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    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS
    1.
    发明申请
    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 审中-公开
    用于预测和预防保留的装置和方法

    公开(公告)号：US20140005534A1

    公开(公告)日：2014-01-02

    申请号：US14019466

    申请日：2013-09-05

    申请人： Xuanmin HE ,  John B. SIMPSON ,  Michael H. ROSENTHAL ,  John F. BLACK

    发明人： Xuanmin HE ,  John B. SIMPSON ,  Michael H. ROSENTHAL ,  John F. BLACK

    IPC分类号： A61B5/02 ,  A61B17/22 ,  A61F2/06 ,  A61B5/00 ,  A61M31/00

    CPC分类号： A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/4836 ,  A61B17/22 ,  A61F2/06 ,  A61M31/005 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30101

    摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

    摘要翻译： 本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。 预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。 例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。 可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。 用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

    Methods using pressure to obtain fluids and cellular material from breast ducts
    4.
    发明授权
    Methods using pressure to obtain fluids and cellular material from breast ducts 有权
    使用压力从乳房导管获得流体和细胞材料的方法

    公开(公告)号：US06494859B2

    公开(公告)日：2002-12-17

    申请号：US09301058

    申请日：1999-04-28

    申请人： Susan M. Love ,  David Hung ,  Xuanmin He

    发明人： Susan M. Love ,  David Hung ,  Xuanmin He

    IPC分类号： A61M100

    CPC分类号： A61B10/0045

    摘要： Methods, kits, and apparatus for obtaining cellular, chemical, and other materials from breast ducts are described. A single milk duct is accessed and washed with a washing fluid to obtain marker materials from the lining the duct. The washing fluid is then collected, and the marker materials in the washing fluid identified and analyzed. Usually, the washing fluid is introduced using a syringe through a lumen of a dual-lumen catheter. The ductal volume is filled with the washing fluid and excess fluid flows outwardly through a second lumen of the dual-lumen catheter, from which it is collected. Methods and kits provide for collection of fluid and cells by a lavage procedure that includes applying external pressure to the breast to improve the yield of fluid and cells from the breast duct.

    摘要翻译： 描述了从乳房导管获得细胞，化学和其他材料的方法，试剂盒和装置。 单个牛奶管被接入并用洗涤液洗涤，以从管道衬里获得标记材料。 然后收集洗涤液，并鉴定和分析洗涤液中的标记物质。 通常，使用注射器通过双腔导管的内腔引入洗涤液。 导管体积填充有洗涤液，过量的流体向外流过双腔导管的第二腔，从其收集。 方法和试剂盒通过灌洗程序提供流体和细胞的收集，其包括向乳房施加外部压力以提高流体和来自乳房导管的细胞的产量。

    Devices, methods and systems for collecting material from a breast duct
    5.
    发明授权
    Devices, methods and systems for collecting material from a breast duct 有权
    用于从乳房管收集材料的装置，方法和系统

    公开(公告)号：US06413228B1

    公开(公告)日：2002-07-02

    申请号：US09473510

    申请日：1999-12-28

    申请人： David Hung ,  Christopher G. M. Ken ,  Xuanmin He ,  Phillip M. Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    发明人： David Hung ,  Christopher G. M. Ken ,  Xuanmin He ,  Phillip M. Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    IPC分类号： A61B1000

    CPC分类号： A61M3/0279 ,  A61B10/0041 ,  A61B10/0045 ,  A61M3/0262 ,  A61M2210/1007 ,  G01N33/57415

    摘要： The invention provides methods, devices and systems for collecting breast ductal fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductal access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for indentification of breast precancer or cancer in patient.

    摘要翻译： 本发明提供了用于收集乳腺导管液的方法，装置和系统，包括细胞材料和用于分析的其它有用标记物。 所述方法通常包括进入至少一个乳房导管并从该管道收集与乳房中所有其他导管分开的材料。 这些装置包括导管进入装置，其提供从与乳房中的所有其他导管分开的单个管道收集流体的机会。 系统采用一起使用的方法和装置，其提供用于分析特定于被访问的乳房导管的患者的乳房状况的系统。 方法，装置和系统对于患者中乳腺癌前病变或癌症的鉴别特别有用。

    Devices, methods and systems for collecting material from a breast duct
    6.
    发明申请
    Devices, methods and systems for collecting material from a breast duct 审中-公开
    用于从乳房管收集材料的装置，方法和系统

    公开(公告)号：US20070270708A1

    公开(公告)日：2007-11-22

    申请号：US11880811

    申请日：2007-07-24

    申请人： David Hung ,  Christopher Ken ,  Xuanmin He ,  Phillip Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    发明人： David Hung ,  Christopher Ken ,  Xuanmin He ,  Phillip Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    IPC分类号： A61B10/02

    CPC分类号： A61B10/02 ,  A61B10/0041 ,  A61B10/0045 ,  A61B10/0283

    摘要： The invention provides methods, devices and systems for collecting breast ductal fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductal access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for indentification of breast precancer or cancer in patient.

    摘要翻译： 本发明提供了用于收集乳腺导管液的方法，装置和系统，包括细胞材料和用于分析的其它有用标记物。 所述方法通常包括进入至少一个乳房导管并从该管道收集与乳房中所有其他导管分开的材料。 这些装置包括导管进入装置，其提供从与乳房中的所有其他导管分开的单个管道收集流体的机会。 系统采用一起使用的方法和装置，其提供用于分析特定于被访问的乳房导管的患者的乳房状况的系统。 方法，装置和系统对于患者中乳腺癌前病变或癌症的鉴别特别有用。

    Devices and methods for predicting and preventing restenosis
    8.
    发明授权
    Devices and methods for predicting and preventing restenosis 有权
    用于预测和预防再狭窄的装置和方法

    公开(公告)号：US08548571B2

    公开(公告)日：2013-10-01

    申请号：US12963536

    申请日：2010-12-08

    申请人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    发明人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    IPC分类号： A61B1/07 ,  A61B6/00

    CPC分类号： A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/4836 ,  A61B17/22 ,  A61F2/06 ,  A61M31/005 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30101

    摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

    摘要翻译： 本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。 预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。 例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。 可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。 用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。

    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS
    9.
    发明申请
    DEVICES AND METHODS FOR PREDICTING AND PREVENTING RESTENOSIS 有权
    用于预测和预防保留的装置和方法

    公开(公告)号：US20110263936A1

    公开(公告)日：2011-10-27

    申请号：US12963536

    申请日：2010-12-08

    申请人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    发明人： Xuanmin He ,  John B. Simpson ,  Michael H. Rosenthal ,  John F. Black

    IPC分类号： A61B1/04

    CPC分类号： A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/4836 ,  A61B17/22 ,  A61F2/06 ,  A61M31/005 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30101

    摘要： The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

    摘要翻译： 本发明涉及用于预测再狭窄的方法和装置，以及用于治疗动脉粥样硬化以预防或减少再狭窄发生率的方法和装置。 预测狭窄外周动脉再狭窄的方法可能包括血管的定量组织学。 例如，治疗狭窄动脉（特别是外周动脉）的方法可包括确定组织中炎症细胞包涵体的超细胞程度和一种或多种脂质丰富度和程度的步骤。 可以确定基于组织中炎症细胞包涵体的超细胞性和脂质丰富性和/或程度的再狭窄指数。 用于治疗或预防再狭窄的系统可以包括用于成像组织区域的一种或多种成像模式，并且确定超细胞程度的水平以及组织区域中炎症细胞包含的脂质丰富程度和程度的一个或多个。