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公开(公告)号：US20190233441A1
公开(公告)日：2019-08-01
申请号：US16373435
申请日：2019-04-02
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20180339998A1
公开(公告)日：2018-11-29
申请号：US15936086
申请日：2018-03-26
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , A61K45/06 , C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/496 , A61K31/497 , A61K31/513 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/438 , C07D495/04 , C07D491/048 , C07D487/04 , A61K31/501
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US10131675B2
公开(公告)日：2018-11-20
申请号：US15699095
申请日：2017-09-08
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Snahel Patel , Terry Kellar , Malcolm Huestis , Daniel Shore , Michael Siu
IPC: C07D498/14 , C07D491/14 , C07D519/00 , A61K31/5383 , A61K45/06 , A61K31/553
Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein ring A and R1-R2 have any of the values defined in the specification. The compounds and salts are useful for treating DLK mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as methods of using said compounds, salts, or compositions as DLK inhibitors and for treating neurodegeneration diseases and disorders.
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公开(公告)号：US20180170927A1
公开(公告)日：2018-06-21
申请号：US15839788
申请日：2017-12-12
Applicant: Genentech, Inc.
Inventor： Snahel Patel , Gregory Hamilton
IPC: C07D471/04 , C07D487/04 , C07D498/04 , A61P1/00 , A61P1/04 , A61P9/10 , A61P25/00 , A61P13/12 , A61P1/16 , A61P11/00 , A61P1/18 , A61P17/06
Abstract: The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20180117044A1
公开(公告)日：2018-05-03
申请号：US15852235
申请日：2017-12-22
Applicant: Genentech, Inc.
Inventor： Anthony O. Estrada , Alan G. Olivero , Snahel Patel , Michael Siu , Joseph Lyssikatos
IPC: A61K31/506 , A61K31/444 , A61K35/30 , C07D487/14 , A61K31/553 , C07D417/14 , C07D487/18 , A61K31/55 , C07D401/14 , A61K31/5377 , C07D495/08 , A61K31/4545 , C07D519/00 , A61K31/5386 , A61K45/06 , C07D471/08 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/18 , C07D487/08 , C07D491/08
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula all have the meaning as defined herein.
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Patent Agency Ranking
公开(公告)号：US09873709B2
公开(公告)日：2018-01-23
申请号：US15499662
申请日：2017-04-27
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US09399636B2
公开(公告)日：2016-07-26
申请号：US14550528
申请日：2014-11-21
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Malcolm Huestis , Cuong Ly , Snahel Patel , Michael Siu , Xianrui Zhao
IPC: C07D401/14 , C07D401/12 , C07D405/14 , C07D487/08 , C07D491/107
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D487/08 , C07D491/107
Abstract: The present invention provides for compounds of Formula I and various embodiments thereof, and compositions comprising compounds of Formula I and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6, m, n and the C-linked Ring have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula I as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 本发明提供式I化合物及其各种实施方案，以及包含式I化合物及其各种实施方案的组合物。 在式I化合物中，基团R 1，R 2，R 3，R 4，R 5，R 6，m，n和C连接的环具有如本文所述的含义。 本发明还提供使用式I化合物的方法和包含式I化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症。
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公开(公告)号：US20160158234A1
公开(公告)日：2016-06-09
申请号：US15041375
申请日：2016-02-11
Applicant: Genentech, Inc.
Inventor： Anthony O. Estrada , Alan G Olivero , Snahel Patel , Michael Siu
IPC: A61K31/506 , A61K31/444 , A61K31/5377 , A61K31/55
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula all have the meaning as defined herein.
Abstract translation: 本发明提供式I化合物及其实施方案及其盐用于治疗疾病（如神经变性疾病）。 式中的R 1，R 2，R 3，X 1，X 2，A和Cy变量均具有如本文所定义的含义。
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公开(公告)号：US20160046608A1
公开(公告)日：2016-02-18
申请号：US14928034
申请日：2015-10-30
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Snahel Patel
IPC: C07D401/14 , C07D409/14 , A61K31/5377 , C07D491/08 , C07D413/14 , A61K35/30 , A61K31/5386 , C07D405/14 , C07D471/04 , A61K31/553 , C07D487/04 , C07D491/107 , A61K31/506 , C07D498/08
CPC classification number: C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61K35/30 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/08 , C07D491/107 , C07D493/08 , C07D498/08
Abstract: The present invention provides for pyrimidine compounds of Formula I-I and embodiments thereof In Formula I-I in which R1, R2, R3, R4, R5, R6, m, n and the “het” ring are as described herein. Also provided are pharmaceutical compositions comprising compounds of Formula I and methods of using such compounds and compositions.
Abstract translation: 本发明提供了式I-I的嘧啶化合物及其实施方案。在其中R 1，R 2，R 3，R 4，R 5，R 6，m，n和“het”环如本文所述的式I-I中。 还提供了包含式I化合物和使用这些化合物和组合物的方法的药物组合物。
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公开(公告)号：US20160002228A1
公开(公告)日：2016-01-07
申请号：US14800829
申请日：2015-07-16
Applicant: Genentech, Inc.
Inventor： Anthony ESTRADA , Wen Liu , Snahel Patel , Michael Siu
IPC: C07D471/04 , C07D405/14 , C07D401/14
CPC classification number: A61K31/4439 , A61K31/437 , A61K31/4545 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 本发明提供式（I）化合物及其各种实施方案，以及包含式（I）化合物及其各种实施方案的组合物。 在式I化合物中，基团R 1，R 2，R 3，R 4，R 5，R 6和R 7具有如本文所述的含义。 本发明还提供了使用式I化合物和包含式（I）化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症的方法。
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