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公开(公告)号:US06982267B2
公开(公告)日:2006-01-03
申请号:US10026651
申请日:2001-12-18
申请人: Andrew Stamford , Youhao Dong , Stuart W. McCombie , Yusheng Wu
发明人: Andrew Stamford , Youhao Dong , Stuart W. McCombie , Yusheng Wu
IPC分类号: C07D241/26 , C07D409/04 , A61K31/4965 , A61K31/497 , A61K3/04
CPC分类号: C07D401/12 , A61K31/4523 , A61K31/4535 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要: The present invention relates to compounds represented by the structural Formula I: or a pharmaceutically acceptable salt thereof, which are useful for the treatment of metabolic and eating disorders such as obesity and hyperphagia, and for the treatment of diabetes and associated disorders.
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公开(公告)号:US06946476B2
公开(公告)日:2005-09-20
申请号:US10177345
申请日:2002-06-20
申请人: Andrew Stamford , Youhao Dong , Stuart W. McCombie , Yusheng Wu
发明人: Andrew Stamford , Youhao Dong , Stuart W. McCombie , Yusheng Wu
IPC分类号: A61K31/4523 , A61K31/4535 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D213/02 , A61K31/4418 , A61K31/4436 , A61P3/04 , C07D409/04
CPC分类号: C07D401/12 , C07D213/75 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds represented by the structural Formula I: or a pharmaceutically acceptable salt thereof, which are useful for the treatment of metabolic and eating disorders such as obesity and hyperphagia, and for the treatment of diabetes and associated disorders.
摘要翻译: 本发明涉及由结构式I表示的化合物或其药学上可接受的盐,其可用于治疗代谢和进食障碍如肥胖症和食欲过盛,以及用于治疗糖尿病和相关疾病。
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公开(公告)号:US06894063B2
公开(公告)日:2005-05-17
申请号:US10096390
申请日:2002-03-12
申请人: William J. Greenlee , Ying Huang , Joseph M. Kelly , Stuart W. McCombie , Andrew W. Stamford , Yusheng Wu
发明人: William J. Greenlee , Ying Huang , Joseph M. Kelly , Stuart W. McCombie , Andrew W. Stamford , Yusheng Wu
IPC分类号: C07C275/30 , C07C311/07 , C07D211/58 , C07D211/96 , C07D401/04 , C07D401/06 , C07D409/12 , C07D409/14 , C07D417/04 , A61K31/445 , A61K31/41 , A61K31/435 , C07C281/00 , C07D421/00
CPC分类号: C07D401/04 , C07C275/30 , C07C311/07 , C07C2601/14 , C07D211/58 , C07D211/96 , C07D401/06 , C07D409/12 , C07D409/14 , C07D417/04
摘要: A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more diseases associated with the neuropeptide Y Y5 receptor are disclosed.
摘要翻译: 一类新颖的化合物,例如神经肽Y Y5受体的拮抗剂,制备此类化合物的方法,含有一种或多种这类化合物的药物组合物,制备包含一种或多种此类化合物的药物制剂的方法,以及治疗,预防或改善方法 公开了与神经肽Y Y5受体相关的一种或多种疾病。
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公开(公告)号:US08324398B2
公开(公告)日:2012-12-04
申请号:US10566150
申请日:2004-07-28
申请人: Yusheng Wu , Shili Chen , Yi Chen , Roger Hanselmann , Rongliang Lou , Jiacheng Zhou
发明人: Yusheng Wu , Shili Chen , Yi Chen , Roger Hanselmann , Rongliang Lou , Jiacheng Zhou
IPC分类号: C07D263/20
CPC分类号: C07D263/20 , C07D263/32 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D473/00 , C07D487/04
摘要: The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译: 本发明涉及制备联芳基恶唑烷酮的方法。 这些化合物可用作抗感染,抗增殖,抗炎和促动力。
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45.
公开(公告)号:US07705026B2
公开(公告)日:2010-04-27
申请号:US12275941
申请日:2008-11-21
申请人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号: A61K31/422 , A61K31/421 , C07D263/20 , C07D263/24
CPC分类号: C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译: 本发明一般涉及抗感染,抗增殖,抗炎和促动力的领域。 更具体地,本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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46.
公开(公告)号:US07456206B2
公开(公告)日:2008-11-25
申请号:US11486769
申请日:2006-07-14
申请人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号: A61K31/421 , C07D413/12 , C07D263/04
CPC分类号: C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译: 本发明一般涉及抗感染,抗增殖,抗炎和促动力的领域。 更具体地,本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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公开(公告)号:US07157472B2
公开(公告)日:2007-01-02
申请号:US10609638
申请日:2003-06-30
申请人: Andrew W. Stamford , Yusheng Wu
发明人: Andrew W. Stamford , Yusheng Wu
IPC分类号: A61K31/454 , C07D401/12
CPC分类号: C07D401/12
摘要: The present invention discloses compounds which, are receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
摘要翻译: 本发明公开了作为NPY Y5的受体拮抗剂的化合物以及这些化合物的制备方法。 在另一个实施方案中,本发明公开了包含这种NPY Y5受体拮抗剂的药物组合物以及使用它们治疗肥胖,代谢紊乱,进食障碍如食欲过盛和糖尿病的方法。
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48.
公开(公告)号:US20090118502A1
公开(公告)日:2009-05-07
申请号:US12275941
申请日:2008-11-21
申请人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Josseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Josseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号: C07D413/02 , C07D401/02
CPC分类号: C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译: 本发明一般涉及抗感染,抗增殖,抗炎和促动力的领域。 更具体地,本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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公开(公告)号:US20060264426A1
公开(公告)日:2006-11-23
申请号:US11486769
申请日:2006-07-14
申请人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/52 , A61K31/498 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/422 , C07D473/02 , C07D417/02 , C07D403/02
CPC分类号: C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
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公开(公告)号:US06617348B1
公开(公告)日:2003-09-09
申请号:US09922372
申请日:2001-08-03
申请人: Jef Karel De Brabander , Yusheng Wu
发明人: Jef Karel De Brabander , Yusheng Wu
IPC分类号: A61K31335
CPC分类号: C07D313/00 , C07D493/08
摘要: The present invention provides compounds having improved stability over that of natural benzolactones, and a process for synthesizing these compounds. These compounds exhibit anti-cancer activity and inhibit V-ATPase activity.
摘要翻译: 本发明提供了具有比天然苯甲酸内酯更稳定的化合物,以及合成这些化合物的方法。 这些化合物表现出抗癌活性并抑制V-ATP酶活性。
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