公开(公告)号：US20060074220A1

公开(公告)日：2006-04-06

申请号：US10219062

申请日：2002-08-12

申请人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

发明人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

IPC分类号： C07K14/47

CPC分类号： C07K14/705 ,  C07K14/47 ,  G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20060074221A1

公开(公告)日：2006-04-06

申请号：US10219064

申请日：2002-08-13

申请人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

发明人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

IPC分类号： C07K14/47 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K16/18

CPC分类号： C07K14/705 ,  C07K14/47 ,  G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20050014225A1

公开(公告)日：2005-01-20

申请号：US10858981

申请日：2004-06-01

申请人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Margaret Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Margaret Roy ,  William Wood

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/1709

摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070207147A1

公开(公告)日：2007-09-06

申请号：US11552437

申请日：2006-10-24

申请人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

发明人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K14/705 ,  C07K14/47 ,  G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20060074223A1

公开(公告)日：2006-04-06

申请号：US10218784

申请日：2002-08-12

申请人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

发明人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

IPC分类号： C07K16/18

CPC分类号： C07K14/705 ,  C07K14/47 ,  G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20060073476A1

公开(公告)日：2006-04-06

申请号：US10233134

申请日：2002-08-29

申请人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

发明人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

IPC分类号： C12Q1/68 ,  C12P21/06

CPC分类号： C07K14/47 ,  C07K14/435 ,  C12N9/00 ,  C12N2510/00 ,  C12P21/02

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20050059115A1

公开(公告)日：2005-03-17

申请号：US10943353

申请日：2004-09-17

申请人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Margaret Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Margaret Roy ,  William Wood

IPC分类号： A61K38/00 ,  A61K38/17 ,  C07H21/02 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N1/18 ,  C12N1/21 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/70578 ,  C07K16/18 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2799/026 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5085 ,  G01N33/57484 ,  G01N33/68

摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20070174922A1

公开(公告)日：2007-07-26

申请号：US10373512

申请日：2003-02-24

申请人： Nico Ghilardi ,  Frederic de Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

发明人： Nico Ghilardi ,  Frederic de Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/7158

摘要： The present invention is directed to novel polypeptides having sequence similarity to Interleukin 6 receptor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及与白细胞介素6受体具有序列相似性的新型多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070136829A1

公开(公告)日：2007-06-14

申请号：US11548639

申请日：2006-10-11

申请人： Nico Ghilardi ,  Frederic De Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

发明人： Nico Ghilardi ,  Frederic De Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/7158

摘要： The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.

摘要翻译： 本发明涉及GLM-R多肽的新型多肽及其变体以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 还提供了用于检测调节GLM-R的活性的试剂的方法。 还提供了用于诊断和治疗特征在于单核细胞或巨噬细胞过度或不丰富的疾病的方法。

公开(公告)号：US20060177897A1

公开(公告)日：2006-08-10

申请号：US11191669

申请日：2005-07-27

申请人： Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Colin Watanabe ,  William Wood

发明人： Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Colin Watanabe ,  William Wood

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/705 ,  C12N1/21 ,  C12N5/06 ,  C12N15/74 ,  C12N1/18

CPC分类号： C07K14/705 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/30 ,  C07K2319/40

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。