公开(公告)号：US20080234623A1

公开(公告)日：2008-09-25

申请号：US12064030

申请日：2006-08-18

申请人： Andreas Strauss ,  Mustafa Akdis

发明人： Andreas Strauss ,  Mustafa Akdis

IPC分类号： A61M1/00 ,  B01D69/00

CPC分类号： A61M1/1698 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1013 ,  A61M1/1017 ,  A61M1/1022 ,  A61M1/1031 ,  A61M1/262 ,  A61M1/267 ,  B01D63/02 ,  B01D2313/04 ,  B01D2313/20 ,  F04D7/04 ,  F04D29/047

摘要： A device and method for enriching and/or depleting substances in a liquid is disclosed. An exemplary device comprises a membrane module that consists essentially of concentric elements and that has a separation element in which the substance to be enriched and/or depleted is carried, and whereby the liquid is carried outside of the separation element. The exemplary device also comprises a drive module that encompasses a drive unit for driving a conveying element that conveys the liquid, the drive unit having a radial magnetic coupling for a central impeller located on the inside. The exemplary device further comprises a conveying module for conveying the liquid through the device, housing the conveying element, whereby the drive module is adapted to be inserted into and removed from the membrane module with a liquid-tight closure. The exemplary device further an oxygenator having an outside fiber bundle and an inside fiber bundle. Finally, the exemplary device comprises an electromagnetic drive unit disposed between the outside fiber bundle and the inside fiber bundle.

摘要翻译： 公开了一种用于富集和/或消耗液体中的物质的装置和方法。 示例性装置包括膜组件，该膜组件基本上由同心元件组成，并且具有分离元件，在该分离元件中携带要富集和/或耗尽的物质，并且由此将液体携带在分离元件的外部。 示例性装置还包括驱动模块，该驱动模块包围用于驱动输送液体的输送元件的驱动单元，该驱动单元具有位于内侧的中央叶轮的径向磁耦合。 示例性装置还包括用于将液体输送通过装置的输送模块，容纳输送元件，由此驱动模块适于用液密封闭件将其插入和移出膜组件。 该示例性装置还包括具有外部纤维束和内部纤维束的充氧器。 最后，该示例性装置包括设置在外部纤维束和内部纤维束之间的电磁驱动单元。

公开(公告)号：US20070037228A1

公开(公告)日：2007-02-15

申请号：US11438033

申请日：2006-05-19

申请人： Joachim Moecks ,  Andreas Strauss ,  Gerhard Zugmaier

发明人： Joachim Moecks ,  Andreas Strauss ,  Gerhard Zugmaier

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6872 ,  G01N2333/4756 ,  G01N2333/485 ,  G01N2333/495 ,  G01N2800/52

摘要： The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor alpha, and a HER2 biomarker in a biological sample from the patient and predicting the response to the treatment with the HER inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed.

摘要翻译： 本发明涉及预测患者中用HER抑制剂治疗反应的方法，其包括以下步骤：评估生物标志物或生物标志物的组合，所述生物标志物或选自下组的生物标志物组合，所述生物标志物是由两性调节蛋白，表皮生长因子，转化生长因子 α和来自患者的生物样品中的HER2生物标志物，并通过评估第一步的结果预测患者中用HER抑制剂治疗的反应。 公开了其中使用这些标记的其它用途和方法。

公开(公告)号：US20060260578A1

公开(公告)日：2006-11-23

申请号：US11419301

申请日：2006-05-19

申请人： Olaf Boese ,  Gerhard Scheidig ,  Andreas Strauss ,  Rainer Ottersbach

发明人： Olaf Boese ,  Gerhard Scheidig ,  Andreas Strauss ,  Rainer Ottersbach

IPC分类号： F01L1/34

CPC分类号： F01L1/3442 ,  F01L1/022 ,  F01L1/024 ,  F01L1/026 ,  F01L2001/34469 ,  F01L2001/34496 ,  F01L2101/00 ,  F01L2103/00

摘要： The invention relates to an apparatus (1) for the variable setting of the control times of gas exchange valves of an internal combustion engine, having a stator (2) and an output element (3) which is arranged coaxially with respect to the former, the two components being mounted such that they can rotate with respect to one another, and having a housing (11) which is configured separately with respect to the stator (2) and with respect to the output element (3) and which surrounds the stator (2) and the output element (3) at least partly and prevents engine oil escaping from the apparatus (1), an outer circumferential surface of the stator (2) being configured in the circumferential direction with a radial profile, into which the housing (11) protrudes in such a way that a form-fitting connection of both components is produced in the circumferential direction.

摘要翻译： 本发明涉及一种用于可变设定内燃机的气体交换阀的控制时间的装置（1），其具有相对于前者同轴设置的定子（2）和输出元件（3） 两个部件被安装成使得它们可以相对于彼此旋转，并且具有壳体（11），该壳体相对于定子（2）和相对于输出元件（3）分开构成并围绕定子 （2）和所述输出元件（3）至少部分地防止发动机油从所述设备（1）逸出，所述定子（2）的外圆周表面沿周向配置有径向轮廓，所述壳体 （11）以这样的方式突出，使得在圆周方向上产生两个部件的形状配合连接。

公开(公告)号：US20050252467A1

公开(公告)日：2005-11-17

申请号：US11124841

申请日：2005-05-09

申请人： Andreas Strauss ,  Andreas Rohr ,  Jens Hoppe ,  Viktor Lichtenwald ,  Jochen Auchter ,  Rainer Ottersbach

发明人： Andreas Strauss ,  Andreas Rohr ,  Jens Hoppe ,  Viktor Lichtenwald ,  Jochen Auchter ,  Rainer Ottersbach

IPC分类号： F01L1/04 ,  F01L1/34 ,  F01L1/344

CPC分类号： F01L1/3442 ,  F01L1/34 ,  F01L2001/0475 ,  F01L2001/34433

摘要： A device for changing the control times of an internal combustion engine (camshaft adjuster (1)) having a pressure medium distributor (21) arranged within a camshaft (11) is provided. The pressure medium distributor (21) is provided at its front end with a radially extending shoulder (42), this shoulder (42) forming part of the camshaft axial mounting.

摘要翻译： 提供了一种用于改变具有布置在凸轮轴（11）内的压力介质分配器（21）的内燃机（凸轮轴调节器（1））的控制时间的装置。 压力介质分配器（21）在其前端处设置有径向延伸的肩部（42），该肩部（42）形成凸轮轴轴向安装的一部分。

公开(公告)号：US06892685B2

公开(公告)日：2005-05-17

申请号：US10735889

申请日：2003-12-15

申请人： Rainer Ottersbach ,  Andreas Strauss ,  Mike Kohrs ,  Jochen Auchter

发明人： Rainer Ottersbach ,  Andreas Strauss ,  Mike Kohrs ,  Jochen Auchter

IPC分类号： F01L1/34 ,  F15B13/04 ,  F15B13/044 ,  F16K11/07 ,  F01L1/04

CPC分类号： F15B13/04 ,  F01L1/34 ,  F01L2001/3443 ,  F15B13/0402 ,  Y10T137/86694 ,  Y10T137/8671 ,  Y10T137/86767

摘要： The invention concerns a control device for adjusting the relative angular position of a driven shaft, particularly a camshaft of an internal combustion engine, said device comprising a drive pinion that is rotatably connected to the shaft, an adjusting element (1) for the angular adjustment of the drive pinion relative to the shaft, two chambers (2, 3) that are alternately supplied with hydraulic fluid and a control valve (6) for actuating the adjusting element (1), said control valve being connected to the chambers (2, 3) of the adjusting element (1) through pressure medium channels (4, 5). The control valve (6) comprises a valve body (7) that has two working connections A and B for the pressure medium channels (4, 5), a delivery connection P for the supply of hydraulic fluid and a discharge connection T for the discharge of hydraulic fluid, and the control valve (6) further comprises a sliding valve control piston (8) for setting different hydraulic resistances W between the individual connections. In an intermediate adjusted position of the valve control piston (8), for setting an intermediate phase angle, a lower hydraulic resistance W prevails between the delivery connection P and that one of the working connections A and B at which a design-related, higher fluid leakage V occurs.

摘要翻译： 本发明涉及一种用于调节从动轴，特别是内燃机的凸轮轴的相对角位置的控制装置，所述装置包括可旋转地连接到轴的驱动小齿轮，用于角度调节的调节元件（1） 所述驱动小齿轮相对于所述轴，交替地供应有液压流体的两个腔室（2,3）和用于致动所述调节元件（1）的控制阀（6），所述控制阀连接到所述腔室（2， 3）通过压力介质通道（4,5）调节元件（1）。 控制阀（6）包括阀体（7），其具有用于压力介质通道（4,5）的两个工作连接件A和B，用于供应液压流体的输送连接件P和用于排放的排放连接件 的液压流体，并且所述控制阀（6）还包括用于在各个连接之间设定不同的液压阻力W的滑阀控制活塞（8）。 在阀控制活塞（8）的中间调节位置，为了设定中间相位角，在输送连接P和工作连接A和B之间的一个工作连接A和B处设置较低的液压阻力W. 发生流体泄漏V。

公开(公告)号：US06889641B2

公开(公告)日：2005-05-10

申请号：US10735888

申请日：2003-12-15

申请人： Rainer Ottersbach ,  Andreas Strauss ,  Mike Kohrs ,  Jochen Auchter

发明人： Rainer Ottersbach ,  Andreas Strauss ,  Mike Kohrs ,  Jochen Auchter

IPC分类号： F01L1/34 ,  F15B13/04 ,  F15B13/044 ,  F16K11/07

CPC分类号： F15B13/04 ,  F01L1/34 ,  F01L2001/3443 ,  F15B13/0402 ,  Y10T137/86694 ,  Y10T137/8671 ,  Y10T137/86767

摘要： The invention concerns a control device for adjusting the relative angular position of a driven shaft, particularly a camshaft of an internal combustion engine, said device comprising a drive pinion that is rotatably connected to the shaft, an adjusting element (1) for the angular adjustment of the drive pinion relative to the shaft, two chambers (2, 3) that are alternately supplied with hydraulic fluid and a control valve (6) for actuating the adjusting element (1), said control valve being connected to the chambers (2, 3) of the adjusting element (1) through pressure medium channels (4, 5). The control valve (6) comprises a valve body (7) that has two working connections A and B for the pressure medium channels (4, 5), a delivery connection P for the supply of hydraulic fluid and a discharge connection T for the discharge of hydraulic fluid, and the control valve (6) further comprises a sliding valve control piston (8) for setting different hydraulic resistances W between the individual connections. In an intermediate adjusted position of the valve control piston (8), for setting an intermediate phase angle, a lower hydraulic resistance W prevails between the delivery connection P and that one of the working connections A and B at which a design-related, higher fluid leakage V occurs.

公开(公告)号：US06566062B1

公开(公告)日：2003-05-20

申请号：US09508524

申请日：2000-05-02

申请人： Andreas Strauss ,  Gunther Thumm ,  Johannes Pohlner ,  Friedrich Götz

发明人： Andreas Strauss ,  Gunther Thumm ,  Johannes Pohlner ,  Friedrich Götz

IPC分类号： C12Q100

CPC分类号： C12Q1/02

摘要： A method for identifying a nucleic acid which codes for a polypeptide factor affecting the covalent bonding of polypeptides to the surface of Gram-positive bacteria, comprising the following steps: a) providing a sample of Gram-positive bacteria which can be genetically altered and contain or produce at least one enzymatic reporter substance which is or can become covalently bonded to the surface of the Gram-positive bacteria, said at least one reporter substance having a different enzymatic activity when not covalently bonded to the surface of the Gram-positive bacteria from that exhibited when it is covalently bonded to the surface of the Gram-positive bacteria; b) causing genetic alterations in Gram-positive bacteria of the sample; c) assaying the enzymatic activity of the reporter substance of the Gram-positive bacteria of the sample; d) separating Gram-positive bacteria which exhibit a different enzymatic activity of the reporter substance from that observed for covalent bonding of the reporter substance to the surface of the Gram-positive bacteria; e) isolating the nucleic acid of the Gram-positive bacteria separated in step d); f) identifying at least one segment of the nucleic acid isolated in step e) that carries the genetic alteration; g) based on the segment identified in step f), identifying a nucleic acid which codes for a polypeptide factor affecting the covalent bonding of polypeptides to the surface of Gram-positive bacteria.

摘要翻译： 一种用于鉴定编码影响多肽与革兰氏阳性细菌表面的共价键的多肽因子的核酸的方法，包括以下步骤：a）提供革兰氏阳性菌的样品，所述革兰氏阳性菌可被遗传改变并含有 或产生至少一种酶促报告物质，其是或可以共价键合到革兰氏阳性细菌的表面，所述至少一种报告物质在不共价结合到革兰氏阳性细菌的表面时具有不同的酶活性 当它与革兰氏阳性菌的表面共价结合时显示; b）引起样品的革兰氏阳性菌的遗传改变; c）测定样品革兰氏阳性菌的报道物质的酶活性 ; d）分离出与报道物质不同的酶活性的革兰氏阳性细菌与用于共价键合观察到的那些 e向所述革兰氏阳性细菌的表面提供记录物质; e）分离在步骤d）中分离的革兰氏阳性菌的核酸; f）鉴定在步骤e）中分离的核酸的至少一个片段，其携带 遗传改变; g）基于步骤f）中鉴定的区段，鉴定编码影响多肽与革兰氏阳性菌表面共价键的多肽因子的核酸。

公开(公告)号：US06453858B2

公开(公告)日：2002-09-24

申请号：US09915871

申请日：2001-07-26

申请人： Martin Scheidt ,  Andreas Strauss ,  Michael Haag

发明人： Martin Scheidt ,  Andreas Strauss ,  Michael Haag

IPC分类号： F01L134

CPC分类号： F01L1/3442

摘要： The invention concerns a device for varying valve timing of gas exchange valves of an internal combustion engine, particularly a hydraulic camshaft adjusting device of a rotary piston type, said device comprising a drive pinion (2) connected in driving relationship to a crankshaft of the internal combustion engine and a winged wheel (3) connected rotationally fast to a camshaft of the internal combustion engine. The drive pinion (2) comprises a hollow space formed by a circumferential wall (4) and two side walls (5, 6), at least one hydraulic working chamber (10) being formed in the hollow space by at least two limiting walls (8, 9). The winged wheel (3) comprises at least one radial wing (12), and with each wing (12) it divides one hydraulic working chamber (10) into two hydraulic pressure chambers (13, 14) which, when pressurized by a hydraulic pressure medium effect a pivoting or a fixing of the winged wheel (3) relative to the drive pinion (2). When the internal combustion engine is switched off, the camshaft is rotated into a preferred basic position for starting the internal combustion engine, and in this position, the winged wheel (3) can be mechanically coupled to the drive pinion (2) by a lock. The novel lock is configured as a cage-guided free-wheel (16) arranged between the winged wheel (3) and the drive pinion (2) and comprises at least one clamping body (17) that blocks the direction of rotation of the winged wheel (3) opposed to the basic position of the camshaft. The cage (18) of the free-wheel (16) is configured at least partly as a pressure application surface (19) for the hydraulic pressure medium for unlocking the free-wheel (16).

公开(公告)号：US06418897B1

公开(公告)日：2002-07-16

申请号：US09913907

申请日：2001-08-17

申请人： Peter Urban ,  Andreas Strauss ,  Dieter Goppelt

发明人： Peter Urban ,  Andreas Strauss ,  Dieter Goppelt

IPC分类号： F01L1344

CPC分类号： F01L1/3442

摘要： The invention concerns a device for the angular adjustment of a camshaft relative to the crankshaft of an internal combustion engine, particularly a vane-type adjuster (1) comprising a stator (12) that is driven by the crankshaft preferably through a traction element and a drive pinion (11), and a vane rotor (18) that can be pressurized by pressure oil and is rotationally fixed to the camshaft while possessing a means, preferably an axially displaceable fixing pin (37) for effecting a releasable, rotational fixing of the vane rotor. The drawback of oil leakage in common vane-type adjusters is avoided by the fact that all components of the vane-type adjuster (1) that have contact with pressure oil are arranged in an oil-tight housing (2).

摘要翻译： 本发明涉及一种用于凸轮轴相对于内燃机的曲轴的角度调节的装置，特别是包括定子（12）的叶片式调节器（1），该定子由曲轴优选地通过牵引元件和 驱动小齿轮（11）和叶片转子（18），其可以被压力油加压并且旋转地固定到凸轮轴，同时具有装置，优选地是可轴向移动的固定销（37），用于实现可释放的旋转固定 叶片转子。 通过与压力油接触的叶片式调节器（1）的所有部件都布置在不透油的壳体（2）中，可以避免普通叶片式调节器中漏油的缺点。

公开(公告)号：US06418893B1

公开(公告)日：2002-07-16

申请号：US09696576

申请日：2000-10-25

申请人： Jochen Auchter ,  Andreas Strauss

发明人： Jochen Auchter ,  Andreas Strauss

IPC分类号： F01L134

CPC分类号： F01L1/3442 ,  F01L2001/34479

摘要： The invention relates to a hydraulic camshaft adjusting device (1) of a rotary piston type that is disposed on a camshaft (3) mounted in the cylinder head (2) of an internal combustion engine and comprises a drive pinion (4) that is in driving relation with a crankshaft through a gearing (6), and a winged wheel (5) that is fixedly mounted on the camshaft (3). The drive pinion (4) is made up of a circumferential wall (7), a camshaft-distal side wall (8) and a camshaft-proximate side wall (9), which walls (7, 8, 9) together define a hollow space (10) in which at least one hydraulic working chamber is formed by at least two limiting walls (11). The winged wheel (5) comprises at least one wing (14), and each wing (14) divides a hydraulic working chamber into two hydraulic pressure chambers. In accordance with the invention, the camshaft-proximate side wall (9) of the drive pinion (4) is configured as a weight- and design space-saving thin-walled component which is shaped out of a circular blank and comprises a bent edge region (17) that is bent at a right angle and partially surrounds the circumferential wall (7) of the drive pinion (4), said camshaft-proximate side wall (9) being undetachably fixed to the drive pinion (4) by a separate connection (18).

摘要翻译： 本发明涉及一种旋转活塞式液压凸轮轴调节装置（1），该液压凸轮轴调节装置（1）设置在安装在内燃机的气缸盖（2）中的凸轮轴（3）上，并包括一个驱动小齿轮（4） 通过齿轮（6）与曲轴的驱动关系，以及固定地安装在凸轮轴（3）上的翼轮（5）。 驱动小齿轮（4）由圆周壁（7），凸轮轴 - 远侧侧壁（8）和凸轮轴 - 近侧壁（9）构成，所述壁（7,8,9） 空间（10），其中至少一个液压工作室由至少两个限制壁（11）形成。 翼轮（5）包括至少一个翼（14），并且每个翼（14）将液压工作室分成两个液压室。 根据本发明，驱动小齿轮（4）的凸轮轴靠近的侧壁（9）被构造为由圆形坯料成形的重量和设计节省空间的薄壁部件，并且包括弯曲边缘 区域（17），其以直角弯曲并且部分地围绕所述驱动小齿轮（4）的周壁（7），所述凸轮轴近侧壁（9）通过单独的方式不可移动地固定到所述驱动小齿轮（4） 连接（18）。