), lacto-N-tetraose (LNT), and lacto-N-neotetraose (LNnT), and optionally one or more excipients. The method further includes increasing in the gastrointestinal microbiota of the non-infant human during the treatment period, the relative abundance of Bifidobacterium adolescentis and reducing in the non-infant human during the treatment period, a precursor condition for a metabolic disorder associated with development of one or more of obesity-induced pre-diabetes and type 2 diabetes, the precursor condition selected from gut permeability, metabolic endotoxemia, low-grade metabolic inflammation, and body fat percentage.

公开(公告)号：US20170095491A1

公开(公告)日：2017-04-06

申请号：US15183391

申请日：2016-06-15

Applicant: GLYCOM A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Salomonsson

IPC: A61K31/702

CPC classification number: A61K31/702 ,  A61K2300/00

Abstract: The application relates to synthetic compositions containing one or more human milk oligosaccharides for regulating satiety or reducing propensity to obesity.

公开(公告)号：US10828313B2

公开(公告)日：2020-11-10

申请号：US15104794

申请日：2015-12-08

Applicant: GLYCOM A/S

Inventor： Emma Salomonsson ,  Bruce McConnell ,  Thierry Hennet ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61K31/7012 ,  A61K31/7004 ,  A61K9/00

Abstract: The invention relates to a synthetic composition comprising one or more human milk monosaccharides and/or one or more human milk oligosaccharides for use in reducing intestinal permeability, endotoxemia and/or low-grade inflammation in patients with metabolic disorders.

公开(公告)号：US20180169122A1

公开(公告)日：2018-06-21

申请号：US15897099

申请日：2018-02-14

Applicant: Glycom A/S

Inventor： Thierry Hennet ,  Bruce McConnell ,  Emma Salomonsson ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A23C9/20 ,  A23L33/21 ,  A61K31/7012 ,  A61K31/7004

CPC classification number: A61K31/702 ,  A23C9/206 ,  A23L33/21 ,  A23V2002/00 ,  A61K31/7004 ,  A61K31/7012 ,  A61P1/04 ,  A61K2300/00

Abstract: The application relates to a method for treating a patient with irritable bowel syndrome (IBS), the method comprising administering to the patient a mixture comprising 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT).

公开(公告)号：US20170258820A1

公开(公告)日：2017-09-14

申请号：US15523379

申请日：2015-10-29

Applicant: Glycom A/S

Inventor： Thierry Hennet ,  Bruce McConnell ,  Emma Salomonsson ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A23L33/125 ,  A61K31/7016 ,  A23L33/00 ,  A61K31/7012 ,  A61K31/7004

CPC classification number: A61K31/702 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/7016 ,  A61K35/20 ,  A61P1/04 ,  A61K2300/00

Abstract: The application relates to synthetic composition containing one or more human milk mono- or oligosaccharides which promote mucosal healing in inflammatory GI conditions of humans.

公开(公告)号：US20160310514A1

公开(公告)日：2016-10-27

申请号：US15104794

申请日：2015-12-08

Applicant: GLYCOM A/S

Inventor： Emma Salomonsson ,  Bruce McConnell ,  Thierry Hennet ,  Louise Kristine Vigsnaes

IPC: A61K31/702 ,  A61K9/00

Abstract: The invention relates to a synthetic composition comprising one or more human milk monosaccharides and/or one or more human milk oligosaccharides for use in reducing intestinal permeability, endotoxemia and/or low-grade inflammation in patients with metabolic disorders.

Abstract translation: 本发明涉及包含一种或多种人乳单糖和/或一种或多种用于降低代谢紊乱患者的肠通透性，内毒素血症和/或低度炎症的人乳寡糖的合成组合物。