公开(公告)号：US09061991B2

公开(公告)日：2015-06-23

申请号：US13579045

申请日：2011-02-16

申请人： Yuuki Asuma ,  Tatsuya Suzuki ,  Jun Takehara ,  Tsugihiko Hidaka ,  Kuniko Asada ,  Ryoma Miyake ,  Yasumasa Dekishima ,  Hiroshi Kawabata

发明人： Yuuki Asuma ,  Tatsuya Suzuki ,  Jun Takehara ,  Tsugihiko Hidaka ,  Kuniko Asada ,  Ryoma Miyake ,  Yasumasa Dekishima ,  Hiroshi Kawabata

IPC分类号： C07C1/32 ,  C07C13/04 ,  C07C67/343 ,  C07B53/00 ,  C07B57/00 ,  C07C67/313 ,  C07C227/04 ,  C07C227/32 ,  C07C269/02 ,  C07C247/22 ,  C12P41/00 ,  C12P7/62

CPC分类号： C07C67/343 ,  C07B53/00 ,  C07B57/00 ,  C07B2200/07 ,  C07C67/313 ,  C07C227/04 ,  C07C227/32 ,  C07C247/22 ,  C07C269/02 ,  C07C2601/02 ,  C12P7/62 ,  C12P41/005 ,  C07C69/743 ,  C07C229/48 ,  C07C271/24

摘要： It is an object of the present invention to provide a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-butene derivative having a leaving group at each of the 1- and 4-positions is reacted with a malonic ester in the presence of a base, a specific amount of an alkali metal alkoxide or an alkali metal hydride is used as the base, and further a specific amount of a malonic ester is used to produce a cyclopropane diester, and further, chiral or achiral 1-amino-1-alkoxy-carbonyl-2-vinylcyclopropane and a salt thereof are synthesized using the cyclopropane diester.

摘要翻译： 本发明的目的是提供一种制备（1R，2S）/（1S，2R）-1-氨基-1-烷氧基羰基-2-乙烯基环丙烷的新方法，其可用作肝炎治疗剂的合成中间体 C及其合成中间体。 根据本发明，当在碱存在下使具有1位和4位的离去基团的反式-2-丁烯衍生物与丙二酸酯反应时，将特定量的碱金属醇盐或 使用碱金属氢化物作为碱，进一步使用特定量的丙二酸酯来制备环丙烷二酯，此外，手性或非手性1-氨基-1-烷氧基 - 羰基-2-乙烯基环丙烷及其盐 使用环丙烷二酯合成。

公开(公告)号：US20130184420A1

公开(公告)日：2013-07-18

申请号：US13876665

申请日：2011-09-22

申请人： Hiroshi Kawabata

发明人： Hiroshi Kawabata

IPC分类号： C08L71/02 ,  C08F220/04 ,  C07C43/15 ,  C08F228/02

CPC分类号： C08L71/02 ,  C04B24/2641 ,  C04B24/2647 ,  C07C43/15 ,  C08F216/1416 ,  C08F220/04 ,  C08F220/06 ,  C08F228/02 ,  C08F290/062 ,  C08G65/2609 ,  C08G65/30 ,  C08L2205/05 ,  C08L33/02

摘要： To provide a monomer composition containing an unsaturated polyalkylene glycol ether-based monomer and having excellent stability.Provided is a monomer composition containing an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R1O)nR2  (1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R1O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition mole number of oxyalkylene groups and is a number of 5 to 500; and R2 represents a hydrogen atom or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.

摘要翻译： 提供含有不饱和聚亚烷基二醇醚类单体并具有优异稳定性的单体组合物。 本发明提供含有以下化学式（1）表示的不饱和聚亚烷基二醇醚类单体的单体组合物：YO（R1O）nR2（1）[式中，Y表示碳原子数2〜7的烯基， R1O表示碳原子数为2〜18的一种或两种以上的氧化烯基; n表示氧化烯基的平均加成摩尔数，为5〜500的数。 R2表示氢原子或碳原子数1〜30的烃基]，有机酸和水，pH4〜13。

公开(公告)号：US08140846B2

公开(公告)日：2012-03-20

申请号：US12117569

申请日：2008-05-08

申请人： Takeshi Natsuno ,  Masaaki Yamamoto ,  Satoshi Washio ,  Hiroshi Kawabata

发明人： Takeshi Natsuno ,  Masaaki Yamamoto ,  Satoshi Washio ,  Hiroshi Kawabata

IPC分类号： H04L9/32

CPC分类号： H04L63/0442 ,  G06F21/10 ,  G06F21/51 ,  G06F21/52 ,  G06F21/54 ,  G06F2221/2113 ,  H04L63/0823 ,  H04M1/72525

摘要： Management server 16 may obtain application programs from content server 20 in response to requests of mobile terminal 11. Management server 16 may transmit the obtained application programs to mobile terminal 11 with information concerning reliabilities of the application programs. After mobile terminal 11 receives the application programs from management server 16, mobile terminal 11 manages operations of the application programs. Operations of the application programs are coordinated with operations of other programs using the information concerning the reliabilities corresponding to the application programs. Management of the coordinated operations of the application programs avoids problems concerning information security, where valuable information may be distributed unexpectedly because of operations of low reliable application programs. As a result, convenience of users of mobile terminals 11 can be improved without deteriorating the information security of mobile terminals 11.

公开(公告)号：US08015616B2

公开(公告)日：2011-09-06

申请号：US12394671

申请日：2009-02-27

申请人： Kazuhiro Yamada ,  Nobuyuki Watanabe ,  Masayuki Tsuda ,  Dai Kamiya ,  Mao Asai ,  Fumiaki Miura ,  Satoshi Washio ,  Atsuki Tomioka ,  Hiroshi Kawabata ,  Takashi Kondo

发明人： Kazuhiro Yamada ,  Nobuyuki Watanabe ,  Masayuki Tsuda ,  Dai Kamiya ,  Mao Asai ,  Fumiaki Miura ,  Satoshi Washio ,  Atsuki Tomioka ,  Hiroshi Kawabata ,  Takashi Kondo

IPC分类号： H04N7/16

CPC分类号： H04L63/10 ,  G06F21/53 ,  H04M1/274516 ,  H04M1/72525 ,  H04M1/72561

摘要： Mobile unit 16 which can activate Java-AP software receives SDF (Security Descriptive File) 204 from administering server unit 18 which a trustworthy organization (a communication provider which administers mobile packet communication network 15) administers, and obtains ADF 205 from IP server unit 13 by using URL contained in the SDF, and obtains Jar file 206 from IP server unit 13 by using ADF 205, and installs in itself Java-AP containing these files. Java-AP, which is achieved by activating the installed Java-AP software, operates within the range of authorization expressed by policy information contained in SDF 204.

摘要翻译： 可以激活Java-AP软件的移动单元16从管理服务器单元18（管理移动分组通信网络15的通信提供者）管理服务器单元18接收SDF（安全描述文件）204，并从IP服务器单元13获得ADF 205 通过使用包含在SDF中的URL，并且通过使用ADF 205从IP服务器单元13获取Jar文件206，并且自己安装包含这些文件的Java-AP。 通过激活安装的Java-AP软件实现的Java-AP在由包含在SDF 204中的策略信息所表示的授权范围内运行。

公开(公告)号：US07706786B2

公开(公告)日：2010-04-27

申请号：US12117554

申请日：2008-05-08

申请人： Takeshi Natsuno ,  Masaaki Yamamoto ,  Satoshi Washio ,  Hiroshi Kawabata

发明人： Takeshi Natsuno ,  Masaaki Yamamoto ,  Satoshi Washio ,  Hiroshi Kawabata

IPC分类号： H04M3/00

CPC分类号： H04L63/0442 ,  G06F21/10 ,  G06F21/51 ,  G06F21/52 ,  G06F21/54 ,  G06F2221/2113 ,  H04L63/0823 ,  H04M1/72525

摘要： Management server 16 may obtain application programs from content server 20 in response to requests of mobile terminal 11. Management server 16 may transmit the obtained application programs to mobile terminal 11 with information concerning reliabilities of the application programs. After mobile terminal 11 receives the application programs from management server 16, mobile terminal 11 manages operations of the application programs. Operations of the application programs are coordinated with operations of other programs using the information concerning the reliabilities corresponding to the application programs. Management of the coordinated operations of the application programs avoids problems concerning information security, where valuable information may be distributed unexpectedly because of operations of low reliable application programs. As a result, convenience of users of mobile terminals 11 can be improved without deteriorating the information security of mobile terminals 11.

摘要翻译： 管理服务器16可以响应于移动终端11的请求从内容服务器20获得应用程序。管理服务器16可以向移动终端11发送关于应用程序的可靠性的信息。 在移动终端11从管理服务器16接收到应用程序之后，移动终端11管理应用程序的操作。 应用程序的操作与其他程序的操作协调，使用与应用程序相对应的可靠性信息。 管理应用程序的协调运行避免了信息安全方面的问题，由于低可靠性应用程序的运行，可能会意外分发有价值的信息。 结果，可以提高移动终端11的用户的便利性，而不会恶化移动终端11的信息安全。

公开(公告)号：US20090199012A1

公开(公告)日：2009-08-06

申请号：US12394671

申请日：2009-02-27

申请人： Kazuhiro Yamada ,  Nobuyuki Watanabe ,  Masayuki Tsuda ,  Dai Kamiya ,  Mao Asai ,  Fumiaki Miura ,  Satoshi Washio ,  Atsuki Tomioka ,  Hiroshi Kawabata ,  Takashi Kondo

发明人： Kazuhiro Yamada ,  Nobuyuki Watanabe ,  Masayuki Tsuda ,  Dai Kamiya ,  Mao Asai ,  Fumiaki Miura ,  Satoshi Washio ,  Atsuki Tomioka ,  Hiroshi Kawabata ,  Takashi Kondo

IPC分类号： H04L9/32 ,  H04L9/00

CPC分类号： H04L63/10 ,  G06F21/53 ,  H04M1/274516 ,  H04M1/72525 ,  H04M1/72561

摘要： Mobile unit 16 which can activate Java-AP software receives SDF (Security Descriptive File) 204 from administering server unit 18 which a trustworthy organization (a communication provider which administers mobile packet communication network 15) administers, and obtains ADF 205 from IP server unit 13 by using URL contained in the SDF, and obtains Jar file 206 from IP server unit 13 by using ADF 205, and installs in itself Java-AP containing these files. Java-AP, which is achieved by activating the installed Java-AP software, operates within the range of authorization expressed by policy information contained in SDF 204

公开(公告)号：US07530114B2

公开(公告)日：2009-05-05

申请号：US10500885

申请日：2003-01-07

申请人： Kazuhiro Yamada ,  Nobuyuki Watanabe ,  Masayuki Tsuda ,  Dai Kamiya ,  Mao Asai ,  Fumiaki Miura ,  Satoshi Washio ,  Atsuki Tomioka ,  Hiroshi Kawabata ,  Takashi Kondo

发明人： Kazuhiro Yamada ,  Nobuyuki Watanabe ,  Masayuki Tsuda ,  Dai Kamiya ,  Mao Asai ,  Fumiaki Miura ,  Satoshi Washio ,  Atsuki Tomioka ,  Hiroshi Kawabata ,  Takashi Kondo

IPC分类号： H04L9/28

CPC分类号： H04L63/10 ,  G06F21/53 ,  H04M1/274516 ,  H04M1/72525 ,  H04M1/72561

摘要： Mobile unit 16 which can activate Java-AP software receives SDF (Security Descriptive File) 204 from administering server unit 18 which a trustworthy organization (a communication provider which administers mobile packet communication network 15) administers, and obtains ADF 205 from IP server unit 13 by using URL contained in the SDF, and obtains Jar file 206 from IP server unit 13 by using ADF 205, and installs in itself Java-AP containing these files. Java-AP, which is achieved by activating the installed Java-AP software, operates within the range of authorization expressed by policy information contained in SDF 204.

摘要翻译： 可以激活Java-AP软件的移动单元16从管理服务器单元18（管理移动分组通信网络15的通信提供者）管理服务器单元18接收SDF（安全描述文件）204，并从IP服务器单元13获得ADF 205 通过使用包含在SDF中的URL，并且通过使用ADF 205从IP服务器单元13获取Jar文件206，并且自己安装包含这些文件的Java-AP。 通过激活安装的Java-AP软件实现的Java-AP在由包含在SDF 204中的策略信息所表示的授权范围内运行。

公开(公告)号：US20080235359A1

公开(公告)日：2008-09-25

申请号：US12117600

申请日：2008-05-08

申请人： Takeshi Natsuno ,  Masaaki Yamamoto ,  Satoshi Washio ,  Hiroshi Kawabata

发明人： Takeshi Natsuno ,  Masaaki Yamamoto ,  Satoshi Washio ,  Hiroshi Kawabata

IPC分类号： G06F15/177

CPC分类号： H04L63/0442 ,  G06F21/10 ,  G06F21/51 ,  G06F21/52 ,  G06F21/54 ,  G06F2221/2113 ,  H04L63/0823 ,  H04M1/72525

摘要： Management server 16 may obtain application programs from content server 20 in response to requests of mobile terminal 11. Management server 16 may transmit the obtained application programs to mobile terminal 11 with information concerning reliabilities of the application programs. After mobile terminal 11 receives the application programs from management server 16, mobile terminal 11 manages operations of the application programs. Operations of the application programs are coordinated with operations of other programs using the information concerning the reliabilities corresponding to the application programs. Management of the coordinated operations of the application programs avoids problems concerning information security, where valuable information may be distributed unexpectedly because of operations of low reliable application programs. As a result, convenience of users of mobile terminals 11 can be improved without deteriorating the information security of mobile terminals 11.

摘要翻译： 管理服务器16可以响应于移动终端11的请求从内容服务器20获得应用程序。 管理服务器16可以将获得的应用程序传送到移动终端11，该信息涉及应用程序的可靠性。 在移动终端11从管理服务器16接收到应用程序之后，移动终端11管理应用程序的操作。 应用程序的操作与其他程序的操作协调，使用与应用程序相对应的可靠性信息。 管理应用程序的协调运行避免了信息安全方面的问题，由于低可靠性应用程序的运行，可能会意外分发有价值的信息。 结果，可以提高移动终端11的用户的便利性，而不会恶化移动终端11的信息安全。

公开(公告)号：US20070197201A1

公开(公告)日：2007-08-23

申请号：US10583622

申请日：2004-12-15

申请人： Satoshi Washio ,  Hiroshi Kawabata ,  Tomoo Yamaguchi

发明人： Satoshi Washio ,  Hiroshi Kawabata ,  Tomoo Yamaguchi

IPC分类号： H04M3/00

CPC分类号： G06F21/10 ,  H04M1/72525 ,  H04M1/72552

摘要： In a communication terminal using UIM, when a message disabling use of a content is received not by a communication terminal containing the content to disabled, but by another communication terminal containing the same content, the content stored in a storage unit of the communication terminal which has received the message is not disabled. Mobile phone 100-1 using UIM stores a program in correlation with a telephone number stored in the UIM. When mobile phone 100-1 receives a management message to delete a program, mobile phone 100-1 interprets the content of the management message. Mobile phone 100-1 obtains a telephone number from the UIM, and deletes the content stored in correlation with the telephone number according to the management message interpreted.

摘要翻译： 在使用UIM的通信终端中，当禁止使用内容的消息不被包含要禁止的内容的通信终端接收到，而是由包含相同内容的另一通信终端接收到存储在通信终端的存储单元中的内容 已收到消息未被禁用。 使用UIM的移动电话100-1存储与存储在UIM中的电话号码相关的节目。 当手机100-1接收到管理消息以删除节目时，移动电话100-1解释管理消息的内容。 移动电话100-1从UIM获得电话号码，并根据解释的管理消息删除与电话号码相关联存储的内容。

公开(公告)号：US20060216758A1

公开(公告)日：2006-09-28

申请号：US11448552

申请日：2006-06-07

申请人： Hiroshi Kawabata ,  H. Koeffler

发明人： Hiroshi Kawabata ,  H. Koeffler

IPC分类号： G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/715 ,  C07K16/28

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K14/705 ,  C07K14/70582 ,  G01N2500/00

摘要： The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the nucleic acids of the present invention, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides. Methods of detecting TfR2 protein in a cell are also provided.

摘要翻译： 本发明提供编码TfR2多肽或其片段的分离的核酸，以及由此编码的分离的TfR2多肽。 进一步提供含有本发明的核酸，转化的宿主细胞，其反义寡核苷酸和含有特异性结合本发明多肽的抗体的组合物的载体。 还提供了检测细胞中TfR2蛋白的方法。