公开(公告)号：US20240316088A1

公开(公告)日：2024-09-26

申请号：US18602064

申请日：2024-03-12

Applicant: N.V. Nutricia

Inventor： Leo Samuel Payne ,  Gerrit Hols ,  Danielle Stefanie Counotte ,  Sarah Glyn-Jones

IPC: A61K31/7072 ,  A61K9/16 ,  A61K31/14 ,  A61K31/202 ,  A61K35/20

CPC classification number: A61K31/7072 ,  A61K9/1617 ,  A61K9/1652 ,  A61K31/14 ,  A61K31/202 ,  A61K35/20

Abstract: The invention pertains to a solid composition suitable for treating adult animals that suffer from brain-related disorders, brain-related decline or brain-related diseases, preferably suitable for treating adult animals that suffer from brain-related disorders, the composition containing (i) a uridine source, wherein the amount of the sum of all uridine sources, calculated on the basis of the weight of the molar equivalent of uridine monophosphate (UMP), is 0.3-15 g per 100 g dry weight of the composition, (ii) a polyunsaturated fatty acid, preferably an omega-3 polyunsaturated fatty acid, (iii) choline bitartrate, (iv) a buffering salt component, and (v) a milk protein source, wherein the milk protein source is a milk powder, and the buffering salt component containing at least one food approved salt, with a buffering capacity between pH 5-8, the buffering salt component preferably containing a mixture of food-approved salts, or a food-approved salt and its conjugated acid or base.

公开(公告)号：US20240298669A1

公开(公告)日：2024-09-12

申请号：US18269225

申请日：2021-12-23

Applicant: CORNELL UNIVERSITY

Inventor： Syed S.H. RIZVI ,  Bindvi ARORA

IPC: A23J3/26 ,  A23J1/20 ,  A23J3/08 ,  A23L29/00 ,  A23L29/10 ,  A23L29/30 ,  A61K35/20 ,  A61K47/02

CPC classification number: A23J3/26 ,  A23J1/20 ,  A23J3/08 ,  A23L29/015 ,  A23L29/10 ,  A23L29/30 ,  A61K35/20 ,  A61K47/02

Abstract: Disclosed are orally dissolving protein extrudates, methods of making the orally dissolving protein extrudates, and edible foods containing the orally dissolving protein extrudates. The orally dissolving protein extrudates can contain milk protein concentrate and be made using supercritical fluid extrusion. The supercritical fluid extrusion can be with a dispersing agent that is a calcium chelating agent such as sodium hexametaphosphate.

公开(公告)号：US20240285690A1

公开(公告)日：2024-08-29

申请号：US18657395

申请日：2024-05-07

Applicant: PBM Nutritionals, LLC

Inventor： Michael Bernard Miklus ,  Anja Monika Wittke ,  Pedro Antonio Prieto ,  Cynthia M. Barber

IPC: A61K35/20 ,  A23L2/66 ,  A23L33/00 ,  A23L33/12 ,  A23L33/125 ,  A23L33/15 ,  A23L33/19 ,  A61K9/00 ,  A61K31/202 ,  A61K31/355 ,  A61K31/375 ,  A61K31/661

CPC classification number: A61K35/20 ,  A23L2/66 ,  A23L33/12 ,  A23L33/125 ,  A23L33/15 ,  A23L33/19 ,  A23L33/40 ,  A61K9/0056 ,  A61K9/0095 ,  A61K31/202 ,  A61K31/355 ,  A61K31/375 ,  A61K31/661 ,  A23V2002/00

Abstract: A nutritional composition that includes a milk fat globule membrane component, at least one human milk oligosaccharide, and at least one additional component chosen from the group consisting of DHA, ARA, Vitamin E, Vitamin C, and sphingomyelin. The nutritional composition is in the form of a ready-to-drink composition, a food supplement, an extruded food bar, or a solid oral dosage form. The nutritional composition is typically administered or provided to adults, children, or infants through consumption.

公开(公告)号：US20240285688A1

公开(公告)日：2024-08-29

申请号：US17774483

申请日：2019-11-07

Applicant: N.V. Nutricia

Inventor： Sérgio Bernardo Castro de Oliveira ,  Vaida Urbonaite-Zuke ,  Clémentine Julie Mélanie Dejax ,  John Mark Anthony Gonsalves ,  Marko Mank ,  Bernd Stahl ,  Aveenash Bala

IPC: A61K35/20 ,  A23C9/142 ,  A23C21/02 ,  A23C21/08 ,  A23J3/08 ,  A23J3/34 ,  A23L33/00 ,  A23L33/18 ,  A23L33/19 ,  A61K9/00 ,  A61K35/00 ,  A61K35/744 ,  A61K38/17 ,  B01D61/14 ,  B01D61/16 ,  C12P21/06

CPC classification number: A61K35/20 ,  A23C9/1425 ,  A23C21/02 ,  A23C21/08 ,  A23J3/08 ,  A23J3/343 ,  A23L33/18 ,  A23L33/19 ,  A23L33/40 ,  A61K9/0095 ,  A61K35/744 ,  A61K38/1709 ,  B01D61/146 ,  B01D61/16 ,  C12P21/06 ,  A23C2210/252 ,  A61K2035/115 ,  B01D2311/04 ,  B01D2311/08

Abstract: The invention concerns a process for preparing an ultrafiltered whey protein hydrolysate comprising tolerogenic peptides wherein an emulsifier and/or a chaotropic agent is added before ultrafiltration. The invention further concerns the product obtainable by the process.

公开(公告)号：US12029742B2

公开(公告)日：2024-07-09

申请号：US17859330

申请日：2022-07-07

Applicant: Duke University

Inventor： Eric J. Benner

IPC: A61K31/575 ,  A61K35/20 ,  C12N5/079

CPC classification number: A61K31/575 ,  A61K35/20 ,  C12N5/0622 ,  C12N2500/36 ,  C12N2506/08 ,  A61K31/575 ,  A61K2300/00 ,  A61K35/20 ,  A61K2300/00

Abstract: Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.

公开(公告)号：US11951144B2

公开(公告)日：2024-04-09

申请号：US17268316

申请日：2018-09-12

Applicant: PM-INTERNATIONAL AG

Inventor： Rolf Sorg ,  Tobias Kühne ,  Christian Lauinger ,  Wilhelm Messer

IPC: A61K36/00 ,  A23L33/105 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A23L33/15 ,  A23L33/16 ,  A23L33/22 ,  A61K31/12 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/522 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K33/06 ,  A61K33/30 ,  A61K33/34 ,  A61K35/20 ,  A61K36/064 ,  A61K36/67 ,  A61K36/9068 ,  A61K47/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A61K47/69

CPC classification number: A61K36/67 ,  A23L33/105 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A23L33/15 ,  A23L33/16 ,  A23L33/22 ,  A61K31/12 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/522 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K33/06 ,  A61K33/30 ,  A61K33/34 ,  A61K35/20 ,  A61K36/064 ,  A61K36/9068 ,  A61K47/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A61K47/6951 ,  A23V2002/00 ,  A23V2400/113 ,  A23V2400/173

Abstract: A composition, containing



a pepper component,
a curcumin-cyclodextrin mixture and
a mixture of fruits, vegetables and spices.

公开(公告)号：US11865161B2

公开(公告)日：2024-01-09

申请号：US16389451

申请日：2019-04-19

Applicant: HAMLET PHARMA AB

Inventor： Catharina Svanborg ,  Manoj Puthia ,  Chin Shing Ho

IPC: A61K38/38 ,  A61K31/201 ,  A61K35/20 ,  A23L33/18 ,  A61P35/00 ,  A61K9/00 ,  A61K47/12

CPC classification number: A61K38/38 ,  A23L33/18 ,  A61K9/0095 ,  A61K31/201 ,  A61K35/20 ,  A61K47/12 ,  A61P35/00 ,  A61K31/201 ,  A61K2300/00 ,  A61K38/38 ,  A61K2300/00 ,  A61K35/20 ,  A61K2300/00

Abstract: A biologically active complex comprising a polypeptide having the sequence of a naturally occurring protein or a variant thereof, wherein said polypeptide is at least partially unfolded as compared to the said naturally occurring protein for example as a result of a modification of at least one cysteine residue; or a peptide of up to 50 amino acids; and a fatty acid or lipid or a salt thereof, for use in prophylactic treatment of cancers, in particular of the gastrointestinal tract. Compositions that may comprise the complex and have use as nutraceuticals are obtainable from milk or milk fractions and form a further aspect of the invention.
Methods of treatment in particular for the prevention of cancer form a further aspect of the invention.

公开(公告)号：US20230346849A1

公开(公告)日：2023-11-02

申请号：US17732831

申请日：2022-04-29

Applicant: Teresa Bono

Inventor： Teresa Bono

IPC: A61K35/57 ,  A61K35/20 ,  A61K47/46 ,  A61K31/7004 ,  A61K9/00 ,  A61K36/87 ,  A23L33/00 ,  A23L33/125 ,  A23L33/19 ,  A23F5/24 ,  C12G1/00

CPC classification number: A61K35/57 ,  A61K35/20 ,  A61K47/46 ,  A61K31/7004 ,  A61K9/0095 ,  A61K36/87 ,  A23L33/40 ,  A23L33/125 ,  A23L33/19 ,  A23F5/243 ,  C12G1/00 ,  A23V2002/00 ,  C12G2200/21

Abstract: The present invention provides an appetite suppression composition added to coffee, whereby the composition includes a synergistic combination of egg yolk protein sugar and milk protein that imparts appetite suppression over 4-6 hours.

公开(公告)号：US20230338425A1

公开(公告)日：2023-10-26

申请号：US18133886

申请日：2023-04-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHOLOGY ,  HB Advisors

Inventor： Sun Hwa KIM ,  Yoosoo YANG ,  Hyo Suk KIM ,  Gi-Jung KWAK ,  Ye Ji JANG

IPC: A23L33/10 ,  A61Q19/02 ,  A61K35/20 ,  A61K8/98 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/08

CPC classification number: A61K35/20 ,  A23L33/10 ,  A61K8/98 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/02 ,  A61Q19/08

Abstract: The present invention relates to a novel use of milk exosomes, and more specifically, provides a method of enhancing immunity of a subject including administering a therapeutically effective amount of exosomes isolated from milk or goat milk to the subject.

公开(公告)号：US20230302074A1

公开(公告)日：2023-09-28

申请号：US18204044

申请日：2023-05-31

Applicant: LISA GENG

Inventor： LISA GENG

IPC: A61K36/185 ,  A61K36/27 ,  A61K36/328 ,  A61K36/9066 ,  A61K36/82 ,  A61K36/54 ,  A61K36/81 ,  A23L33/105 ,  A23L33/12 ,  A61P25/28 ,  A61K31/07 ,  A61K31/197 ,  A61K31/198 ,  A61K31/202 ,  A61K31/205 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K33/04 ,  A61K33/06 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K35/20 ,  A61K36/24 ,  A23L33/00 ,  A23L27/10 ,  A23L27/12

CPC classification number: A61K36/185 ,  A61K36/27 ,  A61K36/328 ,  A61K36/9066 ,  A61K36/82 ,  A61K36/54 ,  A61K36/81 ,  A23L33/105 ,  A23L33/12 ,  A61P25/28 ,  A61K31/07 ,  A61K31/197 ,  A61K31/198 ,  A61K31/202 ,  A61K31/205 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K33/04 ,  A61K33/06 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K35/20 ,  A61K36/24 ,  A23L33/30 ,  A23L27/10 ,  A23L27/12 ,  A23V2002/00

Abstract: Nutrient compositions comprising botanical extracts and methods of their use for treating, inter alia, autism or apraxia and/or ameliorating one or more symptoms thereof are disclosed. The use of such compositions for enhancing cognitive function and/or one or more aspects thereof, or for treating stroke or seizures and/or ameliorating one or more symptoms thereof are also disclosed.