公开(公告)号：US20060058705A1

公开(公告)日：2006-03-16

申请号：US11213279

申请日：2005-08-26

申请人： Joseph Leonetti ,  Larry Smith

发明人： Joseph Leonetti ,  Larry Smith

IPC分类号： A61H1/00

CPC分类号： A61B17/2251 ,  A61B8/4272 ,  A61B8/4281 ,  A61B2017/2253

摘要： In vivo biocompatible hydrogels to couple and transmit high intensity ultrasound for hemostasis and ablation during surgery, the hydrogels having 4-40 wt. % of a polymer comprising acrylates and the balance water. A group of hydrogels based on cross-linked methacrylate one of which is polyethyleneglycol methacrylate, can form rigid, low acoustic attenuation coupling members and are in vivo biocompatible. These coupling members consist of hydrogel formulations having mechanical and acoustic properties such that ultrasound transmission standoff members of various dimensions and structural configurations function as efficient ultrasound transmission media and devices within which the ultrasound beam can be transferred to a focal point at the end of the standoff or in close proximity to it.

摘要翻译： 体内生物相容性水凝胶联合和传输高强度超声在手术中止血和消融，水凝胶具有4-40wt。 ％的包含丙烯酸酯和余量的水的聚合物。 一组基于交联甲基丙烯酸酯的水凝胶是甲基丙烯酸聚乙二醇酯，可以形成刚性的低声衰减耦合元件，并且具有体内生物相容性。 这些联接构件由具有机械和声学特性的水凝胶制剂组成，使得各种尺寸和结构配置的超声波传输支架构件起到有效的超声波传输介质和装置的作用，在超声波传输介质和装置中，超声波束可以在其间传递到焦点 或者靠近它。

公开(公告)号：US20050074407A1

公开(公告)日：2005-04-07

申请号：US10951220

申请日：2004-09-27

申请人： Larry Smith

发明人： Larry Smith

IPC分类号： A61K9/14 ,  A61K49/00 ,  A61K49/22

CPC分类号： A61K49/222

摘要： An vivo biocompatible and bio-excretable lubricant and ultrasound coupling fluid or gel comprising polyvinylpyrrolidone (PVP) and/or polyvinyl alcohol (PVA). The inventive couplant fluid or gel comprises polyvinylpyrrolidone and/or polyvinyl alcohol solutions in water to which humectants such as alkylene glycols and/or polyalkylene glycols are added to achieve desired tactile and drying characteristics. Additionally, such fluids and gels may be prepared by addition of organic and inorganic cross-linkers.

摘要翻译： 包含聚乙烯吡咯烷酮（PVP）和/或聚乙烯醇（PVA）的体内生物相容性和生物排泄性润滑剂和超声耦合流体或凝胶。 本发明的联接剂流体或凝胶包含在水中的聚乙烯吡咯烷酮和/或聚乙烯醇溶液，其中加入润湿剂例如亚烷基二醇和/或聚亚烷基二醇以实现期望的触觉和干燥特性。 此外，这种流体和凝胶可以通过加入有机和无机交联剂来制备。

公开(公告)号：US5666720A

公开(公告)日：1997-09-16

申请号：US494699

申请日：1995-06-26

申请人： Larry Smith

发明人： Larry Smith

IPC分类号： B41J32/02 ,  B41J33/10 ,  B23P19/00

CPC分类号： B41J32/02 ,  B41J33/10 ,  Y10T29/53465

摘要： An apparatus for stuffing a snailed endless new pre-inked ribbon into a ribbon cartridge is provided, said apparatus comprising a cabinet having a top plate mounted thereon, a ribbon stock reel assembly mounted on the top plate for supporting a new pre-inked ribbon supply reel containing a length of new pre-inked ribbon, a ribbon stock reel brake assembly mounted in the cabinet and attached to the ribbon stock reel assembly, an idler with an adjustable collar for providing tension on the new pre-inked ribbon between the new pre-inked ribbon supply reel on the ribbon stock reel assembly and a counting wheel, a counting wheel, a proximity sensor, an electrical motor for pulling the new pre-inked ribbon from the ribbon stock reel assembly past the idler around the counting wheel and stuffing said new pre-inked ribbon into a ribbon cartridge, a universal jig having cartridge securing means for holding the ribbon cartridge to be stuffed mounted on the top plate, a programmed counter, a control panel having a main power switch, main power indicator, a main power fuse, a reset switch, an electrical motor control which has an electrical motor off-on/speed control, an electrical motor power indicator, an electrical motor direction switch, and an electrical motor power fuse and the wiring necessary to interconnect the various electronic components.

摘要翻译： 提供了一种用于将无尽的新的预先着墨的丝带填充到色带盒中的装置，所述设备包括一个安装在其上的顶板的机壳，安装在顶板上的色带库存卷轴组件，用于支撑新的预先墨水色带供应 包含一段新的预先着墨色带的卷轴，安装在机壳中并连接到色带库存卷轴组件上的色带库存卷轴制动组件，具有可调节环的惰轮，用于在新的预先着墨色带之间的新的预先着墨的色带上提供张力 色带库存卷轴组件上的色带供应卷轴和计数轮，计数轮，接近传感器，用于从色带库存卷轴组件拉出新的预先着色色带的电动机通过计数轮周围的惰轮和填充物 所述新的预先着色的色带进入色带盒，通用夹具具有用于保持待填充的色带盒安装在顶板上的盒固定装置，编程计数器，连续 具有主电源开关，主电源指示器，主电源保险丝，复位开关，具有电动机接通/速度控制的电动机控制，电动机功率指示器，电动机方向开关和 电动机功率保险丝和互连各种电子部件所需的布线。

公开(公告)号：USD348001S

公开(公告)日：1994-06-21

申请号：US2574

申请日：1992-12-21

申请人： Larry Smith

设计人： Larry Smith

公开(公告)号：US5217277A

公开(公告)日：1993-06-08

申请号：US881344

申请日：1992-05-11

申请人： Glen L. Rasnick ,  Larry Smith ,  James Mitchell ,  Kenneth C. Peacock ,  Ronald H. Cordover

发明人： Glen L. Rasnick ,  Larry Smith ,  James Mitchell ,  Kenneth C. Peacock ,  Ronald H. Cordover

IPC分类号： A47B43/02 ,  A47C7/62 ,  A47C7/70

CPC分类号： A47B43/02 ,  A47C7/62 ,  A47C7/70 ,  Y10S297/07

摘要： A collapsible table is concealed and stored in the hollow chamber of an upholstered seat arm. The table is pivotally connected to the seat arm by a two-segment spar which supports the table in the extended position and is collapsible for returning the table to the stored position in the arm chamber. A handle is easily manipulable by a seat occupant for collapsing the spar and returning the table to its storage position. The outer upholstered panel of the arm carries the male member of a latch for pivotal movement of the panel to permit access to the chamber and extension of the table. The table carries a cup holder which is pivotal between concealed and extended positions and which is automatically returned to its concealed position by engagement with the front post of the arm when the table is returned to its storage position.

摘要翻译： 可折叠的桌子被隐藏并存储在软垫座椅臂的中空室中。 桌子通过两段翼梁可枢转地连接到座椅臂，该两段翼梁支撑桌子处于延伸位置，并且可折叠以使桌子返回到臂室中的存储位置。 手柄容易被座椅乘员操纵，用于折叠翼梁并将工作台返回到其存放位置。 臂的外装饰板承载闩锁的阳构件以使面板枢转运动，以允许进入腔室并延伸桌子。 桌子上装有一个在隐藏和伸出位置之间枢转的杯架，当桌子返回到其存放位置时，它通过与臂的前柱接合而自动返回到其隐藏位置。

公开(公告)号：US20160029498A1

公开(公告)日：2016-01-28

申请号：US14740586

申请日：2015-06-16

申请人： Ryan Messmore ,  Byron Hall ,  Larry Smith ,  Jeff Koebrich

发明人： Ryan Messmore ,  Byron Hall ,  Larry Smith ,  Jeff Koebrich

IPC分类号： H05K5/02 ,  G09F13/22 ,  H05K5/00 ,  F21V29/67 ,  F21V29/83

CPC分类号： G09F13/22 ,  F21V29/677 ,  F21V29/83 ,  G09F9/33 ,  G09F2013/222 ,  H05K5/0017 ,  H05K5/0213 ,  H05K7/20 ,  H05K7/20972

摘要： An electronic sign includes a planar lighting module emitting visible light. A cabinet supportingly engages the lighting module. An air chamber is between the cabinet and the lighting module. A vertical partition is within the air chamber and extends between a bottom wall and a top wall of the cabinet, and between the lighting module and a rear wall of the cabinet. The partition divides the air chamber into first and second sections. An electric fan is within the cabinet and transfers air from the first to the second section. The cabinet and/or the lighting module include a plurality of throughholes fluidly interconnecting the air chamber to ambient air. A first subset of the throughholes are more closely fluidly connected to the first section than to the second section. A second subset of the throughholes are more closely fluidly connected to the second section than to the first section.

摘要翻译： 电子标志包括发射可见光的平面照明模块。 一个橱柜支持与照明模块接合。 机柜和照明模块之间有一个空气室。 垂直隔板在空气室内并在机柜的底壁和顶壁之间以及在照明模块和机柜的后壁之间延伸。 隔板将空气室分成第一和第二部分。 电风扇位于机柜内，并将空气从第一部分传送到第二部分。 机柜和/或照明模块包括将空气室与环境空气流体连接的多个通孔。 通孔的第一子集与第二部分更紧密地流体连接到第一部分。 通孔的第二子集比第一部分更紧密地流体地连接到第二部分。

公开(公告)号：US20120187136A1

公开(公告)日：2012-07-26

申请号：US13013397

申请日：2011-01-25

申请人： Larry Smith

发明人： Larry Smith

IPC分类号： B65D25/00 ,  A47B23/00 ,  F16M11/04

CPC分类号： A45F3/44 ,  A47G19/30 ,  A47G23/0225 ,  A47G2023/0275

摘要： Refreshment holders having a multiple element, segmented support pole that can be configured to hold accessories such as an inverted-plunger shaped beverage holder, trays, ice chests, buckets, and support stands. The refreshment holders holds beverages in an insulated beverage holder, small items such as nuts, dip, and chips, and ice.

摘要翻译： 茶点保持器具有多个元件的分段支撑杆，其可被构造成保持诸如倒置柱塞形的饮料保持器，托盘，冰箱，铲斗和支撑架等附件。 茶点持有者在绝缘饮料架中保持饮料，小物品如坚果，浸渍和碎屑以及冰。

公开(公告)号：US20110201209A1

公开(公告)日：2011-08-18

申请号：US12707589

申请日：2010-02-17

申请人： Sharath Hosali ,  Gregory Smith ,  Larry Smith

发明人： Sharath Hosali ,  Gregory Smith ,  Larry Smith

IPC分类号： H01L21/3105 ,  B05C11/02

CPC分类号： H01L21/56 ,  H01L24/96 ,  H01L2924/10329 ,  H01L2924/14 ,  H01L2924/00

摘要： Methods and systems for planarization of a die-to-wafer integration. A planarization coating may be applied to the die-to-wafer assembly, and a planarization plate may be used in the planarization process. The planarization plate may include perforations configured to allow a portion of the planarization coating to extrude through the planarization plate.

摘要翻译： 用于平面化晶片到晶片集成的方法和系统。 可以将平坦化涂层施加到晶片到晶片组件，并且可以在平坦化工艺中使用平坦化板。 平坦化板可以包括穿孔，其被配置为允许平坦化涂层的一部分通过平坦化板挤出。

公开(公告)号：US20080181930A1

公开(公告)日：2008-07-31

申请号：US12022520

申请日：2008-01-30

申请人： Theron R. Rodstrom ,  Larry Smith ,  Youqin Tian ,  David Allen Marsh ,  Alan L. Weiner ,  Shivalik Bakshi

发明人： Theron R. Rodstrom ,  Larry Smith ,  Youqin Tian ,  David Allen Marsh ,  Alan L. Weiner ,  Shivalik Bakshi

IPC分类号： A61F2/14 ,  A61K31/343

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61F9/00781

摘要： The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.

摘要翻译： 本发明涉及用于向眼睛持续释放药物的可植入眼部装置以及用于制造和使用这些装置的方法。 在一个实施方案中，本发明提供了一种装置，其包括：（a）包含前列腺素和硅氧烷的基质的主体; （b）主体外表面上的聚对二甲苯涂层; 和（c）从聚对二甲苯涂层的外表面延伸到主体的外表面的一个或多个孔。

公开(公告)号：US07223408B2

公开(公告)日：2007-05-29

申请号：US10530253

申请日：2003-10-02

申请人： Maria Cristina Cassetti ,  Larry Smith ,  Jeffrey K. Pullen ,  Susan P. McElhiney

发明人： Maria Cristina Cassetti ,  Larry Smith ,  Jeffrey K. Pullen ,  Susan P. McElhiney

IPC分类号： A61K39/12

CPC分类号： A61K39/0011 ,  A61K38/162 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/585 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/20022 ,  C12N2710/20032 ,  C12N2710/20034 ,  C12N2710/24143 ,  C12N2770/36143

摘要： The present invention provides immunogenic and pharmaceutical compositions for the treatment and prevention of human papillomavirus (HPV)-associated cancers and in particular, cervical cancer. In particular, this invention relates to fusion proteins, and the nucleic acids encoding these fusion proteins, used to generate immune responses against HPV. Specifically, this invention provides for fusions of HPV E6 and E7 in which the E6 and/or E7 contains one or more mutations. These mutations abrogate the transformation activity of these oncogenic proteins and, thus, confer safety to the E6/E7 fusions. In addition, these fusions maintain or increase the immunogenic efficacy of E6 and E7. Any gene or protein delivery method can be used to deliver or package the immunogenic compositions of the present invention.

摘要翻译： 本发明提供用于治疗和预防人乳头状瘤病毒（HPV）相关癌症，特别是宫颈癌的免疫原性和药物组合物。 特别地，本发明涉及融合蛋白和编码这些融合蛋白的核酸，用于产生针对HPV的免疫应答。 具体地，本发明提供了HPV E6和E7的融合体，其中E6和/或E7含有一个或多个突变。 这些突变消除了这些致癌蛋白的转化活性，从而赋予了E6 / E7融合的安全性。 此外，这些融合保持或增加E6和E7的免疫原性功效。 任何基因或蛋白质递送方法可用于递送或包装本发明的免疫原性组合物。