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公开(公告)号：US20060264426A1
公开(公告)日：2006-11-23
申请号：US11486769
申请日：2006-07-14
申请人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/52 , A61K31/498 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/422 , C07D473/02 , C07D417/02 , C07D403/02
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
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公开(公告)号：US20050203147A1
公开(公告)日：2005-09-15
申请号：US11118808
申请日：2005-04-29
申请人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： A61K31/421 , A61K31/4439 , A61K31/497 , A61K31/501 , C07D255/02 , C07D257/04 , C07D263/20 , C07D263/32 , C07D263/38 , C07D403/10 , C07D413/02 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D473/00 , C07D487/04
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译： 本发明一般涉及抗感染，抗增殖，抗炎和促动力的领域。 更具体地，本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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公开(公告)号：US20050043317A1
公开(公告)日：2005-02-24
申请号：US10859476
申请日：2004-06-02
申请人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： A61K31/421 , A61K31/4439 , A61K31/497 , A61K31/501 , C07D255/02 , C07D257/04 , C07D263/20 , C07D263/32 , C07D263/38 , C07D403/10 , C07D413/02 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D473/00 , C07D487/04
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
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4.发明申请公开(公告)号：US20060264385A1
公开(公告)日：2006-11-23
申请号：US11359820
申请日：2006-02-21
申请人： Deping Wang , Joyce Sutcliffe , Adegboyega Oyelere , Timothy McConnell , Joseph Ippolito , John Abelson , Dane Springer , Joseph Salvino , Rongliang Lou , Joel Goldberg , Jay Farmer , Erin Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce Sutcliffe , Adegboyega Oyelere , Timothy McConnell , Joseph Ippolito , John Abelson , Dane Springer , Joseph Salvino , Rongliang Lou , Joel Goldberg , Jay Farmer , Erin Duffy , Ashoke Bhattacharjee
IPC分类号： A61K31/7052 , A61K31/7048 , C07H17/08
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
摘要翻译： 本发明提供了一种可用作抗感染，抗增殖，抗炎和促动力的双功能杂环化合物。 本发明还提供了制备双官能杂环化合物的方法，以及使用这些化合物作为抗感染剂，抗增殖剂，抗炎剂和/或促动力剂的方法。
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公开(公告)号：US20080119419A1
公开(公告)日：2008-05-22
申请号：US12004957
申请日：2007-12-21
申请人： Deping Wang , Joyce Sutcliffe , Adegboyega Oyelere , Timothy McConnell , Joseph Ippolito , John Abelson , Dane Springer , Joseph Salvino , Joel Goldberg , Rongliang Lou , Jay Farmer , Erin Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce Sutcliffe , Adegboyega Oyelere , Timothy McConnell , Joseph Ippolito , John Abelson , Dane Springer , Joseph Salvino , Joel Goldberg , Rongliang Lou , Jay Farmer , Erin Duffy , Ashoke Bhattacharjee
IPC分类号： A61K31/7048 , A61K31/42 , A61K31/44 , A61P29/00 , A61P31/00 , A61K31/497 , A61K31/5375
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
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公开(公告)号：US20080045585A1
公开(公告)日：2008-02-21
申请号：US10590782
申请日：2005-02-25
申请人： Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/335 , A61P43/00 , C07D269/00
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译： 本发明提供可用作治疗剂的大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20060270680A1
公开(公告)日：2006-11-30
申请号：US10559222
申请日：2004-06-02
申请人： Joel Goldberg , Shili Chen , Jay Farmer , Alia Orbin , Joseph Salvino , Jiacheng Zhou
发明人： Joel Goldberg , Shili Chen , Jay Farmer , Alia Orbin , Joseph Salvino , Jiacheng Zhou
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , A61K31/422 , C07D413/02
CPC分类号： C07D263/20
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译： 本发明一般涉及抗感染，抗增殖，抗炎和促动力的领域。 更具体地，本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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8.发明申请Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same 审中-公开双功能大环内酯类杂环化合物及其制备和使用方法公开(公告)号：US20070270357A1
公开(公告)日：2007-11-22
申请号：US10579706
申请日：2004-11-18
申请人： Jay Farmer , Joel Goldberg , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran
发明人： Jay Farmer , Joel Goldberg , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran
IPC分类号： A61K31/7052 , A61F2/06 , A61P31/04 , C07H17/08 , C07H17/00 , A61K31/7048
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of bifunctional compounds useful as therapeutic agents. These compounds have both a macrolide ring and at least one heterocyclic moiety. The present invention further relates to processes for the preparation of such compounds, to intermediates useful in their preparation, to the use of the compounds as therapeutic agents, and to pharmaceuticals compositions containing them.
摘要翻译： 本发明一般涉及抗感染，抗增殖，抗炎和促动力的领域。 更具体地，本发明涉及可用作治疗剂的双功能化合物家族。 这些化合物具有大环内酯环和至少一个杂环部分。 本发明还涉及制备这些化合物的方法，可用于其制备的中间体，作为治疗剂的用途，以及含有它们的药物组合物。
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9.发明申请Bifunctional macrolide heterocyclic compounds and methods of making and using the same 审中-公开双功能大环内酯类杂环化合物及其制备及使用方法公开(公告)号：US20070149463A1
公开(公告)日：2007-06-28
申请号：US10577903
申请日：2004-10-29
申请人： Adegboyega Oyelere , Jay Farmer
发明人： Adegboyega Oyelere , Jay Farmer
IPC分类号： A61K31/7052 , C07H17/08
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of bifunctional compounds useful as therapeutic agents. These compounds have both a macrolide ring and at least one heterocyclic moiety. The present invention further relates to processes for the preparation of such compounds, to intermediates useful in their preparation, to the use of the compounds as therapeutic agents, and to pharmaceuticals compositions containing them.
摘要翻译： 本发明一般涉及抗感染，抗增殖，抗炎和促动力的领域。 更具体地，本发明涉及可用作治疗剂的双功能化合物家族。 这些化合物具有大环内酯环和至少一个杂环部分。 本发明还涉及制备这些化合物的方法，可用于其制备的中间体，作为治疗剂的用途，以及含有它们的药物组合物。
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10.发明申请Bifunctional heterocyclic compounds and methods of making and using the same 审中-公开双官能杂环化合物及其制备和使用方法公开(公告)号：US20070072811A1
公开(公告)日：2007-03-29
申请号：US10547889
申请日：2004-03-05
IPC分类号： A61K31/7008 , A61K31/7056 , C07H17/02
摘要： The invention provides a family of bifunctional heterocyclic compounds useful as antiinfective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
摘要翻译： 本发明提供了一种双功能杂环化合物，可用作抗感染性，抗增殖性，抗炎和促动力剂。 本发明还提供了制备双官能杂环化合物的方法，以及使用这些化合物作为抗感染剂，抗增殖剂，抗炎剂和/或促动力剂的方法。
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