公开(公告)号：US20100044947A1

公开(公告)日：2010-02-25

申请号：US12544087

申请日：2009-08-19

申请人： Minoru Teshigawara ,  Jun Yasutani ,  Takeshi Yazawa ,  Hiroyuki Saito ,  Takaaki Ishida ,  Koichiro Kawaguchi ,  Toshiro Yoshiike ,  Shuichi Tokuda

发明人： Minoru Teshigawara ,  Jun Yasutani ,  Takeshi Yazawa ,  Hiroyuki Saito ,  Takaaki Ishida ,  Koichiro Kawaguchi ,  Toshiro Yoshiike ,  Shuichi Tokuda

IPC分类号： B65H7/02 ,  B65H5/06

CPC分类号： B41J3/4071 ,  B41J11/009 ,  B41J13/0027

摘要： A recording apparatus includes a conveying roller and an ejection roller for conveying a recording medium. The recording apparatus also includes a controller which controls the conveying roller and the ejection roller. The controller selectively performs a conveyance control process for the rollers when the recording medium leaves the conveying roller.

摘要翻译： 记录装置包括输送辊和用于输送记录介质的排出辊。 记录装置还包括控制输送辊和排出辊的控制器。 当记录介质离开输送辊时，控制器选择性地执行辊的输送控制处理。

公开(公告)号：US07527371B2

公开(公告)日：2009-05-05

申请号：US11204342

申请日：2005-08-16

申请人： Haruyuki Yanagi ,  Nozomu Nishiberi ,  Toshiya Matsumoto ,  Hiroyuki Saito ,  Kentaro Onuma

发明人： Haruyuki Yanagi ,  Nozomu Nishiberi ,  Toshiya Matsumoto ,  Hiroyuki Saito ,  Kentaro Onuma

IPC分类号： B41J2/01 ,  B41J29/38 ,  B41J29/393 ,  B41J23/00 ,  B65H3/06 ,  B65H9/16 ,  B65H5/02

CPC分类号： B41J13/025

摘要： An ink jet printing apparatus that can print high quality images under simple control includes a conveying roller disposed upstream of a printing section to convey a print medium, a pinch roller that rotates in cooperation with the conveying roller and discharging rollers that convey the print medium downstream of the printing section. The pinch roller, before a trailing end of the print medium reaches a nip portion between the conveying roller and the pinch roller, moves from a pressure contact position with respect to the conveying roller. A conveyance amount of the print medium varies between before and after separation of the pinch roller from the conveying roller.

摘要翻译： 可以在简单的控制下打印高质量图像的喷墨打印设备包括设置在打印部分的上游以传送打印介质的输送辊，与输送辊协作旋转的夹送辊和向下传送打印介质的排出辊 的打印部分。 在打印介质的尾端到达输送辊和压紧辊之间的压合部分之前的压紧辊相对于输送辊从压力接触位置移动。 打印介质的输送量在夹送辊与输送辊分离之前和之后变化。

公开(公告)号：US07517965B2

公开(公告)日：2009-04-14

申请号：US10522086

申请日：2003-07-17

申请人： Takaki Koga ,  Tsukasa Suzuki ,  Hiroyuki Saito

发明人： Takaki Koga ,  Tsukasa Suzuki ,  Hiroyuki Saito

IPC分类号： C07K16/00

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/76

摘要： The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.

摘要翻译： 本发明提供抑制活化蛋白C（aPC）失活的抗-APC抗体及其用途。 本发明人筛选了抗-APC抗体，并成功地分离了包含抑制血液中的aPC失活活性的抗-APC抗体。 本发明的抗体可用于通过抑制aPC灭活来维持PCPC活性，因此可用于维持aPC生物活性，例如抑制血液凝固系统活化的活性和抗炎活性。 此外，本发明提供本发明的抗体在aPC治疗中用于血栓形成和败血症等疾病的用途。 通过使本发明的抗体与aPC结合，可以延长使用aPC施用的治疗中aPC的治疗效果。 本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

公开(公告)号：US20090074874A1

公开(公告)日：2009-03-19

申请号：US12226693

申请日：2007-04-24

申请人： Yuko Amano ,  Yasuki Kato ,  Mitsunori Harada ,  Naoya Shibata ,  Hiroyuki Saito

发明人： Yuko Amano ,  Yasuki Kato ,  Mitsunori Harada ,  Naoya Shibata ,  Hiroyuki Saito

IPC分类号： A61K9/10

CPC分类号： A61K31/4745 ,  A61K9/1075 ,  A61K31/704 ,  A61K47/6907

摘要： The present invention provides a method of encapsulating a low molecular weight drug in a polymer micelle, the method comprising the steps of: (a) dissolving or dispersing the drug having an electric charge in an aqueous medium; (b) preparing an aqueous medium containing a polymer micelle comprising a block copolymer having an overall hydrophobic region and a hydrophilic region, the overall hydrophobic region containing hydrophobic side chains and side chains having an electric charge opposite to that of the low molecular weight drug in random order; (c) mixing the aqueous medium having the low molecular weight drug dissolved or dispersed therein and the aqueous medium containing the polymer micelle; and (d) adjusting the pH of the mixed aqueous medium to a pH at which the encapsulation of the low molecular weight drug is stabilized.

摘要翻译： 本发明提供一种将低分子量药物包封在聚合物胶束中的方法，该方法包括以下步骤：（a）将具有电荷的药物溶解或分散在水性介质中; （b）制备含有聚合物胶束的水性介质，所述聚合物胶束包含具有总疏水区域和亲水区域的嵌段共聚物，所述整个疏水区域含有疏水侧链和具有与低分子量药物相反的电荷的侧链 随机顺序; （c）将溶解或分散在其中的低分子量药物的水性介质和含有聚合物胶束的水性介质混合; 和（d）将混合水性介质的pH调节至低分子量药物的包封稳定的pH。

公开(公告)号：US07481506B2

公开(公告)日：2009-01-27

申请号：US11445286

申请日：2006-06-02

申请人： Hiroyuki Saito ,  Nobutsune Kobayashi

发明人： Hiroyuki Saito ,  Nobutsune Kobayashi

IPC分类号： B41J29/38

CPC分类号： B41J29/38

摘要： In a printing apparatus which prints using a printhead, a printing controller for feedback-controlling driving of a motor includes a control information generation unit which generates control information for a driving torque of the motor on the basis of a first driving pattern, a comparison unit which compares the control information and a threshold for determining an overload on driving of the motor, and a setting unit which sets a second driving pattern for changing a load on driving of the motor by the control information, instead of the first driving pattern, on the basis of the comparison result of the comparison unit. Control of the motor is switched in accordance with the load state.

摘要翻译： 在使用打印头进行打印的打印装置中，用于对马达进行反馈控制的打印控制器包括：控制信息生成单元，其基于第一驱动模式生成用于马达的驱动转矩的控制信息;比较单元 其比较控制信息和用于确定电动机的驱动过载的阈值;以及设定单元，其通过控制信息而不是第一驱动模式来设置用于改变电动机的驱动负载的第二驱动模式，而不是第一驱动模式 比较单位的比较结果的基础。 根据负载状态切换电动机的控制。

公开(公告)号：US20080048382A1

公开(公告)日：2008-02-28

申请号：US11831114

申请日：2007-07-31

申请人： Yuichiro Suzuki ,  Hiroyuki Saito ,  Kentaro Onuma ,  Hiroyuki Kakishima

发明人： Yuichiro Suzuki ,  Hiroyuki Saito ,  Kentaro Onuma ,  Hiroyuki Kakishima

IPC分类号： B65H7/02 ,  G06K7/015

CPC分类号： B65H5/062 ,  B65H7/02 ,  B65H2220/01 ,  B65H2220/09 ,  B65H2404/14 ,  B65H2513/104 ,  B65H2513/50 ,  B65H2553/51 ,  B65H2557/33 ,  B65H2220/02

摘要： A conveyance apparatus increases the conveyance precision of a conveyance unit. The conveyance apparatus has first and second conveyance rollers. The conveyance apparatus includes a DC motor serving as a driving source for the conveyance rollers, a first encoder which outputs a first pulse signal in accordance with rotation of the first conveyance roller, a second encoder which outputs a second pulse signal in accordance with rotation of the second conveyance roller, and a control unit having a first mode in which the DC motor is controlled based on first information about the first pulse signal when executing a conveyance operation to convey a sheet by using the first and second conveyance rollers, and a second mode in which the DC motor is controlled based on second information about the second pulse signal when executing a conveyance operation to convey a sheet by using the second conveyance roller.

摘要翻译： 输送装置增加输送单元的输送精度。 输送装置具有第一输送辊和第二输送辊。 输送装置包括作为输送辊的驱动源的直流电动机，第一编码器，其根据第一输送辊的旋转输出第一脉冲信号;第二编码器，其根据旋转方向输出第二脉冲信号 第二传送辊和控制单元，其具有第一模式，其中当执行通过使用第一和第二传送辊传送纸张的传送操作时，基于关于第一脉冲信号的第一信息来控制DC电动机，以及第二传送辊 模式，其中当执行通过使用第二传送辊传送片材的传送操作时，基于关于第二脉冲信号的第二信息来控制DC电动机。

公开(公告)号：US20070036785A1

公开(公告)日：2007-02-15

申请号：US11585172

申请日：2006-10-24

申请人： Tadamitsu Kishimoto ,  Asao Katsume ,  Hiroyuki Saito

发明人： Tadamitsu Kishimoto ,  Asao Katsume ,  Hiroyuki Saito

IPC分类号： A61K39/395

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  A61K38/00 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2319/00 ,  C12N15/8509

摘要： Pharmaceutical compositions for prevention or treatment of diseases caused by interleukin-6 production, comprising an antibody to interleukin-6 receptor (IL-6R antibody). As the IL-6R antibody, an antibody of animals other than the human such as mice, rats, etc., a chimeric antibody between these and a human antibody, a reshaped human antibody, etc. may be used. The pharmaceutical compositions are useful for prevention or treatment of diseases caused by interleukin-6 production such as plasmacytosis, anti-IgGl-emia, anemia, nephritis, etc.

摘要翻译： 用于预防或治疗由白细胞介素-6产生引起的疾病的药物组合物，其包含白细胞介素-6受体抗体（IL-6R抗体）。 作为IL-6R抗体，除了人以外的动物的抗体，例如小鼠，大鼠等，可以使用它们与人抗体之间的嵌合抗体，重构的人抗体等。 药物组合物可用于预防或治疗由白细胞介素-6产生引起的疾病，如浆细胞病，抗IgG1-emia，贫血，肾炎等。

公开(公告)号：US20070002118A1

公开(公告)日：2007-01-04

申请号：US11508982

申请日：2006-08-24

申请人： Hiroyuki Saito ,  Haruo Uchida ,  Nozomu Nishiberi ,  Koya Iwakura ,  Kentaro Onuma ,  Kenji Shigeno ,  Motoyuki Taguchi ,  Shinya Sonoda

发明人： Hiroyuki Saito ,  Haruo Uchida ,  Nozomu Nishiberi ,  Koya Iwakura ,  Kentaro Onuma ,  Kenji Shigeno ,  Motoyuki Taguchi ,  Shinya Sonoda

IPC分类号： B41J2/01

CPC分类号： B41J3/4071 ,  B41J3/60 ,  B65H85/00 ,  B65H2301/33214 ,  B65H2301/33312

摘要： Disclosed is a recording apparatus that helps to achieve a reduction in size and cost. The recording apparatus has a U-turn sheet feeding mechanism for reversing and feeding a recording medium and a duplex transport mechanism for reversing the recording medium and performing printing on both sides thereof, in which the same transport path serves as a transport path for transporting the recording medium from a U-turn sheet feeding roller to a main transport roller for transporting the recording medium to a printing portion and as a transport path for reversal in duplex transport. Further, a transport roller provided in the transport path from the U-turn sheet feeding roller to the main transport roller for transporting the recording medium to the printing portion is the same as a transport roller for duplex transport. A single transport roller serves both as the U-turn transport roller and as the duplex transport roller.

摘要翻译： 公开了一种有助于实现尺寸和成本的减小的记录装置。 记录装置具有用于反转和馈送记录介质的U形舌片进给机构和用于反转记录介质并在其两侧执行打印的双面传送机构，其中相同的传送路径用作传送路径 记录介质从U形片材进给辊到用于将记录介质传送到打印部分的主传送辊以及用于双面传送的反转的传送路径。 此外，设置在从U形舌片进给辊到用于将记录介质传送到打印部分的主传送辊的传送路径中的传送辊与用于双面传送的传送辊相同。 单个输送辊既用作U形转运辊，也用作双面输送辊。

公开(公告)号：US20060269613A1

公开(公告)日：2006-11-30

申请号：US10570819

申请日：2004-09-06

申请人： Yasuaki Ogawa ,  Shoko Nagasaki ,  Chieko Tsuchiya ,  Sohei Higashi ,  Hiroyuki Saito

发明人： Yasuaki Ogawa ,  Shoko Nagasaki ,  Chieko Tsuchiya ,  Sohei Higashi ,  Hiroyuki Saito

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/17 ,  A61K31/4745

CPC分类号： A61K9/5153

摘要： A drug and a biodegradable polymer having at least one carboxyl group are encapsulated into nanoparticle which is formed by a block copolymer having a hydrophilic segment and a hydrophobic segment. This invention thus provides a drug-encapsulated nanoparticle which shows an increased in vivo drug-stability.

摘要翻译： 具有至少一个羧基的药物和可生物降解的聚合物被包封成由具有亲水链段和疏水链段的嵌段共聚物形成的纳米粒子。 因此，本发明提供了显示体内药物稳定性增加的药物包封的纳米颗粒。

公开(公告)号：US20060257169A1

公开(公告)日：2006-11-16

申请号：US11382817

申请日：2006-05-11

申请人： Hiroyuki Saito ,  Hidetaka Yamaguchi ,  Masatoshi Takano ,  Motohiro Maseki

发明人： Hiroyuki Saito ,  Hidetaka Yamaguchi ,  Masatoshi Takano ,  Motohiro Maseki

IPC分类号： G03G15/10

CPC分类号： G03G15/104

摘要： A wet type image forming apparatus having a developing solution container a preparatory developing solution container, which is adapted to store developing solution to be supplied to the developing solution container, and an attachment unit to which the preparatory developing solution container is attached, is provided. The preparatory developing solution container includes a coupling portion removably coupled to the attachment unit, a developing solution path being formed in the coupling portion to allow the developing solution to flow therein, a blocking system blocking the developing solution path, and a stirring unit stirring the developing solution in the preparatory developing solution container. The attachment unit includes a releasing system to open the developing solution path blocked by the blocking system when the coupling portion of the preparatory developing solution container is coupled to the attachment unit.

摘要翻译： 具有显影液容器的湿式图像形成装置，该显影液容器是适于存储供给到显影液容器的显影液的预备显影液容器，以及附着有显影液容器的安装单元。 预备显影液容器包括可拆卸地联接到附接单元的联接部分，形成在联接部分中以使显影液流动的显影液路径，阻挡显影液路径的阻挡系统和搅拌器 在准备开发解决方案容器中开发解决方案。 所述附接单元包括释放系统，用于当所述预备显影液容器的联接部分联接到所述附接单元时，打开由所述阻挡系统阻挡的所述显影液路径。