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    Medical Devices Containing Rapamycin Analogs
    41.
    发明申请
    Medical Devices Containing Rapamycin Analogs 审中-公开
    含雷帕霉素类似物的医疗器械

    公开(公告)号：US20090047323A1

    公开(公告)日：2009-02-19

    申请号：US12255603

    申请日：2008-10-21

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    IPC分类号： A61F2/04 ,  A61K31/436 ,  A61K31/565

    CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

    摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

    摘要翻译： 一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层， 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于式（I）。 该药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

    Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances for treatment of vascular disorder
    42.
    发明申请
    Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances for treatment of vascular disorder 有权
    将含有四唑的雷帕霉素类似物与其他用于治疗血管疾病的治疗物质的方法

    公开(公告)号：US20090022774A1

    公开(公告)日：2009-01-22

    申请号：US12143689

    申请日：2008-06-20

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha

    IPC分类号： A61F2/04 ,  A61K31/436 ,  A61P9/00 ,  A61K31/565

    CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

    摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

    摘要翻译： 一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层， 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于：该药物可与另一药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂 ，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

    Method Of Treating Disorders Using Compositions Comprising Zotarolimus And Paclitaxel
    43.
    发明申请
    Method Of Treating Disorders Using Compositions Comprising Zotarolimus And Paclitaxel 有权
    使用佐他莫司和紫杉醇组合治疗疾病的方法

    公开(公告)号：US20080213278A1

    公开(公告)日：2008-09-04

    申请号：US12034612

    申请日：2008-02-20

    申请人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    发明人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    IPC分类号： A61K39/395 ,  A61K31/4353 ,  A61P35/00 ,  A61P37/00 ,  A61K31/56

    CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M31/002

    摘要： A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    摘要翻译： 公开了包含唑他罗莫司和紫杉醇的系统和组合物，以及递送方法，其中药物具有彼此补充的效果。 公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，该载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一层，并且涂层相关 与治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

    Medical Devices Containing Rapamycin Analogs
    44.
    发明申请
    Medical Devices Containing Rapamycin Analogs 审中-公开
    含雷帕霉素类似物的医疗器械

    公开(公告)号：US20080175884A1

    公开(公告)日：2008-07-24

    申请号：US12041537

    申请日：2008-03-03

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    IPC分类号： A61K9/00 ,  A61K31/4745 ,  A61K31/56

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/606 ,  C07D498/18

    摘要： A medical device comprises a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to drugs of Formula (I). The drugs of Formula (I) can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

    摘要翻译： 医疗装置包括能够容纳或支撑药学上可接受的载体或赋形剂的支持结构，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包括涂层，并且包含 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于式（I）的药物。 式（I）的药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物， 细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

    Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
    46.
    发明授权
    Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens 有权
    药物输送系统，试剂盒和将唑妥洛莫司和紫杉醇施用于血管腔的方法

    公开(公告)号：US07378105B2

    公开(公告)日：2008-05-27

    申请号：US11464659

    申请日：2006-08-15

    申请人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    发明人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    IPC分类号： A61F2/00 ,  A61K31/44

    CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M31/002

    摘要： A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    摘要翻译： 公开了包含唑他罗莫司和紫杉醇的系统和组合物，以及递送方法，其中药物具有彼此补充的效果。 公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，该载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一层，并且涂层相关 与治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。