公开(公告)号：US10828637B2

公开(公告)日：2020-11-10

申请号：US15792732

申请日：2017-10-24

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Viktor Shkolnikov ,  Milo Overbay

IPC: B01L3/00 ,  G01N21/64 ,  B29C39/00 ,  B01L9/00 ,  A61K49/00 ,  G01N21/65

Abstract: A microfluidic chip may include a substrate, chamber supported by the substrate, a sacrificial material in the chamber, a spectroscopically active nano particle assembly anchored within the chamber by the sacrificial material and a fluid supply port connected to the chamber. Each spectroscopically active nano particle assembly may include a cluster of nanoparticles.

公开(公告)号：US20200256800A1

公开(公告)日：2020-08-13

申请号：US16606429

申请日：2017-10-24

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N21/65 ,  B82Y15/00

Abstract: A surface enhanced luminescence analyte nano pillar stage may include a substrate, an array of closable pillars extending from the substrate and a fluid supply connected to the array of pillars. The fluid supply is to at least partially replenish fluid amongst the pillars of the array that has evaporated to maintain a level of the fluid amongst the pillars of the array below tops of the pillars.

公开(公告)号：US10724959B2

公开(公告)日：2020-07-28

申请号：US15764322

申请日：2015-11-13

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Steven Barcelo ,  Anita Rogacs ,  Helen A Holder

IPC: G01J3/44 ,  G01N21/65 ,  G01N27/22 ,  G01N33/04 ,  G01N21/64 ,  G01N1/44 ,  B01L3/00 ,  G01N33/22

Abstract: In an example implementation, a substance detection method includes sensing for fluid in a chamber of a substance detection device. When fluid is sensed in the chamber, the method includes sensing again for fluid in the chamber. When no fluid is sensed in the chamber, the method includes initiating a substance detection process.

公开(公告)号：US10712280B2

公开(公告)日：2020-07-14

申请号：US16098067

申请日：2016-07-22

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Robert G. Walmsley ,  Helen A. Holder ,  Steven J. Simske ,  Anita Rogacs ,  Viktor Shkolnikov

IPC: G01N21/65 ,  B82Y15/00

Abstract: A gas conduit directs a flow of gas from a gas flow source. A surface enhanced luminescence (SEL) stage is within the conduit and includes a substrate and nano fingers projecting from the substrate. A heater heats the nano fingers to a temperature so as to soften the nano fingers such that the nano fingers collapse towards each other to capture molecules entrained in the gas therebetween.

公开(公告)号：US10648916B2

公开(公告)日：2020-05-12

申请号：US16076344

申请日：2017-01-31

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Ning Ge ,  Viktor Shkolnikov ,  Anita Rogacs ,  Steven J. Simske

IPC: G01J3/44 ,  G01N21/65 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A surface enhanced luminescence (SEL) sensor may include a substrate and nano fingers projecting from the substrate. The nano fingers may include a nano finger extending along an axis. The nano finger may include a plasmonically active cap and a pillar supporting the plasmonically active cap. The pillar may have an asymmetric material composition with respect to the axis.

公开(公告)号：US10466177B2

公开(公告)日：2019-11-05

申请号：US15772493

申请日：2016-02-28

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Viktor Shkolnikov ,  Anita Rogacs ,  Paul J. Benning

IPC: G01N21/64 ,  G01N21/65 ,  G01N21/17

Abstract: A sample comprising a first substance and a second substance is modified by breaking down molecular bonds of the second substance of the sample to form a modified sample having altered surface enhanced luminescence (SEL) characteristics to reduce overlapping of SEL characteristics of the first substance in the second substance. Surface enhanced luminescence data resulting from excitation of the modified sample is collected. Characteristics of the first substance based upon the collected surface enhanced luminescence data are identified.

公开(公告)号：US20190170650A1

公开(公告)日：2019-06-06

申请号：US16098058

申请日：2016-07-21

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Anita Rogacs ,  Steven J. Simske ,  Milo Overbay ,  Viktor Shkolnikov

IPC: G01N21/65

Abstract: A surface enhanced Raman spectroscopy (SERS) sensor may include a nano structured surface and a nonstoichiometric oxide layer. The nano structured surfers may include a first peak, a second peak and a valley between the first peak and the second peak. The non-stoichiometric oxide layer may include a first portion on the first peak and a second portion on the second peak.

公开(公告)号：US20190145899A1

公开(公告)日：2019-05-16

申请号：US16098100

申请日：2016-07-22

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Viktor Shkolnikov ,  Anita Rogacs

IPC: G01N21/65 ,  B01L3/02 ,  G01N21/64 ,  G01J3/44

Abstract: An apparatus may include a surface enhanced luminescence (SEL) stage on an interior of a pipette tip.

公开(公告)号：US20180275065A1

公开(公告)日：2018-09-27

申请号：US15764240

申请日：2016-01-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Anita Rogacs ,  Viktor Shkolnikov ,  Ning Ge

IPC: G01N21/65 ,  G01J3/44 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/648

Abstract: An analyte detection system includes an analyte detection package to be presented to a reading device, and a focus mechanism to adjust a focal point of the analyte detection package relative to the reading device, with the analyte detection package including a surface-enhanced luminescence analyte stage, the reading device including optics to receive scattered radiation emitted luminescence from the analyte stage, and the focus mechanism to adjust the focal point relative to the optics.

公开(公告)号：US20230003723A1

公开(公告)日：2023-01-05

申请号：US17781462

申请日：2020-01-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Anita Rogacs ,  Fausto D'APUZZO ,  Erica SQUIRES ,  Tynan BECKER

IPC: G01N33/53 ,  G01N35/10

Abstract: In one example an apparatus can include a controller communicatively coupled to a droplet dispenser to deposit antibody fluid on a matrix of an immunoblotting array, the controller is to align the droplet dispenser with a protein band included in the matrix, instruct the droplet dispenser to deposit a first antibody fluid on to the protein band of the matrix, and instruct the droplet dispenser to deposit a second antibody fluid on to the protein band of the matrix, adjacent to the first antibody fluid.