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    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS
    41.
    发明申请
    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 有权
    用于预测和预防保留的装置和方法

    公开(公告)号：US20110263936A1

    公开(公告)日：2011-10-27

    申请号：US12963536

    申请日：2010-12-08

    申请人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    发明人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    IPC分类号： A61B1/04

    CPC分类号： A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/4836 ,  A61B17/22 ,  A61F2/06 ,  A61M31/005 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30101

    摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

    摘要翻译： 本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。 预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。 例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。 可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。 用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

    Debulking Catheters And Methods
    42.
    发明申请
    Debulking Catheters And Methods 审中-公开
    脱胶导管和方法

    公开(公告)号：US20110257042A1

    公开(公告)日：2011-10-20

    申请号：US13090138

    申请日：2011-04-19

    申请人： John B. Simpson

    发明人： John B. Simpson

    IPC分类号： C40B40/08 ,  C40B40/10

    CPC分类号： A61K35/12 ,  A61B10/0096 ,  A61B10/02 ,  A61B10/0266 ,  A61B10/04 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B90/90 ,  A61B2017/00778 ,  A61B2017/320791 ,  G16H10/60

    摘要： A debulking catheter comprising a tissue debulking assembly for removing a continuous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly disposed at least partially within the distal portion. The tissue debulking assembly is radially movable to expose at least a portion of the assembly through a window on the catheter body. The catheter is advanced transluminally through the body lumen to contact material in the body lumen and remove a plane of continuous material that has a length that is typically longer than a length of the window on the catheter. The continuous material may be directed into a collection chamber. Thereafter, the material may be removed from the collection chamber and preserved or tested.

    摘要翻译： 减压导管，其包括用于从体腔移除连续的材料束的组织减积组件。 本发明的导管通常包括具有近端部分和远端部分的导管本体和至少部分地设置在远端部分内的组织减灭组件。 组织减灭组件可径向移动，以使组件的至少一部分通过导管主体上的窗口露出。 导管通过身体腔内腔进行前进以接触体腔中的材料并移除连续材料的平面，其长度通常长于导管上窗口的长度。 连续材料可以被引导到收集室中。 此后，材料可以从收集室中取出并保存或测试。

    TESTING A PATIENT POPULATION HAVING A CARDIOVASCULAR CONDITION FOR DRUG EFFICACY
    43.
    发明申请
    TESTING A PATIENT POPULATION HAVING A CARDIOVASCULAR CONDITION FOR DRUG EFFICACY 审中-公开
    测试患有血液病毒的患者人群对药物的影响

    公开(公告)号：US20110236902A1

    公开(公告)日：2011-09-29

    申请号：US13154057

    申请日：2011-06-06

    申请人： Angela Soito ,  John B. Simpson

    发明人： Angela Soito ,  John B. Simpson

    IPC分类号： C12Q1/68 ,  C12Q1/24

    CPC分类号： A61B17/320783 ,  A61B10/0233 ,  A61B10/0275 ,  A61B2010/0225

    摘要： Lumenectomy material is tested to determine the efficacy of a test drug in a patient population having a cardiovascular condition. The material is removed from at least a first and a second patient and tested for one or more markers of a cardiovascular condition. The first patient is administered the test drug, and the second patient is administered a placebo. At a later date, more lumenectomy material is removed and tested for the same marker or markers. The presence, absence or amount of the markers is compared in the first patient receiving the drug and the second patient receiving the placebo to determine whether the drug is effective in the patient population. The drugs tested include drugs believed to be effective in treating a cardiovascular condition. The markers used can include any marker that can indicate the effectiveness of the drug being tested.

    摘要翻译： 测试肿瘤切除术材料以测定具有心血管病症的患者群体中测试药物的功效。 从至少第一和第二患者移除材料并测试一种或多种心血管病症的标志物。 给予第一名患者试验药物，第二名患者服用安慰剂。 在以后，更多的腔切除材料被去除并测试相同的标记或标记。 在接受药物的第一个患者和接受安慰剂的第二个患者中比较存在，不存在或量的标记物，以确定药物在患者群体中是否有效。 所测试的药物包括被认为有效治疗心血管疾病的药物。 所使用的标记物可以包括可以指示待测试药物的有效性的任何标记物。

    Testing lumenectomy samples for markers of non-vascular diseases
    44.
    发明授权
    Testing lumenectomy samples for markers of non-vascular diseases 有权
    测试非血管疾病标志物的腔内切除术样本

    公开(公告)号：US07989207B2

    公开(公告)日：2011-08-02

    申请号：US11356460

    申请日：2006-02-17

    申请人： Angela Soito ,  John B. Simpson

    发明人： Angela Soito ,  John B. Simpson

    IPC分类号： G01N33/48 ,  G01N1/04

    CPC分类号： G01N33/68 ,  A61B10/0233 ,  A61B17/22 ,  Y10T436/25

    摘要： Lumenectomy material is tested to determine the presence or likelihood of a condition of a patient. The lumenectomy material is in the form of at least one continuous tissue strand collected in vivo from an inner surface of a body lumen of the patient. The presence of at least one marker of a disease is determined. The disease may be hypertension, hyperlipidemia, depression, obesity, metabolic syndrome, insulin resistance, kidney damage, or diabetes. The patient is identified as having or as likely to develop the disease if a marker of the disease is identified in the lumenectomy material of the patient.

    摘要翻译： 测量肿瘤切除术材料以确定患者状况的存在或可能性。 所述内腔切除术材料是从患者体腔的内表面在体内收集的至少一个连续组织线的形式。 确定存在至少一种疾病的标志物。 该疾病可以是高血压，高脂血症，抑郁症，肥胖，代谢综合征，胰岛素抵抗，肾损伤或糖尿病。 如果在患者的内腔切除术材料中鉴定出疾病的标志物，则该患者被鉴定为具有或可能发展该疾病。

    Debulking catheters and methods
    45.
    发明授权
    Debulking catheters and methods 有权
    去污导管和方法

    公开(公告)号：US07887556B2

    公开(公告)日：2011-02-15

    申请号：US10288581

    申请日：2002-11-04

    申请人： John B. Simpson ,  Himanshu Patel ,  Greg Stine

    发明人： John B. Simpson ,  Himanshu Patel ,  Greg Stine

    IPC分类号： A61B17/22

    CPC分类号： A61B17/320758 ,  A61B8/12 ,  A61B17/2202 ,  A61B17/320725 ,  A61B17/320783 ,  A61B2017/00685 ,  A61B2017/2927 ,  A61B2017/320032 ,  A61B2017/320791

    摘要： A method of removing material from a blood flow lumen generally includes providing a device having a cutting element and an opening, advancing the device through the blood flow lumen to a site where material is to be removed, forcing the opening toward a wall of the site where material is to be removed, and moving the cutting element and the opening so that material in the blood flow lumen is cut by the cutting element and directed into the opening for removal as the cutting element and opening are moved through the blood flow lumen. In some embodiments, the device may be deflected or bent to force the opening toward a wall to remove material. The cutting element may be rotatable and may have an axis that is movable, that is not parallel to the longitudinal axis of the device, or both. In some embodiments, the cutting element is movable between retracted and deployed positions for advancing the device to a site for treatment and for removing material, respectively.

    摘要翻译： 从血流腔中去除材料的方法通常包括提供具有切割元件和开口的装置，将装置通过血流腔前进到要除去材料的部位，迫使开口朝向部位的壁 其中要去除材料，并且移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，通过切割元件切割血流腔中的材料并将其引导到用于移除的开口中。 在一些实施例中，该装置可能被偏转或弯曲以迫使开口朝向壁以移除材料。 切割元件可以是可旋转的并且可以具有可移动的轴线，其不平行于装置的纵向轴线或两者。 在一些实施例中，切割元件可在缩回和展开位置之间移动，以将装置分别推进到处理场所和用于移除材料。

    GUIDEWIRE SUPPORT CATHETER
    46.
    发明申请
    GUIDEWIRE SUPPORT CATHETER 有权
    GUIDEWIRE支持导管

    公开(公告)号：US20100274270A1

    公开(公告)日：2010-10-28

    申请号：US12689748

    申请日：2010-01-19

    申请人： Himanshu N. Patel ,  John B. Simpson

    发明人： Himanshu N. Patel ,  John B. Simpson

    IPC分类号： A61B17/22 ,  A61M25/09

    CPC分类号： A61B5/066 ,  A61B17/320758 ,  A61B2017/003 ,  A61B2017/00309 ,  A61B2017/22038 ,  A61B2017/320775 ,  A61M25/01 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/0155 ,  A61M25/0172

    摘要： Described herein are guidewire positioning and support devices, method for using them, method of treating a subject using them, and systems including such guidewire positioning and support devices. These devices typically include a rotatable distal tip region that may include one or more wedges. The wedges may be extendable from the rotatable distal tip. The distal end of the device may be steerable, and may be steered while still rotating the distal end of the device. The wedges (which may include sharp forward-cutting blades and blunt lateral portions) can be extended from the distal housing and locked in any position (extended, partially extended or retracted) and rotated clockwise and/or counterclockwise while locked in a retracted, extended or partially extended position. The distal region of the device may also be controllable steered from the proximal end of the device. Systems including these guidewire support catheters are also described, as are method of using them, including methods of treating chronic total occlusions.

    摘要翻译： 这里描述的是导丝定位和支撑装置，使用它们的方法，使用它们处理对象的方法，以及包括这种导丝定位和支撑装置的系统。 这些装置通常包括可旋转的远侧末梢区域，其可以包括一个或多个楔形物。 楔形物可以从可旋转的远端延伸。 装置的远端可以是可操纵的，并且可以在仍然旋转装置的远端的同时转向。 可以从远侧壳体延伸楔形物（其可以包括锋利的前切割刀片和钝的侧面部分）并且锁定在任何位置（延伸，部分延伸或缩回）并且在锁定在缩回的延伸部中时顺时针和/或逆时针旋转 或部分延伸位置。 装置的远端区域也可以从装置的近端受到控制。 还描述了包括这些导丝支撑导管的系统，以及使用它们的方法，包括治疗慢性完全闭塞的方法。

    Debulking catheters and methods
    47.
    发明授权
    Debulking catheters and methods 有权
    去污导管和方法

    公开(公告)号：US07699790B2

    公开(公告)日：2010-04-20

    申请号：US10896741

    申请日：2004-07-21

    申请人： John B. Simpson

    发明人： John B. Simpson

    IPC分类号： A61B10/00 ,  A61B17/32

    CPC分类号： A61B17/320758 ,  A61B17/320783 ,  A61B2017/00685 ,  A61B2017/2927 ,  A61B2017/320032

    摘要： A debulking catheter comprising a tissue debulking assembly for removing a contiguous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly disposed at least partially within the distal portion. The tissue debulking assembly is radially movable to expose at least a portion of the assembly through a window on the catheter body. The catheter is advanced transluminally through the body lumen to contact material in the body lumen and remove a plane of contiguous material that has a length that is typically longer than a length of the window on the catheter. The contiguous material may be directed into a collection chamber. Thereafter, the material may be removed from the collection chamber and preserved or tested.

    摘要翻译： 一种减压导管，其包括用于从体腔移除相邻的材料束的组织减积组件。 本发明的导管通常包括具有近端部分和远端部分的导管本体和至少部分地设置在远端部分内的组织减灭组件。 组织减灭组件可径向移动，以使组件的至少一部分通过导管主体上的窗口露出。 导管通过身体腔内腔进行前进以接触体腔内的材料，并移除相邻材料的平面，其长度通常长于导管上的窗口的长度。 连续的材料可以被引导到收集室中。 此后，材料可以从收集室中取出并保存或测试。

    Single lumen atherectomy catheter device
    50.
    发明授权
    Single lumen atherectomy catheter device 失效
    单腔粥样斑块切除术导管装置

    公开(公告)号：US4669469A

    公开(公告)日：1987-06-02

    申请号：US834950

    申请日：1986-02-28

    申请人： Hanson S. Gifford, III ,  John B. Simpson

    发明人： Hanson S. Gifford, III ,  John B. Simpson

    IPC分类号： A61B17/32 ,  A61B17/22

    CPC分类号： A61B17/320783 ,  A61B17/22031 ,  A61B2017/22038 ,  A61B2017/22052

    摘要： Atherectomy device for removing material from an atheroma in the vascular system. A cutter is mounted in a cylindrical housing having a cutout on one side thereof at the distal end of a catheter. The catheter has a single luminal opening, and a flexible drive cable for operating the cutter passes through this opening. An inflatable balloon is positioned outside the housing opposite the cutout, and a medium for inflating the balloon is introduced through the luminal opening of the catheter.

    摘要翻译： 用于从血管系统中的动脉粥样化组织中去除材料的动脉粥样硬化切除装置。 切割器安装在圆柱形壳体中，在其导管的远端具有在其一侧上的切口。 导管具有单个管腔开口，并且用于操作切割器的柔性驱动电缆通过该开口。 可充气气球位于外壳的与切口相对的外侧，用于使球囊充气的介质通过导管的管腔开口引入。