公开(公告)号：US20080092911A1

公开(公告)日：2008-04-24

申请号：US10920570

申请日：2004-08-18

申请人： Joseph H. Schulman ,  John C. Gord ,  James H. Wolfe

发明人： Joseph H. Schulman ,  John C. Gord ,  James H. Wolfe

IPC分类号： A61B19/00

CPC分类号： A61N1/37288 ,  A61B5/0008 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/07 ,  A61B5/076 ,  A61B5/1071 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0209 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/3787

摘要： A system for monitoring temperature in a body, the system comprising at least one implantable device, wherein the implantable device(s) is operable to sense temperature in the body and to generate status signals based on the sensed temperature in the body. The system further comprising a system control unit for wirelessly communicating with the implantable device(s), and the system control unit comprising a signal receiver for receiving the status signals, and also a programmable controller for producing notification signals based on the received status signals. A notification unit can alternatively communicate with the system control unit or the implantable device(s) for disclosing the sensed body temperature based on the notification signals.

摘要翻译： 一种用于监测身体温度的系统，所述系统包括至少一个可植入装置，其中所述可植入装置可操作以感测身体中的温度并基于身体中感测的温度产生状态信号。 所述系统还包括用于与所述可植入装置进行无线通信的系统控制单元，所述系统控制单元包括用于接收状态信号的信号接收器，以及用于基于接收的状态信号产生通知信号的可编程控制器。 通知单元还可以与系统控制单元或可植入装置通信，用于基于通知信号公开感测体温。

公开(公告)号：US07286883B2

公开(公告)日：2007-10-23

申请号：US11152444

申请日：2005-06-13

申请人： Joseph H. Schulman ,  Janusz Kuzma

发明人： Joseph H. Schulman ,  Janusz Kuzma

IPC分类号： A61N1/05

CPC分类号： H01R4/70 ,  A61N1/05 ,  A61N1/37205 ,  A61N1/3752 ,  H01R13/20 ,  H01R13/6273 ,  H01R24/20 ,  H01R24/28 ,  H01R2101/00 ,  H01R2201/12 ,  Y10S439/909

摘要： Methods are utilized for connecting electrically conductive wire to a miniature, implantable sensor or stimulator device for detecting electrical signals or stimulating living tissue. The implantable device has an electrically conductive end on its case which is intimately connected to a doorknob electrode for communicating electrical signals between the living tissue and the device by a biocompatible wire. A spring clip removably attaches to the doorknob electrode so that the wire may be easily attached to the doorknob electrode during surgery. An insulating rubber boot, which may be silicone, surrounds the case end, doorknob electrode, and spring clip to isolate the living tissue from the conductive components. The components are all biocompatible materials.

摘要翻译： 方法用于将导电线连接到用于检测电信号或刺激活体组织的微型可植入传感器或刺激器装置。 可植入装置在其壳体上具有导电端，其紧密连接到门把手电极，用于通过生物相容的导线传送活体组织和装置之间的电信号。 弹簧夹可拆卸地附接到门把手电极，使得线在手术期间可以容易地附接到门把手电极。 可以是硅树脂的绝缘橡胶套围绕壳体端，门把手电极和弹簧夹，以将活体组织与导电组件隔离。 组件都是生物相容性材料。

公开(公告)号：US07252005B2

公开(公告)日：2007-08-07

申请号：US10921750

申请日：2004-08-18

申请人： Joseph H. Schulman

发明人： Joseph H. Schulman

IPC分类号： G01L9/00

CPC分类号： A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0257 ,  A61B2562/0247 ,  A61N1/37205 ,  A61N1/3787 ,  G01L19/0645 ,  G01L19/086

摘要： System and apparatus for measuring pressure including a microelectronic device, an interface member attached to the microelectronic device, a pressure sensor having a diaphragm responsive to external pressure exerted upon the diaphragm, wherein the interface member is positioned between the microelectronic device and the pressure sensor and is attached to the pressure sensor providing a first cavity between the pressure sensor diaphragm and the interface member and wherein the pressure in the first cavity is set at an initial predetermined pressure.

摘要翻译： 用于测量压力的系统和装置，包括微电子器件，附接到微电子器件的接口部件，具有响应于施加在隔膜上的外部压力的隔膜的压力传感器，其中接口部件位于微电子器件和压力传感器之间， 附接到所述压力传感器，其在所述压力传感器膜片和所述界面构件之间提供第一空腔，并且其中所述第一腔体中的压力被设定在初始预定压力。

公开(公告)号：US07114502B2

公开(公告)日：2006-10-03

申请号：US10719715

申请日：2003-11-21

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

IPC分类号： A61B19/00

CPC分类号： A61N1/3787 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/07 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4519 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37288

摘要： A device configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing, typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm, having a non-circular, e.g., an oval or polygon shaped, cross-section containing a power source for powering electronic circuitry within including a controller, an address storage means, a data signal receiver and an input/output transducer. When used as a stimulator, such a device is useful in a wide variety of applications to stimulate nerves and associated neural pathways. Alternatively, devices of the present invention are configurable to monitor a biological parameter. Furthermore, a placement structure is shown for facilitating placement of the implantable device proximate to neural/muscular tissue.

摘要翻译： 一种被配置为植入患者皮肤下面以用于组织例如神经或肌肉，刺激和/或参数监测和/或数据通信的装置。 根据本发明的装置包括通常具有小于60mm的轴向尺寸和小于6mm的横向尺寸的密封外壳，其具有非圆形例如椭圆形或多边形横截面 包括用于为包括控制器，地址存储装置，数据信号接收器和输入/输出换能器的电子电路供电的电源。 当用作刺激剂时，这种装置可用于各种应用以刺激神经和相关的神经通路。 或者，本发明的装置可配置为监测生物参数。 此外，示出了放置结构，以便于将可植入装置置于靠近神经/肌肉组织的位置。

公开(公告)号：US07024249B2

公开(公告)日：2006-04-04

申请号：US10081346

申请日：2002-02-21

申请人： Ralph M. Weisner ,  David L. Canfield ,  Richard J. Nelson ,  Joseph H. Schulman

发明人： Ralph M. Weisner ,  David L. Canfield ,  Richard J. Nelson ,  Joseph H. Schulman

IPC分类号： A61N1/32

CPC分类号： A61N1/3727 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37264

摘要： A magnetic control system for selectively enabling/disabling an implantable device's operation using externally applied pulsed magnetic means, e.g., a controlled electromagnet or the like. Typically, such implantable devices stimulate a neural pathway or muscle and/or block pain or muscle stimulation according to programmable settings. Preferably, once programmed from an external programmer, such implantable devices can operate “independently” using the externally provided programmed information. However, in certain circumstances, it may be desired to stop/pause the operation of such selected implanted device while not affecting other such devices. Accordingly, embodiments of the present invention include a magnetic sensor, preferably a magnetoresistive, Hall effect, saturated core reactors, or the like, to sense an externally provided magnetic field. By externally applying pulsed magnetic fields in sequences of controlled polarities, durations, intensities, etc., and sensing these identifiable sequences and transitions, the operation of the implantable device may be enabled/disabled.

公开(公告)号：US06990372B2

公开(公告)日：2006-01-24

申请号：US10121881

申请日：2002-04-11

申请人： Christian Y. Perron ,  Joseph H. Schulman ,  Lee J. Mandell

发明人： Christian Y. Perron ,  Joseph H. Schulman ,  Lee J. Mandell

IPC分类号： A61B5/04

CPC分类号： A61N1/37288 ,  A61N1/37205

摘要： A programmable signal analysis device for detecting and counting neurological and muscular events in living tissue that incorporates one or more signal threshold levels to identify an event, a counter to count events, and a timer to determine event frequency as events per unit time. The threshold levels and counter/timer operating modes/parameters are digitally programmable to identify and count events, i.e., electrical signals having defined parameters. Such a circuit is of particular use in a microstimulator/sensor which is capable of being injected into living tissue at the site of interest. The microstimulator/sensor is used to stimulate a neural pathway or muscle and/or to block a neural pathway to alleviate pain or block stimulation of a muscle.

公开(公告)号：US06799070B2

公开(公告)日：2004-09-28

申请号：US10056848

申请日：2002-01-23

申请人： James H. Wolfe ,  John C. Gord ,  Joseph H. Schulman

发明人： James H. Wolfe ,  John C. Gord ,  Joseph H. Schulman

IPC分类号： A61N136

CPC分类号： A61N1/025 ,  A61N1/3706 ,  A61N1/378 ,  A61N1/3782 ,  A61N1/3981 ,  H02J7/345 ,  H02M3/07

摘要： Battery driven voltage control circuitry charges an output capacitor, which periodically supplies a current pulse. The circuitry converts battery voltage VBAT to a charging voltage VUPC based upon programmed parameters and the voltage VCOMPL at the capacitor. The circuitry includes a voltage converter for multiplying VBAT to produce VUPC. VCOMPL is sampled to determine its “droop” at the end of an output current pulse. If the droop is lower than a threshold, then the voltage converter increases the charging voltage. If the droop is above a threshold, then the voltage converter reduces the charging voltage. This feedback maintains the output voltage within an acceptable operating range to produce an efficacious output current pulse for stimulation without causing unproductive energy loss. In order to avoid premature depletion of battery energy, VUPC is compared with VCOMPL to determine the optimum clock rate to be used to convert VBAT to VUPC.

摘要翻译： 电池驱动电压控制电路对输出电容充电，周期性地提供电流脉冲。 该电路根据编程参数和电容器上的电压VCOMPL将电池电压VBAT转换为充电电压VUPC。 该电路包括用于乘以VBAT以产生VUPC的电压转换器。 VCOMPL被采样以确定其在输出电流脉冲结束时的“下降”。 如果下降低于阈值，则电压转换器增加充电电压。 如果下降高于阈值，则电压转换器降低充电电压。 该反馈将输出电压维持在可接受的工作范围内，以产生用于刺激的有效输出电流脉冲，而不会导致非生产性能量损失。 为了避免电池能量过早耗尽，VUPC与VCOMPL进行比较，以确定用于将VBAT转换为VUPC的最佳时钟速率。

公开(公告)号：US06512939B1

公开(公告)日：2003-01-28

申请号：US09604179

申请日：2000-06-27

申请人： Michael S. Colvin ,  Joseph H. Schulman ,  Lyle Dean Canfield ,  Rajiv Shah

发明人： Michael S. Colvin ,  Joseph H. Schulman ,  Lyle Dean Canfield ,  Rajiv Shah

IPC分类号： A61B505

CPC分类号： A61B5/14865 ,  A61B5/0031

摘要： Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose, are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments, a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used. In a further embodiment, the monitoring systems use enzyme and electrolyte reservoir bulbs in fluid communication with the enzyme and electrolyte reservoirs, respectively, and positioned near the skin surface, thereby providing ready access to the enzyme and electrolyte solutions without the need for explantation of the device. Further provided herein is an enzyme solution comprising microspheres in association with the enzyme; whereby the enzyme is immobilized by the microspheres and the microspheres are in a fluid, flowable solution. Also provided herein is a method of extending the useful life of an implantable enzyme-based monitoring system, which method comprises providing means, within the system, to replenish the enzyme and/or electrolyte solution.

摘要翻译： 本文描述了适于长期体内使用的改进的可植入监测系统，以测量一种或多种规定物质如葡萄糖的浓度。 特别地，描述了可植入酶的葡萄糖监测系统，其包括以下至少一个：用于在酶反应消耗的时候补充酶溶液的装置; 用于补充洗涤电极组件的电解液的装置; 并且微处理装置近似于电极组件。 在优选实施例中，微处理器组件与固定电极组件的基板气密地相关联。 此外，监测系统采用与酶和电解质室流体连通的一个或多个储存器系统，其中使用酶和电解质溶液。 在另一个实施方案中，监测系统使用分别与酶和电解质储存器流体连通并且定位在皮肤表面附近的酶和电解质储存器灯泡，从而提供对酶和电解质溶液的准备进入，而不需要移除 设备。 本文进一步提供了包含与酶结合的微球的酶溶液; 由此通过微球固定酶，并且微球体处于流动的可流动溶液中。 本文还提供了延长可植入酶的监测系统的使用寿命的方法，该方法包括在系统内提供补充酶和/或电解质溶液的装置。

公开(公告)号：US06507758B1

公开(公告)日：2003-01-14

申请号：US09515383

申请日：2000-02-29

申请人： Robert J. Greenberg ,  Abraham N. Seidman ,  Joseph H. Schulman

发明人： Robert J. Greenberg ,  Abraham N. Seidman ,  Joseph H. Schulman

IPC分类号： A61N118

CPC分类号： A61N1/36046 ,  A61F9/08

摘要： This invention is for directly modulating a beam of photons onto the retinas of patients who have extreme vision impairment or blindness. Its purpose is to supply enough imaging energy to retinal prosthetics implanted in the eye which operate essentially by having light (external to the eye) activating photoreceptors, or photo-electrical material. The invention provides sufficient light amplification and does it logarithmically. While it has sufficient output light power, the output light level still remains at a safe level. Most preferred embodiments of this invention provide balanced biphasic stimulation with no net charge injection into the eye. Both optical and electronic magnification for the image, as for example, using an optical zoom lens, is incorporated. Otherwise, it would not be feasible to zoom in on items of particular interest or necessity. Without proper adjustment, improper threshold amplitudes would obtain, as well as uncomfortable maximum thresholds. Therefore, to adjust for these, a way of proper adjustment for the threshold amplitudes and maximum comfortable thresholds is provided. Furthermore, to the extent that individual stimulation sites in the retina give different color perceptions, upon stimulation, then colors of the viewed scene is correlated with specific stimulation sites to provide a certain amount of color vision.

摘要翻译： 本发明用于将光束束直接调制到具有极端视力障碍或失明的患者的视网膜上。 其目的是为植入眼睛的视网膜假体提供足够的成像能量，其基本上通过使光（外部的眼睛）激活感光器或光电材料。 本发明提供足够的光放大，并且它是对数的。 虽然它具有足够的输出光功率，但输出光级仍然保持在一个安全的水平。 本发明最优选的实施方案提供平衡的双相刺激，而没有净电荷注入眼睛。 包括用于图像的光学和电子倍率，例如使用光学变焦透镜。 否则，放大特别感兴趣或必要的项目是不可行的。 没有适当的调整，不正确的阈值振幅将获得，以及不舒适的最大阈值。 因此，为了适应这些，提供了适当调整阈值振幅和最大舒适阈值的方法。 此外，在视网膜中的个别刺激部位产生不同的颜色感觉的情况下，在刺激时，所观看场景的颜色与特定刺激部位相关联，以提供一定量的色觉。

公开(公告)号：US06035237A

公开(公告)日：2000-03-07

申请号：US447455

申请日：1995-05-23

申请人： Joseph H. Schulman ,  Alfred E. Mann ,  John C. Gord ,  Ronald J. Lebel

发明人： Joseph H. Schulman ,  Alfred E. Mann ,  John C. Gord ,  Ronald J. Lebel

IPC分类号： A61N1/08 ,  A61N1/32 ,  A61N1/36 ,  A61N1/16

CPC分类号： A61N1/36142 ,  A61N1/36125

摘要： An implantable living tissue stimulator avoids the use of conventional coupling capacitors in its output stage, yet still prevents an average dc current flow from flowing through living tissue in electrical contact with the stimulator. The output stage generates and applies a biphasic stimulating current pulse to selected paired output terminals. The terminals, in turn, are electrically connected to respective electrodes which are positioned so as to contact the living tissue to be stimulated. In one embodiment, special circuitry is employed within the output stage to block dc current flow through the living tissue and to balance the electrical charge that is delivered to the living tissue. In another embodiment, the electrodes themselves are made from a material that allows them to function as a capacitor. In yet an additional embodiment, the coupling capacitors are integrated into the leads that connect the output terminals of the output stage with the electrodes.

摘要翻译： 植入式生物组织刺激器避免了在其输出阶段使用传统的耦合电容器，但仍然阻止平均直流电流流过活组织与刺激器电接触。 输出级产生并将双相刺激电流脉冲施加到选定的配对输出端子。 这些端子又电连接到相应的电极，这些电极定位成接触待刺激的生物体组织。 在一个实施例中，在输出级内采用特殊电路来阻止直流电流流过活组织并平衡输送到生物体组织的电荷。 在另一个实施例中，电极本身由允许它们用作电容器的材料制成。 在又一个实施例中，耦合电容器集成到将输出级的输出端与电极连接的引线中。