Modified hyaluronic acid for use in musculoskeletal tissue repair
    46.
    发明授权
    Modified hyaluronic acid for use in musculoskeletal tissue repair 有权
    用于肌肉骨骼组织修复的改性透明质酸

    公开(公告)号:US07091191B2

    公开(公告)日:2006-08-15

    申请号:US10741511

    申请日:2003-12-19

    IPC分类号: A61K31/70 C08B37/00

    CPC分类号: C08B37/0072 A61K31/728

    摘要: The present invention includes hyaluronic acid complexes of a monovalent alkali metal salt of hyaluronic acid and a tetra alkyl ammonium halide that are suitable for incorporation with tissue scaffolds that are suitable for use in repair and/or regeneration of muscoloskeletal tissue and that include a biodegradable, porous substrate made from a biodegradable, hydrophobic polymer, where the hyaluronic acid complex is substantially insoluble in water at room temperature, yet soluble in mixtures of organic and aqueous solvents in which the selected hydrophobic polymer is soluble.

    摘要翻译: 本发明包括透明质酸的一价碱金属盐和四烷基卤化铵的透明质酸配合物,其适用于与适用于修复和/或再生肌肉骨骼组织的组织支架结合,并且包括可生物降解的, 由可生物降解的疏水性聚合物制成的多孔基材,其中透明质酸络合物在室温下基本上不溶于水,但可溶于选择的疏水性聚合物可溶的有机和水性溶剂的混合物中。