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公开(公告)号:US09981147B2
公开(公告)日:2018-05-29
申请号:US15228626
申请日:2016-08-04
申请人: W. Davis Lee , Mark R. Amato , James P. Bennett
发明人: W. Davis Lee , Mark R. Amato , James P. Bennett
CPC分类号: A61N5/1081 , A61B6/032 , A61B6/4216 , A61B6/4258 , A61B6/5205 , A61N5/1039 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要: The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source.
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公开(公告)号:US10112060B2
公开(公告)日:2018-10-30
申请号:US15847772
申请日:2017-12-19
申请人: W. Davis Lee , Mark R. Amato , James P. Bennett
发明人: W. Davis Lee , Mark R. Amato , James P. Bennett
摘要: The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source.
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公开(公告)号:US20180200538A1
公开(公告)日:2018-07-19
申请号:US15919067
申请日:2018-03-12
申请人: James P. Bennett , W. Davis Lee , Mark R. Amato
发明人: James P. Bennett , W. Davis Lee , Mark R. Amato
CPC分类号: A61N5/1077 , A61B6/00 , A61B6/03 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1082 , A61N2005/1051 , A61N2005/1052 , A61N2005/1054 , A61N2005/1061 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/087 , G21K1/093 , G21K5/04 , G21K5/10 , H01J35/14
摘要: The invention comprises a method and apparatus for treating a tumor of a patient with charged particles, comprising the step of developing a multi-modality treatment plan, the multi-modality treatment plan directing: (1) use of a first beam type to treat a first volume of the tumor, the first beam type a first mass per particle and (2) use of a second beam type to treat a second volume of the tumor, the second beam type comprising a second mass per particle, where the second mass per particle is at least ten percent different than the first mass per particle and the second volume differs from the first volume. The multi-modality treatment plan is optionally formed by selectively merging treatment plans using the respective particle types or is developed using properties of the multiple particle types.
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公开(公告)号:US09974978B2
公开(公告)日:2018-05-22
申请号:US15239773
申请日:2016-08-17
CPC分类号: A61N5/1069 , A61B6/03 , A61B6/032 , A61B6/0457 , A61B6/4014 , A61B6/4092 , A61B6/4258 , A61B6/4266 , A61B6/4417 , A61B6/4435 , A61B6/5205 , A61B6/5247 , A61N5/1037 , A61N5/1039 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/105 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G01N23/046 , G01N2223/107 , G01N2223/203 , G21K1/093 , G21K5/04
摘要: A scintillation material is longitudinally packaged in a circumferentially surrounding sheath, where the sheath has a lower index of refraction than the scintillation material, to form a scintillation optic or scintillation fiber optic. The scintillation material yields secondary photons upon passage of a charged particle beam, such as a positively charged residual particle beam having transmitted through a sample. The internally generated secondary photons within the sheath are guided to a detector element by the difference in index of refraction. Multiple scintillation optics are assembled to form a two-dimensional scintillation array coupled to a two-dimensional detector array, such as for use in determination of state of the residual charged particle beam, determination of an exit point of the particle beam from the sample, path of the treatment beam, and/or tomographic imaging.
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公开(公告)号:US20180117362A1
公开(公告)日:2018-05-03
申请号:US15847772
申请日:2017-12-19
申请人: W. Davis Lee , Mark R. Amato , James P. Bennett
发明人: W. Davis Lee , Mark R. Amato , James P. Bennett
CPC分类号: A61N5/1081 , A61B6/032 , A61B6/4216 , A61B6/4258 , A61B6/5205 , A61N5/1039 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要: The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source.
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公开(公告)号:US20160339272A1
公开(公告)日:2016-11-24
申请号:US15228626
申请日:2016-08-04
申请人: W. Davis Lee , Mark R. Amato , James P. Bennett
发明人: W. Davis Lee , Mark R. Amato , James P. Bennett
IPC分类号: A61N5/10
CPC分类号: A61N5/1081 , A61B6/032 , A61B6/4216 , A61B6/4258 , A61B6/5205 , A61N5/1039 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要: The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source.
摘要翻译: 本发明包括其用于从离子源提取离子的装置和方法,例如用于癌症治疗或断层摄影成像。 提取装置使用三极管提取系统,其中离子源和/或第一电极保持在第一电位; 保持在第二电位的提取电极; 位于离子源和提取电极之间的选通电极,在靠近离子源电位的第一抑制电位和离子源电位与提取电极电势之间的第二提取电位之间振荡和/或交替。 任选地,离子源包括电子回旋共振离子源。
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公开(公告)号:US10279198B2
公开(公告)日:2019-05-07
申请号:US15868966
申请日:2018-01-11
摘要: A scintillation material is longitudinally packaged in a circumferentially surrounding sheath, where the sheath has a lower index of refraction than the scintillation material, to form a scintillation optic or scintillation fiber optic. The scintillation material yields secondary photons upon passage of a charged particle beam, such as a positively charged residual particle beam having transmitted through a sample. The internally generated secondary photons within the sheath are guided to a detector element by the difference in index of refraction. Multiple scintillation optics are assembled to form a two-dimensional scintillation array coupled to a two-dimensional detector array, such as for use in determination of state of the residual charged particle beam, determination of an exit point of the particle beam from the sample, path of the treatment beam, and/or tomographic imaging.
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公开(公告)号:US20180133512A1
公开(公告)日:2018-05-17
申请号:US15868966
申请日:2018-01-11
CPC分类号: A61N5/1069 , A61B6/03 , A61B6/032 , A61B6/0457 , A61B6/4014 , A61B6/4092 , A61B6/4258 , A61B6/4266 , A61B6/4417 , A61B6/4435 , A61B6/5205 , A61B6/5247 , A61N5/1037 , A61N5/1039 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/105 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G01N23/046 , G01N2223/107 , G01N2223/203 , G21K1/093 , G21K5/04
摘要: A scintillation material is longitudinally packaged in a circumferentially surrounding sheath, where the sheath has a lower index of refraction than the scintillation material, to form a scintillation optic or scintillation fiber optic. The scintillation material yields secondary photons upon passage of a charged particle beam, such as a positively charged residual particle beam having transmitted through a sample. The internally generated secondary photons within the sheath are guided to a detector element by the difference in index of refraction. Multiple scintillation optics are assembled to form a two-dimensional scintillation array coupled to a two-dimensional detector array, such as for use in determination of state of the residual charged particle beam, determination of an exit point of the particle beam from the sample, path of the treatment beam, and/or tomographic imaging.
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49.
公开(公告)号:US20170216632A1
公开(公告)日:2017-08-03
申请号:US15489396
申请日:2017-04-17
IPC分类号: A61N5/10
CPC分类号: A61N5/1081 , A61B6/032 , A61B6/037 , A61B6/4258 , A61B6/5205 , A61N5/103 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1051 , A61N2005/1052 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/093 , G21K5/04
摘要: The invention comprises a method and apparatus for directing a positively charged particle beam to a tumor of a patient, comprising the steps of: (1) transporting the positively charged particle beam sequentially from a synchrotron, through a beam transport line, and through a nozzle system toward the tumor, the beam transport line comprising a rotatable beamline section; (2) pre-rotating the positively charged particle beam using a solenoid, the solenoid positioned in the beam transport line between the synchrotron and the rotatable beamline section; and (3) rotating the rotatable beamline section, where the step of pre-rotating maintains a geometric relationship between a radial cross-section of the positively charged particle beam and magnet surfaces in the rotatable beamline section as a function of rotation of the rotatable beamline section, which reduces otherwise changed dispersive forces as the rotatable beamline is positioned in separate areas about the patient.
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公开(公告)号:US20210025027A1
公开(公告)日:2021-01-28
申请号:US16523974
申请日:2019-07-26
申请人: W. Davis Lee , Mark R. Amato
发明人: W. Davis Lee , Mark R. Amato
摘要: The invention comprises a method and apparatus for generating a rare earth from a rare earth oxide, comprising the sequential steps of: (1) reducing temperature about the rare earth oxide to less than zero degrees Celsius; (2) reducing pressure to boil off contaminant water in a powder sample of the rare earth oxide at a molecular escape velocity not disturbing the powdered rare earth oxide; and (3) heating the rare earth oxide to greater than 1000° C. in the presence hydrogen gas while optionally: (1) collecting and determining mass of a water product to determine a consumption mass of the starting hydrogen gas in a main reaction process using the equation RE2O3+3H2→2RE+3 H2O, wherein “RE” comprises at a rare earth and (2) injecting replacement hydrogen gas into the main reaction chamber up to the consumption mass.
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