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109 条记录 (耗时 0.054 秒)

    Sealing of thief zones
    41.
    发明授权
    Sealing of thief zones 有权
    密封小偷区

    公开(公告)号：US08733441B2

    公开(公告)日：2014-05-27

    申请号：US13129950

    申请日：2009-11-18

    申请人： Michael Jensen

    发明人： Michael Jensen

    IPC分类号： E21B33/138 ,  E21B43/27 ,  C09K8/46 ,  C09K8/467

    CPC分类号： C04B28/14 ,  C04B28/16 ,  C09K8/46 ,  C09K8/5045

    摘要： The present invention provides a method for selectively sealing a thief zone in a hydrocarbon reservoir located in a calcium-rich formation and penetrated by a borehole comprising injecting into the thief zone a sealing fluid comprising a mixture of and hydronium ions (H+) and a source of sulfate ions (SO42−) which mixture can provide precipitation of a designated calcium sulfate compound.

    摘要翻译： 本发明提供了一种用于选择性地密封位于富钙地层中并被钻孔穿透的烃储层中的小偷区的方法，包括将包含水合氢离子（H +）和源的混合物的密封流体 的硫酸根离子（SO42-），该混合物可以提供指定的硫酸钙化合物的沉淀。

    Wind turbine configuration management system, and central computer system therefor
    42.
    发明授权
    Wind turbine configuration management system, and central computer system therefor 失效
    风力发电机配置管理系统及其中央计算机系统

    公开(公告)号：US08509956B2

    公开(公告)日：2013-08-13

    申请号：US12937382

    申请日：2009-06-08

    申请人： Michael Jensen

    发明人： Michael Jensen

    IPC分类号： G06F19/00

    CPC分类号： F03D7/047 ,  F03D7/048 ,  Y02E10/721 ,  Y02E10/723

    摘要： A wind turbine configuration management system, a central computer system and a method is provided. The configuration management system includes a central computer system and a wind turbine control system controlling a wind turbine. The central computer system is coupled to the wind turbine control system over a communication network. A processing unit of the central computer is configured to periodically request configuration data from the wind turbine control system, receive configuration data from the wind turbine control system and to compare the received configuration data to a stored data.

    摘要翻译： 提供了一种风力涡轮机配置管理系统，中央计算机系统和方法。 配置管理系统包括中央计算机系统和控制风力涡轮机的风力涡轮机控制系统。 中央计算机系统通过通信网络耦合到风力涡轮机控制系统。 中央计算机的处理单元被配置为周期性地请求来自风力涡轮机控制系统的配置数据，从风力涡轮机控制系统接收配置数据，并将接收到的配置数据与存储的数据进行比较。

    WIND PARK NETWORK SYSTEM
    43.
    发明申请
    WIND PARK NETWORK SYSTEM 审中-公开
    WIND PARK网络系统

    公开(公告)号：US20130103801A1

    公开(公告)日：2013-04-25

    申请号：US13805682

    申请日：2010-09-24

    申请人： Ulrich Vestergaard B. Hansen ,  Jannik Hoejgaard ,  Michael Jensen ,  Vivek Kulkarni

    发明人： Ulrich Vestergaard B. Hansen ,  Jannik Hoejgaard ,  Michael Jensen ,  Vivek Kulkarni

    IPC分类号： H04L29/06

    CPC分类号： H04L65/1013 ,  F03D7/047 ,  F03D7/048 ,  H02J3/386 ,  H04L12/40176 ,  H04L12/462 ,  H04L2012/4026 ,  Y02E10/723 ,  Y02E10/763

    摘要： A wind park network system is provided. The network system has a first and a second networks, a first and a second wind turbines representing a first and a second network elements, a first central unit and a second central unit for transmitting messages within the first and the second networks respectively. The first and the second wind turbines are connected to the first and the second central units within the first and the second networks respectively. The first and the second central units are connected. The first and the second networks are in a star topology and operate independently from each other such that a redundant network topology for the first and the second networks is realized.

    摘要翻译： 提供风电场网络系统。 网络系统具有第一和第二网络，分别代表第一和第二网络元件的第一和第二风力涡轮机，第一中央单元和第二中央单元，用于分别在第一和第二网络内传输消息。 第一和第二风力涡轮机分别连接到第一和第二网络内的第一和第二中央单元。 第一和第二中央单元相连。 第一和第二网络是星形拓扑并且彼此独立地操作，使得实现用于第一和第二网络的冗余网络拓扑。

    Chimeric immunoreceptor useful in treating human gliomas
    44.
    发明授权
    Chimeric immunoreceptor useful in treating human gliomas 有权
    嵌合免疫受体可用于治疗人神经胶质瘤

    公开(公告)号：US08324353B2

    公开(公告)日：2012-12-04

    申请号：US13046518

    申请日：2011-03-11

    申请人： Michael Jensen

    发明人： Michael Jensen

    IPC分类号： C07K16/46 ,  C07K19/00 ,  C12N5/0783 ,  C12N5/22 ,  C12N15/63

    CPC分类号： A61K38/2086 ,  A61K35/17 ,  A61K38/1774 ,  C07H21/04 ,  C07K14/5437 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/7155 ,  C07K16/46 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/0636 ,  C12N15/63

    摘要： The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targeting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.

    摘要翻译： 本发明涉及嵌合跨膜免疫受体（命名为zetakines），其由细胞外结构域组成，所述细胞外结构域包含与能够将细胞外结构域连接至细胞表面的支持区连接的可溶性受体配体，跨膜区和细胞内信号结构域。 当在T淋巴细胞表面上表达时，Zetakines将T细胞活性直接导向表达可溶性受体配体特异性受体的那些特异性细胞。 替扎林嵌合免疫受体代表了用于重定向T细胞的抗原特异性的抗体型免疫受体的新型延伸，应用于各种癌症的治疗，特别是通过人类恶性利用的自身免疫/旁分泌细胞因子系统。 在一个优选的实施方案中是包含与IgG的Fc区连接的IL-13Rα2特异性IL-13突变体IL-13（E13Y）的细胞外靶向结构域的人胶质瘤特异性免疫受体，人CD4的跨膜结构域和人 CD3ζ链。

    Chimeric immunoreceptor useful in treating human gliomas
    45.
    发明授权
    Chimeric immunoreceptor useful in treating human gliomas 有权
    嵌合免疫受体可用于治疗人神经胶质瘤

    公开(公告)号：US07514537B2

    公开(公告)日：2009-04-07

    申请号：US11274344

    申请日：2005-11-16

    申请人： Michael Jensen

    发明人： Michael Jensen

    IPC分类号： C07K16/46 ,  C12N5/22 ,  C12N15/63

    CPC分类号： C07K14/5437 ,  C07K14/7051 ,  C07K14/7155 ,  C07K2319/00 ,  C07K2319/30

    摘要： The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signaling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targeting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.

    摘要翻译： 本发明涉及由跨膜结构域组成的嵌合跨膜免疫受体，其包含与能够将细胞外结构域连接至细胞表面的支持区连接的可溶性受体配体，跨膜区和细胞内信号结构域。 当在T淋巴细胞表面上表达时，Zetakines将T细胞活性直接导向表达可溶性受体配体特异性受体的那些特异性细胞。 替扎林嵌合免疫受体代表了用于重定向T细胞的抗原特异性的抗体型免疫受体的新型延伸，应用于各种癌症的治疗，特别是通过人类恶性利用的自身免疫/旁分泌细胞因子系统。 在一个优选的实施方案中是包含与IgG的Fc区连接的IL-13Rα2-特异性IL-13突变体IL-13（E13Y）的细胞外靶向结构域的人胶质瘤特异性免疫受体，人CD4的跨膜结构域和人 CD3ζ链。

    Chemically cleavable phosphoramidite linkers
    46.
    发明申请
    Chemically cleavable phosphoramidite linkers 审中-公开
    化学上可裂解的亚磷酰胺接头

    公开(公告)号：US20090047712A1

    公开(公告)日：2009-02-19

    申请号：US11893596

    申请日：2007-08-15

    申请人： Keith Anderson ,  Michael Jensen ,  Ronald W. Davis

    发明人： Keith Anderson ,  Michael Jensen ,  Ronald W. Davis

    IPC分类号： C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C07H19/00 ,  C12P19/34

    CPC分类号： C07H21/00 ,  C07H19/00 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    摘要： The present invention provides phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linkers have the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleave to produce 5′ and 3′ ends that are fully biologically compatible, (iii) cleave completely under conditions that are already used in cleavage/deprotection processes so they are fully compatible with conditions that are common in laboratories and do not require additives that necessitate further purification after cleavage, (iv) integrate easily onto commercially available synthesizers because they are compatible with standard coupling chemistry, and (v) are compatible with DNA, RNA, forward, reverse, and synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.

    摘要翻译： 本发明提供了可用于串联合成两种或多种寡核苷酸的亚磷酰胺接头。 本发明的接头具有以下所需的性质：（i）与先前公布的接头相比，提高了对碱性条件的稳定性，（ii）切割产生完全生物相容的5'和3'末端，（iii）在条件下完全切割 已经用于裂解/去保护过程，因此它们与实验室常见的条件完全相容，并且不需要在裂解后需要进一步纯化的添加剂，（iv）容易地与市售的合成仪结合，因为它们与标准偶联化学相容， （v）与DNA，RNA，正向，反向和合成化学物质相容。 此外，本发明的接头可以连接到固体支持物。 因此，本发明的接头提供了现有技术的显着进步。

    Method for producing CE7-specific redirected immune cells
    47.
    发明授权
    Method for producing CE7-specific redirected immune cells 有权
    生产CE7特异性重定向免疫细胞的方法

    公开(公告)号：US07354762B2

    公开(公告)日：2008-04-08

    申请号：US11849643

    申请日：2007-09-04

    申请人： Michael Jensen

    发明人： Michael Jensen

    IPC分类号： C12N5/06 ,  C12N5/08 ,  C12P21/06 ,  C12P21/08 ,  C07K16/00 ,  A61K39/395 ,  C07H21/04

    CPC分类号： C07K14/7051 ,  A61K48/00 ,  C07H21/04 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30

    摘要： Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma are disclosed. In one embodiment, the immune cell is a T cell and the cell surface protein is a single chain FvFc:ζ receptor where Fv designates the VH and VL chains of a single chain monoclonal antibody to CE7 linked by peptide, Fc represents a hinge-CH2-CH3 region of a human IgG1, and ζ represents the intracellular signaling domain of the zeta chain of human CD3. DNA constructs encoding a chimeric T-cell receptor and a method of making a redirected T cell expressing a chimeric T cell receptor by electroporation using naked DNA encoding the receptor are also disclosed.

    摘要翻译： 基因工程化的CE7特异性重定向免疫细胞，其表达具有细胞外结构域的细胞表面蛋白，所述胞外结构域包含对CE7特异性的受体，细胞内信号结构域和跨膜结构域，以及用于此类细胞用于CE7 +神经母细胞瘤的细胞免疫治疗的方法 被披露。 在一个实施方案中，免疫细胞是T细胞，细胞表面蛋白是单链FvFc：ζ受体，其中Fv表示一个或更多个的V H链和V L链 通过肽连接的针对CE7的单链单克隆抗体，Fc表示人IgG 1的铰链-C 2 H 2 C 3 H 3区， 并且zeta表示人CD3的Zeta链的细胞内信号结构域。 还公开了编码嵌合T细胞受体的DNA构建体和通过使用编码受体的裸DNA通过电穿孔制备表达嵌合T细胞受体的重定向T细胞的方法。

    MULTITHREADING INSTRUCTION SCHEDULER EMPLOYING THREAD GROUP PRIORITIES
    48.
    发明申请
    MULTITHREADING INSTRUCTION SCHEDULER EMPLOYING THREAD GROUP PRIORITIES 有权
    采用螺纹组合优先的多用途指令调度器

    公开(公告)号：US20070113053A1

    公开(公告)日：2007-05-17

    申请号：US11620362

    申请日：2007-01-05

    申请人： Michael Jensen ,  Ryan Kinter

    发明人： Michael Jensen ,  Ryan Kinter

    IPC分类号： G06F9/30

    CPC分类号： G06F9/3851 ,  G06F9/3836 ,  G06F9/3857 ,  G06F9/3859 ,  G06F9/3885 ,  G06F9/4881

    摘要： A concurrent instruction dispatch apparatus includes a group indicator for each of a plurality of threads that indicates which one of a plurality of groups of the threads the thread belongs to. A group priority indicator for each group indicates an instruction dispatch priority relative to the other groups. Selection logic selects a thread for dispatching an instruction thereof based on the group and group priority indicators. A bifurcated scheduler includes first scheduler logic that issues instructions of the threads to an execution unit, second scheduler logic that enforces a thread scheduling policy, and an interface. A group indicator indicates which group each thread belongs to, a priority for each group, and execution information for each thread. The first scheduler logic issues the instructions based on the group priorities and group indicators, and the second scheduler logic updates the group indicators based on the instruction execution information.

    摘要翻译： 并行指令调度装置包括指示线程所属的多个线程组中的哪一组的多个线程中的每一个的组指示符。 每个组的组优先级指示符指示相对于其他组的指令调度优先级。 选择逻辑基于组和组优先级指示器选择用于调度其指令的线程。 分叉调度器包括将线程的指令发布到执行单元的第一调度器逻辑，强制执行线程调度策略的第二调度器逻辑和接口。 组指示符指示每个线程所属的组，每个组的优先级以及每个线程的执行信息。 第一调度器逻辑基于组优先级和组指示器发出指令，并且第二调度器逻辑基于指令执行信息更新组指示符。